LOCUS       NP_001101260             744 aa            linear   ROD 22-OCT-2024
DEFINITION  targeting protein for Xklp2 isoform a [Rattus norvegicus].
ACCESSION   NP_001101260 XP_001060281 XP_001060351 XP_230735
VERSION     NP_001101260.1
DBSOURCE    REFSEQ: accession NM_001107790.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 744)
  AUTHORS   Roostalu,J., Cade,N.I. and Surrey,T.
  TITLE     Complementary activities of TPX2 and chTOG constitute an efficient
            importin-regulated microtubule nucleation module
  JOURNAL   Nat Cell Biol 17 (11), 1422-1434 (2015)
   PUBMED   26414402
  REMARK    Erratum:[Nat Cell Biol. 2015 Nov;17(11):1512. doi: 10.1038/ncb3265.
            PMID: 26515019]
REFERENCE   2  (residues 1 to 744)
  AUTHORS   Wei,J.H., Zhang,Z.C., Wynn,R.M. and Seemann,J.
  TITLE     GM130 Regulates Golgi-Derived Spindle Assembly by Activating TPX2
            and Capturing Microtubules
  JOURNAL   Cell 162 (2), 287-299 (2015)
   PUBMED   26165940
REFERENCE   3  (residues 1 to 744)
  AUTHORS   Bibby,R.A., Tang,C., Faisal,A., Drosopoulos,K., Lubbe,S.,
            Houlston,R., Bayliss,R. and Linardopoulos,S.
  TITLE     A cancer-associated aurora A mutant is mislocalized and
            misregulated due to loss of interaction with TPX2
  JOURNAL   J Biol Chem 284 (48), 33177-33184 (2009)
   PUBMED   19801554
REFERENCE   4  (residues 1 to 744)
  AUTHORS   Mori,D., Yamada,M., Mimori-Kiyosue,Y., Shirai,Y., Suzuki,A.,
            Ohno,S., Saya,H., Wynshaw-Boris,A. and Hirotsune,S.
  TITLE     An essential role of the aPKC-Aurora A-NDEL1 pathway in neurite
            elongation by modulation of microtubule dynamics
  JOURNAL   Nat Cell Biol 11 (9), 1057-1068 (2009)
   PUBMED   19668197
REFERENCE   5  (residues 1 to 744)
  AUTHORS   Zhao,B., Smallwood,A., Yang,J., Koretke,K., Nurse,K., Calamari,A.,
            Kirkpatrick,R.B. and Lai,Z.
  TITLE     Modulation of kinase-inhibitor interactions by auxiliary protein
            binding: crystallography studies on Aurora A interactions with
            VX-680 and with TPX2
  JOURNAL   Protein Sci 17 (10), 1791-1797 (2008)
   PUBMED   18662907
REFERENCE   6  (residues 1 to 744)
  AUTHORS   Bird,A.W. and Hyman,A.A.
  TITLE     Building a spindle of the correct length in human cells requires
            the interaction between TPX2 and Aurora A
  JOURNAL   J Cell Biol 182 (2), 289-300 (2008)
   PUBMED   18663142
REFERENCE   7  (residues 1 to 744)
  AUTHORS   Cassimeris,L. and Morabito,J.
  TITLE     TOGp, the human homolog of XMAP215/Dis1, is required for centrosome
            integrity, spindle pole organization, and bipolar spindle assembly
  JOURNAL   Mol Biol Cell 15 (4), 1580-1590 (2004)
   PUBMED   14718566
REFERENCE   8  (residues 1 to 744)
  AUTHORS   Bayliss,R., Sardon,T., Vernos,I. and Conti,E.
  TITLE     Structural basis of Aurora-A activation by TPX2 at the mitotic
            spindle
  JOURNAL   Mol Cell 12 (4), 851-862 (2003)
   PUBMED   14580337
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_230735.2, XP_001060351.1, XP_001060281.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR26643292.14968.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN06680417, SAMN06680424 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..744
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     Protein         1..744
                     /product="targeting protein for Xklp2 isoform a"
                     /note="TPX2, microtubule-associated protein homolog;
                     targeting protein for Xklp2; TPX2, microtubule-associated,
                     homolog"
                     /calculated_mol_wt=85320
     Region          1..68
                     /region_name="Aurora-A_bind"
                     /note="Aurora-A binding; pfam09041"
                     /db_xref="CDD:430383"
     Region          202..>283
                     /region_name="TPX2_importin"
                     /note="Cell cycle regulated microtubule associated
                     protein; pfam12214"
                     /db_xref="CDD:463495"
     Region          365..487
                     /region_name="TPX2_importin"
                     /note="Cell cycle regulated microtubule associated
                     protein; pfam12214"
                     /db_xref="CDD:463495"
     Region          658..730
                     /region_name="TPX2"
                     /note="Targeting protein for Xklp2 (TPX2) domain;
                     pfam06886"
                     /db_xref="CDD:462029"
     CDS             1..744
                     /gene="Tpx2"
                     /coded_by="NM_001107790.3:345..2579"
                     /note="isoform a is encoded by transcript variant 4"
                     /db_xref="GeneID:311546"
                     /db_xref="RGD:1311894"
ORIGIN      
        1 maqvptaysf daptdfinfs sldaeedten idswfdekan lenkflrqsg igepfqgkts
       61 lrkaklqqgc vtplkavdnt yyketekenl qkqsipsndc pslnakravt gttpiqpqrr
      121 svrlsaqkdl eqkeknhvas vemkakrcta pttdyppnkk mkvshkkkpe eeeegsapat
      181 srkdetlera kgkhtvpavp parektvkst eeqelekslr mqqevvemrk kneefkklal
      241 agpgqpvkks tsqvtktvdf hfltderikq hpksqeeyke vnfmselrkh sstpargtrg
      301 ctiikpfnls kgkkrtfdea astyvpiaqq veafhkrtpn ryhlrnkkde sllpskpvnk
      361 ivrdpqtpil qtkyraravt cksaaekeae eleklqqykf kareldprif esgpilpkrp
      421 pvkpptqpvg fdleiekrih ereskkkped eqfefhsrpc ptkiledvvg vpekkvipat
      481 vpkspvfalk nrirvpvked eeeekpvvik aqpvphygvp ykppipetrn vevcpfsfdt
      541 rdkerqlqke kkikemqkge vpkfkalpvp hfdtinlpek kvknatqaep fsletdkrga
      601 ykaeiwkhql eeeqkqqkea acfkarpntv ifqepfvpkk ekksaaenps gslvqepfql
      661 atekrakerq elekkmaeme awklqqlaev rqqeeeqqke elarlrkelv hkanpirkys
      721 avevksselp ltvpvspkfs trfq
//
