LOCUS       NM_133560               6041 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus trafficking kinesin protein 2 (Trak2), mRNA.
ACCESSION   NM_133560
VERSION     NM_133560.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6041)
  AUTHORS   Loss,O. and Stephenson,F.A.
  TITLE     Localization of the kinesin adaptor proteins trafficking kinesin
            proteins 1 and 2 in primary cultures of hippocampal pyramidal and
            cortical neurons
  JOURNAL   J Neurosci Res 93 (7), 1056-1066 (2015)
   PUBMED   25653102
REFERENCE   2  (bases 1 to 6041)
  AUTHORS   Lin,M.Y. and Sheng,Z.H.
  TITLE     Regulation of mitochondrial transport in neurons
  JOURNAL   Exp Cell Res 334 (1), 35-44 (2015)
   PUBMED   25612908
  REMARK    Review article
REFERENCE   3  (bases 1 to 6041)
  AUTHORS   Randall,T.S., Moores,C. and Stephenson,F.A.
  TITLE     Delineation of the TRAK binding regions of the kinesin-1 motor
            proteins
  JOURNAL   FEBS Lett 587 (23), 3763-3769 (2013)
   PUBMED   24161670
REFERENCE   4  (bases 1 to 6041)
  AUTHORS   van Spronsen,M., Mikhaylova,M., Lipka,J., Schlager,M.A., van den
            Heuvel,D.J., Kuijpers,M., Wulf,P.S., Keijzer,N., Demmers,J.,
            Kapitein,L.C., Jaarsma,D., Gerritsen,H.C., Akhmanova,A. and
            Hoogenraad,C.C.
  TITLE     TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking
            to axons and dendrites
  JOURNAL   Neuron 77 (3), 485-502 (2013)
   PUBMED   23395375
REFERENCE   5  (bases 1 to 6041)
  AUTHORS   Li,Y., Lim,S., Hoffman,D., Aspenstrom,P., Federoff,H.J. and
            Rempe,D.A.
  TITLE     HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters
            mitochondrial distribution and transport
  JOURNAL   J Cell Biol 185 (6), 1065-1081 (2009)
   PUBMED   19528298
REFERENCE   6  (bases 1 to 6041)
  AUTHORS   Kirk,E., Chin,L.S. and Li,L.
  TITLE     GRIF1 binds Hrs and is a new regulator of endosomal trafficking
  JOURNAL   J Cell Sci 119 (Pt 22), 4689-4701 (2006)
   PUBMED   17062640
  REMARK    GeneRIF: GRIF1 may participate in microtubule-based transport of
            early endosomes by acting as an adaptor linking Hrs-containing
            endosomes to kinesin.
REFERENCE   7  (bases 1 to 6041)
  AUTHORS   Fransson,S., Ruusala,A. and Aspenstrom,P.
  TITLE     The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in
            mitochondrial trafficking
  JOURNAL   Biochem Biophys Res Commun 344 (2), 500-510 (2006)
   PUBMED   16630562
REFERENCE   8  (bases 1 to 6041)
  AUTHORS   Brickley,K., Smith,M.J., Beck,M. and Stephenson,F.A.
  TITLE     GRIF-1 and OIP106, members of a novel gene family of coiled-coil
            domain proteins: association in vivo and in vitro with kinesin
  JOURNAL   J Biol Chem 280 (15), 14723-14732 (2005)
   PUBMED   15644324
REFERENCE   9  (bases 1 to 6041)
  AUTHORS   Iyer,S.P., Akimoto,Y. and Hart,G.W.
  TITLE     Identification and cloning of a novel family of coiled-coil domain
            proteins that interact with O-GlcNAc transferase
  JOURNAL   J Biol Chem 278 (7), 5399-5409 (2003)
   PUBMED   12435728
REFERENCE   10 (bases 1 to 6041)
  AUTHORS   Beck,M., Brickley,K., Wilkinson,H.L., Sharma,S., Smith,M.,
            Chazot,P.L., Pollard,S. and Stephenson,F.A.
  TITLE     Identification, molecular cloning, and characterization of a novel
            GABAA receptor-associated protein, GRIF-1
  JOURNAL   J Biol Chem 277 (33), 30079-30090 (2002)
   PUBMED   12034717
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AJ288898.2 and BC088393.1.
            
            On Sep 20, 2005 this sequence version replaced NM_133560.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088393.1, AJ288898.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3459              AJ288898.2         1-3459
            3460-3805           BC088393.1         3459-3804
            3806-6041           BC088393.1         3807-6042
FEATURES             Location/Qualifiers
     source          1..6041
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q31"
     gene            1..6041
                     /gene="Trak2"
                     /gene_synonym="Als2cr3; GRIF-1"
                     /note="trafficking kinesin protein 2"
                     /db_xref="GeneID:171086"
                     /db_xref="RGD:620915"
     exon            1..172
                     /gene="Trak2"
                     /gene_synonym="Als2cr3; GRIF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            173..461
                     /gene="Trak2"
                     /gene_synonym="Als2cr3; GRIF-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             371..3112
                     /gene="Trak2"
                     /gene_synonym="Als2cr3; GRIF-1"
                     /note="GABA-A receptor interacting factor-1; O-GlcNAc
                     transferase-interacting protein of 98 kDa; amyotrophic
                     lateral sclerosis 2 chromosomal region candidate gene 3
                     protein homolog; amyotrophic lateral sclerosis 2
                     (juvenile) chromosome region, candidate 3 homolog;
                     amyotrophic lateral sclerosis 2 (juvenile) chromosome
                     region candidate 3; trafficking protein, kinesin binding
                     2"
                     /codon_start=1
                     /product="trafficking kinesin-binding protein 2"
                     /protein_id="NP_598244.2"
                     /db_xref="GeneID:171086"
                     /db_xref="RGD:620915"
                     /translation="MSLSQNAIFKSQTGEENLMSSNHRDSESITDVCSNEDLPEVELV
                     NLLEEQLPQYKLRVDSLFLYENQDWSQSSHQQQDASETLSPVLAEETFRYMILGTDRV
                     EQMTKTYNDIDMVTHLLAERDRDLELAARIGQALLKRNHVLSEQNESLEEQLGQAFDQ
                     VNQLQHELSKKEELLRIVSIASEESETDSSCSTPLRFNESFSLSQGLLQLDMMHEKLK
                     ELEEENMALRSKACHIKTETFTYEEKEQKLINDCVNELRETNAQMSRMTEELSGKSDE
                     LLRYQEEISSLLSQIVDLQHKLKEHVIEKEELRLHLQASKDAQRQLTMELHELQDRNM
                     ECLGMLHESQEEIKELRNKAGPSAHLCFSQAYGVFAGESLAAEIEGTMRKKLSLDEES
                     VFKQKAQQKRVFDTVKVANDTRGRSVTFPVLLPIPGSNRSSVIMTAKPFESGVQQTED
                     KTLPNQGSSTEVPGNSHPRDPPGLPEDSDLATALHRLSLRRQNYLSEKQFFAEEWERK
                     LQILAEQEEEVSSCEALTENLASFCTDQSETTELGSAGCLRGFMPEKLQIVKPLEGSQ
                     TLHHWQQLAQPNLGTILDPRPGVITKGFTQMPKDAVYHISDLEEDEEVGITFQVQQPL
                     QLEQKPAPPPPVTGIFLPPMTSAGGPVSVATSNPGKCLSFTNSTFTFTTCRILHPSDI
                     TQVTPSSGFPSLSCGSSAGSASNTAVNSPAASYRLSIGESITNRRDSTITFSSTRSLA
                     KLLQERGISAKVYHSPASENPLLQLRPKALATPSTPPNSPSQSPCSSPVPFEPRVHVS
                     ENFLASRPAETFLQEMYGLRPSRAPPDVGQLKMNLVDRLKRLGIARVVKTPVPRENGK
                     SREAEMGLQKPDSAVYLNSGGSLLGGLRRNQSLPVMMGSFGAPVCTTSPKMGILKED"
     exon            462..656
                     /gene="Trak2"
                     /gene_synonym="Als2cr3; GRIF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            657..733
                     /gene="Trak2"
                     /gene_synonym="Als2cr3; GRIF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            734..850
                     /gene="Trak2"
                     /gene_synonym="Als2cr3; GRIF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            851..1060
                     /gene="Trak2"
                     /gene_synonym="Als2cr3; GRIF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1139
                     /gene="Trak2"
                     /gene_synonym="Als2cr3; GRIF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1270
                     /gene="Trak2"
                     /gene_synonym="Als2cr3; GRIF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1345
                     /gene="Trak2"
                     /gene_synonym="Als2cr3; GRIF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1483
                     /gene="Trak2"
                     /gene_synonym="Als2cr3; GRIF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1560
                     /gene="Trak2"
                     /gene_synonym="Als2cr3; GRIF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1761
                     /gene="Trak2"
                     /gene_synonym="Als2cr3; GRIF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..2060
                     /gene="Trak2"
                     /gene_synonym="Als2cr3; GRIF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2327
                     /gene="Trak2"
                     /gene_synonym="Als2cr3; GRIF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2328..2433
                     /gene="Trak2"
                     /gene_synonym="Als2cr3; GRIF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2434..6015
                     /gene="Trak2"
                     /gene_synonym="Als2cr3; GRIF-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgcagctcca aggtcgccct gtgatgatgt gagggcgcct accagttcct gccacgcccg
       61 ggggttagct gcagcagtgg tagcttcagc tgctgctctc aggctgccgc agcattaggg
      121 gcttctttct gagcgagtgc gggcgttgga gcgaggacgc cgggccattc ccgccatgac
      181 tgtccagggg tggtaaccac atgagagcgc ttactgctgc agatgtcacc tgactcttca
      241 cagagaatct gtcctaaaga aaatatctat atgaccactt ccatttcttt actaaatggc
      301 ttaatggatt tcctttactc cgattcatac gaaagctgcc cctttcaacc aaagcaagaa
      361 aggattctgc atgagtctgt cccagaatgc cattttcaag tcacaaacag gtgaagaaaa
      421 cctcatgagt agcaaccata gagactcgga gagcatcact gatgtctgct ccaatgagga
      481 tctccctgag gtcgagctgg tcaacttgct ggaagagcag ctgccacagt ataagctaag
      541 agtggactct ctctttctct acgaaaacca agactggtcc cagtcatcac accagcagca
      601 ggatgcatct gagaccctct ctccagtcct ggctgaggag accttccgct acatgattct
      661 aggcacagac agagtagagc agatgaccaa aacctacaat gacattgaca tggtcacgca
      721 tctcctggca gagagggacc gagatctaga gctggctgct cggattgggc aagccctgct
      781 aaagcggaac catgtcttat ctgagcagaa tgaatctctg gaggagcagc tgggacaagc
      841 ctttgatcaa gtcaatcagc tgcagcacga gctgtccaag aaagaggagc tgctccgaat
      901 cgtctccatc gcctcagagg agagtgagac ggattccagc tgttccacac ccctccggtt
      961 caatgagtcc ttcagcttat ctcaaggcct gctgcagctg gacatgatgc acgagaagct
     1021 caaggagctg gaagaagaga acatggccct tcggtccaag gcttgtcaca tcaagacaga
     1081 aacatttacc tatgaagaga aggaacaaaa gctcatcaat gactgtgtta atgaactccg
     1141 tgagaccaat gcacagatgt ccagaatgac tgaagagctg tcgggaaaga gcgatgagct
     1201 gcttcggtac caagaagaga tctcttccct gctgtctcag atcgtagacc ttcagcacaa
     1261 actgaaagaa catgtgatcg agaaggaaga actgagactt cacctgcagg cgtccaaaga
     1321 tgcccagcga cagctgacga tggagcttca cgagttacag gacagaaaca tggagtgcct
     1381 gggaatgtta catgagtctc aagaagaaat aaaagagctt cggaacaaag ccggcccttc
     1441 cgctcatctc tgcttctccc aggcttacgg ggtttttgca ggggagtcac tggcagctga
     1501 gattgaaggg accatgcgta aaaagctgag tttggatgag gaatctgtct ttaaacaaaa
     1561 ggcccagcaa aaacgggtgt ttgatactgt caaggttgcc aacgacacac ggggccgctc
     1621 tgtcacattc ccagtcctgc tgcccatccc aggctccaac cgttcaagtg tcatcatgac
     1681 agcaaagccc tttgagtccg gtgttcagca aacagaggac aaaacactcc cgaaccaagg
     1741 gagcagcaca gaggttccag ggaactctca tcccagggac cccccaggac tccctgaaga
     1801 tagtgacctg gctacagcat tgcatcgcct tagcctgaga agacagaact acctaagtga
     1861 gaagcagttc ttcgctgaag aatgggaacg gaagctccag attctggctg agcaggagga
     1921 agaagttagc agctgtgagg ccctcacgga gaaccttgcc tcattctgca ctgaccagtc
     1981 agagaccacg gagctcggca gtgccggctg ccttcgaggc ttcatgccag aaaagttaca
     2041 gattgtcaag cccctagaag gatcacagac gctacatcat tggcagcagc ttgctcaacc
     2101 aaacttggga accatccttg atccacgccc aggcgtcatc actaaaggct tcacgcagat
     2161 gcccaaggat gccgtctatc acatctcgga tttggaggag gatgaagaag tggggatcac
     2221 ttttcaggtt cagcagcctc ttcaactgga gcagaagcct gcaccacccc cgccagtaac
     2281 gggtatcttc ctgccgccca tgacctcagc agggggacca gtctcagttg caacttcgaa
     2341 cccaggaaag tgtctctcat tcacgaactc aacattcacc ttcaccacct gcaggatctt
     2401 acacccctct gacatcactc aggtcacccc tagctctggt ttcccatcac tgtcctgtgg
     2461 aagcagtgcg ggcagtgcat ccaacacggc tgtgaactct cctgctgcgt cctacagact
     2521 gagcattggt gaatccatca caaaccggcg cgactccacc ataacgttca gtagcacgag
     2581 gagcttagcc aaactcctgc aggagcgagg catctccgcc aaagtgtacc acagcccagc
     2641 ttcagaaaac ccccttctac agcttcgccc caaggccctg gccacccctt ccacaccacc
     2701 aaattccccg tcgcagtcac catgttcctc ccccgtgccc tttgaacccc gtgtccatgt
     2761 ctccgagaat ttcttggctt ccagaccagc tgaaacattc ctgcaagaaa tgtatggctt
     2821 gagaccttca agggcccctc ctgatgttgg ccagctgaag atgaacttgg tggacaggct
     2881 gaagaggctg ggaatagcca gggtggtcaa gacccctgtt ccccgggaga atgggaaaag
     2941 ccgagaggca gaaatgggtc ttcaaaaacc agactctgct gtctatttaa attctggtgg
     3001 cagtttattg ggtggactga ggaggaatca gagtctccca gtcatgatgg gtagctttgg
     3061 agccccagtt tgcacaacct cgcccaaaat gggtatcctg aaggaagact gaggggtcca
     3121 cattaactga cctcgtaaat aaattagcac atgaaggata gatgcactga gaattgggac
     3181 cggcctaact tgagagaaaa gggatgttgt agaaggattg tgaatgtgga gagggcgtag
     3241 tgagggatag agcgtttgga agaggtcttt gaggatggag tctagtaacg tggggactag
     3301 tgagtaattt ggagacagaa atggaagaaa gggctagttg ttcctttagc tacatttttc
     3361 ttgccttgaa aacaagtgaa tagagaaata aaccaaattc tatcgaaacg tgacagtaat
     3421 accgaagtgc tggcaccttg tctctagaga acacaagcag gaagcgcctg cctacgaagg
     3481 aaacccgggg cagcccaggc tgttgctggg aggaggctgt tccggagagt tggtgcatgc
     3541 gcagagtggt gtgagccgag cctgtgggag atgccttccc tgctggtccc tgatcaaatg
     3601 catccatcca atggtgcact ctcagcgtta gcaaaataag gaattttatc ttgtccttta
     3661 catcagaaat ggagactttc ttatccgggg actttggggc acggagaacc caaacaccac
     3721 ccagatagat ccctttgtat ttgtgattat tagaacttca gtttttttta agcttgtatt
     3781 tttgtacaac acaacaaaaa aaaaataaca atgtgattgg gcttggaggg atttaagagg
     3841 aaaataaggg taaattgaaa ttaaaaactt ttttagacta tttcttctgg acaacatggt
     3901 ggcccaggaa tgcaaacatt attgcctgtt tctccgtttt ccttggaggc cagagggttt
     3961 aaaccagaag tgcaatcagg cagtaggcag taaattatgt tgtatattta tatatttaaa
     4021 ttttttaaga aaagttagtt gtaactaact ttatccaaag tgtgctatgc atatttttaa
     4081 tgaaagatga catgtatttg cacaaaaatt ctcaggcaca taaaattata aactggagta
     4141 aaacccaggt gcttgctttg agagtgtgtt tttgttggat tttgttgttt tccttgtatc
     4201 cactaaagca tctgcctctc tcttggtatt tgcaatagag acgggtctag ttcatgggac
     4261 agctaagctt tcccctctgt ttcttcttta agaagctgaa gagcaagtga ggcctgaagc
     4321 tggctttcgg cattcagccc gagctgcagg cctcaggctg gcgatgagca gagctgtgcc
     4381 ctgaggtggt cacagtctgc ctctgctttg tctcctcggg gagatgaggt gggactgctc
     4441 attttgtttg tcaaggcaga gagtctttta cttggtcctc ttggtgctta acttggaaat
     4501 aatttgcttg caagaaattg ttttctgccg gggagttttg tcttcctctc ttggcctcct
     4561 ccccaaggag agatgcactc agagggttag aaaacccaac atccacacaa tgttaggaac
     4621 acagtggatt ttctatattt ctagcatctt taataaactt ttctaaattt ctcagaaaca
     4681 aagggtggag agatgcccat cccttcgccc cccttgccca gtctagcttc tgtcaacagt
     4741 tcatcacacg cgtgtatgaa ggactccggg ttagccagtg accctgtcta aagcaggcat
     4801 taacaagaat tctgctgttt caatttccta gatattccaa ctcatgtttt aaaaacagcg
     4861 tttgcattcc tagtctataa ctgagtacct ccctcggcag aacctgaaag ctgtgccttg
     4921 gatcctgaag aaaggctctc cctgttgcct ggacattcac agcttctaag gaagggacag
     4981 cacagagtag ggaagtgtgg ggcggagggg gcagtagtgt tcaccaggtt tacacacggt
     5041 accactatag tgaactagat tttcatggag ttctgtgttg acgataattc ggtgcttttg
     5101 tcagtgccta agtggccact ggaagcagag ttgtgtcttg gcagccagat gacacgactg
     5161 attaaagaaa gccagacttg ggtttttgaa aattaaactg atcttgatgt tctgtcaaaa
     5221 caaattgtac ccatgcatgc ttgtctctaa cagtgaatcc tgtcttaaaa ctgggttttg
     5281 ctgattttca gttttcacta aagttatttt ggtacagcct gagaacctgt tatgtgagac
     5341 tatctgcaat atatgacaag aactagaacc ttcaagtgag ttctttctcc acaggatact
     5401 gttcacagtt tttgtttttc attcatgtca gctggtgtgt gcgttcatgc ttgcctgggg
     5461 aaacccaact gttctctcct tcaggagtct cagtagtgat ctctcaggca ctcccacgta
     5521 ccctgctacc tattcagaga gtctccttga gctcagaatt aaaactgccc tgaatttttg
     5581 aagaccccaa accttatgta aatagccact gttaattaag tgggttttgt tttttaggct
     5641 tttgcttgcc cttggtctga cataatgatc agaccctgtc agggtaggat gtcagaggag
     5701 gctcacccac attttacaca gtattccagg ttcctagtgc atcattagta gcgggtggtt
     5761 ctcacgtgag cttgacctct gtagccaggg ctgtctgtgt ggggccttct ctgccatcag
     5821 gtgtgtgctc agtgcactgc aggcatgcac accagtccac tgccacgtgt ggccccagca
     5881 tggggtcctg ggggctccag gaaaacatta tcctgtcata tcgccaatag ctctttatgc
     5941 gcttcctttg cttcatcaat tgtaaatcag ataataaatt gtaaatcaga caataaacac
     6001 aagaggcttc ttaaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
