LOCUS       NM_001107754            2753 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus TNF receptor associated factor 6 (Traf6), mRNA.
ACCESSION   NM_001107754 XM_001079281 XM_230377
VERSION     NM_001107754.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2753)
  AUTHORS   Yang,P., Wang,Y., Ge,W., Jing,Y., Hu,H., Yin,J., Xue,M., Wang,Y.,
            Li,X., Li,X., Shi,Y., Tan,J., Li,Y. and Yan,S.
  TITLE     m6A methyltransferase METTL3 contributes to sympathetic
            hyperactivity post-MI via promoting TRAF6-dependent mitochondrial
            ROS production
  JOURNAL   Free Radic Biol Med 209 (Pt 2), 342-354 (2023)
   PUBMED   37898386
  REMARK    GeneRIF: m6A methyltransferase METTL3 contributes to sympathetic
            hyperactivity post-MI via promoting TRAF6-dependent mitochondrial
            ROS production.
REFERENCE   2  (bases 1 to 2753)
  AUTHORS   Wei,B., Su,Z., Yang,H., Feng,Y., Meng,C. and Liang,Z.
  TITLE     Inhibition of TRAF6 improves hyperlipidemic acute pancreatitis by
            alleviating pyroptosis in vitro and in vivo rat models
  JOURNAL   Biol Direct 18 (1), 23 (2023)
   PUBMED   37165439
  REMARK    GeneRIF: Inhibition of TRAF6 improves hyperlipidemic acute
            pancreatitis by alleviating pyroptosis in vitro and in vivo rat
            models.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2753)
  AUTHORS   Xia,P., Marjan,M., Liu,Z., Zhou,W., Zhang,Q., Cheng,C., Zhao,M.,
            Tao,Y., Wang,Z. and Ye,Z.
  TITLE     Chrysophanol postconditioning attenuated cerebral
            ischemia-reperfusion injury induced NLRP3-related pyroptosis in a
            TRAF6-dependent manner
  JOURNAL   Exp Neurol 357, 114197 (2022)
   PUBMED   35932799
  REMARK    GeneRIF: Chrysophanol postconditioning attenuated cerebral
            ischemia-reperfusion injury induced NLRP3-related pyroptosis in a
            TRAF6-dependent manner.
REFERENCE   4  (bases 1 to 2753)
  AUTHORS   Zhang,T. and Ge,J.
  TITLE     Mechanism of CREB1 in cardiac function of rats with heart failure
            via regulating the microRNA-376a-3p/TRAF6 axis
  JOURNAL   Mamm Genome 33 (3), 490-501 (2022)
   PUBMED   35217880
  REMARK    GeneRIF: Mechanism of CREB1 in cardiac function of rats with heart
            failure via regulating the microRNA-376a-3p/TRAF6 axis.
REFERENCE   5  (bases 1 to 2753)
  AUTHORS   Wei,B., Wu,Q., Yang,X., Lai,C., Su,Z. and Liang,Z.
  TITLE     Effect of TRAF6 in acute pancreatitis-induced intestinal barrier
            injury via TLR4/NF-kappaB signal pathway
  JOURNAL   Tissue Cell 76, 101792 (2022)
   PUBMED   35405432
  REMARK    GeneRIF: Effect of TRAF6 in acute pancreatitis-induced intestinal
            barrier injury via TLR4/NF-kappaB signal pathway.
REFERENCE   6  (bases 1 to 2753)
  AUTHORS   Zapata,J.M., Pawlowski,K., Haas,E., Ware,C.F., Godzik,A. and
            Reed,J.C.
  TITLE     A diverse family of proteins containing tumor necrosis factor
            receptor-associated factor domains
  JOURNAL   J Biol Chem 276 (26), 24242-24252 (2001)
   PUBMED   11279055
REFERENCE   7  (bases 1 to 2753)
  AUTHORS   Lomaga,M.A., Henderson,J.T., Elia,A.J., Robertson,J., Noyce,R.S.,
            Yeh,W.C. and Mak,T.W.
  TITLE     Tumor necrosis factor receptor-associated factor 6 (TRAF6)
            deficiency results in exencephaly and is required for apoptosis
            within the developing CNS
  JOURNAL   J Neurosci 20 (19), 7384-7393 (2000)
   PUBMED   11007897
REFERENCE   8  (bases 1 to 2753)
  AUTHORS   Naito,A., Azuma,S., Tanaka,S., Miyazaki,T., Takaki,S., Takatsu,K.,
            Nakao,K., Nakamura,K., Katsuki,M., Yamamoto,T. and Inoue,J.
  TITLE     Severe osteopetrosis, defective interleukin-1 signalling and lymph
            node organogenesis in TRAF6-deficient mice
  JOURNAL   Genes Cells 4 (6), 353-362 (1999)
   PUBMED   10421844
REFERENCE   9  (bases 1 to 2753)
  AUTHORS   Lomaga,M.A., Yeh,W.C., Sarosi,I., Duncan,G.S., Furlonger,C., Ho,A.,
            Morony,S., Capparelli,C., Van,G., Kaufman,S., van der Heiden,A.,
            Itie,A., Wakeham,A., Khoo,W., Sasaki,T., Cao,Z., Penninger,J.M.,
            Paige,C.J., Lacey,D.L., Dunstan,C.R., Boyle,W.J., Goeddel,D.V. and
            Mak,T.W.
  TITLE     TRAF6 deficiency results in osteopetrosis and defective
            interleukin-1, CD40, and LPS signaling
  JOURNAL   Genes Dev 13 (8), 1015-1024 (1999)
   PUBMED   10215628
REFERENCE   10 (bases 1 to 2753)
  AUTHORS   Ninomiya-Tsuji,J., Kishimoto,K., Hiyama,A., Inoue,J., Cao,Z. and
            Matsumoto,K.
  TITLE     The kinase TAK1 can activate the NIK-I kappaB as well as the MAP
            kinase cascade in the IL-1 signalling pathway
  JOURNAL   Nature 398 (6724), 252-256 (1999)
   PUBMED   10094049
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC168921.1.
            
            On Sep 4, 2008 this sequence version replaced NM_001107754.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168921.1, SRR8487227.172149.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132263, SAMD00132265
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2753
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q31"
     gene            1..2753
                     /gene="Traf6"
                     /note="TNF receptor associated factor 6"
                     /db_xref="GeneID:311245"
                     /db_xref="RGD:1306853"
     exon            1..168
                     /gene="Traf6"
                     /inference="alignment:Splign:2.1.0"
     exon            169..486
                     /gene="Traf6"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..1783
                     /gene="Traf6"
                     /EC_number="2.3.2.27"
                     /note="E3 ubiquitin-protein ligase TRAF6; TNF
                     receptor-associated factor 6, E3 ubiquitin protein ligase;
                     RING-type E3 ubiquitin transferase TRAF6"
                     /codon_start=1
                     /product="TNF receptor-associated factor 6"
                     /protein_id="NP_001101224.1"
                     /db_xref="GeneID:311245"
                     /db_xref="RGD:1306853"
                     /translation="MSLLNCENSCASSQSSSDCCAAMANSCSAAMKDDSVSGCVSTGN
                     LSSSFMEEIQGYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACITKSIRDAG
                     HKCPVDNEILLENQLFPDNFAKREILSLTVKCPNKGCVQKMELRHLEDHQVHCEFALV
                     ICPQCQRFFQKCQINKHIIEDCPRRQVSCVNCAVPMPYEEKEIHDQSCPLANIICEYC
                     GTILIREQMPNHYDLDCPTAPVPCTFSVFGCHEKMQRNHLARHLQENTQLHMRLLAQA
                     VHNVNLSLRPCDASSPSRGCRPEDPNYEETVKQLEGRLVRQDHQIRELTAKMETQSMH
                     VSELKRTIRSLEDKVAEMEAQQCNGIYIWKIGNFGMHLKSQEEERPVVIHSPGFYTGR
                     PGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGTIRLTILDQSEAVI
                     RQNHEEVMDAKPELLAFQRPTIPRNPKGFGYVTFMHLEALRQGTFIKDDTLLVRCEVS
                     TRFDMGGLRKEGFQPRSTDAGV"
     exon            487..637
                     /gene="Traf6"
                     /inference="alignment:Splign:2.1.0"
     exon            638..796
                     /gene="Traf6"
                     /inference="alignment:Splign:2.1.0"
     exon            797..868
                     /gene="Traf6"
                     /inference="alignment:Splign:2.1.0"
     exon            869..946
                     /gene="Traf6"
                     /inference="alignment:Splign:2.1.0"
     exon            947..2707
                     /gene="Traf6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcggctggg gctgaggctc cggccgtcgg cggacgcagt agccgcggcc caggaaccgg
       61 gagtttggcg tcggagacac ttgatctcgg agtgctgcgt gtataggcgg cgcgtggcgg
      121 cccgggggag ctttctagtc ggttgtgaag cctctgcgtg tgcgatcgat tgactgacaa
      181 caaagctact atgagtctct taaactgtga aaacagctgt gcgtccagcc agtcttcaag
      241 cgactgctgt gctgccatgg ccaactcctg cagtgctgcc atgaaagatg acagtgtgag
      301 tggctgtgtc agcacgggga acctgtccag ctccttcatg gaggagatcc agggatatga
      361 tgtggagttt gacccacctt tggaaagcaa gtatgagtgc cccatctgct tgatggcttt
      421 acgggaagca gtgcaaacac catgtggcca caggttctgc aaagcctgca tcaccaagtc
      481 cataagggat gcaggtcaca agtgcccagt tgacaatgaa atactgctgg aaaatcaact
      541 gtttcctgac aattttgcaa agcgagagat tctttccctg acggtaaagt gtccaaataa
      601 aggctgtgtg caaaagatgg agctgagaca tctcgaggat catcaagtac attgtgaatt
      661 cgctctagtg atttgtcccc aatgccaacg ttttttccaa aagtgccaga ttaataaaca
      721 cattatcgag gattgtccca ggagacaggt ttcttgtgta aactgtgctg tgcccatgcc
      781 gtatgaagag aaagagatcc acgatcaaag ctgtcctctg gcaaatatca tctgtgaata
      841 ctgtggtaca atcctcataa gagaacagat gcctaatcat tatgatctag actgcccaac
      901 agctccagtc ccctgcacat tcagtgtgtt tggctgtcac gaaaagatgc agaggaatca
      961 cttggcacgg cacttgcaag agaacaccca gttgcacatg agactgttgg cccaggctgt
     1021 tcataatgtt aacctctctt tgcggccatg cgatgcctcc tctccatccc ggggatgtcg
     1081 tcctgaggac ccaaattatg aggaaacggt caaacagttg gaggggcgcc tagtaagaca
     1141 ggaccatcaa atccgggagc tgaccgccaa aatggaaacg cagagcatgc atgtgagcga
     1201 gctcaagcgg accattcgaa gcctcgagga caaagttgcc gagatggaag cacagcagtg
     1261 taatggcatt tacatttgga agattggcaa ctttgggatg cacttgaaat cccaagaaga
     1321 ggaaagacct gtggtcattc atagccctgg attctacaca ggcagacctg ggtacaagct
     1381 gtgcatgcgc ctgcacctcc agctaccgac ggctcagcgc tgtgcaaact acatttccct
     1441 ctttgtccac acaatgcaag gagagtatga cagccacctc ccctggccct tccagggtac
     1501 aatacgcctc acgatccttg atcagtctga agcagtaata aggcaaaacc acgaagaggt
     1561 catggatgct aagccagaac tgcttgcctt tcagcggccc accatcccac ggaaccccaa
     1621 aggttttggc tatgtgacat tcatgcacct ggaagcctta agacagggaa ccttcatcaa
     1681 ggatgatacg ttattagtgc gctgtgaagt ctctacccgc tttgacatgg ggggccttcg
     1741 gaaggagggg ttccagccac ggagtactga tgcaggcgtg tagcctccac ttacctgtgt
     1801 tcaaaaacta ggagccatat ggaaaaaccg tgccttccgc acctggtcca gtaaacaaac
     1861 ggtgggagag gtgtaaggcc agcagcagat gtcatcagcg aggtcacatt acacttctta
     1921 ccgttaacca atatctgggg caattcccat ggggacctcc gtgtcccctg tgtcttcaga
     1981 accttaacat ttgaagggcc agacgctcat caatttgtca gggaacctct tcactgtgct
     2041 tccatgggct tttttgtcca tgtactttac tgaaaaaaaa aaaggccaga attaatgtac
     2101 tggagctcaa tcgtttaata ctggtgcctt aaacacttaa agtgctttta gggcatgtat
     2161 taaacgtgag gatcaccatt gcctgtgctg ctgccagtgg aaaggttact gctctggtgt
     2221 tgagttctca tttagttgac ccctgtgaat ttcagaggct ttgaaccatg atccctggaa
     2281 agctgaagtt ctcatgtact ccctcctcca ttgaccaggg actggtttaa cccttactta
     2341 taaatagcac gaatgtattg tccattgaac accaagggtt tctcccctgc cttcattgtt
     2401 gaaatatgct ctaggcagca tcttcccggt ttgtaagact gtggtcatgt ggttgccaac
     2461 tgttcagtgt gactgtcatg taacctttct tgtctgttca gtatagcttg gtttccacag
     2521 cctgtcgcac atcttctgtt gcttgcaaac acaaaatcgc cagcctaaac aagtgatcag
     2581 ctcaccagcc attaaatggc atctcatgga tgatgacagc aattcttata gccaggaaac
     2641 ttcagccctc ttaactacct tccaatttag cttagttgat tgaaataaaa ctgatttcct
     2701 caaggggaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
