LOCUS       NM_001419184            2686 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus transmembrane phosphoinositide 3-phosphatase and
            tensin homolog 2 (Tpte2), transcript variant 1, mRNA.
ACCESSION   NM_001419184 XM_039094733
VERSION     NM_001419184.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2686)
  AUTHORS   Walker,S.M., Downes,C.P. and Leslie,N.R.
  TITLE     TPIP: a novel phosphoinositide 3-phosphatase
  JOURNAL   Biochem J 360 (Pt 2), 277-283 (2001)
   PUBMED   11716755
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 29, 2023 this sequence version replaced XM_039094733.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.75757.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-452               JAXUCZ010000016.1  76455195-76455646   c
            453-548             JAXUCZ010000016.1  76454000-76454095   c
            549-599             JAXUCZ010000016.1  76446036-76446086   c
            600-656             JAXUCZ010000016.1  76441144-76441200   c
            657-710             JAXUCZ010000016.1  76439980-76440033   c
            711-767             JAXUCZ010000016.1  76438290-76438346   c
            768-821             JAXUCZ010000016.1  76436608-76436661   c
            822-869             JAXUCZ010000016.1  76431172-76431219   c
            870-920             JAXUCZ010000016.1  76428144-76428194   c
            921-974             JAXUCZ010000016.1  76426388-76426441   c
            975-1028            JAXUCZ010000016.1  76423948-76424001   c
            1029-1094           JAXUCZ010000016.1  76421876-76421941   c
            1095-1145           JAXUCZ010000016.1  76417103-76417153   c
            1146-1307           JAXUCZ010000016.1  76415170-76415331   c
            1308-1427           JAXUCZ010000016.1  76413066-76413185   c
            1428-1527           JAXUCZ010000016.1  76410913-76411012   c
            1528-1591           JAXUCZ010000016.1  76410734-76410797   c
            1592-1656           JAXUCZ010000016.1  76409246-76409310   c
            1657-1717           JAXUCZ010000016.1  76400189-76400249   c
            1718-1799           JAXUCZ010000016.1  76399341-76399422   c
            1800-1888           JAXUCZ010000016.1  76399133-76399221   c
            1889-1950           JAXUCZ010000016.1  76391298-76391359   c
            1951-2031           JAXUCZ010000016.1  76389173-76389253   c
            2032-2137           JAXUCZ010000016.1  76384322-76384427   c
            2138-2229           JAXUCZ010000016.1  76381084-76381175   c
            2230-2322           JAXUCZ010000016.1  76375532-76375624   c
            2323-2393           JAXUCZ010000016.1  76362951-76363021   c
            2394-2686           JAXUCZ010000016.1  76361333-76361625   c
FEATURES             Location/Qualifiers
     source          1..2686
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..2686
                     /gene="Tpte2"
                     /gene_synonym="Tpte"
                     /note="transmembrane phosphoinositide 3-phosphatase and
                     tensin homolog 2"
                     /db_xref="GeneID:364629"
                     /db_xref="RGD:1305825"
     exon            1..452
                     /gene="Tpte2"
                     /gene_synonym="Tpte"
                     /inference="alignment:Splign:2.1.0"
     exon            453..548
                     /gene="Tpte2"
                     /gene_synonym="Tpte"
                     /inference="alignment:Splign:2.1.0"
     CDS             490..2514
                     /gene="Tpte2"
                     /gene_synonym="Tpte"
                     /EC_number="3.1.3.48"
                     /note="transmembrane phosphatase with tensin homology"
                     /codon_start=1
                     /product="phosphatidylinositol-3,4,5-trisphosphate
                     3-phosphatase TPTE2"
                     /protein_id="NP_001406113.1"
                     /db_xref="GeneID:364629"
                     /db_xref="RGD:1305825"
                     /translation="MQGVKKSHLYLWMEHYGYDGPASSRVYSQLSRRRRNANKKVLSS
                     TSKSTKLNGSIGYDGNEETTTFTNGSSIDSMSYQDDMKSSNCMDPTSEKRYGNDSSLY
                     TIDGTLNNGTTLYEMNSLSELSKEVYLNDSALLRGKEAASELSQVSSTMKTQSSVSTS
                     ILSTSDLISEEIQEEQINKCKLNQISKLYDEDEHVDIRESYWSTVKKFVHFLVSSVAF
                     RIFGILLIFLDVFLVAIDLHATEKNIYIPLEYRAISLAIALFFLVDVLLRVYVEGRQR
                     YFSDVLNTLDAVVIGVTVLVAVIYTLYDKQFLRNIPRLAVLLRPLRLLILVRILQLAH
                     QKRQLEKLTRQLVSGNKRRYKKDGFDLDLTYVTERIIAMSFPSSGRESFYRNPIKEVV
                     RFLDTKHPNHYQVYNLCSERSYDPKRFHYRVRRIMIDDHNVPTLEEMLLFSKEVNDWM
                     AQDPENVVAIHCKGGKGRTGTMVCACLIASEIVLNAKASLYFFGERRTDKSNSSKFQG
                     VETPSQNRYVKYFEKLKTSYQLTLPPKKVLVIKRFTVYSIHGVGKGNGSDLEIQIMMW
                     QETIFSCFNSKNCMIFHDVETDKVIINVFNCPALYDDVKVKFLCPNLPKYYDDCPFFF
                     WFHTSFIRNNRLYLPRSELDNTHKQKTWKIYGPKFAVEVYFEEISSTVMY"
     exon            549..599
                     /gene="Tpte2"
                     /gene_synonym="Tpte"
                     /inference="alignment:Splign:2.1.0"
     exon            600..656
                     /gene="Tpte2"
                     /gene_synonym="Tpte"
                     /inference="alignment:Splign:2.1.0"
     exon            657..710
                     /gene="Tpte2"
                     /gene_synonym="Tpte"
                     /inference="alignment:Splign:2.1.0"
     exon            711..767
                     /gene="Tpte2"
                     /gene_synonym="Tpte"
                     /inference="alignment:Splign:2.1.0"
     exon            768..821
                     /gene="Tpte2"
                     /gene_synonym="Tpte"
                     /inference="alignment:Splign:2.1.0"
     exon            822..869
                     /gene="Tpte2"
                     /gene_synonym="Tpte"
                     /inference="alignment:Splign:2.1.0"
     exon            870..920
                     /gene="Tpte2"
                     /gene_synonym="Tpte"
                     /inference="alignment:Splign:2.1.0"
     exon            921..974
                     /gene="Tpte2"
                     /gene_synonym="Tpte"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1028
                     /gene="Tpte2"
                     /gene_synonym="Tpte"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1094
                     /gene="Tpte2"
                     /gene_synonym="Tpte"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1145
                     /gene="Tpte2"
                     /gene_synonym="Tpte"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1307
                     /gene="Tpte2"
                     /gene_synonym="Tpte"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1427
                     /gene="Tpte2"
                     /gene_synonym="Tpte"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1527
                     /gene="Tpte2"
                     /gene_synonym="Tpte"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1591
                     /gene="Tpte2"
                     /gene_synonym="Tpte"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1656
                     /gene="Tpte2"
                     /gene_synonym="Tpte"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1717
                     /gene="Tpte2"
                     /gene_synonym="Tpte"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1799
                     /gene="Tpte2"
                     /gene_synonym="Tpte"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1888
                     /gene="Tpte2"
                     /gene_synonym="Tpte"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..1950
                     /gene="Tpte2"
                     /gene_synonym="Tpte"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2031
                     /gene="Tpte2"
                     /gene_synonym="Tpte"
                     /inference="alignment:Splign:2.1.0"
     exon            2032..2137
                     /gene="Tpte2"
                     /gene_synonym="Tpte"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2229
                     /gene="Tpte2"
                     /gene_synonym="Tpte"
                     /inference="alignment:Splign:2.1.0"
     exon            2230..2322
                     /gene="Tpte2"
                     /gene_synonym="Tpte"
                     /inference="alignment:Splign:2.1.0"
     exon            2323..2393
                     /gene="Tpte2"
                     /gene_synonym="Tpte"
                     /inference="alignment:Splign:2.1.0"
     exon            2394..2686
                     /gene="Tpte2"
                     /gene_synonym="Tpte"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gataaagacc ttggggtgag ggtctgagca aggattttcc attccacttg ctggatccgt
       61 gttatctcat tctcactagg agaattttaa aagtgaacgt tttaggggaa gttctgttgg
      121 gcgaggctgg ggagcaaaga gggtttcctg ggggttgtta gggatacttg aacaggaagg
      181 tttgccttgc gctcatctgg ggagaacaca gatatgcctc ttgcttctcg gaggaacacc
      241 cagagcctcc accctggaca cgggaacttt tagactggca gatgtggtac tacccttgtt
      301 tctggccatg aattgactga tttcgttgat ttgggaggaa attaatatga aaagagaatg
      361 gagaaaaaga aaagctgtta ttctgaaggg cagcgggaga gaagactggt ggcaggaact
      421 ggagtgaact cagctcccgc ttcagtcaag agattaattg taaattgagt ttaatcacaa
      481 ggcaatacca tgcagggagt caaaaagagc catttgtatc tctggatgga gcactacgga
      541 tacgatgggc ctgcaagttc cagggtgtat tctcagctct ccagaagaag acgcaatgca
      601 aacaaaaagg tgttatcgag cacgtcgaag tccactaaac taaacggcag cattggctat
      661 gacggaaatg aagagacaac cacgttcact aacggaagta gcattgacag tatgtcgtat
      721 caagatgaca tgaaatcgtc aaattgcatg gaccccacca gtgaaaaaag atatggaaat
      781 gattcgtcat tatacaccat tgacggaact ttgaacaacg gcacaaccct gtatgaaatg
      841 aattccttga gtgaattatc gaaagaagta tacctgaacg attctgcttt gctacgtggt
      901 aaagaagctg ccagcgaact tagccaagtc tcaagtacaa tgaaaacaca atcatctgtg
      961 tcgaccagca ttctcagcac atctgattta atatcagaag aaatccagga agagcaaatc
     1021 aacaaatgca agttaaacca gatctccaag ctgtacgacg aggacgagca tgttgacatc
     1081 cgagagtcat actggagcac agttaagaaa tttgtgcatt tccttgtgtc ctcagttgcc
     1141 ttcagaatat ttggaatact cctgatcttt ctggatgtat ttcttgtggc tatcgatcta
     1201 catgccactg aaaagaatat ttatattcct ttggaatatc gggccatttc tttagctatt
     1261 gctttatttt tccttgtgga tgttcttctc cgagtgtatg tagaagggag acagcgttat
     1321 ttctctgacg tgctgaacac cctagatgct gttgtcatcg gcgtgactgt gctcgtggct
     1381 gtcatttata cactttatga caaacagttt ctcagaaata ttccaagact ggcagtctta
     1441 cttcggcctc tgcgactgct catcctggta agaattttgc agctggccca tcagaagcga
     1501 caactggaaa agctgactcg gcagctggtt tcgggtaaca agcgacgcta caagaaggat
     1561 ggcttcgacc tggacctcac ttacgtcact gagcgcatta ttgccatgtc atttccatca
     1621 tctggaaggg agtccttcta tagaaatcca attaaggaag ttgtcaggtt cctcgacacc
     1681 aagcatccaa accactatca agtctacaat ctatgcagtg agagatctta tgaccctaag
     1741 cgcttccact acagggtccg cagaatcatg attgatgatc ataacgtacc taccctcgag
     1801 gaaatgttgt tgttctccaa ggaagtaaat gattggatgg cccaagatcc tgaaaatgtt
     1861 gtagcaattc actgtaaggg aggaaaaggg agaactggaa ccatggtgtg tgcctgcctc
     1921 attgccagtg aaatagtcct aaacgcaaag gcaagtctgt acttttttgg agagcgacgg
     1981 acagataaaa gtaacagctc taagtttcaa ggagtagaga ccccttctca gaatagatat
     2041 gttaaatatt ttgaaaaact gaaaactagc taccaattga ctcttcctcc aaaaaaagta
     2101 cttgtgataa aaagattcac tgtttactcc attcatggtg ttggaaaagg caatggaagt
     2161 gatctagaaa tacaaataat gatgtggcag gagacgattt tttcctgttt taattccaaa
     2221 aattgtatga tatttcatga tgttgaaaca gacaaagtaa taattaatgt gttcaactgt
     2281 ccggctctat atgatgatgt aaaagtgaaa tttctctgtc cgaatcttcc taaatactat
     2341 gatgactgcc cctttttctt ttggtttcat acatctttta ttcgaaataa caggctttat
     2401 ctaccaagaa gcgaattgga taatacccat aaacaaaaaa catggaaaat ttatggtcca
     2461 aagtttgcag tcgaggtgta ttttgaggag ataagctcca cggttatgta ctagctgttg
     2521 aataagtgcc gctccccttc ttggatagaa ttatgttcca gatccgtgct acatagtcat
     2581 gtcttctaac ctatgttttt gatggtatgt ccgtatttta tatatatgtg agtgtatatg
     2641 catgtacata tgtttctggg aaatatatta aatgtataca ggaaaa
//
