LOCUS       NM_001134565            4857 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus trafficking kinesin protein 1 (Trak1), mRNA.
ACCESSION   NM_001134565 XM_001077998 XM_236715
VERSION     NM_001134565.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4857)
  AUTHORS   Wu,H., Liu,Y., Li,H., Du,C., Li,K., Dong,S., Meng,Q. and Zhang,H.
  TITLE     TRAK1-Mediated Abnormality of Mitochondrial Fission Increases
            Seizure Susceptibility in Temporal Lobe Epilepsy
  JOURNAL   Mol Neurobiol 58 (3), 1237-1247 (2021)
   PUBMED   33119838
  REMARK    GeneRIF: TRAK1-Mediated Abnormality of Mitochondrial Fission
            Increases Seizure Susceptibility in Temporal Lobe Epilepsy.
REFERENCE   2  (bases 1 to 4857)
  AUTHORS   Loss,O. and Stephenson,F.A.
  TITLE     Localization of the kinesin adaptor proteins trafficking kinesin
            proteins 1 and 2 in primary cultures of hippocampal pyramidal and
            cortical neurons
  JOURNAL   J Neurosci Res 93 (7), 1056-1066 (2015)
   PUBMED   25653102
REFERENCE   3  (bases 1 to 4857)
  AUTHORS   Lin,M.Y. and Sheng,Z.H.
  TITLE     Regulation of mitochondrial transport in neurons
  JOURNAL   Exp Cell Res 334 (1), 35-44 (2015)
   PUBMED   25612908
  REMARK    Review article
REFERENCE   4  (bases 1 to 4857)
  AUTHORS   van Spronsen,M., Mikhaylova,M., Lipka,J., Schlager,M.A., van den
            Heuvel,D.J., Kuijpers,M., Wulf,P.S., Keijzer,N., Demmers,J.,
            Kapitein,L.C., Jaarsma,D., Gerritsen,H.C., Akhmanova,A. and
            Hoogenraad,C.C.
  TITLE     TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking
            to axons and dendrites
  JOURNAL   Neuron 77 (3), 485-502 (2013)
   PUBMED   23395375
REFERENCE   5  (bases 1 to 4857)
  AUTHORS   Li,Y., Lim,S., Hoffman,D., Aspenstrom,P., Federoff,H.J. and
            Rempe,D.A.
  TITLE     HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters
            mitochondrial distribution and transport
  JOURNAL   J Cell Biol 185 (6), 1065-1081 (2009)
   PUBMED   19528298
REFERENCE   6  (bases 1 to 4857)
  AUTHORS   Webber,E., Li,L. and Chin,L.S.
  TITLE     Hypertonia-associated protein Trak1 is a novel regulator of
            endosome-to-lysosome trafficking
  JOURNAL   J Mol Biol 382 (3), 638-651 (2008)
   PUBMED   18675823
REFERENCE   7  (bases 1 to 4857)
  AUTHORS   Gilbert,S.L., Zhang,L., Forster,M.L., Anderson,J.R., Iwase,T.,
            Soliven,B., Donahue,L.R., Sweet,H.O., Bronson,R.T., Davisson,M.T.,
            Wollmann,R.L. and Lahn,B.T.
  TITLE     Trak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic
            mice
  JOURNAL   Nat Genet 38 (2), 245-250 (2006)
   PUBMED   16380713
  REMARK    Erratum:[Nat Genet. 2006 Mar;38(3):389. Anderson, Jeffrey R
            [added]]
REFERENCE   8  (bases 1 to 4857)
  AUTHORS   Brickley,K., Smith,M.J., Beck,M. and Stephenson,F.A.
  TITLE     GRIF-1 and OIP106, members of a novel gene family of coiled-coil
            domain proteins: association in vivo and in vitro with kinesin
  JOURNAL   J Biol Chem 280 (15), 14723-14732 (2005)
   PUBMED   15644324
REFERENCE   9  (bases 1 to 4857)
  AUTHORS   Iyer,S.P., Akimoto,Y. and Hart,G.W.
  TITLE     Identification and cloning of a novel family of coiled-coil domain
            proteins that interact with O-GlcNAc transferase
  JOURNAL   J Biol Chem 278 (7), 5399-5409 (2003)
   PUBMED   12435728
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 9, 2022 this sequence version replaced NM_001134565.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.2366532.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               JAXUCZ010000008.1  129924808-129924964
            158-352             JAXUCZ010000008.1  129946789-129946983
            353-429             JAXUCZ010000008.1  129978190-129978266
            430-546             JAXUCZ010000008.1  129985045-129985161
            547-647             JAXUCZ010000008.1  129987286-129987386
            648-756             JAXUCZ010000008.1  129988566-129988674
            757-835             JAXUCZ010000008.1  129990578-129990656
            836-966             JAXUCZ010000008.1  129991410-129991540
            967-1041            JAXUCZ010000008.1  129993118-129993192
            1042-1173           JAXUCZ010000008.1  129993862-129993993
            1174-1250           JAXUCZ010000008.1  129995816-129995892
            1251-1487           JAXUCZ010000008.1  129996993-129997229
            1488-1804           JAXUCZ010000008.1  129998029-129998345
            1805-2023           JAXUCZ010000008.1  130003988-130004206
            2024-2126           JAXUCZ010000008.1  130010859-130010961
            2127-4857           JAXUCZ010000008.1  130014140-130016870
FEATURES             Location/Qualifiers
     source          1..4857
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..4857
                     /gene="Trak1"
                     /gene_synonym="OIP106; RGD1307844"
                     /note="trafficking kinesin protein 1"
                     /db_xref="GeneID:316085"
                     /db_xref="RGD:1307844"
     exon            1..157
                     /gene="Trak1"
                     /gene_synonym="OIP106; RGD1307844"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..2889
                     /gene="Trak1"
                     /gene_synonym="OIP106; RGD1307844"
                     /note="trafficking protein, kinesin binding 1"
                     /codon_start=1
                     /product="trafficking kinesin-binding protein 1"
                     /protein_id="NP_001128037.1"
                     /db_xref="GeneID:316085"
                     /db_xref="RGD:1307844"
                     /translation="MALAIQLRQPSRAQPLPGLDHTLAGTNSCDVCNSTNLPEVEIIS
                     LLEEQLPHYKLRADTIYGYDHDDWLHTPLISPDANIDLTTEQIEETLKYFLLCAERVG
                     QMTKTYNDIDAVTRLLEEKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEV
                     SQLRHELSMKDELLQFYTSAAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKD
                     LEEENVVLRSEACQLKTETITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDA
                     ARQQEEITHLLSQIVDLQKKAKSCAVENEELVQHLGAAKDAQRQLTAELRELEDKYAE
                     CMEMLHEAQEELKNLRNKTMPTSRRYHSLGLFPMDSLAAEIEGTMRKELQLEEPESPD
                     ITHQKRVFETVRNVNQVVKQRSLTPSPMNIPGSNQSSAMNSLLSSCVSTPRSSFYGSD
                     VSHVVLDNKTNSILLETEAADLGNEEHNKKPGTPGTPGSHDLETALRRLSLRRENYLS
                     ERRFFEEEQERKLRELAEKGELHSGSLTPTESIMSLGTHSRFSEFTGFSGMSFSSRSY
                     LPEKLQIVKPLEGSATLHHWQQLAQPHLGGILDPRPGVVTKGFRTLDVDLDEVYCLND
                     FEEDDTGDHISLAGLATSTTIQHMETSAHHPGKCMSQTNSTFTFTTCRILHPSDELTR
                     VTPSLNSAPAPSCSSTSHLKSTPVATPCTPRRLSLAESFTNVRESTTTMSTSLGLVWL
                     LKERGISAAVYDPQSWDRAGRGSLLHSYTPRMAVIPSTPPNSPMQTPSASPPSFEFKC
                     TSPPYNNFLASKPASSILREVREKKHVRSSESQTDVSVSNLNLVDKVRRFGVARVVNS
                     GRAHIPTLTEDQGPLLCGPTGPAHALVPGGLVPEGLPLGCPSGIRRNRSFPTMVGSSV
                     QMRAPVILTSGILMGAKLPKQTSLR"
     exon            158..352
                     /gene="Trak1"
                     /gene_synonym="OIP106; RGD1307844"
                     /inference="alignment:Splign:2.1.0"
     exon            353..429
                     /gene="Trak1"
                     /gene_synonym="OIP106; RGD1307844"
                     /inference="alignment:Splign:2.1.0"
     exon            430..546
                     /gene="Trak1"
                     /gene_synonym="OIP106; RGD1307844"
                     /inference="alignment:Splign:2.1.0"
     exon            547..647
                     /gene="Trak1"
                     /gene_synonym="OIP106; RGD1307844"
                     /inference="alignment:Splign:2.1.0"
     exon            648..756
                     /gene="Trak1"
                     /gene_synonym="OIP106; RGD1307844"
                     /inference="alignment:Splign:2.1.0"
     exon            757..835
                     /gene="Trak1"
                     /gene_synonym="OIP106; RGD1307844"
                     /inference="alignment:Splign:2.1.0"
     exon            836..966
                     /gene="Trak1"
                     /gene_synonym="OIP106; RGD1307844"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1041
                     /gene="Trak1"
                     /gene_synonym="OIP106; RGD1307844"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1173
                     /gene="Trak1"
                     /gene_synonym="OIP106; RGD1307844"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1250
                     /gene="Trak1"
                     /gene_synonym="OIP106; RGD1307844"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1487
                     /gene="Trak1"
                     /gene_synonym="OIP106; RGD1307844"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1804
                     /gene="Trak1"
                     /gene_synonym="OIP106; RGD1307844"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..2023
                     /gene="Trak1"
                     /gene_synonym="OIP106; RGD1307844"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..2126
                     /gene="Trak1"
                     /gene_synonym="OIP106; RGD1307844"
                     /inference="alignment:Splign:2.1.0"
     exon            2127..4857
                     /gene="Trak1"
                     /gene_synonym="OIP106; RGD1307844"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagcggtgg ccaagctctc gtggaggacc actccgtctc ccagtcccct ctggagtttg
       61 cgtctgccca tggcattggc gattcagctc aggcagccct ccagggccca acctctgccg
      121 ggactcgacc acacactggc tgggacaaac tcctgtgacg tgtgcaacag caccaacctt
      181 ccagaagtgg agatcattag cctgctggag gagcagctgc cccactacaa gctaagagcg
      241 gacaccatct atggttatga ccacgatgac tggctgcaca cgcccctcat ctccccagat
      301 gccaacatcg acctcacaac cgagcagatc gaagagacgc tgaagtactt ccttctatgt
      361 gccgaaagag ttggccagat gactaagaca tacaatgaca ttgatgctgt cacaaggctt
      421 cttgaggaga aagagcggga tttggagctg gctgcgagga tcggccagtc attgttgaag
      481 aagaacaaga ccctaactga gaggaacgaa ctgctggaag agcaggtgga gcacatccgg
      541 gaagaggtgt ctcagctccg ccatgagctg tccatgaagg atgagctgct tcagttctac
      601 accagtgccg cggaggagag tgagcctgag tctgtctgct caaccccgct gaagaggaac
      661 gagtcatcct cctccgtcca gaattacttc cacctggact ctcttcagaa gaagctgaag
      721 gacctcgaag aggagaacgt cgtacttcga tctgaggctt gtcagctgaa gacggagacc
      781 atcacctatg aggagaagga gcagcagctg gtgaacgact gtgtgaagga gctgagggat
      841 gctaacgtcc agattgcgag catctctgag gagctggcca agaagacgga agatgccgcc
      901 cgccagcagg aggagatcac gcacctgctg tcgcaaatcg tggacttgca gaagaaggcg
      961 aaatcctgtg cggtggaaaa tgaagaactt gtccagcacc tgggcgctgc caaggatgcg
     1021 cagcgccaac tcacagccga gcttcgagag ctggaggata agtacgccga atgcatggag
     1081 atgcttcatg aggctcagga ggaactgaag aacctgcgga acaagacgat gcccacatcc
     1141 cggcgctacc actccctggg cctgttcccc atggactcct tggctgccga aattgaggga
     1201 accatgcgca aggagctgca gctggaagag ccggagtccc cagacatcac ccaccagaag
     1261 cgtgtctttg agacggtgag aaatgtcaat caagtggtca agcagagatc gctaacccct
     1321 tcccccatga acatcccggg ctccaaccag tcttcagcca tgaactccct cctgtccagc
     1381 tgcgtcagca ccccccgttc cagcttctac ggcagcgatg tcagccacgt ggtcctcgat
     1441 aacaaaacca acagcatcct cctggaaact gaggcagccg acctggggaa tgaggagcac
     1501 aataagaagc cgggcacacc aggcacacca ggctcccatg acctggagac ggcacttagg
     1561 cggctatccc tgcgccgaga gaactaccta tctgagcgga ggttcttcga ggaggagcag
     1621 gagaggaagc tgcgagagct ggctgagaag ggagagctgc acagtggctc gctcacgccc
     1681 accgagagca tcatgtccct gggcacacac tcacgcttct ccgagttcac gggcttctcc
     1741 ggcatgtcct tcagcagccg ctcctacctg cccgagaagc tgcagatcgt gaagccactc
     1801 gaaggttcag ccacacttca ccattggcag caattggccc agcctcacct cgggggcatc
     1861 ctggaccccc gccctggtgt ggtcaccaag ggcttccgga ctttggacgt tgacctggat
     1921 gaagtgtact gccttaacga ctttgaggaa gatgacacag gtgaccacat ttctctggcg
     1981 ggcctagcta cctccacaac aattcagcac atggagacct cagcgcacca ccctgggaag
     2041 tgcatgtcac agaccaactc gactttcacc tttaccacct gccgcatcct gcacccttca
     2101 gacgagctca cgcgggtcac gccaagcctt aactcagccc cagctccatc ttgtagcagc
     2161 accagccact tgaaatccac gccggtggcc acgccatgca ccccccggag actgagcctg
     2221 gccgagtcct tcacaaacgt ccgcgagtcc acgacaacca tgagcacgtc cctggggctg
     2281 gtgtggttgc tgaaggaacg aggcatctca gcggctgtgt acgaccccca gagttgggac
     2341 agagccggca ggggctccct cctccactct tataccccta ggatggctgt gatcccgtcc
     2401 accccaccaa attcccctat gcagacgccc tcggcctccc cgccctcctt cgagttcaag
     2461 tgcacgagcc ctccctacaa caacttcctg gcttccaagc ctgccagctc catcctgagg
     2521 gaggtgaggg agaagaagca cgtgaggagc agtgagagcc agacggacgt gtctgtctcc
     2581 aaccttaacc ttgtggacaa agtcaggagg tttggggtgg ccagagtggt gaactcagga
     2641 cgagcccaca tccccacctt gactgaggat cagggacctc tcctctgtgg accgaccggg
     2701 ccagcacacg ctcttgtccc tgggggcctg gtccccgagg gactgcctct tgggtgcccc
     2761 agtggcatcc gacggaatcg cagcttcccc accatggtcg ggtccagcgt gcagatgagg
     2821 gctcctgtaa tcctcacctc tggcatctta atgggtgcta agctccccaa acagactagc
     2881 ttgcggtgag gctgggggat cgctgcccca tctgctccct gcctcctgtc cccgacagag
     2941 cactcacacc cttgtctcct ctgaggtctg cttcttctga gctagacaga tcaaccgtgt
     3001 gcctcgagga gggaggtgga cctccacatg gtgtgtatac aggactctct cttccaatcc
     3061 acaggaagta ataaccctac aaggtcacac tctggggagg atggcgcctg agctcaccta
     3121 ggggaaggtg gtgtcctttc ttccttactt ttaagaagca ctgaaattcc caaggctgtt
     3181 cttatcccat ggataggaat ctggtgaatt ctgcctaaga ctgtctggtt gcacacgcag
     3241 ctgccacgtg gcacaggtct ccttgcttgc ctgtgacagc cgaccgggct gcccgctctc
     3301 agagagttgt cctttcagtc gtaggtggcc cagcttcatc aaggcaaggt ctgcactatc
     3361 ctgccccgac ggcctgtctg ttctctagac atgacttctt ctcatgtctc tgacttgaag
     3421 ttaaccttgc attttgtcac aagttgtcag ggttagagcc tgacgcgaaa agaatgtatt
     3481 tacactccga cgacgcacca tcaggcggcc cctccgagtt ctgttcgttt gattttcctt
     3541 ttcttttcca tttttagaat tttcatttgc agggaagtct cagtactggc agtttctctc
     3601 ttggttctga caccaaaatg caaggggcgc acacgctgac ttgctaatga catagcttat
     3661 ttccgggacc cagtgtcaca cagccaggtt gatatgtgac cagttatcac tgtaaccata
     3721 ggatcaaggg gaaaagggac aagaccgtta gccctataca cagtggaggg gaggggccga
     3781 atccatagca caccgcagtg catcctgggt cagggtgtgt cagggttgat ggctgctggc
     3841 ccctttgcac tctgaaggga gctcgggccg tgtggtagaa ctctgtggcc attctgtggc
     3901 tgcatttttt tttccagtcc tctcgtttca aaactagaat tacgtttcct ccccatcccc
     3961 caagtgtact gtccccattt ccacccatag gaaaagacca gaggtgctta tgagtggaag
     4021 aagcgggagc aagtgagtga cctgggtcgg tcgccgtcag ctgtgcagtg acgaactttt
     4081 atttattatc cacgtgtgct gtattttaat cagatgccct ctctgcttcc agctccagcc
     4141 tctgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgacagag
     4201 agagagagag agagagagag agagagagag agagagagag agattgattc cggcccaggt
     4261 atatattatt tatttacttt tgtctgagga tggctgtaca tctgtgtgtc acatggtcac
     4321 ctgccccaga catctgtgga agatgtagca ccctgtgtac tagaaattat cacacgaaca
     4381 acccctcccc cagcaaaaga tgtgtccttg aatcgagcga gggtcacctt atgtccacca
     4441 aggatgctcg agaaggtccc caagcagcaa acttcagtcc cactatttca aactatttat
     4501 tctccagacg gagctggttc atcatgttct cagctctcct ggctgccgtg tacgtgtgca
     4561 gtcactccaa gtaacatacc cttttatttg aatgtatttt taaagcagta ggtaggacgg
     4621 caaaggaggg tgaccacctt ggcgtggatg gaccgtgtca catgttcaga ggggcctcct
     4681 gtccgcactg gaaacgccag tgtgagaacc ggcacttcag aggtcgtgat agtgtagtta
     4741 gcaaaccggt gatcaacatt gagccacact acctaaaagc ctgttgtaat gcatcagacc
     4801 ggtgacaaga tttcattcac taacgaatat caataaaaca agctcaaagg atggaaa
//
