LOCUS       NM_001024309            2731 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus taperin (Tprn), mRNA.
ACCESSION   NM_001024309 XM_575084
VERSION     NM_001024309.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2731)
  AUTHORS   Liu,C., Luo,N., Tung,C.Y., Perrin,B.J. and Zhao,B.
  TITLE     GRXCR2 Regulates Taperin Localization Critical for Stereocilia
            Morphology and Hearing
  JOURNAL   Cell Rep 25 (5), 1268-1280 (2018)
   PUBMED   30380417
REFERENCE   2  (bases 1 to 2731)
  AUTHORS   Chen,M., Wang,Q., Zhu,G.H., Hu,P., Zhou,Y., Wang,T., Lai,R.S.,
            Xiao,Z.A. and Xie,D.H.
  TITLE     Progressive hearing loss and degeneration of hair cell stereocilia
            in taperin gene knockout mice
  JOURNAL   Biochem Biophys Res Commun 479 (4), 703-707 (2016)
   PUBMED   27693694
REFERENCE   3  (bases 1 to 2731)
  AUTHORS   Zhao,B., Wu,Z. and Muller,U.
  TITLE     Murine Fam65b forms ring-like structures at the base of stereocilia
            critical for mechanosensory hair cell function
  JOURNAL   Elife 5, e14222 (2016)
   PUBMED   27269051
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2731)
  AUTHORS   Rehman,A.U., Morell,R.J., Belyantseva,I.A., Khan,S.Y., Boger,E.T.,
            Shahzad,M., Ahmed,Z.M., Riazuddin,S., Khan,S.N., Riazuddin,S. and
            Friedman,T.B.
  TITLE     Targeted capture and next-generation sequencing identifies C9orf75,
            encoding taperin, as the mutated gene in nonsyndromic deafness
            DFNB79
  JOURNAL   Am J Hum Genet 86 (3), 378-388 (2010)
   PUBMED   20170899
REFERENCE   5  (bases 1 to 2731)
  AUTHORS   Li,Y., Pohl,E., Boulouiz,R., Schraders,M., Nurnberg,G., Charif,M.,
            Admiraal,R.J., von Ameln,S., Baessmann,I., Kandil,M., Veltman,J.A.,
            Nurnberg,P., Kubisch,C., Barakat,A., Kremer,H. and Wollnik,B.
  TITLE     Mutations in TPRN cause a progressive form of autosomal-recessive
            nonsyndromic hearing loss
  JOURNAL   Am J Hum Genet 86 (3), 479-484 (2010)
   PUBMED   20170898
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1 and BC083928.1.
            
            On Jun 11, 2008 this sequence version replaced NM_001024309.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic data because transcript data was not available for all
            regions of the RefSeq transcript. The extent of this transcript is
            supported by orthologous data from mouse RefSeq NM_175286.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083928.1, SRR26643289.8193.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-666               JAXUCZ010000003.1  28474322-28474987
            667-2731            BC083928.1         1-2065
FEATURES             Location/Qualifiers
     source          1..2731
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p13"
     gene            1..2731
                     /gene="Tprn"
                     /note="taperin"
                     /db_xref="GeneID:499749"
                     /db_xref="RGD:1562935"
     CDS             1..2262
                     /gene="Tprn"
                     /codon_start=1
                     /product="taperin"
                     /protein_id="NP_001019480.2"
                     /db_xref="GeneID:499749"
                     /db_xref="RGD:1562935"
                     /translation="MAGLGRLDPGPRTVMPAWKREILERRRAKLAALSGGPGSGAAPD
                     GPNERLVLAESLGPLSQNPFMRLESERRRGARPAQQLLELYCRVPGVRTIRADNILII
                     ESAPGFPPAVPPASSIRAAEVVVYEEPQPGRVSRLLEKFDSPAAPRRRGSPERFRPAL
                     PQLPVAPASAATRAPTNRSLAPAPPVLPSQPAPPISPVPVAQRAGQRSACCEPAHPDG
                     TAGPGARRSDFLQKTGSNSFTVHPRGLPGSAVNRSLSNGPMTQESPAGPANGLSGSPP
                     VPGKWKPKVESKEPSLHPPPSPGTPSATPVGPPAFLAPSPASATPSQRQWVSSATSAN
                     DSFEIRPSSKPDMETIPIGDLQARALANLRVNSRNSFVLIPKRKAPGNYPSAAGRQFE
                     EPKGEVGWASQSQGLGSQLVSTVDGAPALEKSSLAAEMQWAVREGGCPRPAISDTDKS
                     VRRQRPASPPPFLPATTEAEPAEGLGVPGLTKNGQEPVRPGLPVTFIDEVDSEEAAFQ
                     EAKLPSSAVGVPSQYHLHPSTPGHTSELLNRGSNTFTVVPKRKPGTLQEPHLSQTNGQ
                     FQQGAEEQDADSLSGPHTTLENALKKRYPTVNEIEVIGGYLALQKSCLIKAGSSRKKM
                     KISFNDKSLHTTFEYPSESSLAQEEAEEEEEEEEEEEGEDGEEEEVGPDSEKSFTVLL
                     PRATFVSSVGPESSSGLSSYTPKHSMAFSKWQEQTLVQAPTEVELPPKEVMLTPASQN
                     DLSDFRSEPALYF"
     exon            1..1869
                     /gene="Tprn"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..2092
                     /gene="Tprn"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2199
                     /gene="Tprn"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2731
                     /gene="Tprn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggccggcc tggggcggct cgatccgggg ccgcgaaccg tgatgcccgc ctggaaacgg
       61 gagatacttg agcggaggcg agctaaactg gccgctctga gcggaggccc gggatctgga
      121 gcggcaccgg atgggcctaa cgagcggctg gtgctggcgg agagtctggg tccactaagc
      181 cagaacccgt tcatgcgact tgaatcggag aggcggcgcg gggcgcggcc cgctcagcag
      241 ctgctggagc tgtactgtcg tgtgcccggc gtgcggacca ttcgagccga caacatcctc
      301 atcatcgagt cagcgccagg gttcccgccc gctgtgccgc ccgcttcgag catccgcgct
      361 gccgaggtag tggtgtacga ggagccacag cccggccggg tcagccgcct gctagaaaag
      421 ttcgactcgc ctgctgcgcc ccgccgccgc gggagcccag agcgcttccg ccctgcgctc
      481 ccgcagcttc ccgtggcgcc tgcatctgct gccacgcgcg ctcctaccaa tcggtcgttg
      541 gctcctgccc caccggtgct ccctagccag cccgcacccc ctatttcgcc tgtccccgtt
      601 gcccagcgcg cgggtcagcg ctctgcctgt tgcgagcccg cgcaccccga cggcactgcc
      661 ggccccgggg cccggcgcag cgacttccta caaaagaccg gcagcaactc cttcactgtc
      721 cacccccgag gcctgcccgg cagtgcggtc aatcgctcgc tttctaatgg acccatgact
      781 caggaatccc ctgccggccc tgccaatggg ttgtcgggct ctccgcctgt accgggcaag
      841 tggaagccaa aggtggagtc aaaggaaccc tccctccacc cacccccaag ccctgggacc
      901 ccaagtgcca ctccagttgg gccccctgcc ttcctggcgc ccagcccagc cagtgccact
      961 cccagtcagc gccagtgggt ctcctctgcc accagcgcca atgactcctt cgaaataagg
     1021 ccatcctcca agccagacat ggaaactatc ccaattgggg accttcaggc cagagccctg
     1081 gccaacctca gagtgaactc ccgcaactcc ttcgtgttga tccccaagcg caaagcccct
     1141 gggaactatc cttcggcggc ggggaggcaa ttcgaggagc caaaggggga ggtgggctgg
     1201 gcctctcaga gccaggggct cggatcccag ctggtgtcta cagtggatgg tgcacctgcc
     1261 ctagagaaga gttccttggc tgctgagatg cagtgggcag ttagggaggg aggctgcccc
     1321 aggccagcca tttctgacac agacaagtct gttaggaggc agaggccagc ctcaccacct
     1381 ccatttctac cagccactac tgaagctgag ccggctgaag gcttgggggt tcctggcttg
     1441 accaagaatg gccaggagcc tgtgaggcca ggacttccag tcaccttcat tgatgaagta
     1501 gactcagagg aggcggcctt tcaagaagcc aaactgccct cttcagcagt tggtgtgcct
     1561 tcccagtacc acctgcaccc ttccacacct gggcacacct cagagctcct caaccgaggt
     1621 agcaacactt tcacagtagt gcccaagagg aagccaggga cccttcagga gccacactta
     1681 agtcagacta atgggcagtt ccagcaaggg gcagaggaac aggatgctga tagcctctcg
     1741 ggaccccaca ctaccctgga gaatgcccta aagaaacgat accccactgt gaatgagatt
     1801 gaggtgatcg gtggttacct ggccctgcag aagtcctgcc tcatcaaggc tggctcctcc
     1861 agaaaaaaga tgaagatctc cttcaatgac aagagcctgc acacaacatt tgagtaccct
     1921 tctgagagct ctctggccca ggaggaggca gaggaggaag aagaggagga ggaggaggaa
     1981 gaaggagagg atggtgaaga ggaggaagtg gggcctgact cagagaaatc cttcacagtt
     2041 ctcttgcccc gggccacatt tgtaagcagt gtgggacctg agagcagctc aggtctgtcc
     2101 agctacactc caaagcattc catggccttc agcaagtggc aggagcagac actggtgcag
     2161 gctccaactg aggtggagct cccaccaaaa gaggtcatgc tcacacctgc cagtcagaat
     2221 gatctctcgg acttccgcag cgagccagcc ctctatttct gacccctgca actgtcagga
     2281 tggccaagac ttagccccag gtgtggtggt cctggaagcc agtcaatacc caggagccct
     2341 gactgtattc tgtgcccctt ccacctggct ctccctgcct tctttctgtg ttgtctcctt
     2401 ctgcctttag ggccagatct gaatctcacg ccaatgaaga acaggtggga attgcctgtg
     2461 ggacaggctg acatctgtcc atattgtctc atctgtgatg aggtggaggc ctgagcagat
     2521 cttgtcccaa ggtgctgttg gacatttcag cctctacctt ttggggagtg gccactgtca
     2581 ggagtaagag gctaccatag ctatttgttc tttgccgaaa tccaagctca tgattctact
     2641 atggtggacc tcagccactc ctcatgaaag atggcagggt gttttttttt ctcccctcag
     2701 atattggaat caataaacag cactgtaaca a
//
