LOCUS       NM_001007701            2778 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus translocation associated membrane protein 1
            (Tram1), mRNA.
ACCESSION   NM_001007701 XM_232596
VERSION     NM_001007701.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2778)
  AUTHORS   Yin,D., Chen,Y., Lu,R., Fan,B., Zhu,S., Xu,X. and Xu,Z.
  TITLE     Translocation Associated Membrane Protein 1 Contributes to Chronic
            Constriction Injury-Induced Neuropathic Pain in the Dorsal Root
            Ganglion and Spinal Cord in Rats
  JOURNAL   J Mol Neurosci 66 (4), 535-546 (2018)
   PUBMED   30338452
  REMARK    GeneRIF: TRAM1 expression increased in the dorsal root ganglion
            neurons and dorsal horn neurons after chronic constriction injury.
REFERENCE   2  (bases 1 to 2778)
  AUTHORS   Cai,Y., Shen,Y., Xu,G., Tao,R., Yuan,W., Huang,Z. and Zhang,D.
  TITLE     TRAM1 protects AR42J cells from caerulein-induced acute
            pancreatitis through ER stress-apoptosis pathway
  JOURNAL   In Vitro Cell Dev Biol Anim 52 (5), 530-536 (2016)
   PUBMED   27105999
  REMARK    GeneRIF: TRAM1 can protect pancreatic inflammation by regulation of
            necrosis-apoptosis switch in AR42J rat pancreatic acinar cells.
REFERENCE   3  (bases 1 to 2778)
  AUTHORS   Tamborero,S., Vilar,M., Martinez-Gil,L., Johnson,A.E. and
            Mingarro,I.
  TITLE     Membrane insertion and topology of the translocating
            chain-associating membrane protein (TRAM)
  JOURNAL   J Mol Biol 406 (4), 571-582 (2011)
   PUBMED   21237175
REFERENCE   4  (bases 1 to 2778)
  AUTHORS   Wang,B., Heath-Engel,H., Zhang,D., Nguyen,N., Thomas,D.Y.,
            Hanrahan,J.W. and Shore,G.C.
  TITLE     BAP31 interacts with Sec61 translocons and promotes
            retrotranslocation of CFTRDeltaF508 via the derlin-1 complex
  JOURNAL   Cell 133 (6), 1080-1092 (2008)
   PUBMED   18555783
REFERENCE   5  (bases 1 to 2778)
  AUTHORS   Knight,B.C. and High,S.
  TITLE     Membrane integration of Sec61alpha: a core component of the
            endoplasmic reticulum translocation complex
  JOURNAL   Biochem J 331 (Pt 1) (Pt 1), 161-167 (1998)
   PUBMED   9512475
REFERENCE   6  (bases 1 to 2778)
  AUTHORS   Voigt,S., Jungnickel,B., Hartmann,E. and Rapoport,T.A.
  TITLE     Signal sequence-dependent function of the TRAM protein during early
            phases of protein transport across the endoplasmic reticulum
            membrane
  JOURNAL   J Cell Biol 134 (1), 25-35 (1996)
   PUBMED   8698819
REFERENCE   7  (bases 1 to 2778)
  AUTHORS   Gorlich,D., Hartmann,E., Prehn,S. and Rapoport,T.A.
  TITLE     A protein of the endoplasmic reticulum involved early in
            polypeptide translocation
  JOURNAL   Nature 357 (6373), 47-52 (1992)
   PUBMED   1315422
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083851.1.
            
            On Nov 29, 2004 this sequence version replaced XM_232596.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083851.1, SRR8487226.175627.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2778
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q11"
     gene            1..2778
                     /gene="Tram1"
                     /note="translocation associated membrane protein 1"
                     /db_xref="GeneID:312903"
                     /db_xref="RGD:1359100"
     exon            1..279
                     /gene="Tram1"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..1281
                     /gene="Tram1"
                     /note="translocating chain-associating membrane protein 1"
                     /codon_start=1
                     /product="translocating chain-associated membrane protein
                     1"
                     /protein_id="NP_001007702.1"
                     /db_xref="GeneID:312903"
                     /db_xref="RGD:1359100"
                     /translation="MAIRKKSNKNPPVLSHEFVLQNHADIVSCLAMLFLLGLMFEITA
                     KGAIIFVALQYNVTRPATEEQAAESASLYYYGIKDLATVFFYMLVAIIVHAIIQEYVL
                     DKINRRMHFSKTKHSKFNESGQLSAFYLFACVWGTFILVSENYISDPTILWRAYPHNL
                     MTFQMKFFYISQLAYWLHAFPELYFQKTKKEDIPRQLVYIGLYLFHIAGAYLLNLNHL
                     GLVLLVLHYFVEFLFHISRLFYFSDEKYQKGFSLWAVLFVLGRLLTLILSVLTVGFGL
                     ARAENQKLDFSTGNFNVLAVRIAVLASICITQAFMMWKFINFQLRRWREHSAFQAPPV
                     KRKPAVTKGRSSRKGTENGVNGTVTSNGADSPRSRKEKSS"
     exon            280..343
                     /gene="Tram1"
                     /inference="alignment:Splign:2.1.0"
     exon            344..465
                     /gene="Tram1"
                     /inference="alignment:Splign:2.1.0"
     exon            466..582
                     /gene="Tram1"
                     /inference="alignment:Splign:2.1.0"
     exon            583..641
                     /gene="Tram1"
                     /inference="alignment:Splign:2.1.0"
     exon            642..726
                     /gene="Tram1"
                     /inference="alignment:Splign:2.1.0"
     exon            727..797
                     /gene="Tram1"
                     /inference="alignment:Splign:2.1.0"
     exon            798..902
                     /gene="Tram1"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1046
                     /gene="Tram1"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1207
                     /gene="Tram1"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..2755
                     /gene="Tram1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggctgtgg gatgggaagt gaagccccag cgagcggctg tggtggggct gtgcggagca
       61 gccagcggga ggcggcggcg gcagcgcggc ggtgagcagc cgagagcgcg gagccgggcg
      121 gaggaagcac ctgcaggcac aggcggcggc tccaccatgg cgattcgcaa gaagagcaac
      181 aagaacccgc cggtgttgag ccatgaattc gtgctgcaga atcacgcgga catcgtctcc
      241 tgtctggcga tgctcttcct gctggggctt atgttcgaga taacagcaaa aggagccatc
      301 atctttgtcg cccttcagta caacgttacc cgccctgcaa cagaagaaca agctgctgaa
      361 tcagcatccc tttattacta tggtatcaaa gatttggcta cagtgttctt ctacatgcta
      421 gtggcgataa ttgttcatgc cataattcag gagtatgtgt tggataaaat taaccgacgg
      481 atgcacttct ccaaaacgaa gcacagcaag tttaatgagt ccgggcagct cagtgcgttc
      541 tacctttttg cctgtgtgtg gggcacattc attctcgtct ccgaaaacta tatctcagac
      601 ccgacgatcc tgtggagagc gtatccccat aacctgatga catttcaaat gaagtttttc
      661 tacatatccc agttggcgta ttggctccat gcattccctg aactctactt ccagaaaacc
      721 aaaaaagaag atattcctcg ccagcttgtc tacatcggtc tttacctctt ccacattgct
      781 ggggcttacc ttctgaactt gaaccatctg ggccttgttc ttctggtgct gcactatttc
      841 gttgaatttc ttttccacat ttctcgtcta ttttatttta gtgacgagaa gtaccagaaa
      901 gggttttctc tttgggcggt tctttttgtt ttgggaagac ttctgaccct aattctttca
      961 gtcctcactg ttggctttgg cctggcaaga gcagagaacc agaagctgga cttcagtact
     1021 gggaacttca atgtgttggc ggttaggatc gcggtcctag cgtccatttg catcactcaa
     1081 gccttcatga tgtggaagtt cattaacttc cagcttcgga ggtggaggga acattctgcc
     1141 ttccaggccc ctcccgtgaa aaggaaaccg gctgtgacca aaggcaggtc ttccagaaaa
     1201 ggaacagaga atggtgtgaa cggcacggtc acgtcgaatg gagccgactc tcctcggagc
     1261 aggaaagaga agtcttccta atgggccgga aactgactga ctgatgtccc ccaaagaatc
     1321 tgctttctac tctgtccttc agcactagcg actcttctgt tcttgaaaat acagtttgct
     1381 ctttgatttt gctgttgcac tgttcctgca ttgtgagggg cgtctgaggg gagggtgatt
     1441 gattactctg aggtgattga ttactctgac tgagaaatac tttagcttag actcagctac
     1501 ctgccttcaa atagtttagg gaccaccttt ttgttttttt gtttttcctt tttgtcttta
     1561 atgtttttcc ctaatggttt agggagaaac catttacaaa caccccccca cacacacaca
     1621 taaccagtga acatttttct tgctctcacc aattttttac aatattatag caaggtgacc
     1681 tgttctagga aggtcgtatt ttttaagttg tctttcaggg tgaaatggaa atactataaa
     1741 gtcagatgtc aaacttttaa tgttttcagt gttctctaat ttttaggagt tttttgtagc
     1801 ctttacacct gaaaaaaaaa aaaaaagatt tgtaaaatca cccaaataat tgtgtgcttt
     1861 attttctaag tcgtggttgt acatgctaca tcccattaaa atgtcctgat agccgctgca
     1921 aggtctgttg tcatctactg gagcagatgt ctcgttagca taaggaagtg aagtacttag
     1981 gaagtaaagt ctgtgcattt caacatttat cgtctggcag tcagacagtg tttcctgtga
     2041 ggaggaatag tcaactcgtg tagccctttt gatatgttta gtacctaacc gggctgcttg
     2101 taaatttgat gcacatagca tcttaatgag atagcagtta acctgcaagc cctttaaaga
     2161 agtaatgcct gtttgattta catctgtaga aaacaggtca ggtaattata tttgggaaac
     2221 taatgcacta actttaaaga aattgaaaat tcaggtggat agtcttaaca gaagacatgc
     2281 tttatgttat agctttggac ccatctttaa ttgagaaatg tttatctgta taaaacatat
     2341 ttttggataa atatatatat atatatattt gtatctacag aaaggctcta aacgcatttg
     2401 agtaaaatcc tggttccctt ttctacgcct gtcctcgcac cctgcgcttg ttctgtctgc
     2461 tgttgtcaca gcacatgcag tgctccatcc gtccctgttt ctcactctgt caccagctaa
     2521 acaatgtccg tgccatgttg agtatattcg ctacaagcct cagcctgtgg gtaggttgcc
     2581 atgctgctgg aaagctgttc tttctcttct ctaggtgttt accttcttcc tgggaaaagt
     2641 agtcgctctc ggtagcagta ccaagtttca gtggaaccaa atttctgccc ttaaaactgg
     2701 cattatattg aacgatacat tgagaaatca gtcgaataaa aaatttttac tttcaaaaaa
     2761 aaaaaaaaaa aaaaaaaa
//
