LOCUS       NM_001415153            2653 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus TNF receptor associated factor 7 (Traf7),
            transcript variant 1, mRNA.
ACCESSION   NM_001415153 XM_006245982
VERSION     NM_001415153.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2653)
  AUTHORS   He,H., Wu,Z., Li,S., Chen,K., Wang,D., Zou,H., Chen,H., Li,Y.,
            Liu,Z. and Qu,C.
  TITLE     TRAF7 enhances ubiquitin-degradation of KLF4 to promote
            hepatocellular carcinoma progression
  JOURNAL   Cancer Lett 469, 380-389 (2020)
   PUBMED   31730901
REFERENCE   2  (bases 1 to 2653)
  AUTHORS   Stevers,M., Rabban,J.T., Garg,K., Van Ziffle,J., Onodera,C.,
            Grenert,J.P., Yeh,I., Bastian,B.C., Zaloudek,C. and Solomon,D.A.
  TITLE     Well-differentiated papillary mesothelioma of the peritoneum is
            genetically defined by mutually exclusive mutations in TRAF7 and
            CDC42
  JOURNAL   Mod Pathol 32 (1), 88-99 (2019)
   PUBMED   30171198
REFERENCE   3  (bases 1 to 2653)
  AUTHORS   Xu,D., Zhao,W., Wang,C., Zhu,H., He,M., Zhu,X., Liu,W., Wang,F.,
            Fan,J., Chen,C., Cui,D. and Cui,Z.
  TITLE     Up-regulation of TNF Receptor-associated Factor 7 after spinal cord
            injury in rats may have implication for neuronal apoptosis
  JOURNAL   Neuropeptides 71, 81-89 (2018)
   PUBMED   30100091
  REMARK    GeneRIF: TRAF7 was up-regulated significantly after spinal cord
            injury, which was paralleled with the levels of the apoptotic
            protein active caspase-3. Immunofluorescent labeling showed that
            TRAF7 was co-localizated with active caspase-3 in neurons.
REFERENCE   4  (bases 1 to 2653)
  AUTHORS   Tokita,M.J., Chen,C.A., Chitayat,D., Macnamara,E., Rosenfeld,J.A.,
            Hanchard,N., Lewis,A.M., Brown,C.W., Marom,R., Shao,Y., Novacic,D.,
            Wolfe,L., Wahl,C., Tifft,C.J., Toro,C., Bernstein,J.A., Hale,C.L.,
            Silver,J., Hudgins,L., Ananth,A., Hanson-Kahn,A., Shuster,S.,
            Magoulas,P.L., Patel,V.N., Zhu,W., Chen,S.M., Jiang,Y., Liu,P.,
            Eng,C.M., Batkovskyte,D., di Ronza,A., Sardiello,M., Lee,B.H.,
            Schaaf,C.P., Yang,Y. and Wang,X.
  CONSRTM   Undiagnosed Diseases Network
  TITLE     De Novo Missense Variants in TRAF7 Cause Developmental Delay,
            Congenital Anomalies, and Dysmorphic Features
  JOURNAL   Am J Hum Genet 103 (1), 154-162 (2018)
   PUBMED   29961569
REFERENCE   5  (bases 1 to 2653)
  AUTHORS   Goode,B., Joseph,N.M., Stevers,M., Van Ziffle,J., Onodera,C.,
            Talevich,E., Grenert,J.P., Yeh,I., Bastian,B.C., Phillips,J.J.,
            Garg,K., Rabban,J.T., Zaloudek,C. and Solomon,D.A.
  TITLE     Adenomatoid tumors of the male and female genital tract are defined
            by TRAF7 mutations that drive aberrant NF-kB pathway activation
  JOURNAL   Mod Pathol 31 (4), 660-673 (2018)
   PUBMED   29148537
REFERENCE   6  (bases 1 to 2653)
  AUTHORS   Morita,Y., Kanei-Ishii,C., Nomura,T. and Ishii,S.
  TITLE     TRAF7 sequesters c-Myb to the cytoplasm by stimulating its
            sumoylation
  JOURNAL   Mol Biol Cell 16 (11), 5433-5444 (2005)
   PUBMED   16162816
REFERENCE   7  (bases 1 to 2653)
  AUTHORS   Xu,L.G., Li,L.Y. and Shu,H.B.
  TITLE     TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces
            apoptosis
  JOURNAL   J Biol Chem 279 (17), 17278-17282 (2004)
   PUBMED   15001576
REFERENCE   8  (bases 1 to 2653)
  AUTHORS   Bouwmeester,T., Bauch,A., Ruffner,H., Angrand,P.O., Bergamini,G.,
            Croughton,K., Cruciat,C., Eberhard,D., Gagneur,J., Ghidelli,S.,
            Hopf,C., Huhse,B., Mangano,R., Michon,A.M., Schirle,M., Schlegl,J.,
            Schwab,M., Stein,M.A., Bauer,A., Casari,G., Drewes,G., Gavin,A.C.,
            Jackson,D.B., Joberty,G., Neubauer,G., Rick,J., Kuster,B. and
            Superti-Furga,G.
  TITLE     A physical and functional map of the human TNF-alpha/NF-kappa B
            signal transduction pathway
  JOURNAL   Nat Cell Biol 6 (2), 97-105 (2004)
   PUBMED   14743216
  REMARK    Erratum:[Nat Cell Biol. 2004 May;6(5):465]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Dec 22, 2022 this sequence version replaced XM_006245982.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.41675.1,
                                           SRR26643298.59214.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                JAXUCZ010000010.1  14056610-14056694   c
            86-201              JAXUCZ010000010.1  14048177-14048292   c
            202-259             JAXUCZ010000010.1  14047866-14047923   c
            260-354             JAXUCZ010000010.1  14045795-14045889   c
            355-471             JAXUCZ010000010.1  14043874-14043990   c
            472-564             JAXUCZ010000010.1  14043325-14043417   c
            565-598             JAXUCZ010000010.1  14043127-14043160   c
            599-782             JAXUCZ010000010.1  14042403-14042586   c
            783-917             JAXUCZ010000010.1  14042160-14042294   c
            918-1135            JAXUCZ010000010.1  14041436-14041653   c
            1136-1209           JAXUCZ010000010.1  14041286-14041359   c
            1210-1258           JAXUCZ010000010.1  14041045-14041093   c
            1259-1386           JAXUCZ010000010.1  14040837-14040964   c
            1387-1469           JAXUCZ010000010.1  14040592-14040674   c
            1470-1509           JAXUCZ010000010.1  14039950-14039989   c
            1510-1626           JAXUCZ010000010.1  14039744-14039860   c
            1627-1749           JAXUCZ010000010.1  14039533-14039655   c
            1750-1869           JAXUCZ010000010.1  14039235-14039354   c
            1870-2001           JAXUCZ010000010.1  14039021-14039152   c
            2002-2121           JAXUCZ010000010.1  14038820-14038939   c
            2122-2653           JAXUCZ010000010.1  14038117-14038648   c
FEATURES             Location/Qualifiers
     source          1..2653
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..2653
                     /gene="Traf7"
                     /gene_synonym="RGD1559653"
                     /note="TNF receptor associated factor 7"
                     /db_xref="GeneID:360491"
                     /db_xref="RGD:1559653"
     exon            1..85
                     /gene="Traf7"
                     /gene_synonym="RGD1559653"
                     /inference="alignment:Splign:2.1.0"
     exon            86..201
                     /gene="Traf7"
                     /gene_synonym="RGD1559653"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..2136
                     /gene="Traf7"
                     /gene_synonym="RGD1559653"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; E3
                     ubiquitin-protein ligase TRAF7; TNF receptor-associated
                     factor 7, E3 ubiquitin protein ligase"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRAF7 isoform 1"
                     /protein_id="NP_001402082.1"
                     /db_xref="GeneID:360491"
                     /db_xref="RGD:1559653"
                     /translation="MSSAKSARYNRFSGGPANLPASDSSGTRMETTFGPTFSTVTTIT
                     KAADGTSTYKQHRRTPSSSSTLAYSPRDEEDGMPPINTPRRSDSAISVRSLHSESSMS
                     LRSTFSLPEEEEEPEPLVFAEQPSVKLCCQLCCSVFKDPVITTCGHTFCRRCALKSEK
                     CPVDNAKLTVVVNNIAVAEQIGELFIHCRHGCRAAGTGKPGVFEVDPRGCPFTIKLSA
                     RKDHESSCDYRPVRCPNNPSCPPLLKMNLEAHLKECEHIKCPHSKYGCTFIGNQDTYE
                     THLETCRFEGLKEFLQQTDDRFHEMHVALAQKDQEIAFLRSMLGKLSEKIDQLEKSLE
                     LKFDVLDENQSKLSEDLMEFRRDASMLNDELSHINARLNMGILGSYDPQQIFKCKGTF
                     VGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGC
                     KLYSGSADCTIIVWDIQNLQKVNTIRAHDNPVCTLVSSHNMLFSGSLKAIKVWDIVGT
                     ELKLKKELTGLNHWVRALVAAQSYLYSGSYQTIKIWDIRTLDCIHVLQTSGGSVYSIA
                     VTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRS
                     LRVWSMDNMICTQTLLRHQGSVTALAVSRGRLFSGAVDSTVKVWTC"
     exon            202..259
                     /gene="Traf7"
                     /gene_synonym="RGD1559653"
                     /inference="alignment:Splign:2.1.0"
     exon            260..354
                     /gene="Traf7"
                     /gene_synonym="RGD1559653"
                     /inference="alignment:Splign:2.1.0"
     exon            355..471
                     /gene="Traf7"
                     /gene_synonym="RGD1559653"
                     /inference="alignment:Splign:2.1.0"
     exon            472..564
                     /gene="Traf7"
                     /gene_synonym="RGD1559653"
                     /inference="alignment:Splign:2.1.0"
     exon            565..598
                     /gene="Traf7"
                     /gene_synonym="RGD1559653"
                     /inference="alignment:Splign:2.1.0"
     exon            599..782
                     /gene="Traf7"
                     /gene_synonym="RGD1559653"
                     /inference="alignment:Splign:2.1.0"
     exon            783..917
                     /gene="Traf7"
                     /gene_synonym="RGD1559653"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1135
                     /gene="Traf7"
                     /gene_synonym="RGD1559653"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1209
                     /gene="Traf7"
                     /gene_synonym="RGD1559653"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1258
                     /gene="Traf7"
                     /gene_synonym="RGD1559653"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1386
                     /gene="Traf7"
                     /gene_synonym="RGD1559653"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1469
                     /gene="Traf7"
                     /gene_synonym="RGD1559653"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1509
                     /gene="Traf7"
                     /gene_synonym="RGD1559653"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1626
                     /gene="Traf7"
                     /gene_synonym="RGD1559653"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1749
                     /gene="Traf7"
                     /gene_synonym="RGD1559653"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..1869
                     /gene="Traf7"
                     /gene_synonym="RGD1559653"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..2001
                     /gene="Traf7"
                     /gene_synonym="RGD1559653"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2121
                     /gene="Traf7"
                     /gene_synonym="RGD1559653"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2653
                     /gene="Traf7"
                     /gene_synonym="RGD1559653"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcctgtacc tttcccggcc ccgggccgag aggggcaaga tgatgccgga gggtgtagcc
       61 gctgctccca ggcagctgcg ggcgggggac actgcccaag gaccctggat gcctctctag
      121 agcatgagct cagccaagag tgcccgctac aaccgcttct ccggggggcc tgccaacctt
      181 cctgcctcag acagcagtgg gaccaggatg gaaacaacct ttgggcctac cttttcgacc
      241 gtcaccacca ttaccaaagc agctgatggg accagcacat acaaacagca tcgcaggacg
      301 ccttcctcct ctagcaccct tgcctattcg ccacgggatg aggaggacgg catgcccccc
      361 atcaacactc ctcgccgctc tgactcagcc atctctgtcc gctccctgca ctccgagtcc
      421 agcatgtccc tgcgctccac gttctcgctg cctgaggagg aagaggagcc ggagccattg
      481 gtgtttgcgg agcagccctc ggtgaagctg tgctgccagc tctgctgcag tgtgttcaag
      541 gaccctgtga tcactacgtg tgggcacacc ttctgcagac gatgcgcctt gaagtcagag
      601 aagtgtcctg tggacaatgc caagctgaca gtggtggtaa acaacattgc agtagctgag
      661 cagattggag agctcttcat acattgtcgg catggctgcc gtgcagcagg cactgggaag
      721 cccggtgtct ttgaggtaga cccaaggggc tgccccttca ccatcaagct tagtgcccgg
      781 aaggaccacg agagtagttg tgactacagg cctgtgcgct gccccaacaa ccccagctgc
      841 ccaccccttc tcaagatgaa cctcgaggcc cacctgaaag aatgcgagca catcaagtgt
      901 ccccactcta agtacgggtg cacatttatt gggaatcagg acacctatga gacgcactta
      961 gaaacatgtc gctttgaggg cctgaaggaa ttcctgcagc agaccgatga ccgcttccac
     1021 gagatgcatg tggcactggc ccagaaggac caggagattg cctttctgcg ttccatgctg
     1081 ggcaaactct cagagaagat tgaccagctg gagaaaagcc ttgagctcaa gttcgatgtc
     1141 ctcgatgaga accagagcaa gctcagtgag gacctcatgg aattccggag ggatgcatcc
     1201 atgttgaatg atgagctgtc tcatatcaat gcacgcctga acatgggtat cctgggatcc
     1261 tatgatcctc agcagatctt caagtgcaaa gggaccttcg tgggacacca gggccctgtc
     1321 tggtgtctct gtgtctactc catgggtgac ctgctcttca gtggctcttc tgacaagacg
     1381 atcaaggtgt gggacacgtg taccacttac aagtgccaaa agacactgga aggtcatgac
     1441 ggtattgtgc tggcgctctg tatccagggg tgcaaactgt acagtgggtc tgcagactgc
     1501 accatcattg tatgggacat ccagaacctg cagaaggtga acaccatccg ggcccatgac
     1561 aaccctgtgt gcacactggt gtcttcccat aacatgctct tcagtggctc ccttaaagcc
     1621 atcaaggtct gggacatcgt gggcactgag ctaaagttga agaaggaact cacaggcctc
     1681 aaccactggg tgcgggcctt ggtggcagca cagagctatc tgtacagtgg ctcttaccag
     1741 acaatcaaga tctgggacat tcggaccctt gactgcatcc atgtcctgca gacatctggt
     1801 ggcagtgtgt attccattgc tgtgacgaat caccacattg tctgtggcac ctatgagaac
     1861 ctcattcatg tatgggacat tgaatccaaa gagcaggtgc ggaccctaac gggccatgtg
     1921 ggcacagtat atgccctggc agtcatttca acaccagacc agaccaaagt cttcagcgca
     1981 tcctatgacc gctccctcag ggtctggagc atggacaaca tgatctgcac acagacgctg
     2041 ctgcgccatc agggcagtgt aactgcactg gctgtctccc ggggccggct cttctcgggg
     2101 gctgtggata gcaccgtgaa ggtttggaca tgctaacaga atccaggcca ggcttgactc
     2161 cttctgggtc tgtaagtcag gctggacctc catgatggcc ttggaatgtc cgcctgtcct
     2221 gtggagacag gtagacaggc tcaaacagct aggcagtgtc ctctctgcct ctgctcagtg
     2281 cggggtcttt cataaggcct cactcttact tctaccagag aaatgcccag gccctgctct
     2341 gggcgccagg tacgatgctt gcccggcccc accattcata tcactccata gacttttgtt
     2401 ttgagacagg gtctcactat gtagctctgg cttgcctgga actcactgtc aaccaggctg
     2461 gcctcaaact cacagatctg cctgcctcca cctcccaagt gctgggagta aaggcatgtg
     2521 ccaccgcccc tggctggacc cagatggacc atgggtcctt tttactcacc ttttctactg
     2581 gttttagact gtatatagat tttattactt ccctgttgaa ataaaagctg cacagactgt
     2641 ggttgtgagt gga
//
