LOCUS       NM_001008508            1792 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus tyrosylprotein sulfotransferase 2 (Tpst2), mRNA.
ACCESSION   NM_001008508 XM_213800
VERSION     NM_001008508.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1792)
  AUTHORS   Teramoto,T., Fujikawa,Y., Kawaguchi,Y., Kurogi,K., Soejima,M.,
            Adachi,R., Nakanishi,Y., Mishiro-Sato,E., Liu,M.C., Sakakibara,Y.,
            Suiko,M., Kimura,M. and Kakuta,Y.
  TITLE     Crystal structure of human tyrosylprotein sulfotransferase-2
            reveals the mechanism of protein tyrosine sulfation reaction
  JOURNAL   Nat Commun 4, 1572 (2013)
   PUBMED   23481380
REFERENCE   2  (bases 1 to 1792)
  AUTHORS   Marcello,M.R., Jia,W., Leary,J.A., Moore,K.L. and Evans,J.P.
  TITLE     Lack of tyrosylprotein sulfotransferase-2 activity results in
            altered sperm-egg interactions and loss of ADAM3 and ADAM6 in
            epididymal sperm
  JOURNAL   J Biol Chem 286 (15), 13060-13070 (2011)
   PUBMED   21339297
REFERENCE   3  (bases 1 to 1792)
  AUTHORS   Hoffhines,A.J., Damoc,E., Bridges,K.G., Leary,J.A. and Moore,K.L.
  TITLE     Detection and purification of tyrosine-sulfated proteins using a
            novel anti-sulfotyrosine monoclonal antibody
  JOURNAL   J Biol Chem 281 (49), 37877-37887 (2006)
   PUBMED   17046811
REFERENCE   4  (bases 1 to 1792)
  AUTHORS   Ouyang,Y.B. and Moore,K.L.
  TITLE     Molecular cloning and expression of human and mouse tyrosylprotein
            sulfotransferase-2 and a tyrosylprotein sulfotransferase homologue
            in Caenorhabditis elegans
  JOURNAL   J Biol Chem 273 (38), 24770-24774 (1998)
   PUBMED   9733778
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Jun 16, 2015 this sequence version replaced NM_001008508.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22399489.615989.1,
                                           SRR21887620.1930341.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676787 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                JAXUCZ010000012.1  50022690-50022741   c
            53-124              JAXUCZ010000012.1  49993967-49994038   c
            125-1036            JAXUCZ010000012.1  49989331-49990242   c
            1037-1235           JAXUCZ010000012.1  49988005-49988203   c
            1236-1286           JAXUCZ010000012.1  49985797-49985847   c
            1287-1335           JAXUCZ010000012.1  49984143-49984191   c
            1336-1792           JAXUCZ010000012.1  49982281-49982737   c
FEATURES             Location/Qualifiers
     source          1..1792
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..1792
                     /gene="Tpst2"
                     /gene_synonym="TPST-2"
                     /note="tyrosylprotein sulfotransferase 2"
                     /db_xref="GeneID:288719"
                     /db_xref="RGD:1305331"
     exon            1..52
                     /gene="Tpst2"
                     /gene_synonym="TPST-2"
                     /inference="alignment:Splign:2.1.0"
     exon            53..124
                     /gene="Tpst2"
                     /gene_synonym="TPST-2"
                     /inference="alignment:Splign:2.1.0"
     exon            125..1036
                     /gene="Tpst2"
                     /gene_synonym="TPST-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..1328
                     /gene="Tpst2"
                     /gene_synonym="TPST-2"
                     /EC_number="2.8.2.20"
                     /codon_start=1
                     /product="protein-tyrosine sulfotransferase 2"
                     /protein_id="NP_001008508.2"
                     /db_xref="GeneID:288719"
                     /db_xref="RGD:1305331"
                     /translation="MRRAPWLGLRPWLGMRLSVRKVLLAVGCALALVLAVQLGQQVLE
                     CRAVLGGVRSPRRMQPEQEELVMLGADHVEYRYGKTMPLIFVGGVPRSGTTLMRAMLD
                     AHPEVRCGEETRIIPRVLAMRQAWTKSGREKLRLDEAGVTDEVLDAAMQAFILEVIAK
                     HGEPARVLCNKDPFTLKSSVYLARLFPNSKFLLMVRDGRASVHSMITRKVTIAGFDLS
                     SYRDCLTKWNKAIEVMYAQCMEVGRDKCLPVYYEQLVLHPRRSLKRILDFLGIAWSDT
                     VLHHEDLIGKPGGVSLSKIERSTDQVIKPVNLEALSKWTGHIPRDVVRDMAQIAPMLA
                     RLGYDPYANPPNYGNPDPIVINNTHRVLKGDYKTPANLKGYFQVNQNSTSPHLGSS"
     exon            1037..1235
                     /gene="Tpst2"
                     /gene_synonym="TPST-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1286
                     /gene="Tpst2"
                     /gene_synonym="TPST-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1335
                     /gene="Tpst2"
                     /gene_synonym="TPST-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1792
                     /gene="Tpst2"
                     /gene_synonym="TPST-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccctggcggc cggcagggag ccggagtctg cgcgggcgcg gattcgggca cggactgtca
       61 gggcaggaag ctgtggtgac caggctcgag gactggtgct tggaaatgag agcctccagg
      121 ggagatgtat accaggtggg cctgctgacc cgtccatgag gcgggccccc tggctgggcc
      181 tgcgaccctg gctgggcatg cgcctgtcgg tgcgtaaggt gctgctggcc gtgggctgcg
      241 ctctggccct ggtgctcgct gtgcagcttg ggcagcaagt actggagtgc cgggcggtgc
      301 tcgggggcgt gcggagccca cggaggatgc aaccggagca ggaggaactg gtgatgctcg
      361 gcgccgacca cgtggagtac cgttacggca agaccatgcc gctcatcttt gtgggcggcg
      421 tgccacgcag tggcaccacc ctcatgcgcg ccatgttgga cgcgcaccct gaggtgcgct
      481 gtggggagga gacgcgcatc atccctcgcg tgctggccat gcggcaggcc tggaccaagt
      541 caggccgcga gaagctgcga ctggacgagg caggtgtgac agatgaggtg ctggacgcgg
      601 ccatgcaggc cttcatcctg gaggtgatcg ccaagcacgg cgagccggca cgcgtgctat
      661 gtaacaagga ccccttcaca ctcaagtcgt ccgtctacct ggcacgcctg ttccccaact
      721 ccaaattcct gctaatggtg cgtgatggcc gggcgtccgt gcactccatg atcacacgca
      781 aggtcaccat cgcgggcttt gacctcagca gctaccgaga ctgcctcacc aagtggaaca
      841 aggccatcga ggtgatgtac gcacagtgca tggaggtggg cagggacaag tgcctgcctg
      901 tgtactatga gcagttggtg ctgcatcccc ggcgctcact caaacgcatc ctggacttcc
      961 tgggcatcgc ctggagtgac acagtcctgc accacgagga cctcattggc aagcctgggg
     1021 gcgtctcctt gtccaagatt gagcggtcca cggaccaggt catcaaaccc gtgaacctgg
     1081 aagctctctc caagtggact ggccacatcc ccagagacgt ggtgagggac atggcccaga
     1141 ttgcccccat gctggcccgg cttggctatg atccgtacgc aaatccaccc aactatggga
     1201 accccgaccc cattgtcatc aacaacacac accgggtctt gaaaggagac tataaaacgc
     1261 cagccaatct gaaaggatat tttcaggtga accagaacag tacctcccca cacctgggaa
     1321 gttcgtgatt tccagtctcc acagggctca gatgcctgag tcctcgacct gcacacggaa
     1381 gctggactaa cccaagcaca tggctctcgg tcatgccagg atggagcagt catacatctc
     1441 ggcagaagct agctcagaac ctctgttctg ggcaacaccg aggagggaga gactacttcg
     1501 gtttcagaga cttggggatt ttctattttt tttttctcct tgagaacttt ttttaaaaga
     1561 attgaatttg ctatcttccc taatggacag gctccttggt gacctcatct cctgggataa
     1621 gacctgtgac ccgtgcctct ccttgactgg acgctgaact caaaggatct atttaagagt
     1681 ttaatatatg ggctctcctc tctttagtcc tactcagttt cacagagaaa agaaattaat
     1741 tatttgaata aagtagacag gctgctgtct gtgccttact tcacacagtg aa
//
