LOCUS       NM_001039163            3400 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus trafficking regulator of GLUT4 (SLC2A4) 1
            (Trarg1), mRNA.
ACCESSION   NM_001039163 XM_340855
VERSION     NM_001039163.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3400)
  AUTHORS   Fazakerley,D.J., Naghiloo,S., Chaudhuri,R., Koumanov,F.,
            Burchfield,J.G., Thomas,K.C., Krycer,J.R., Prior,M.J., Parker,B.L.,
            Murrow,B.A., Stockli,J., Meoli,C.C., Holman,G.D. and James,D.E.
  TITLE     Proteomic Analysis of GLUT4 Storage Vesicles Reveals Tumor
            Suppressor Candidate 5 (TUSC5) as a Novel Regulator of Insulin
            Action in Adipocytes
  JOURNAL   J Biol Chem 290 (39), 23528-23542 (2015)
   PUBMED   26240143
  REMARK    GeneRIF: findings functionally link TUSC5 to GLUT4 trafficking,
            insulin action, insulin resistance, and PPARgamma action in the
            adipocyte
REFERENCE   2  (bases 1 to 3400)
  AUTHORS   Beaton,N., Rudigier,C., Moest,H., Muller,S., Mrosek,N., Roder,E.,
            Rudofsky,G., Rulicke,T., Ukropec,J., Ukropcova,B., Augustin,R.,
            Neubauer,H. and Wolfrum,C.
  TITLE     TUSC5 regulates insulin-mediated adipose tissue glucose uptake by
            modulation of GLUT4 recycling
  JOURNAL   Mol Metab 4 (11), 795-810 (2015)
   PUBMED   26629404
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3400)
  AUTHORS   Koide,H., Shibata,T., Yamada,N., Asaki,T., Nagao,T., Yoshida,T.,
            Noguchi,Y., Tanaka,T., Saito,Y. and Tatsuno,I.
  TITLE     Tumor suppressor candidate 5 (TUSC5) is expressed in brown
            adipocytes
  JOURNAL   Biochem Biophys Res Commun 360 (1), 139-145 (2007)
   PUBMED   17592729
  REMARK    GeneRIF: These data suggested that TUSC5 is involved in the
            differentiation, and its expression is regulated independently of
            the beta-adrenergic pathway in BAT.
REFERENCE   4  (bases 1 to 3400)
  AUTHORS   Shibata,T., Koide,H., Hayashi,R., Nagata,K., Takeo,C., Yoshida,T.,
            Noguchi,Y., Tanaka,T., Saito,Y. and Tatsuno,I.
  TITLE     Molecular cloning and characterization of rat brain endothelial
            cell derived gene-1 (tumor suppressor candidate 5) expressing
            abundantly in adipose tissues
  JOURNAL   Mol Cell Endocrinol 263 (1-2), 38-45 (2007)
   PUBMED   17007998
  REMARK    GeneRIF: detected as a gene dominantly expressed in rat brain
            endothelial cells; abundantly expressed in adipose tissues
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 25, 2020 this sequence version replaced NM_001039163.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB218813.1, SRR26643292.41865.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-812               JAXUCZ010000010.1  62019281-62020092
            813-945             JAXUCZ010000010.1  62034331-62034463
            946-3400            JAXUCZ010000010.1  62037212-62039666
FEATURES             Location/Qualifiers
     source          1..3400
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..3400
                     /gene="Trarg1"
                     /gene_synonym="DSPB1; Tusc5"
                     /note="trafficking regulator of GLUT4 (SLC2A4) 1"
                     /db_xref="GeneID:360576"
                     /db_xref="RGD:1307639"
     exon            1..812
                     /gene="Trarg1"
                     /gene_synonym="DSPB1; Tusc5"
                     /inference="alignment:Splign:2.1.0"
     CDS             435..956
                     /gene="Trarg1"
                     /gene_synonym="DSPB1; Tusc5"
                     /note="tumor suppressor candidate 5 homolog; BEC-1; brain
                     endothelial cell-derived protein 1; dispanin subfamily B
                     member 1"
                     /codon_start=1
                     /product="trafficking regulator of GLUT4 1"
                     /protein_id="NP_001034252.1"
                     /db_xref="GeneID:360576"
                     /db_xref="RGD:1307639"
                     /translation="MANPVQPQLQDPGSTSPLDLPEMEKLLTKVENKDDQALNLSKSL
                     SGALDLEQNGHSLPFKVISEGHRQPSLSGSPSRASSRRASSVVTTSYAQDQEAPKDYL
                     VLAIASCFCPVWPLNLIPLIFSIMSRSSVQQGDLDGARRLGRLARLLSITFIILGIVI
                     IIVAVTVNFTVPK"
     exon            813..945
                     /gene="Trarg1"
                     /gene_synonym="DSPB1; Tusc5"
                     /inference="alignment:Splign:2.1.0"
     exon            946..3400
                     /gene="Trarg1"
                     /gene_synonym="DSPB1; Tusc5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgagcttc cctgcgtctt cacactcact cactggagag cagaggaaag gagcaatctt
       61 ctctttgctc tccctgcttt ctcttgcttc cccgcccatc tgtgcagtca gcagctccag
      121 caaagttggc ctcaaactta aacggagctg aagcctctag cttcctcaga gctccaaggt
      181 ggtggttgtg gtggcagtgg cagtggcagc agcagcagcg gcggcagcag cagcagcagg
      241 cggctccagg ctccagcggt ggactccgag atccttgaga agctcttctg aatcttccag
      301 cacccagcta gcccctagcc ctctgcaaaa cacacccaga ggtttgaaat ctggactggc
      361 ggatggggtg ctgaggaccc tctggagcac gttatcctta tcgggacttg aaaaaaccca
      421 aggcccaagt caacatggcc aacccagtgc agcctcagct tcaagaccca ggctccacct
      481 cacccttgga tctgcccgag atggagaagc ttctcaccaa agtggagaac aaggatgacc
      541 aagccttgaa tctgtccaag tctctgtcag gggctctgga tctggagcag aatggtcaca
      601 gcctaccctt caaggtcatc tccgaggggc accgccaacc ttccctttct ggttcccctt
      661 cccgggccag ctctcggcga gcatcctccg tcgtcaccac ctcctacgcc caggaccaag
      721 aagcccccaa agattacctg gtccttgcca ttgcctcttg cttctgcccc gtctggcccc
      781 tcaacctcat ccccctcatc ttttccatca tgtctcgaag tagtgtgcag cagggggacc
      841 tggatggggc acggaggctg ggccgcctgg cacggctgct tagcatcacc ttcatcatcc
      901 tgggtatcgt tatcatcatc gtggctgtca ctgtcaactt cacagttccg aagtaaccac
      961 agagctgttt ggagcggagg cagacgccag ccagctggag agctccgacc gaacccacat
     1021 gtccccacac attacagagg acaggatggt ggctgccgag tgcccacctg tccccaagct
     1081 ccaaaagcac aaacttggag ggaaatctct acgtcactcc tttgtcagcc cacggcagac
     1141 ggaagggaaa atctggaatg aagttggccg tgaactcaat ctcatagtta catctctcgc
     1201 cttttgacct cagttctcgg gcttgtttct catcccacaa ttcctgggac ttacacgtag
     1261 cgtaaactgc cagaatggga agaaaaccag ccccacagcc aagaaagaag cactgggtgt
     1321 ctatggacat gagcacatct tttctatttt tcttgaaggg gagtaaacag atggcttgca
     1381 tgctttgtgc cgagcatcca ctgtgatccc agccggagcc cagggggaat ctgtcactca
     1441 gcacagaccc tggataccca ctggcaaaga gacaagagcc acatggaaat cctctattga
     1501 tgactggata ggaatagcat ggcacacctg gcactcttgc cgaatgtcaa gctcgaggct
     1561 tctctaccaa ggactctgga tccagagtgt tttccagaac tgcaggttct gcctcttgat
     1621 ttccacctgt gctatacctg caggcaccca tctggaagcc ctagaacttg acctgtccca
     1681 ggtcttgcca cggactcttt ggaggtctgg gatcccattt ggtaacctac acaagtggtt
     1741 caggagcctt atacagggta ttcaggggat cctacacaga agagctgaag tggatcctgg
     1801 cttcagactg ttagccgagc tctaatggat gctctgttcc tggtcctggg tcccaggcca
     1861 ttcacagcag catcagcttt ccccagaggt agctttgaga ctcctactgg actctgttta
     1921 ttcaaaggtt ctgggaagtc tttgctgccg cttgtaaggg agggagctag agaattctta
     1981 ggaaggcatg ttatttcttg acctggagtc caaggagtcc ggcaggagag gctcagctga
     2041 aagggcagtt tggggagtag ggaccatgac tggaagcaaa ggcccagtag gccctagtct
     2101 taggacctag cagaacacgg gaaagaagcc gaacagccct ctgccaaacg gcctcatgct
     2161 cgtcgcatct ctatttctcc atttattttt gcctggctgt gcccacgggg gcttcacctg
     2221 ctggccttgc ctgctctgag ccccgtctac ccatgtcata ctccactggc accaccacct
     2281 tcagctcaga cctgctagag gggcctcccc tgcccagcag ccaggattat tggcttcagg
     2341 gggggggagg ggacaggtct actgccatca ctacactggc tggggatggg aagttcactt
     2401 cctctgagca aaattaggat cctgatccct ccttccccag gctccatgct tggctcccta
     2461 aaatctcaga gatgctggac aggccaagtt agcacagagc gctggctgct gggagaggct
     2521 ctggggtttc agagcagctg cttggaggac tgaggtgttg ggagtgtctc ttagggggtt
     2581 ggtgccccta agtcaggctc ccactgagga agtgaacttg gacttctgtt cctaaagcag
     2641 gaactggctg cccacccttt gtgggacctc tgaaaccaaa ctagggacat cctcgttttc
     2701 tgtgggaagt gagcaggtga acccagagcg agtgtgcgat ttgagaggtt cctacctaaa
     2761 gaacacttgt cctagactcc cgatcctgag tgggtggcct cctaaaggcc ctcccaggac
     2821 agatactgtg tagtcattgt catgatggct tctacaccac tggagtctag gtcacaccca
     2881 gccattcctc cctgtctctt agtcagagct gtacactagg cctgccagtc acaccttcac
     2941 acatgcacac ccgcacacac tcacacactc attcgtactt cagtctggaa caaactgagt
     3001 ctctatatta gggggatggc ttagccagaa caggcaagaa caacctggga gcctcccagt
     3061 ggtttcgggg acccagcctg gaggtcccca agatatcccc tggacagacg gagcacaggg
     3121 caggaggaga gagacattgg ggtggaagga gagtgagtga gagttctctc agtccccagt
     3181 tcccactgga gctcagaggg acggggccct gccatctgaa ctctggcttg gttcagctgc
     3241 cggctgtatg atcccagtgg ctgagcggag tgactcagcc tctcctgggc atcctggtga
     3301 acatcaagaa ttgcctcctc cccaccacac acactagtga ctctgtattt cttggcatgg
     3361 aaagaaataa aactgaacat atatgttctc tgtgtatgta
//
