LOCUS       NM_001031643            1536 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus tRNA aspartic acid methyltransferase 1 (Trdmt1),
            mRNA.
ACCESSION   NM_001031643 XM_214514
VERSION     NM_001031643.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1536)
  AUTHORS   Li,Z., Qi,X., Zhang,X., Yu,L., Gao,L., Kong,W., Chen,W., Dong,W.,
            Luo,L., Lu,D., Zhang,L. and Ma,Y.
  TITLE     TRDMT1 exhibited protective effects against LPS-induced
            inflammation in rats through TLR4-NF-kappaB/MAPK-TNF-alpha pathway
  JOURNAL   Animal Model Exp Med 5 (2), 172-182 (2022)
   PUBMED   35474613
  REMARK    GeneRIF: TRDMT1 exhibited protective effects against LPS-induced
            inflammation in rats through TLR4-NF-kappaB/MAPK-TNF-alpha pathway.
REFERENCE   2  (bases 1 to 1536)
  AUTHORS   Tuorto,F., Liebers,R., Musch,T., Schaefer,M., Hofmann,S.,
            Kellner,S., Frye,M., Helm,M., Stoecklin,G. and Lyko,F.
  TITLE     RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability
            and protein synthesis
  JOURNAL   Nat Struct Mol Biol 19 (9), 900-905 (2012)
   PUBMED   22885326
REFERENCE   3  (bases 1 to 1536)
  AUTHORS   Jurkowski,T.P., Meusburger,M., Phalke,S., Helm,M., Nellen,W.,
            Reuter,G. and Jeltsch,A.
  TITLE     Human DNMT2 methylates tRNA(Asp) molecules using a DNA
            methyltransferase-like catalytic mechanism
  JOURNAL   RNA 14 (8), 1663-1670 (2008)
   PUBMED   18567810
REFERENCE   4  (bases 1 to 1536)
  AUTHORS   Goll,M.G., Kirpekar,F., Maggert,K.A., Yoder,J.A., Hsieh,C.L.,
            Zhang,X., Golic,K.G., Jacobsen,S.E. and Bestor,T.H.
  TITLE     Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2
  JOURNAL   Science 311 (5759), 395-398 (2006)
   PUBMED   16424344
REFERENCE   5  (bases 1 to 1536)
  AUTHORS   Numachi,Y., Yoshida,S., Yamashita,M., Fujiyama,K., Naka,M.,
            Matsuoka,H., Sato,M. and Sora,I.
  TITLE     Psychostimulant alters expression of DNA methyltransferase mRNA in
            the rat brain
  JOURNAL   Ann N Y Acad Sci 1025, 102-109 (2004)
   PUBMED   15542706
REFERENCE   6  (bases 1 to 1536)
  AUTHORS   Hermann,A., Schmitt,S. and Jeltsch,A.
  TITLE     The human Dnmt2 has residual DNA-(cytosine-C5) methyltransferase
            activity
  JOURNAL   J Biol Chem 278 (34), 31717-31721 (2003)
   PUBMED   12794065
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098700.1.
            
            On Aug 12, 2005 this sequence version replaced XM_214514.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098700.1, SRR8487230.148933.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1536
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.3"
     gene            1..1536
                     /gene="Trdmt1"
                     /gene_synonym="Dnmt2"
                     /note="tRNA aspartic acid methyltransferase 1"
                     /db_xref="GeneID:291324"
                     /db_xref="RGD:1306292"
     exon            1..98
                     /gene="Trdmt1"
                     /gene_synonym="Dnmt2"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..1210
                     /gene="Trdmt1"
                     /gene_synonym="Dnmt2"
                     /EC_number="2.1.1.204"
                     /note="tRNA (cytosine-5-)-methyltransferase; DNA
                     (cytosine-5)-methyltransferase-like protein 2; DNA
                     methyltransferase 2"
                     /codon_start=1
                     /product="tRNA (cytosine(38)-C(5))-methyltransferase"
                     /protein_id="NP_001026813.1"
                     /db_xref="GeneID:291324"
                     /db_xref="RGD:1306292"
                     /translation="MEPLRVLELYSGIGGMHHALRESRVPAHVVAAIDVSTVANEVYK
                     HNFPHTHLLAKTIEGISLEEFDKLSFNMILMSPPCQPFTRIGLQGDMSDRRTNSFLYI
                     LDILPRLQKLPKYILLENVKGFEVSSTRGLLIQTMEACGFQYQEFLLSPSSLGIPNSR
                     LRYFLIAKLQSEPLCFQAPGQILMEFPNSGTVQPQEYAVVEEGKLRVRTREPDVCLDS
                     SSTQCSGQDSILFKHETAADIDRKRQQDSDLSVQMLKGFLEDGDTAQYLLPAKSLLRY
                     ALLLDIVKPTSRRSMCFTKGYGSYIEGTGSVLQTAEDVQIENIYKSLPDLPPEEKIAK
                     LSMLKLRYFTPKEIANLLGFPPEFGFPEKTTVKQRYRLLGNSLNVHVVSKLLTVLCE"
     exon            99..208
                     /gene="Trdmt1"
                     /gene_synonym="Dnmt2"
                     /inference="alignment:Splign:2.1.0"
     exon            209..285
                     /gene="Trdmt1"
                     /gene_synonym="Dnmt2"
                     /inference="alignment:Splign:2.1.0"
     exon            286..357
                     /gene="Trdmt1"
                     /gene_synonym="Dnmt2"
                     /inference="alignment:Splign:2.1.0"
     exon            358..423
                     /gene="Trdmt1"
                     /gene_synonym="Dnmt2"
                     /inference="alignment:Splign:2.1.0"
     exon            424..493
                     /gene="Trdmt1"
                     /gene_synonym="Dnmt2"
                     /inference="alignment:Splign:2.1.0"
     exon            494..577
                     /gene="Trdmt1"
                     /gene_synonym="Dnmt2"
                     /inference="alignment:Splign:2.1.0"
     exon            578..921
                     /gene="Trdmt1"
                     /gene_synonym="Dnmt2"
                     /inference="alignment:Splign:2.1.0"
     exon            922..979
                     /gene="Trdmt1"
                     /gene_synonym="Dnmt2"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1109
                     /gene="Trdmt1"
                     /gene_synonym="Dnmt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1506
                     /gene="Trdmt1"
                     /gene_synonym="Dnmt2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctagtttcca ggccgcggtc gcggttgcga gaggatggaa cctctgcgtg tcctggagct
       61 gtacagtggc attgggggca tgcaccacgc gctgcgagaa agccgtgtcc ctgcacatgt
      121 ggtggctgct attgacgtga gcactgttgc taacgaagta tacaagcata acttccctca
      181 tacacactta ctggcaaaga caatcgaagg tatttcactg gaagagtttg acaagctatc
      241 tttcaatatg attttaatga gccctccatg tcagccattc acaagaattg gcctacaggg
      301 ggacatgagt gatcgaagga caaatagctt cttgtatatt ctagatattc tcccaaggtt
      361 acagaagtta cccaagtata ttcttttaga aaatgtcaaa gggtttgaag tttcttctac
      421 aagagggctg ctgatacaaa caatggaagc ctgcggcttt cagtatcaag agtttctgtt
      481 gtctccgtcc tctctaggca ttccaaactc aaggctacgg tattttctca ttgcgaagct
      541 tcagtcagag cctctctgtt tccaggcccc tggccagata ctgatggagt ttcctaatag
      601 tggaacagtt cagccacaag aatatgcagt agttgaagaa ggcaagctga gagtgaggac
      661 aagggagcca gatgtctgcc ttgatagcag cagcacccag tgctctggac aagatagcat
      721 tctttttaag cacgagactg cagcagacat tgacaggaag cgccaacagg acagtgacct
      781 ctctgtgcag atgctgaaag gtttccttga agatggtgac acagctcagt accttctgcc
      841 agcgaagtcg ctgctgcgct acgctctcct cctcgacatc gttaagccca cctccaggag
      901 gtccatgtgc ttcactaaag ggtatggaag ctacatagaa gggacaggct ctgtgttaca
      961 gactgcagag gatgtgcaga ttgagaatat ctacaaatct cttcctgatt tgccaccaga
     1021 agagaagata gctaaattgt caatgcttaa actgcgatat ttcacaccta aagaaattgc
     1081 aaatctcctg ggatttcctc cagaatttgg gtttcctgag aagacaacgg tgaagcagcg
     1141 ttaccggctg ctcggcaaca gcctcaacgt gcatgtcgtc tcaaagctcc ttacagtcct
     1201 gtgtgagtga gagacgtggg agagccgctg aggcgtcaga gtatgcctct aattctagac
     1261 agtcatccca aaattctatc ttgaattaat tcttataaaa ctcaactaaa ttattttagt
     1321 tgcgttttag cgggtaattc agagggaact taaatgtgca tatcttattg tttccttaaa
     1381 tttatattac tgtatctgac aaacttcaca ttgctgtttt tgctttatgg gcaaatattt
     1441 tttataaagc tttaaacatg tacattaaat attttatatt ttgctataaa caaatttaag
     1501 aatgttaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
