LOCUS       NM_001013926             782 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus Tp53rk binding protein (Tprkb), mRNA.
ACCESSION   NM_001013926 XM_216178
VERSION     NM_001013926.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 782)
  AUTHORS   Braun,D.A., Rao,J., Mollet,G., Schapiro,D., Daugeron,M.C., Tan,W.,
            Gribouval,O., Boyer,O., Revy,P., Jobst-Schwan,T., Schmidt,J.M.,
            Lawson,J.A., Schanze,D., Ashraf,S., Ullmann,J.F.P.,
            Hoogstraten,C.A., Boddaert,N., Collinet,B., Martin,G., Liger,D.,
            Lovric,S., Furlano,M., Guerrera,I.C., Sanchez-Ferras,O., Hu,J.F.,
            Boschat,A.C., Sanquer,S., Menten,B., Vergult,S., De Rocker,N.,
            Airik,M., Hermle,T., Shril,S., Widmeier,E., Gee,H.Y., Choi,W.I.,
            Sadowski,C.E., Pabst,W.L., Warejko,J.K., Daga,A., Basta,T.,
            Matejas,V., Scharmann,K., Kienast,S.D., Behnam,B., Beeson,B.,
            Begtrup,A., Bruce,M., Ch'ng,G.S., Lin,S.P., Chang,J.H., Chen,C.H.,
            Cho,M.T., Gaffney,P.M., Gipson,P.E., Hsu,C.H., Kari,J.A., Ke,Y.Y.,
            Kiraly-Borri,C., Lai,W.M., Lemyre,E., Littlejohn,R.O., Masri,A.,
            Moghtaderi,M., Nakamura,K., Ozaltin,F., Praet,M., Prasad,C.,
            Prytula,A., Roeder,E.R., Rump,P., Schnur,R.E., Shiihara,T.,
            Sinha,M.D., Soliman,N.A., Soulami,K., Sweetser,D.A., Tsai,W.H.,
            Tsai,J.D., Topaloglu,R., Vester,U., Viskochil,D.H.,
            Vatanavicharn,N., Waxler,J.L., Wierenga,K.J., Wolf,M.T.F.,
            Wong,S.N., Leidel,S.A., Truglio,G., Dedon,P.C., Poduri,A., Mane,S.,
            Lifton,R.P., Bouchard,M., Kannu,P., Chitayat,D., Magen,D.,
            Callewaert,B., van Tilbeurgh,H., Zenker,M., Antignac,C. and
            Hildebrandt,F.
  TITLE     Mutations in KEOPS-complex genes cause nephrotic syndrome with
            primary microcephaly
  JOURNAL   Nat Genet 49 (10), 1529-1538 (2017)
   PUBMED   28805828
REFERENCE   2  (bases 1 to 782)
  AUTHORS   Wan,L.C., Maisonneuve,P., Szilard,R.K., Lambert,J.P., Ng,T.F.,
            Manczyk,N., Huang,H., Laister,R., Caudy,A.A., Gingras,A.C.,
            Durocher,D. and Sicheri,F.
  TITLE     Proteomic analysis of the human KEOPS complex identifies C14ORF142
            as a core subunit homologous to yeast Gon7
  JOURNAL   Nucleic Acids Res 45 (2), 805-817 (2017)
   PUBMED   27903914
REFERENCE   3  (bases 1 to 782)
  AUTHORS   Miyoshi,A., Kito,K., Aramoto,T., Abe,Y., Kobayashi,N. and Ueda,N.
  TITLE     Identification of CGI-121, a novel PRPK (p53-related protein
            kinase)-binding protein
  JOURNAL   Biochem Biophys Res Commun 303 (2), 399-405 (2003)
   PUBMED   12659830
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001013926.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK475733.1, EX490991.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                JAXUCZ010000004.1  119900499-119900508
            11-99               JAXUCZ010000004.1  119905693-119905781
            100-261             JAXUCZ010000004.1  119908421-119908582
            262-384             JAXUCZ010000004.1  119911335-119911457
            385-561             JAXUCZ010000004.1  119912822-119912998
            562-782             JAXUCZ010000004.1  119913764-119913984
FEATURES             Location/Qualifiers
     source          1..782
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..782
                     /gene="Tprkb"
                     /gene_synonym="Cgi-121; RGD1309786"
                     /note="Tp53rk binding protein"
                     /db_xref="GeneID:297411"
                     /db_xref="RGD:1309786"
     exon            1..10
                     /gene="Tprkb"
                     /gene_synonym="Cgi-121; RGD1309786"
                     /inference="alignment:Splign:2.1.0"
     exon            11..99
                     /gene="Tprkb"
                     /gene_synonym="Cgi-121; RGD1309786"
                     /inference="alignment:Splign:2.1.0"
     exon            100..261
                     /gene="Tprkb"
                     /gene_synonym="Cgi-121; RGD1309786"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..648
                     /gene="Tprkb"
                     /gene_synonym="Cgi-121; RGD1309786"
                     /note="TP53RK-binding protein; Prpk (p53-related protein
                     kinase)-binding protein; TP53RK-binding protein-like;
                     PRPK-binding protein"
                     /codon_start=1
                     /product="EKC/KEOPS complex subunit Tprkb"
                     /protein_id="NP_001013948.2"
                     /db_xref="GeneID:297411"
                     /db_xref="RGD:1309786"
                     /translation="MQLTQQLDLFPECKVTLLLFKDVKNAGDLRKKAMEGSIDGSLIN
                     ANVIVDPFQILVAANKAVHLHKLGKMKTRTLSTEIIFNLSPNNNISEALKKFGISESN
                     TSVLIVYVEDGDKQVHQEHLVSQVEGQQVPLESLPEITRLSEVRKIYKLSSQEERIGT
                     LLDGIICRMSTKDVL"
     exon            262..384
                     /gene="Tprkb"
                     /gene_synonym="Cgi-121; RGD1309786"
                     /inference="alignment:Splign:2.1.0"
     exon            385..561
                     /gene="Tprkb"
                     /gene_synonym="Cgi-121; RGD1309786"
                     /inference="alignment:Splign:2.1.0"
     exon            562..782
                     /gene="Tprkb"
                     /gene_synonym="Cgi-121; RGD1309786"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagactgagg gcattttcca gactgtaaag acccacgctc ctaatctcct ctaatcttga
       61 acttctgatc ctcctcttct gaccttcact ggattctaga gagacctcct tgtctatgaa
      121 atgcagttaa cacagcagct ggacttgttt cccgagtgca aggtgaccct tctgttattt
      181 aaagatgtaa aaaatgcagg agacttgaga aaaaaggcca tggaaggatc tatagatggc
      241 tcattgataa atgccaatgt gattgtcgat ccatttcaaa tacttgtggc agcaaacaaa
      301 gccgttcatc tccacaaact gggaaaaatg aagacaagaa ctctgtctac tgaaattatc
      361 ttcaacctct ccccaaataa taatatttca gaggctttga agaagtttgg catctcagaa
      421 agtaacactt cagttctgat tgtttatgtt gaagatggag acaaacaagt gcatcaggaa
      481 cacctagtat ctcaagtgga aggccagcag gtgcccttgg aaagtcttcc tgaaataaca
      541 aggctctcag aagtcaggaa gatatataaa ctgtcatcac aagaagagag gattgggaca
      601 ttattggatg gtatcatttg tagaatgtca acaaaggatg ttttataagt tgtttaaaat
      661 atcaacagaa aatcatagag gtaattacta gcttttcttt cccacttcta aaattaacat
      721 tctcatcaca ggaaaaggga agaaggtact actaccagtc cgtttgtttt tttacttctt
      781 aa
//
