LOCUS       NM_001039001            2264 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus TNF receptor-associated protein 1 (Trap1), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_001039001
VERSION     NM_001039001.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2264)
  AUTHORS   Liu,L., Zhang,L., Zhao,J., Guo,X., Luo,Y., Hu,W. and Zhao,T.
  TITLE     Tumor Necrosis Factor Receptor-Associated Protein 1 Protects
            against Mitochondrial Injury by Preventing High Glucose-Induced
            mPTP Opening in Diabetes
  JOURNAL   Oxid Med Cell Longev 2020, 6431517 (2020)
   PUBMED   32215175
  REMARK    GeneRIF: Tumor Necrosis Factor Receptor-Associated Protein 1
            Protects against Mitochondrial Injury by Preventing High
            Glucose-Induced mPTP Opening in Diabetes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2264)
  AUTHORS   Xiang,F., Ma,S.Y., Zhang,D.X., Zhang,Q. and Huang,Y.S.
  TITLE     Tumor necrosis factor receptor-associated protein 1 improves
            hypoxia-impaired energy production in cardiomyocytes through
            increasing activity of cytochrome c oxidase subunit II
  JOURNAL   Int J Biochem Cell Biol 79, 239-248 (2016)
   PUBMED   27592455
  REMARK    GeneRIF: tumor necrosis factor receptor-associated protein 1
            protects cardiomyocytes from hypoxia at least partly via
            potentiation of energy generation
REFERENCE   3  (bases 1 to 2264)
  AUTHORS   Matassa,D.S., Amoroso,M.R., Agliarulo,I., Maddalena,F., Sisinni,L.,
            Paladino,S., Romano,S., Romano,M.F., Sagar,V., Loreni,F.,
            Landriscina,M. and Esposito,F.
  TITLE     Translational control in the stress adaptive response of cancer
            cells: a novel role for the heat shock protein TRAP1
  JOURNAL   Cell Death Dis 4 (10), e851 (2013)
   PUBMED   24113185
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2264)
  AUTHORS   Yoshida,S., Tsutsumi,S., Muhlebach,G., Sourbier,C., Lee,M.J.,
            Lee,S., Vartholomaiou,E., Tatokoro,M., Beebe,K., Miyajima,N.,
            Mohney,R.P., Chen,Y., Hasumi,H., Xu,W., Fukushima,H., Nakamura,K.,
            Koga,F., Kihara,K., Trepel,J., Picard,D. and Neckers,L.
  TITLE     Molecular chaperone TRAP1 regulates a metabolic switch between
            mitochondrial respiration and aerobic glycolysis
  JOURNAL   Proc Natl Acad Sci U S A 110 (17), E1604-E1612 (2013)
   PUBMED   23564345
REFERENCE   5  (bases 1 to 2264)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 2264)
  AUTHORS   Pridgeon,J.W., Olzmann,J.A., Chin,L.S. and Li,L.
  TITLE     PINK1 protects against oxidative stress by phosphorylating
            mitochondrial chaperone TRAP1
  JOURNAL   PLoS Biol 5 (7), e172 (2007)
   PUBMED   17579517
REFERENCE   7  (bases 1 to 2264)
  AUTHORS   Masuda,Y., Shima,G., Aiuchi,T., Horie,M., Hori,K., Nakajo,S.,
            Kajimoto,S., Shibayama-Imazu,T. and Nakaya,K.
  TITLE     Involvement of tumor necrosis factor receptor-associated protein 1
            (TRAP1) in apoptosis induced by beta-hydroxyisovalerylshikonin
  JOURNAL   J Biol Chem 279 (41), 42503-42515 (2004)
   PUBMED   15292218
REFERENCE   8  (bases 1 to 2264)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   9  (bases 1 to 2264)
  AUTHORS   Felts,S.J., Owen,B.A., Nguyen,P., Trepel,J., Donner,D.B. and
            Toft,D.O.
  TITLE     The hsp90-related protein TRAP1 is a mitochondrial protein with
            distinct functional properties
  JOURNAL   J Biol Chem 275 (5), 3305-3312 (2000)
   PUBMED   10652318
REFERENCE   10 (bases 1 to 2264)
  AUTHORS   Chen,C.F., Chen,Y., Dai,K., Chen,P.L., Riley,D.J. and Lee,W.H.
  TITLE     A new member of the hsp90 family of molecular chaperones interacts
            with the retinoblastoma protein during mitosis and after heat shock
  JOURNAL   Mol Cell Biol 16 (9), 4691-4699 (1996)
   PUBMED   8756626
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083909.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083909.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2264
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..2264
                     /gene="Trap1"
                     /note="TNF receptor-associated protein 1"
                     /db_xref="GeneID:287069"
                     /db_xref="RGD:1359733"
     exon            1..106
                     /gene="Trap1"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..2139
                     /gene="Trap1"
                     /note="heat shock protein 75 kDa, mitochondrial; HSP 75;
                     TRAP-1; TNFR-associated protein 1; tumor necrosis factor
                     type 1 receptor-associated protein"
                     /codon_start=1
                     /product="heat shock protein 75 kDa, mitochondrial
                     precursor"
                     /protein_id="NP_001034090.1"
                     /db_xref="GeneID:287069"
                     /db_xref="RGD:1359733"
                     /translation="MARELRALLLWGRGLQSALRAPALAGVRRGKPVLHLQKTTVHFR
                     DPTQSLASGISAGQLYSTQAAEDKKEEALHSIISNTEAVQGSVSKHEFQAETKKLLDI
                     VARSLYSEKEVFIRELISNASDALEKLRHKRVCEGQVLPEMEIHLQTDAEKGTITIQD
                     TGIGMTKEELVSNLGTIARSGSKAFLEALQHQAETSSRIIGQFGVGFYSAFMVADKVE
                     VYSRPAAPESPGYQWLSDGSGVFEIAEASGVRPGTKIIIHLKSDCKDFANESRVQDVV
                     TKYSNFVSFPLYLNGRRINTLQAIWMMDPKDISEFQHEEFYRYIAQAYDKPRFILHYK
                     TDAPLNIRSIFYVPEMKPSMFDVSRELGSSVALYSRKVLIQTKATDILPKWLRFVRGV
                     VDSEDIPLNLSRELLQESALIRKLRDVLQQRLIKFFIDQSKKDAEKYAKFFEDYGLFM
                     REGIVTTAEQDIKEDIAKLLRYESSALPAGQLTSLSDYASRMQAGTRNIYYLCAPNRH
                     LAEHSPYYEAMKQKQTEVLFCYEQFDELTLLHLREFDKKKLISVETDIVVDHYKEEKF
                     EDTSPAGERLSEKETEELMAWMRNALGSRVTNVKVTFRLDTHPAMVTVLEMGAARHFL
                     RMQQLAKTQEERAQLLQPTLEINPRHTLIKKLNQLREREPELAQLLVDQIYENAMIAA
                     GLVDDPRAMVGRLNDLLVKALERH"
     exon            107..271
                     /gene="Trap1"
                     /inference="alignment:Splign:2.1.0"
     exon            272..354
                     /gene="Trap1"
                     /inference="alignment:Splign:2.1.0"
     exon            355..495
                     /gene="Trap1"
                     /inference="alignment:Splign:2.1.0"
     exon            496..567
                     /gene="Trap1"
                     /inference="alignment:Splign:2.1.0"
     exon            568..728
                     /gene="Trap1"
                     /inference="alignment:Splign:2.1.0"
     exon            729..838
                     /gene="Trap1"
                     /inference="alignment:Splign:2.1.0"
     exon            839..912
                     /gene="Trap1"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1068
                     /gene="Trap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1189
                     /gene="Trap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1259
                     /gene="Trap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1407
                     /gene="Trap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1593
                     /gene="Trap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1732
                     /gene="Trap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1818
                     /gene="Trap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..1964
                     /gene="Trap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2037
                     /gene="Trap1"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2236
                     /gene="Trap1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttctaagga acagaagcat ggcgcgagag ctgcgagctc tgctgctgtg gggccgcggg
       61 ctgcagtctg cactgagggc tcccgcgctg gcgggagtcc ggcgaggaaa gccagttctg
      121 caccttcaga agaccacagt ccactttagg gaccccacac aaagtctggc ttcagggatc
      181 tctgcaggac agttatatag cacacaggca gctgaggaca agaaggagga ggccctgcac
      241 tccataatca gcaacactga ggctgtgcaa ggttctgtct ccaaacatga gttccaggca
      301 gagacaaaga agcttttgga cattgtagcc cgttcactgt actcggaaaa agaggtattc
      361 atacgagagc tcatctccaa cgccagcgat gccttggaga aactgcggca caagcgggtg
      421 tgtgaaggcc aggtgctgcc agaaatggag attcaccttc agacggatgc cgagaagggc
      481 accatcacca tccaggacac tgggattggg atgaccaagg aggagctggt gtccaacctt
      541 ggcacaatcg ccagatcagg gtcaaaggct ttcctggaag cactgcagca ccaggcagag
      601 accagcagca ggatcatcgg ccagtttgga gtgggcttct attctgcctt catggtggct
      661 gacaaagttg aagtctattc tcgaccggca gccccagaga gcccaggtta ccagtggctt
      721 tcagatggtt ctggagtgtt tgaaattgct gaagcttcag gagttagacc tgggaccaaa
      781 ataatcatcc acctcaagtc agactgcaaa gatttcgcca acgagtcccg ggtgcaagat
      841 gtggtaacaa agtacagtaa ctttgtcagc ttccccctgt accttaacgg aaggcggatt
      901 aacactttgc aggccatctg gatgatggac ccaaaggaca tcagtgaatt tcagcacgag
      961 gaattctacc gttacatcgc acaggcttac gataagcctc gcttcatttt gcactacaag
     1021 acggacgccc cactcaatat ccgcagcatc ttctatgtgc cagagatgaa accatccatg
     1081 tttgacgtga gcagggagct gggctccagt gtggcactgt atagccgcaa ggtgctcatc
     1141 cagaccaagg ctacggatat cctgcccaag tggctgcgct tcgttcgagg tgtggtggac
     1201 agtgaggaca tccccctgaa cctcagccga gagctcctgc aggagagcgc cctcatccgg
     1261 aaactccggg acgttctaca acagagattg atcaaattct tcattgacca gagtaaaaaa
     1321 gatgctgaaa aatatgccaa gttttttgaa gattatggct tgttcatgag ggagggcatt
     1381 gtgaccaccg ctgagcaaga catcaaggag gatattgcaa agctgctacg gtatgagtcc
     1441 tcagccctgc ctgctgggca gctgaccagc ttatcagact acgccagccg aatgcaggct
     1501 ggcacccgca acatctatta cctgtgtgcc cctaaccgtc acctggctga acattcaccc
     1561 tattatgaag ccatgaagca gaaacagact gaggtgctct tctgctacga gcagttcgac
     1621 gagctcactc tgctgcacct gcgggagttt gacaagaaga agctgatctc tgtggagacg
     1681 gacatcgtcg ttgatcacta caaggaggaa aagtttgagg acacatctcc agctggtgag
     1741 cgcctctctg agaaagaaac agaagagcta atggcatgga tgagaaatgc actggggtcc
     1801 cgtgtcacca atgtgaaggt gactttccgc ctggacaccc accctgccat ggtgaccgtg
     1861 ctagagatgg gggctgctcg acatttcctg cgcatgcagc agctggccaa gacccaggag
     1921 gagcgtgctc agttgctaca gcccacactg gagatcaacc ccaggcacac actaataaag
     1981 aaactcaacc agctgaggga gcgtgagccg gagctagccc agctgctagt ggatcagatc
     2041 tatgagaacg ccatgatagc agcaggactc gttgatgatc cccgggccat ggtaggccgc
     2101 ctgaatgacc ttctggtcaa ggccctggag agacactgac agccaagaaa ctggatctag
     2161 tgtcagccca catcttctca ggtgacagat ggacctgcct ggggaggaag gacttaatac
     2221 acagtcagta ccactaaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
