LOCUS       NM_001107815            2098 bp    mRNA    linear   ROD 27-MAR-2023
DEFINITION  Rattus norvegicus Tnf receptor-associated factor 2 (Traf2), mRNA.
ACCESSION   NM_001107815 XM_001077727 XM_231032
VERSION     NM_001107815.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2098)
  AUTHORS   Yuan F, Xu X, Wu Y, Duan S and Wu H.
  TITLE     Gastrodin Ameliorates Acute Rejection via IRE1alpha/TRAF2/NF-kappaB
            in Rats Receiving Liver Allografts
  JOURNAL   Biomed Res Int 2019, 9276831 (2019)
   PUBMED   31828147
  REMARK    GeneRIF: Studied the effect of gastrodin (GAS) on LT, and found the
            endoplasmic reticulum to nucleus signaling 1(IRE1alpha)/Tnf
            receptor-associated factor 2 (TRAF2)/NF-kappaB signal pathway (and
            therefore acute rejection) was suppressed by GAS.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2098)
  AUTHORS   Fragoza R, Das J, Wierbowski SD, Liang J, Tran TN, Liang S, Beltran
            JF, Rivera-Erick CA, Ye K, Wang TY, Yao L, Mort M, Stenson PD,
            Cooper DN, Wei X, Keinan A, Schimenti JC, Clark AG and Yu H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2098)
  AUTHORS   Van Quickelberghe E, De Sutter D, van Loo G, Eyckerman S and
            Gevaert K.
  TITLE     A protein-protein interaction map of the TNF-induced NF-kappaB
            signal transduction pathway
  JOURNAL   Sci Data 5, 180289 (2018)
   PUBMED   30561431
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2098)
  AUTHORS   Xu G, Zhang J, Wang L, Cui Z, Sun X, Liu Z, Zhu Z and Qiu Y.
  TITLE     Up-regulation of TRAF2 Suppresses Neuronal Apoptosis after Rat
            Spinal Cord Injury
  JOURNAL   Tissue Cell 49 (5), 589-596 (2017)
   PUBMED   28843337
  REMARK    GeneRIF: Our data suggest that upregulation of TRAF2 triggered by
            trauma plays an important role in suppressing neuronal apoptosis
            after spinal cord injury
REFERENCE   5  (bases 1 to 2098)
  AUTHORS   Hashem RM, Mohamed RH and Abo-El-matty DM.
  TITLE     Effect of curcumin on TNFR2 and TRAF2 in unilateral ureteral
            obstruction in rats
  JOURNAL   Nutrition 32 (4), 478-485 (2016)
   PUBMED   26732833
  REMARK    GeneRIF: Curcumin decreased TNFR2 and increased TRAF2 to decrease
            the apoptotic pathway in ureteral obstruction rats.
REFERENCE   6  (bases 1 to 2098)
  AUTHORS   Akama KT and Van Eldik LJ.
  TITLE     Beta-amyloid stimulation of inducible nitric-oxide synthase in
            astrocytes is interleukin-1beta- and tumor necrosis factor-alpha
            (TNFalpha)-dependent, and involves a TNFalpha receptor-associated
            factor- and NFkappaB-inducing kinase-dependent signaling mechanism
  JOURNAL   J Biol Chem 275 (11), 7918-7924 (2000)
   PUBMED   10713108
REFERENCE   7  (bases 1 to 2098)
  AUTHORS   Urano F, Wang X, Bertolotti A, Zhang Y, Chung P, Harding HP and Ron
            D.
  TITLE     Coupling of stress in the ER to activation of JNK protein kinases
            by transmembrane protein kinase IRE1
  JOURNAL   Science 287 (5453), 664-666 (2000)
   PUBMED   10650002
REFERENCE   8  (bases 1 to 2098)
  AUTHORS   Natoli G, Costanzo A, Guido F, Moretti F, Bernardo A, Burgio VL,
            Agresti C and Levrero M.
  TITLE     Nuclear factor kB-independent cytoprotective pathways originating
            at tumor necrosis factor receptor-associated factor 2
  JOURNAL   J Biol Chem 273 (47), 31262-31272 (1998)
   PUBMED   9813034
REFERENCE   9  (bases 1 to 2098)
  AUTHORS   Malinin NL, Boldin MP, Kovalenko AV and Wallach D.
  TITLE     MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95
            and IL-1
  JOURNAL   Nature 385 (6616), 540-544 (1997)
   PUBMED   9020361
REFERENCE   10 (bases 1 to 2098)
  AUTHORS   Rothe M, Wong SC, Henzel WJ and Goeddel DV.
  TITLE     A novel family of putative signal transducers associated with the
            cytoplasmic domain of the 75 kDa tumor necrosis factor receptor
  JOURNAL   Cell 78 (4), 681-692 (1994)
   PUBMED   8069916
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC169064.1.
            
            On Sep 4, 2008 this sequence version replaced NM_001107815.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC169064.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2098
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p13"
     gene            1..2098
                     /gene="Traf2"
                     /note="Tnf receptor-associated factor 2"
                     /db_xref="GeneID:311786"
                     /db_xref="RGD:1310457"
     exon            1..15
                     /gene="Traf2"
                     /inference="alignment:Splign:2.1.0"
     exon            16..232
                     /gene="Traf2"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..1538
                     /gene="Traf2"
                     /EC_number="2.3.2.27"
                     /codon_start=1
                     /product="TNF receptor-associated factor 2"
                     /protein_id="NP_001101285.1"
                     /db_xref="GeneID:311786"
                     /db_xref="RGD:1310457"
                     /translation="MAAASVTSPGSLELLQPGFSKTLLGTRLEAKYLCSACRNILRRP
                     FQAQCGHRYCSFCLTSILSSGPQNCAACVHEGLYEEGISILESSSAFPDNAARREVES
                     LPAVCPNDGCTWKGTLKEYESCHEGLCPFLLTECPACKGLVRLSEKKHHTEQECPKRS
                     LSCQHCRAPCSHADLELHYEVCPKFPLTCDGCGKKISQEKLQDHVRTCSKCRVLCRFH
                     AIGCSELVETEDLQDHELQRLREHLALLLSSFLESQASQNQVGPELLQRCQILEQKIA
                     TFENIVCVLNREVERVAVTAEACSRQHRLDQDKIEALSNKVQQLERSIGLKDLAMADL
                     EQKVSELEVSTYDGVFIWKISDFARKRQEAIAGRTPAIFSPAFFTSRYGYKMCLRVYL
                     NGDGTGRGTHLSLFFVVMKGPNDALLQWPFNQKVTLMLLDHNNREHVIDAFRPDVTSS
                     SFQRPVSDMNIASGCPLFCPVSKIEAKNSYVRDDAIFIKAIVDLTGL"
     exon            233..311
                     /gene="Traf2"
                     /inference="alignment:Splign:2.1.0"
     exon            312..410
                     /gene="Traf2"
                     /inference="alignment:Splign:2.1.0"
     exon            411..572
                     /gene="Traf2"
                     /inference="alignment:Splign:2.1.0"
     exon            573..644
                     /gene="Traf2"
                     /inference="alignment:Splign:2.1.0"
     exon            645..719
                     /gene="Traf2"
                     /inference="alignment:Splign:2.1.0"
     exon            720..992
                     /gene="Traf2"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1170
                     /gene="Traf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1319
                     /gene="Traf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..2070
                     /gene="Traf2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgaagacc gttggggctt tgtggtgcgt gggttataac tcacatggct gcagccagtg
       61 tgacttcccc tggctcccta gaactgctgc agcctggctt ctccaagacc cttctgggga
      121 caaggttaga agccaagtac ctgtgttcag cctgcagaaa catcctgcgg aggccattcc
      181 aggcccagtg tgggcaccgc tactgctcct tctgcctgac cagcatcctc agctctgggc
      241 ctcagaactg tgctgcctgt gttcacgaag gcctgtatga agaaggcatt tctattttag
      301 agagcagttc ggcctttcca gataacgctg cccgcagaga ggtggagagc ctgccagccg
      361 tctgtcccaa tgatggatgc acctggaagg ggaccttgaa agaatacgag agctgccacg
      421 aaggactgtg cccattcctg ctgactgagt gccctgcgtg taaaggcctg gttcgcctca
      481 gcgagaagaa gcaccacact gagcaggaat gccccaaaag gagcctgagc tgccagcact
      541 gcagggcacc ctgtagccat gcagacctgg agctacacta cgaggtctgc cccaagtttc
      601 ccttaacctg tgatggctgt ggcaagaaga tctctcagga gaagcttcag gaccatgtca
      661 gaacgtgcag taagtgccgg gtcctctgca ggttccacgc catcggctgc tcggagctgg
      721 tggagactga ggacctgcag gaccacgagc tgcagcgtct acgggaacat ctggccctac
      781 tgctgagctc gttcctggag tcccaagcct cacagaacca ggtggggcca gagctgttac
      841 agcggtgcca gattttggag cagaagatag ccacctttga gaacattgtc tgcgttttga
      901 accgggaggt agagagggta gcagtgactg cagaggcttg tagccggcag caccgtctgg
      961 accaggacaa gattgaggcc ctaagcaaca aggtgcagca gctggagagg agcatcggcc
     1021 tcaaggacct ggccatggct gacctggagc agaaggtctc agagttggag gtgtccacct
     1081 atgatggggt cttcatctgg aagatctccg acttcgccag aaaacgtcag gaagccatcg
     1141 ctggccggac acctgctatc ttctccccag ccttcttcac aagcagatat ggctacaaga
     1201 tgtgtctccg ggtctacttg aatggcgacg gcactgggcg gggaactcat ctgtctctct
     1261 tcttcgtggt gatgaaaggt cccaatgatg ctctcttaca atggcctttt aatcagaagg
     1321 tgactttgat gttgctggac cataacaacc gagagcatgt gatcgacgca ttcaggcctg
     1381 atgtaacttc gtcctccttc cagaggcctg tcagtgacat gaatatcgcc agtggctgcc
     1441 ccctcttctg cccggtgtcc aagatagagg ccaagaattc ctacgtgcgg gatgacgcca
     1501 tcttcatcaa agctattgtg gacctgacag gactctagcc accctactaa gagcagcagc
     1561 tcagtgacga gctgtcacat taggccagcc agggccttcc cacacgaggg tgggcaggtt
     1621 tggtgtgaat gccgaatgcc ggggaggacc tcagcctaaa gccaatcacc atcacacaga
     1681 caggcaggaa ggagcctcca gttggtcctc aactggtaaa ctgagttgga gggtcagctg
     1741 agctcagggt cctgggggaa ccagctgggg atcttctctt gctgtatttt ctgtctgggg
     1801 aagggagaca ccctttggtg gggtactcag aaagggcctc tcaagagaga gcctcaagag
     1861 ctgcaccagg agcaagagtg attggccttc cccagcccag cctttgggaa agaggcaggg
     1921 gctgcccagg aaaggcatgc gcctgcagag tgcagcccag gagagaagcg ctctgggaca
     1981 taggcacgca ctggagcagg gcctgcctgg gctgcacagc cctgccaggt ggcctgtatg
     2041 gaggagaagt gattaaacta ttcagatgtc aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
