LOCUS       NM_001271240            1910 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus TNF receptor-associated factor 1 (Traf1), mRNA.
ACCESSION   NM_001271240 XM_003749450
VERSION     NM_001271240.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1910)
  AUTHORS   Yu,S., Wang,M., Guo,X. and Qin,R.
  TITLE     Curcumin Attenuates Inflammation in a Severe Acute Pancreatitis
            Animal Model by Regulating TRAF1/ASK1 Signaling
  JOURNAL   Med Sci Monit 24, 2280-2286 (2018)
   PUBMED   29657313
  REMARK    GeneRIF: Activation of the TRAF1/ASK1/JNK/NF-kappaB signaling
            pathway is involved in the inflammation of SAP. Curcumin exerts
            anti-inflammatory effects by suppressing this proinflammatory
            pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1910)
  AUTHORS   Yachie,N., Petsalaki,E., Mellor,J.C., Weile,J., Jacob,Y., Verby,M.,
            Ozturk,S.B., Li,S., Cote,A.G., Mosca,R., Knapp,J.J., Ko,M., Yu,A.,
            Gebbia,M., Sahni,N., Yi,S., Tyagi,T., Sheykhkarimli,D., Roth,J.F.,
            Wong,C., Musa,L., Snider,J., Liu,Y.C., Yu,H., Braun,P.,
            Stagljar,I., Hao,T., Calderwood,M.A., Pelletier,L., Aloy,P.,
            Hill,D.E., Vidal,M. and Roth,F.P.
  TITLE     Pooled-matrix protein interaction screens using Barcode Fusion
            Genetics
  JOURNAL   Mol Syst Biol 12 (4), 863 (2016)
   PUBMED   27107012
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1910)
  AUTHORS   Bouwmeester,T., Bauch,A., Ruffner,H., Angrand,P.O., Bergamini,G.,
            Croughton,K., Cruciat,C., Eberhard,D., Gagneur,J., Ghidelli,S.,
            Hopf,C., Huhse,B., Mangano,R., Michon,A.M., Schirle,M., Schlegl,J.,
            Schwab,M., Stein,M.A., Bauer,A., Casari,G., Drewes,G., Gavin,A.C.,
            Jackson,D.B., Joberty,G., Neubauer,G., Rick,J., Kuster,B. and
            Superti-Furga,G.
  TITLE     A physical and functional map of the human TNF-alpha/NF-kappa B
            signal transduction pathway
  JOURNAL   Nat Cell Biol 6 (2), 97-105 (2004)
   PUBMED   14743216
  REMARK    Erratum:[Nat Cell Biol. 2004 May;6(5):465]
REFERENCE   4  (bases 1 to 1910)
  AUTHORS   Wiley,S.R., Cassiano,L., Lofton,T., Davis-Smith,T., Winkles,J.A.,
            Lindner,V., Liu,H., Daniel,T.O., Smith,C.A. and Fanslow,W.C.
  TITLE     A novel TNF receptor family member binds TWEAK and is implicated in
            angiogenesis
  JOURNAL   Immunity 15 (5), 837-846 (2001)
   PUBMED   11728344
REFERENCE   5  (bases 1 to 1910)
  AUTHORS   Zapata,J.M., Pawlowski,K., Haas,E., Ware,C.F., Godzik,A. and
            Reed,J.C.
  TITLE     A diverse family of proteins containing tumor necrosis factor
            receptor-associated factor domains
  JOURNAL   J Biol Chem 276 (26), 24242-24252 (2001)
   PUBMED   11279055
REFERENCE   6  (bases 1 to 1910)
  AUTHORS   Irmler,M., Steiner,V., Ruegg,C., Wajant,H. and Tschopp,J.
  TITLE     Caspase-induced inactivation of the anti-apoptotic TRAF1 during Fas
            ligand-mediated apoptosis
  JOURNAL   FEBS Lett 468 (2-3), 129-133 (2000)
   PUBMED   10692572
REFERENCE   7  (bases 1 to 1910)
  AUTHORS   Rothe,M., Wong,S.C., Henzel,W.J. and Goeddel,D.V.
  TITLE     A novel family of putative signal transducers associated with the
            cytoplasmic domain of the 75 kDa tumor necrosis factor receptor
  JOURNAL   Cell 78 (4), 681-692 (1994)
   PUBMED   8069916
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Feb 10, 2021 this sequence version replaced NM_001271240.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.12219.1,
                                           SRR22582419.1813848.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN16676785,
                                           SAMN16676787 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               JAXUCZ010000003.1  38635576-38635770   c
            196-280             JAXUCZ010000003.1  38633836-38633920   c
            281-346             JAXUCZ010000003.1  38625720-38625785   c
            347-757             JAXUCZ010000003.1  38624808-38625218   c
            758-935             JAXUCZ010000003.1  38623353-38623530   c
            936-1084            JAXUCZ010000003.1  38621467-38621615   c
            1085-1910           JAXUCZ010000003.1  38619506-38620331   c
FEATURES             Location/Qualifiers
     source          1..1910
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p11"
     gene            1..1910
                     /gene="Traf1"
                     /note="TNF receptor-associated factor 1"
                     /db_xref="GeneID:687813"
                     /db_xref="RGD:1596290"
     exon            1..195
                     /gene="Traf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..1303
                     /gene="Traf1"
                     /EC_number="2.3.2.27"
                     /codon_start=1
                     /product="TNF receptor-associated factor 1"
                     /protein_id="NP_001258169.1"
                     /db_xref="GeneID:687813"
                     /db_xref="RGD:1596290"
                     /translation="MASSSAPDENEFQFGCPPAPSQDPSEPRALCCTACLSENLRDDE
                     ERICPKCRADGLQPVSPGSLLTQEKVLPDVAEAGIVCPFAGVGCSFKGSPQSVQEHEA
                     TSQSSHLYLLLGVLKEWKSSPGPNLGSAPMALEQNLSELQLQEAVEVTGDLEVDCYRA
                     PCCESQEELALQHLLKEKLLAQLEEKLRVFANIVAVLNKEVEASHLALAASIHQSQLD
                     REHVLNLEQRVVELQQTLAQKDQVLGKLEHSLRLMEEASFDGTFLWKITNVTKRCHES
                     VCGRTVSLFSPAFYTAKYGYKLCLRLYLNGDGSGKKTHLSLFIVIMRGEYDALLPWPF
                     RNKVTFMLLDQNNREHAIDAFRPDLSSASFQRPQSETNVASGCPLFFPLSKLQSPKHA
                     YVKDDTMFLKCIVDTSA"
     exon            196..280
                     /gene="Traf1"
                     /inference="alignment:Splign:2.1.0"
     exon            281..346
                     /gene="Traf1"
                     /inference="alignment:Splign:2.1.0"
     exon            347..757
                     /gene="Traf1"
                     /inference="alignment:Splign:2.1.0"
     exon            758..935
                     /gene="Traf1"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1084
                     /gene="Traf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1910
                     /gene="Traf1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctttctac agactccaca gggctggtcc tctactttac ttgacagacc tcctggccac
       61 cggaaagccc aagatggcct ccagctcagc ccctgatgaa aacgagtttc aatttggttg
      121 tccccctgct cccagccagg acccatcgga gcccagagct ctctgctgca cagcctgtct
      181 ctctgagaac ctgagagacg atgaggaacg gatctgtcct aaatgcagag cagacggcct
      241 ccaacctgtg agcccaggaa gccttctgac tcaggagaag gttctccctg atgtggctga
      301 ggctggaatc gtgtgtccct ttgcaggtgt tggctgttcc ttcaagggga gcccacagtc
      361 cgtgcaggag catgaggcca cctcgcagtc ctcacacctg tacctgcttc tgggggtcct
      421 aaaggagtgg aaatcctcac caggtcccaa cctgggctct gcacccatgg cactggagca
      481 gaacctgtcg gagctgcagc ttcaggaagc tgtggaagtg acaggggacc tggaggtaga
      541 ctgctaccgg gcaccttgct gtgagagcca ggaagaactg gctttgcagc acctcctgaa
      601 ggagaagctg ctggctcagc tggaggagaa gctgcgtgtg ttcgcgaaca tagttgctgt
      661 cctcaacaag gaagtggagg cttcccacct ggcgctggcc gcctccatcc accagagtca
      721 gttggaccga gagcacgtcc tgaacttgga gcagagggtg gtggagttac agcagaccct
      781 ggctcaaaaa gaccaggttc tgggcaaact tgagcacagt ctgcgactca tggaggaggc
      841 gtcctttgat ggtactttcc tgtggaagat caccaatgtc accaagcggt gccacgaatc
      901 agtgtgtggc aggactgtca gcctcttctc tccagctttc tacactgcca agtacggtta
      961 caagttgtgc ctgcgcctgt acctgaatgg ggatggctca ggcaagaaga cccacctgtc
     1021 cctgttcatt gtcatcatga ggggagaata tgacgctctg ctgccctggc ctttccggaa
     1081 caaggtcacc tttatgctac ttgaccagaa caaccgtgag cacgccattg atgccttccg
     1141 gcctgacctg agctcagcct ccttccagcg gccgcagagt gagaccaacg tggccagcgg
     1201 ctgcccgctc ttcttccccc tcagcaagct gcagtcgccc aagcacgcct acgtaaaaga
     1261 tgatacaatg ttcctcaaat gcattgtgga caccagtgct tagagatgga cccgagtgtc
     1321 tcctgaaggg aaccagctta gactggggga cttagttaga caggcaggcc ctgcccttgg
     1381 agcccacagt ccaggacaag gatgggccga ggttggcatg acttgagtgc cataacatgt
     1441 tggctgtggc taatgtgaga ctggaggaac ttgagctgtg cgtacagaga cagtggagga
     1501 gaagacagaa gtgctctctt cacacagacc acaacaccag gaggccagca tgccagcaag
     1561 tcctgaatgt tgagaccagt ttaggtcaag acgacaagaa cctggcctga ggcatggaca
     1621 ttgagccaag gttgtggagc ctaagtggag gggcactcct actcggacat tctctggagg
     1681 tcagggtata actgggaaaa atgccccatc tctctgttca gactgaaaac taggaccgca
     1741 gggcagaagg gacagacatg aatgtgaatt taacctgtcc tgggttgagt acctacatta
     1801 acagacatgt aaacaggtca gtccagaagc tgtcctggga aatgcttgcc ggctggattt
     1861 gaagaccttt gatgctttta cagataaaac aaacaacagc aaaagccttg
//
