LOCUS       NM_053867                793 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus tumor protein, translationally-controlled 1
            (Tpt1), mRNA.
ACCESSION   NM_053867
VERSION     NM_053867.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 793)
  AUTHORS   He,X., Liu,Z., Pang,Y., Xu,W., Zhao,L. and Li,H.
  TITLE     Downregulation of transcription factor TCTP elevates microRNA-200a
            expression to restrain Myt1L expression, thereby improving
            neurobehavior and oxidative stress injury in cerebral palsy rats
  JOURNAL   Cell Cycle 19 (8), 855-869 (2020)
   PUBMED   32174219
  REMARK    GeneRIF: Downregulation of transcription factor TCTP elevates
            microRNA-200a expression to restrain Myt1L expression, thereby
            improving neurobehavior and oxidative stress injury in cerebral
            palsy rats.
REFERENCE   2  (bases 1 to 793)
  AUTHORS   Cai,W., Fujita,T., Hidaka,Y., Jin,H., Suita,K., Shigeta,M.,
            Kiyonari,H., Umemura,M., Yokoyama,U., Sadoshima,J. and Ishikawa,Y.
  TITLE     Translationally controlled tumor protein (TCTP) plays a pivotal
            role in cardiomyocyte survival through a Bnip3-dependent mechanism
  JOURNAL   Cell Death Dis 10 (8), 549 (2019)
   PUBMED   31320615
  REMARK    GeneRIF: TCTP has a pivotal role in cardiomyocyte survival, at
            least in part through a Bnip3-dependent mechanism.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 793)
  AUTHORS   Ferrer,E., Dunmore,B.J., Hassan,D., Ormiston,M.L., Moore,S.,
            Deighton,J., Long,L., Yang,X.D., Stewart,D.J. and Morrell,N.W.
  TITLE     A Potential Role for Exosomal Translationally Controlled Tumor
            Protein Export in Vascular Remodeling in Pulmonary Arterial
            Hypertension
  JOURNAL   Am J Respir Cell Mol Biol 59 (4), 467-478 (2018)
   PUBMED   29676587
  REMARK    GeneRIF: These data suggest an important role for TCTP in
            regulating the critical vascular cell phenotypes that have been
            implicated in the pathobiology of Pulmonary arterial hypertension.
REFERENCE   4  (bases 1 to 793)
  AUTHORS   Seo,J., Maeng,J. and Kim,H.J.
  TITLE     Translationally Controlled Tumor Protein Stimulates Dopamine
            Release from PC12 Cells via Ca2+-Independent Phospholipase A
            Pathways
  JOURNAL   Int J Mol Sci 17 (10), 1774 (2016)
   PUBMED   27783042
  REMARK    GeneRIF: Tumor protein translationally-controlled -induced dopamine
            release from neuronal PC12 cells was modulated by a
            Ca(2+)-independent mechanism that involved PLA in the process,
            suggesting the regulatory role of TCTP in the neuronal functions.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 793)
  AUTHORS   Ren,J., Mao,X., Chen,M., Zhang,W., Liu,Y., Duan,C., Zhang,H.,
            Sun,C., Wu,W., Zhu,X., Ge,J., Tao,W., Wang,Y. and Lu,H.
  TITLE     TCTP Expression After Rat Spinal Cord Injury: Implications for
            Astrocyte Proliferation and Migration
  JOURNAL   J Mol Neurosci 57 (3), 366-375 (2015)
   PUBMED   26266488
  REMARK    GeneRIF: After acute spinal cord injury, TCTP in astrocytes
            gradually increased, peaking at day 3 and returning to basal levels
            by day 14. TCTP knockdown reduced astrocyte migration and
            proliferation.
REFERENCE   6  (bases 1 to 793)
  AUTHORS   Arcuri,F., Papa,S., Carducci,A., Romagnoli,R., Liberatori,S.,
            Riparbelli,M.G., Sanchez,J.C., Tosi,P. and del Vecchio,M.T.
  TITLE     Translationally controlled tumor protein (TCTP) in the human
            prostate and prostate cancer cells: expression, distribution, and
            calcium binding activity
  JOURNAL   Prostate 60 (2), 130-140 (2004)
   PUBMED   15162379
REFERENCE   7  (bases 1 to 793)
  AUTHORS   Li,F., Zhang,D. and Fujise,K.
  TITLE     Characterization of fortilin, a novel antiapoptotic protein
  JOURNAL   J Biol Chem 276 (50), 47542-47549 (2001)
   PUBMED   11598139
REFERENCE   8  (bases 1 to 793)
  AUTHORS   Guillaume,E., Pineau,C., Evrard,B., Dupaix,A., Moertz,E.,
            Sanchez,J.C., Hochstrasser,D.F. and Jegou,B.
  TITLE     Cellular distribution of translationally controlled tumor protein
            in rat and human testes
  JOURNAL   Proteomics 1 (7), 880-889 (2001)
   PUBMED   11503212
REFERENCE   9  (bases 1 to 793)
  AUTHORS   Yoon,T., Jung,J., Kim,M., Lee,K.M., Choi,E.C. and Lee,K.
  TITLE     Identification of the self-interaction of rat TCTP/IgE-dependent
            histamine-releasing factor using yeast two-hybrid system
  JOURNAL   Arch Biochem Biophys 384 (2), 379-382 (2000)
   PUBMED   11368327
REFERENCE   10 (bases 1 to 793)
  AUTHORS   Kim,M., Jung,Y., Lee,K. and Kim,C.
  TITLE     Identification of the calcium binding sites in translationally
            controlled tumor protein
  JOURNAL   Arch Pharm Res 23 (6), 633-636 (2000)
   PUBMED   11156187
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Nov 26, 2020 this sequence version replaced NM_053867.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U20525.1, FQ232768.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                JAXUCZ010000015.1  57566144-57566239
            97-170              JAXUCZ010000015.1  57566396-57566469
            171-361             JAXUCZ010000015.1  57566907-57567097
            362-467             JAXUCZ010000015.1  57567445-57567550
            468-584             JAXUCZ010000015.1  57567944-57568060
            585-793             JAXUCZ010000015.1  57568760-57568968
FEATURES             Location/Qualifiers
     source          1..793
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q11"
     gene            1..793
                     /gene="Tpt1"
                     /note="tumor protein, translationally-controlled 1"
                     /db_xref="GeneID:116646"
                     /db_xref="RGD:621623"
     exon            1..96
                     /gene="Tpt1"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..587
                     /gene="Tpt1"
                     /note="TCTP; lens epithelial protein"
                     /codon_start=1
                     /product="translationally-controlled tumor protein"
                     /protein_id="NP_446319.1"
                     /db_xref="GeneID:116646"
                     /db_xref="RGD:621623"
                     /translation="MIIYRDLISHDELFSDIYKIREIADGLCLEVEGKMVSRTEGAID
                     DSLIGGNASAEGPEGEGTESTVVTGVDIVMNHHLQETSFTKEAYKKYIKDYMKSLKGK
                     LEEQKPERVKPFMTGAAEQIKHILANFNNYQFFIGENMNPDGMVALLDYREDGVTPFM
                     IFFKDGLEMEKC"
     exon            97..170
                     /gene="Tpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            171..361
                     /gene="Tpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            362..467
                     /gene="Tpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            468..584
                     /gene="Tpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            585..793
                     /gene="Tpt1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgccgctcc ggctgcaccg cgctcgctcc gcgctgtcag gctagcgcca ctgtccccag
       61 ccgtcaccat gatcatctac cgggacctca tcagccatga cgagctgttc tccgacatct
      121 acaagatccg ggagatcgcg gacgggctgt gcctggaggt ggagggcaag atggtcagta
      181 gaacagaggg tgccatcgat gattcactca ttggtggaaa tgcttccgct gaaggtccgg
      241 agggcgaagg taccgaaagc acagtagtca ccggtgttga cattgtcatg aaccatcact
      301 tacaagaaac cagcttcaca aaagaggcct acaaaaagta tatcaaagac tacatgaaat
      361 cactcaaggg caaacttgaa gaacagaaac cagaaagggt aaagcctttt atgactggag
      421 ctgcagagca aattaagcac atccttgcta atttcaataa ctaccagttt tttattggtg
      481 aaaacatgaa tccagatggc atggttgctc tactggacta ccgtgaagat ggtgtgactc
      541 cattcatgat tttctttaag gatggcttag agatggaaaa atgttaacaa attggatcta
      601 tcgcctgtca ccataattgg ctgctgctta ccatccatac aacaccagga cttaggacaa
      661 atgggactga tatcatcttg agcttttatt ttgaccgtga tttatttgga gtggaggcat
      721 tgtttttttt tttttttaaa gaaaaaaaaa catgtcatgt gggttgtcta aaaataaagt
      781 gcatttaaat tca
//
