LOCUS       NM_057119               1978 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus transformer 2 beta (Tra2b), mRNA.
ACCESSION   NM_057119
VERSION     NM_057119.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1978)
  AUTHORS   Liu,X.Y., Li,H.L., Su,J.B., Ding,F.H., Zhao,J.J., Chai,F., Li,Y.X.,
            Cui,S.C., Sun,F.Y., Wu,Z.Y., Xu,P. and Chen,X.H.
  TITLE     Regulation of RAGE splicing by hnRNP A1 and Tra2beta-1 and its
            potential role in AD pathogenesis
  JOURNAL   J Neurochem 133 (2), 187-198 (2015)
   PUBMED   25689357
REFERENCE   2  (bases 1 to 1978)
  AUTHORS   Storbeck,M., Hupperich,K., Gaspar,J.A., Meganathan,K., Martinez
            Carrera,L., Wirth,R., Sachinidis,A. and Wirth,B.
  TITLE     Neuronal-specific deficiency of the splicing factor Tra2b causes
            apoptosis in neurogenic areas of the developing mouse brain
  JOURNAL   PLoS One 9 (2), e89020 (2014)
   PUBMED   24586484
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1978)
  AUTHORS   Karunakaran,D.K., Congdon,S., Guerrette,T., Banday,A.R.,
            Lemoine,C., Chhaya,N. and Kanadia,R.
  TITLE     The expression analysis of Sfrs10 and Celf4 during mouse retinal
            development
  JOURNAL   Gene Expr Patterns 13 (8), 425-436 (2013)
   PUBMED   23932931
REFERENCE   4  (bases 1 to 1978)
  AUTHORS   Karunakaran,D.K., Banday,A.R., Wu,Q. and Kanadia,R.
  TITLE     Expression analysis of an evolutionarily conserved alternative
            splicing factor, Sfrs10, in age-related macular degeneration
  JOURNAL   PLoS One 8 (9), e75964 (2013)
   PUBMED   24098751
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1978)
  AUTHORS   Li,S.J., Li,Y., Cui,S.C., Qi,Y., Zhao,J.J., Liu,X.Y., Xu,P. and
            Chen,X.H.
  TITLE     Splicing factor transformer-2beta (Tra2beta) regulates the
            expression of regulator of G protein signaling 4 (RGS4) gene and is
            induced by morphine
  JOURNAL   PLoS One 8 (8), e72220 (2013)
   PUBMED   23977258
  REMARK    GeneRIF: Tra2beta regulates the expression of RGS4 gene and is
            induced by morphine.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1978)
  AUTHORS   Hofmann,Y. and Wirth,B.
  TITLE     hnRNP-G promotes exon 7 inclusion of survival motor neuron (SMN)
            via direct interaction with Htra2-beta1
  JOURNAL   Hum Mol Genet 11 (17), 2037-2049 (2002)
   PUBMED   12165565
REFERENCE   7  (bases 1 to 1978)
  AUTHORS   Venables,J.P., Elliott,D.J., Makarova,O.V., Makarov,E.M.,
            Cooke,H.J. and Eperon,I.C.
  TITLE     RBMY, a probable human spermatogenesis factor, and other hnRNP G
            proteins interact with Tra2beta and affect splicing
  JOURNAL   Hum Mol Genet 9 (5), 685-694 (2000)
   PUBMED   10749975
REFERENCE   8  (bases 1 to 1978)
  AUTHORS   Nayler,O., Stratling,W., Bourquin,J.P., Stagljar,I., Lindemann,L.,
            Jasper,H., Hartmann,A.M., Fackelmayer,F.O., Ullrich,A. and Stamm,S.
  TITLE     SAF-B protein couples transcription and pre-mRNA splicing to
            SAR/MAR elements
  JOURNAL   Nucleic Acids Res 26 (15), 3542-3549 (1998)
   PUBMED   9671816
REFERENCE   9  (bases 1 to 1978)
  AUTHORS   Tacke,R., Tohyama,M., Ogawa,S. and Manley,J.L.
  TITLE     Human Tra2 proteins are sequence-specific activators of pre-mRNA
            splicing
  JOURNAL   Cell 93 (1), 139-148 (1998)
   PUBMED   9546399
REFERENCE   10 (bases 1 to 1978)
  AUTHORS   Matsuo,N., Ogawa,S., Imai,Y., Takagi,T., Tohyama,M., Stern,D. and
            Wanaka,A.
  TITLE     Cloning of a novel RNA binding polypeptide (RA301) induced by
            hypoxia/reoxygenation
  JOURNAL   J Biol Chem 270 (47), 28216-28222 (1995)
   PUBMED   7499316
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D49708.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D49708.1, FQ212414.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1978
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..1978
                     /gene="Tra2b"
                     /gene_synonym="Sfrs10; Srsf10"
                     /note="transformer 2 beta"
                     /db_xref="GeneID:117259"
                     /db_xref="RGD:619886"
     exon            1..171
                     /gene="Tra2b"
                     /gene_synonym="Sfrs10; Srsf10"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..1002
                     /gene="Tra2b"
                     /gene_synonym="Sfrs10; Srsf10"
                     /note="RA301; TRA2-beta; TRA-2 beta; transformer-2 protein
                     homolog B; splicing factor, arginine/serine-rich 10
                     (transformer 2 homolog, Drosophila); serine/arginine-rich
                     splicing factor 10; transformer 2 beta homolog"
                     /codon_start=1
                     /product="transformer-2 protein homolog beta"
                     /protein_id="NP_476460.1"
                     /db_xref="GeneID:117259"
                     /db_xref="RGD:619886"
                     /translation="MSDSGEQNYGERESRSASRSGSAHGSGKSARHTPARSRSKEDSR
                     RSRSKSRSRSESRSRSRRSSRRHYTRSRSRSRSHRRSRSRSYSRDYRRRHSHSHSPMS
                     TRRRHVGNRANPDPNCCLGVFGLSLYTTERDLREVFSKYGPIADVSIVYDQQSRRSRG
                     FAFVYFENVDDAKEAKERANGMELDGRRIRVDFSITKRPHTPTPGIYMGRPTYGSSRR
                     RDYYDRGYDRGYDDRDYYSRSYRGGGGGGGGWRAAQDRDQIYRRRSPSPYYSRGGYRS
                     RSRSRSYSPRRY"
     exon            172..305
                     /gene="Tra2b"
                     /gene_synonym="Sfrs10; Srsf10"
                     /inference="alignment:Splign:2.1.0"
     exon            306..468
                     /gene="Tra2b"
                     /gene_synonym="Sfrs10; Srsf10"
                     /inference="alignment:Splign:2.1.0"
     exon            469..657
                     /gene="Tra2b"
                     /gene_synonym="Sfrs10; Srsf10"
                     /inference="alignment:Splign:2.1.0"
     exon            658..773
                     /gene="Tra2b"
                     /gene_synonym="Sfrs10; Srsf10"
                     /inference="alignment:Splign:2.1.0"
     exon            774..857
                     /gene="Tra2b"
                     /gene_synonym="Sfrs10; Srsf10"
                     /inference="alignment:Splign:2.1.0"
     exon            858..917
                     /gene="Tra2b"
                     /gene_synonym="Sfrs10; Srsf10"
                     /inference="alignment:Splign:2.1.0"
     exon            918..991
                     /gene="Tra2b"
                     /gene_synonym="Sfrs10; Srsf10"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1978
                     /gene="Tra2b"
                     /gene_synonym="Sfrs10; Srsf10"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1978
                     /gene="Tra2b"
                     /gene_synonym="Sfrs10; Srsf10"
ORIGIN      
        1 gtggtgcgga gcgagtcgac tttggactac tctcttagcg tggcgtcgcg cgaggctgcg
       61 gcggagcctc tgtcaggaag gcgggagctt gacagcttca gtaaagacca gcagcggtga
      121 cagcaacccg gagtcatgag cgacagcggc gagcagaact acggcgagcg ggaatcccgt
      181 tctgcttccc gaagtggaag tgctcatgga tcggggaaat ctgcacggca cacacctgca
      241 aggtctcgct ccaaggaaga ttcaagacgt tctagatcaa agtcaagatc cagatctgaa
      301 tctaggtcta gatccagaag aagttctaga aggcattata caaggtcacg atcacgatct
      361 cgctctcata gacgatcccg gagcaggtct tacagccgag actatcgcag acgccacagc
      421 cacagccatt ctcccatgtc tactcgaagg cgtcatgttg ggaaccgggc aaatcctgac
      481 cccaactgtt gtcttggagt gtttggattg agcttgtaca ccacagaaag agatctaaga
      541 gaagtgttct ctaagtatgg ccccattgct gatgtgtcta ttgtgtatga ccagcagtct
      601 agacggtcaa gaggatttgc ctttgtatat tttgaaaatg tagatgatgc caaggaagct
      661 aaagaacgtg ccaatggaat ggagcttgat ggacgtcgga ttagggtcga tttctctata
      721 acaaaaaggc cccatacccc aacaccagga atttatatgg ggagacccac ttatggcagt
      781 tcacgacgcc gggactatta tgaccgagga tatgatcggg gttatgatga ccgggactat
      841 tacagcagat catacagagg aggaggtgga ggaggaggtg gatggagagc agctcaagat
      901 agagatcaga tttacagaag gcggtcacct tctccttact acagtcgtgg aggatacagg
      961 tctcgttctc gatcaagatc ctactcacct cgtcgctatt aaagcatgaa gttgaagact
     1021 ttctgagacc tgccatagag ctgggatgtt gtttgtggac aatattttct attgtctcct
     1081 gtttaaaaag tgaacagtgc ctagtgaagt taggtgactt ttacaccttt tatgatgact
     1141 acttttggtg gagttgaaat gctgttttca ttctgcattt gtgtagttcg gtgctttgtt
     1201 caaagttaag tgttttcaga aaagtatgtt ttgcatgtat ttttttacag tccaaatttt
     1261 gactgctgag aagtttctat tgtacaaaac ttcatttaaa aggtttttct actgaatcca
     1321 gggtattctg aagatcgaag cctgtgtgta aaatgctacc agatggcaaa aagcaacaat
     1381 aaacaagttt gatttttact tttctttcta aatatcaatg cttaacaaga accattctta
     1441 agttatcagt aaaaaataaa taaataaaaa ttttctttca ggagtccatg aaacttgcca
     1501 tattcgatat acctgcaatt aagtgttaaa aatacgctgt aactctgtac tgctagtatt
     1561 agaacaagaa tctttccata cagctaatgc ttaatgctta cattaatgtg gatttgtcgg
     1621 cctttatgta atctgtatta tatatagcag gggataagag ctacagatag atacatgcct
     1681 ttaaaaggct gtttcttaag gctgttacaa ggagataatg gtatttcaac taatcagcaa
     1741 gtgacaatac attccaccac aaatgtactc ttgttcttct agcctttaga ctatgaaaat
     1801 actgggtgct tcaaagtatg gaatgagaga agggatcacc acacctgtgt catggatgaa
     1861 gactgcctgt tcatttttta aatatgattt tcaggtcctt tgcttaccaa aggaagccca
     1921 attcactcaa atgttttgag aactgtttaa ataaacaagc aagaaaaatt gctgatgc
//
