LOCUS       NM_019180               1102 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus tryptase beta 2 (Tpsb2), mRNA.
ACCESSION   NM_019180
VERSION     NM_019180.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1102)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   2  (bases 1 to 1102)
  AUTHORS   Taketomi,Y., Ueno,N., Kojima,T., Sato,H., Murase,R., Yamamoto,K.,
            Tanaka,S., Sakanaka,M., Nakamura,M., Nishito,Y., Kawana,M.,
            Kambe,N., Ikeda,K., Taguchi,R., Nakamizo,S., Kabashima,K.,
            Gelb,M.H., Arita,M., Yokomizo,T., Nakamura,M., Watanabe,K.,
            Hirai,H., Nakamura,M., Okayama,Y., Ra,C., Aritake,K., Urade,Y.,
            Morimoto,K., Sugimoto,Y., Shimizu,T., Narumiya,S., Hara,S. and
            Murakami,M.
  TITLE     Mast cell maturation is driven via a group III phospholipase
            A2-prostaglandin D2-DP1 receptor paracrine axis
  JOURNAL   Nat Immunol 14 (6), 554-563 (2013)
   PUBMED   23624557
REFERENCE   3  (bases 1 to 1102)
  AUTHORS   Hallgren,J., Spillmann,D. and Pejler,G.
  TITLE     Structural requirements and mechanism for heparin-induced
            activation of a recombinant mouse mast cell tryptase, mouse mast
            cell protease-6: formation of active tryptase monomers in the
            presence of low molecular weight heparin
  JOURNAL   J Biol Chem 276 (46), 42774-42781 (2001)
   PUBMED   11533057
REFERENCE   4  (bases 1 to 1102)
  AUTHORS   Lutzelschwab,C., Pejler,G., Aveskogh,M. and Hellman,L.
  TITLE     Secretory granule proteases in rat mast cells. Cloning of 10
            different serine proteases and a carboxypeptidase A from various
            rat mast cell populations
  JOURNAL   J Exp Med 185 (1), 13-29 (1997)
   PUBMED   8996238
REFERENCE   5  (bases 1 to 1102)
  AUTHORS   Ide,H., Itoh,H., Tomita,M., Murakumo,Y., Kobayashi,T., Maruyama,H.,
            Osada,Y. and Nawa,Y.
  TITLE     cDNA sequencing and expression of rat mast cell tryptase
  JOURNAL   J Biochem 118 (1), 210-215 (1995)
   PUBMED   8537314
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U67909.1.
            
            On Jun 3, 2010 this sequence version replaced NM_019180.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U67909.1, D38455.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN06680412
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1102              U67909.1           2-1103
FEATURES             Location/Qualifiers
     source          1..1102
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..1102
                     /gene="Tpsb2"
                     /gene_synonym="Mcpt6"
                     /note="tryptase beta 2"
                     /db_xref="GeneID:29268"
                     /db_xref="RGD:3065"
     exon            1..15
                     /gene="Tpsb2"
                     /gene_synonym="Mcpt6"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..840
                     /gene="Tpsb2"
                     /gene_synonym="Mcpt6"
                     /EC_number="3.4.21.59"
                     /note="mast cell protease 6; rMCP-6; tryptase-2"
                     /codon_start=1
                     /product="tryptase beta-2 precursor"
                     /protein_id="NP_062053.2"
                     /db_xref="GeneID:29268"
                     /db_xref="RGD:3065"
                     /translation="MLKLLLLLALSPLASLVHAAPCPVKQRVGIVGGREASESKWPWQ
                     VSLRFKFSFWMHFCGGSLIHPQWVLTAAHCVGLHIKSPELFRVQLREQYLYYADQLLT
                     VNRTVVHPHYYTVEDGADIALLELENPVNVSTHIHPTSLPPASETFPSGTSCWVTGWG
                     DIDSDEPLLPPYPLKQVKVPIVENSLCDRKYHTGLYTGDDVPIVQDGMLCAGNTRSDS
                     CQGDSGGPLVCKVKGTWLQAGVVSWGEGCAEANRPGIYTRVTYYLDWIHRYVPQRS"
     exon            16..79
                     /gene="Tpsb2"
                     /gene_synonym="Mcpt6"
                     /inference="alignment:Splign:2.1.0"
     exon            80..245
                     /gene="Tpsb2"
                     /gene_synonym="Mcpt6"
                     /inference="alignment:Splign:2.1.0"
     exon            246..511
                     /gene="Tpsb2"
                     /gene_synonym="Mcpt6"
                     /inference="alignment:Splign:2.1.0"
     exon            512..675
                     /gene="Tpsb2"
                     /gene_synonym="Mcpt6"
                     /inference="alignment:Splign:2.1.0"
     exon            676..1088
                     /gene="Tpsb2"
                     /gene_synonym="Mcpt6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgagacag ccaagatgct gaagctgctg ctgctgctgg cactgtcccc cctggctagt
       61 ctggtgcacg cggccccttg cccagtcaag cagcgagtgg gcattgtggg aggacgagag
      121 gcttctgaaa gtaagtggcc ctggcaggtg agcctgagat ttaaattcag cttctggatg
      181 catttctgtg gcggctccct cattcaccca cagtgggtgc tcactgcggc acactgtgtg
      241 ggactgcaca tcaaaagccc agagctcttc cgtgtacagc ttcgtgagca gtatctatac
      301 tatgcggacc agctactgac tgtgaaccgg accgttgtgc acccccacta ctacacagtc
      361 gaggatgggg cagacattgc cctgctggag cttgagaacc ctgtgaatgt ctccacccat
      421 atccacccca catccctgcc ccctgcctcg gagaccttcc cctcggggac ttcttgctgg
      481 gtaacaggct ggggcgacat tgatagtgac gagcctctcc tgccacctta tcctctgaag
      541 caagtgaagg tccccattgt ggaaaacagc ctgtgtgatc ggaagtacca cactggcctc
      601 tacacaggag atgatgttcc cattgtccag gatggcatgc tgtgtgctgg aaataccagg
      661 agcgactcct gccagggaga ctcagggggc ccactggtct gcaaagtgaa gggtacctgg
      721 ctgcaagcag gagtggtcag ctggggcgag ggctgcgcag aggccaatcg tcctggcatt
      781 tacacccggg tgacgtacta cctggactgg attcaccgct atgtccctca gcgttcctga
      841 gacccatcca gggtcaggga agaaccaggc acctgctgtc tttaactcac tgcttcctgg
      901 ccagatggaa ccctggcctt ctttgtactc tgtctcccct gtcttccggg tgtccctctg
      961 agcccccact ttgttccacc ttgagtccct cgccactcct gtcccctctg cctcccacca
     1021 cacacagctg cactgtgcgg ctccctcttt tctgtggctc attaaagtat gtgaaaattt
     1081 tgctccaaaa aaaaaaaaaa aa
//
