LOCUS       NM_001107185            7527 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus translocated promoter region, nuclear basket
            protein (Tpr), mRNA.
ACCESSION   NM_001107185 XM_001070158 XM_006249972 XM_222745
VERSION     NM_001107185.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7527)
  AUTHORS   Liu,J., Xu,D., Wang,H., Zhang,Y., Chang,Y., Zhang,J., Wang,J.,
            Li,C., Liu,H., Zhao,M., Lin,C., Zhan,Q., Huang,C. and Qian,H.
  TITLE     The subcellular distribution and function of MTA1 in cancer
            differentiation
  JOURNAL   Oncotarget 5 (13), 5153-5164 (2014)
   PUBMED   24970816
REFERENCE   2  (bases 1 to 7527)
  AUTHORS   Kaczmarczyk,M.M., Miller,M.J. and Freund,G.G.
  TITLE     The health benefits of dietary fiber: beyond the usual suspects of
            type 2 diabetes mellitus, cardiovascular disease and colon cancer
  JOURNAL   Metabolism 61 (8), 1058-1066 (2012)
   PUBMED   22401879
  REMARK    Review article
REFERENCE   3  (bases 1 to 7527)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 7527)
  AUTHORS   Rajanala,K. and Nandicoori,V.K.
  TITLE     Localization of nucleoporin Tpr to the nuclear pore complex is
            essential for Tpr mediated regulation of the export of unspliced
            RNA
  JOURNAL   PLoS One 7 (1), e29921 (2012)
   PUBMED   22253824
REFERENCE   5  (bases 1 to 7527)
  AUTHORS   Coyle,J.H., Bor,Y.C., Rekosh,D. and Hammarskjold,M.L.
  TITLE     The Tpr protein regulates export of mRNAs with retained introns
            that traffic through the Nxf1 pathway
  JOURNAL   RNA 17 (7), 1344-1356 (2011)
   PUBMED   21613532
REFERENCE   6  (bases 1 to 7527)
  AUTHORS   Frosst,P., Guan,T., Subauste,C., Hahn,K. and Gerace,L.
  TITLE     Tpr is localized within the nuclear basket of the pore complex and
            has a role in nuclear protein export
  JOURNAL   J Cell Biol 156 (4), 617-630 (2002)
   PUBMED   11839768
REFERENCE   7  (bases 1 to 7527)
  AUTHORS   Hase,M.E., Kuznetsov,N.V. and Cordes,V.C.
  TITLE     Amino acid substitutions of coiled-coil protein Tpr abrogate
            anchorage to the nuclear pore complex but not parallel, in-register
            homodimerization
  JOURNAL   Mol Biol Cell 12 (8), 2433-2452 (2001)
   PUBMED   11514627
REFERENCE   8  (bases 1 to 7527)
  AUTHORS   Bangs,P., Burke,B., Powers,C., Craig,R., Purohit,A. and Doxsey,S.
  TITLE     Functional analysis of Tpr: identification of nuclear pore complex
            association and nuclear localization domains and a role in mRNA
            export
  JOURNAL   J Cell Biol 143 (7), 1801-1812 (1998)
   PUBMED   9864356
REFERENCE   9  (bases 1 to 7527)
  AUTHORS   Cordes,V.C., Hase,M.E. and Muller,L.
  TITLE     Molecular segments of protein Tpr that confer nuclear targeting and
            association with the nuclear pore complex
  JOURNAL   Exp Cell Res 245 (1), 43-56 (1998)
   PUBMED   9828100
REFERENCE   10 (bases 1 to 7527)
  AUTHORS   Cordes,V.C., Reidenbach,S., Rackwitz,H.R. and Franke,W.W.
  TITLE     Identification of protein p270/Tpr as a constitutive component of
            the nuclear pore complex-attached intranuclear filaments
  JOURNAL   J Cell Biol 136 (3), 515-529 (1997)
   PUBMED   9024684
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On or before Oct 17, 2014 this sequence version replaced
            XM_006249972.1, XM_222745.4, XM_001070158.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-159               JAXUCZ010000013.1  64974419-64974577
            160-456             JAXUCZ010000013.1  64974911-64975207
            457-561             JAXUCZ010000013.1  64976519-64976623
            562-635             JAXUCZ010000013.1  64979439-64979512
            636-732             JAXUCZ010000013.1  64983468-64983564
            733-836             JAXUCZ010000013.1  64984824-64984927
            837-1001            JAXUCZ010000013.1  64985094-64985258
            1002-1094           JAXUCZ010000013.1  64987668-64987760
            1095-1175           JAXUCZ010000013.1  64988550-64988630
            1176-1263           JAXUCZ010000013.1  64988705-64988792
            1264-1404           JAXUCZ010000013.1  64989973-64990113
            1405-1496           JAXUCZ010000013.1  64990467-64990558
            1497-1694           JAXUCZ010000013.1  64991297-64991494
            1695-1802           JAXUCZ010000013.1  64994031-64994138
            1803-2029           JAXUCZ010000013.1  64994964-64995190
            2030-2193           JAXUCZ010000013.1  64995736-64995899
            2194-2327           JAXUCZ010000013.1  64996512-64996645
            2328-2476           JAXUCZ010000013.1  64996732-64996880
            2477-2639           JAXUCZ010000013.1  64997637-64997799
            2640-2774           JAXUCZ010000013.1  64998904-64999038
            2775-2915           JAXUCZ010000013.1  64999428-64999568
            2916-3081           JAXUCZ010000013.1  65001334-65001499
            3082-3248           JAXUCZ010000013.1  65009465-65009631
            3249-3401           JAXUCZ010000013.1  65010390-65010542
            3402-3518           JAXUCZ010000013.1  65010927-65011043
            3519-3722           JAXUCZ010000013.1  65011383-65011586
            3723-3907           JAXUCZ010000013.1  65011695-65011879
            3908-4055           JAXUCZ010000013.1  65012689-65012836
            4056-4193           JAXUCZ010000013.1  65013708-65013845
            4194-4325           JAXUCZ010000013.1  65013946-65014077
            4326-4456           JAXUCZ010000013.1  65015439-65015569
            4457-4664           JAXUCZ010000013.1  65016698-65016905
            4665-4808           JAXUCZ010000013.1  65017878-65018021
            4809-5007           JAXUCZ010000013.1  65018199-65018397
            5008-5213           JAXUCZ010000013.1  65019614-65019819
            5214-5275           JAXUCZ010000013.1  65020016-65020077
            5276-5484           JAXUCZ010000013.1  65020865-65021073
            5485-5757           JAXUCZ010000013.1  65022960-65023232
            5758-5906           JAXUCZ010000013.1  65024077-65024225
            5907-5990           JAXUCZ010000013.1  65024690-65024773
            5991-6185           JAXUCZ010000013.1  65026265-65026459
            6186-6317           JAXUCZ010000013.1  65027441-65027572
            6318-6408           JAXUCZ010000013.1  65027813-65027903
            6409-6593           JAXUCZ010000013.1  65029455-65029639
            6594-6662           JAXUCZ010000013.1  65030801-65030869
            6663-6757           JAXUCZ010000013.1  65030951-65031045
            6758-6864           JAXUCZ010000013.1  65031910-65032016
            6865-6960           JAXUCZ010000013.1  65033202-65033297
            6961-7117           JAXUCZ010000013.1  65033416-65033572
            7118-7236           JAXUCZ010000013.1  65034549-65034667
            7237-7332           JAXUCZ010000013.1  65036820-65036915
            7333-7527           JAXUCZ010000013.1  65037408-65037602
FEATURES             Location/Qualifiers
     source          1..7527
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q21"
     gene            1..7527
                     /gene="Tpr"
                     /note="translocated promoter region, nuclear basket
                     protein"
                     /db_xref="GeneID:304862"
                     /db_xref="RGD:1310664"
     exon            1..159
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..7388
                     /gene="Tpr"
                     /note="translocated promoter region (to activated MET
                     oncogene); megator; NPC-associated intranuclear protein;
                     translocated promoter region protein"
                     /codon_start=1
                     /product="nucleoprotein TPR"
                     /protein_id="NP_001100655.2"
                     /db_xref="GeneID:304862"
                     /db_xref="RGD:1310664"
                     /translation="MTSRGFDGSRRGSLRRAGARETASEAADGAAQASGLRASPCSFA
                     SPSAAAATTPADMAAVLQQVLERPELNKLPKSTQNKLEKFLAEQQSEIDCLKGRHEKF
                     KVESEQQYFEIEKRLSQSQERLVNETRECQNLRLELEKLNNQVKVLTEKNKELETAQD
                     RNLGIQSQFTRAKEELEAEKRDLIRTNERLSQEVEYLTEDVKRLNEKLKESNTTKGEL
                     QLKLDELQASDVTVKYREKRLEQEKELLHNQNSWLNTELKTKTDELLALGREKGNEIL
                     ELKCTLENKKEEVLRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNE
                     LNAHIKLSNLYKSAADDSEAKSNELTRAVDELHKLLKEAGEANKTIQDHLLQVEESKD
                     QMEKEMLEKIGKLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMK
                     LTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVA
                     SLSAKLEQAMKEIQRLQEDTDKANKHSSVLERDNQRMEIQIKDLSQQIRVLLMELEEA
                     RGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLFALRELGETREREE
                     QETTSSKIAELQNKLENSLTELEQLRESRQHQMQLVDSIVRQRDMYRILLSQTTGMAI
                     PLQASSLDDISLVSTPKRSSTSQTVSTPAPEPIIESTETIEAKAALKQLQEIFENYKK
                     EKMDSEKLQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSL
                     QERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQ
                     QRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENE
                     VEQRHTLTRNLDVQLLDTKRQLDTEINLHLNTKELLKNAQKDIATLKQHLNNMEAQLA
                     SQSTQRTGKGQPGDRDDVDDLKSQLRQAEEQVNDLKERLKTSASNVEQYRAMVTSLED
                     SLNKEKQVTEEVHKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRKAIESMEQQ
                     LTELKKTLSSVQSEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHA
                     ADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERVLKDEVSKSVSR
                     CEDLEKQNRLLHDQIEKLSDKVVTSMKEVVQSPLNISLNEEGKSQEQILEILRFIRRE
                     KEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMK
                     KTETMNVVMETNKMLREEKERLEQNLQQMQAKVRKLELDILPLQEANAELSEKSGMLQ
                     AEKKLLEEDVKRWKARNQHLINQQKDPDTEEYRKLLSEKEIHTKRIQQLNEEVGRLKA
                     EIARSNASLTNNQNLIQSLKEDLSKVRTEKESIQKDLDAKIIDIQEKVKTITQVKKIG
                     RRYKTQFEELKAQQKAMETSTQSSGDHQEQHISVQEMQELKDNLSQSETKTKSLEGQV
                     ENLQKTLSEKETEARSLQEQTAQLQSELSRLRQELQDKTTKEEQLRQQMNEKDEKTWK
                     AITVARSKIAHLSGVKDQLTKENEELKQRNGALDQQKDELDVRMTALKSQYEGRISRL
                     ERELREHQERHLEQRDEPQEPTNKAPEQQRQITLKTTPASGERGIASTSDPPTANIKP
                     TPVVSTPSKVTAAAMAGNKSTPRASIRPMVTPATVTNPTTTPTATVMPTTQVESQEAM
                     QSEGPVEHVPVFGSTSGSVRSTSPNVQPSISQPLLTVQQQTQATAFVQPTQQSHPQIE
                     PANQELSPNIVEVVQSSPVERPSTSTAVFGTVSATPSSSLPKRAREEEEDSTIEAGDQ
                     VSDDTVEMPLPKKLKTVTPVGTEEEVMAEESTDGEAETQTYNQDSQDSIGEGVTQGDY
                     TPMEDSEETSQSLQIDLGPLQSDQQTTSSQDGQGKGDDVIVIDSDDEDDDEENDGEHE
                     DYEEDEDEDDDEEDDTGMGDEGEDSNEGTGSADGNDGYEADDAEGGDGTDPGTETEES
                     MGGAESNQRAADSQNSGEGNTSAAESSFSQEVAREQQPTSASERQTPQAPQSPRRPPH
                     PLPPRLTIHAPPQELGPPVQRIQMTRRQSVGRGLQLTPGIGGMQQHFFDDEDRTVPST
                     PTLVVPHRTDGFAEAIHSPQVAGVPRFRFGPPEDMPQTSSSHSDLGQLASQGGLGMYE
                     TPLFLAHEEESGGRSVPTTPLQVAAPVTVFTESTTSDASEHASQSVPMVTTSTGTLST
                     TNETPAGDDGDEVFVETESEGISSEAGLEIDSQQEEEPVQASDESDLPSTSQDPPSSS
                     SVDTSSSQPKPFRRVRLQTTLRQGVRGRQFNRQRGISHAMGGRGGINRGNIN"
     exon            160..456
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            457..561
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            562..635
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            636..732
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            733..836
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            837..1001
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1094
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1175
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1263
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1404
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1496
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1694
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1802
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..2029
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2193
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            2194..2327
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            2328..2476
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            2477..2639
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            2640..2774
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            2775..2915
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            2916..3081
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            3082..3248
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            3249..3401
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            3402..3518
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            3519..3722
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            3723..3907
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            3908..4055
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            4056..4193
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            4194..4325
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            4326..4456
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            4457..4664
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            4665..4808
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            4809..5007
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            5008..5213
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            5214..5275
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            5276..5484
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            5485..5757
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            5758..5906
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            5907..5990
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            5991..6185
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            6186..6317
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            6318..6408
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            6409..6593
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            6594..6662
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            6663..6757
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            6758..6864
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            6865..6960
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            6961..7117
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            7118..7236
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            7237..7332
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
     exon            7333..7527
                     /gene="Tpr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagagagtga ggcctgcacc ccgccccttt cggggcaccc ttgggatcgt ggcggtagcc
       61 cagagccttt cgggacgccc tgccgtgatc cgtgccctct agtggctcgg tttctagaag
      121 tggccagagg agtacccatg acttcccggg gttttgacgg gtcccgtcgc gggagtctcc
      181 ggcgggcagg cgcgcgggag actgcgagcg aggcggcgga cggggcggct caggcgtctg
      241 ggctccgcgc atctccttgc tccttcgctt ctccttcagc cgctgctgcc acgaccccgg
      301 ccgacatggc ggcggtgttg cagcaagtgc tggagcgccc ggagctgaac aagctgccta
      361 agtcgaccca gaacaaactt gagaagttcc tggctgaaca gcagtccgaa atcgactgcc
      421 tgaaggggcg gcacgagaaa tttaaggtgg agagtgagca acaatacttt gagatagaga
      481 agagactatc ccagagtcag gagaggcttg ttaatgaaac ccgggagtgt cagaacttga
      541 ggctggagct tgagaagcta aataaccaag taaaagtatt aactgagaaa aacaaagaac
      601 ttgaaactgc tcaagaccgc aatctaggca ttcagagcca gtttacaaga gcaaaggaag
      661 agttagaagc tgaaaaaaga gatttaatca gaaccaatga gaggttatct caggaagttg
      721 aatatttaac agaggatgtt aaacgtctaa acgaaaaact taaagaaagc aatacaacga
      781 agggtgaact tcagttaaag ctggatgaac ttcaagcttc tgatgtcact gtgaagtacc
      841 gagaaaaacg cttagaacaa gaaaaggaat tgctacacaa tcaaaattca tggctaaaca
      901 cagagttgaa aaccaaaact gatgagctat tggctctagg aagagaaaag ggaaatgaaa
      961 ttctggaact taagtgtact cttgaaaaca aaaaggaaga ggttttgaga ctggaagaac
     1021 agatgaatgg cttgaaaaca tcaaatgagc atcttcagaa acatgtagag gatttgttga
     1081 caaaattgaa agaggccaaa gaacagcagg ccagtatgga agagaaattc cacaatgagt
     1141 taaatgctca cataaagctc tctaacctat acaagagcgc tgctgacgac tcagaggcga
     1201 agagtaatga actaactcgg gcagtggatg agctgcacaa actgctcaaa gaagctggag
     1261 aagccaacaa aacaatacaa gatcatcttc tacaagtgga agaatctaaa gaccaaatgg
     1321 aaaaagaaat gcttgagaaa ataggaaaat tggaaaagga attagagaat gcaaatgacc
     1381 tgctttccgc tacaaaacgt aaaggagcta tattatctga agaagagctt gcagccatgt
     1441 ctcctaccgc agcagccgtc gctaaaattg taaagcccgg catgaaacta actgagctat
     1501 ataatgctta tgtggaaact caggatcagt tgctgttgga aaaactagaa aataaaagga
     1561 ttaataagta tctggatgag atagtaaaag aagtggaagc caaagcaccg attttgaaac
     1621 gccagcgtga agagtatgag cgtgcgcaga aagctgtggc cagtctgtct gcaaagcttg
     1681 agcaagccat gaaggagatt cagcgattgc aggaggacac tgataaagcc aacaaacatt
     1741 catcagtact tgaaagggat aatcagagga tggaaataca aataaaagat ctttcacaac
     1801 agataagagt gctcttgatg gaacttgaag aagcaagggg taaccatgta attcgggatg
     1861 aggaggtcag ctctgctgac ataagtagtt catctgaagt aatatcgcag catctagtat
     1921 cttacaggaa cattgaagag cttcagcagc agaatcagcg tctgctgttt gctcttcgag
     1981 aacttgggga aaccagggaa cgagaagaac aagagacaac ttcctctaaa attgctgaac
     2041 ttcagaataa actggagaac tctctcactg aactggaaca gctccgtgag tcacgacagc
     2101 atcagatgca gcttgttgat tccatagttc gtcagcgtga catgtaccga attttgttgt
     2161 cacaaacaac gggaatggcc attccattac aagcttcaag tttagatgat atttctcttg
     2221 tgtcaactcc aaaacgttca agtacatcac agactgtttc tactcctgct ccggaaccca
     2281 tcattgagtc tacagagacc atagaagcaa aggctgccct taagcagttg caggaaatct
     2341 ttgagaacta taaaaaagaa aaaatggaca gtgagaaact gcagaatgag cagctagaga
     2401 aacttcaaga gcaagtcaca gacctgcgct cacaaaacac caaaatttct actcagctag
     2461 atttcgcttc taaacgttac gaaatgcttc aagataatgt agaaggatat cgccgagaaa
     2521 taacatctct acaagagaga aatcagaaac tcactgcaac tacgcagaag caggaacaga
     2581 tcatcaacac gatgacacaa gacttgagag gagccaatga gaagctagct gttgcagaag
     2641 taagagcaga aaatttgaag aaggaaaaag aaatgcttaa attgtctgaa gtccgtctgt
     2701 ctcagcaaag agagtctttg ttagctgaac agaggggaca gaacttgttg ctgactaatc
     2761 tgcaaaccat ccagggcata ctagagcgat ctgagactga aaccaaacaa aggctgagta
     2821 gccaaataga aaaattggag catgagatct ctcacctgaa gaagaagttg gaaaacgagg
     2881 tggaacaaag acatacactt acgaggaatc tagatgttca actactagat accaagagac
     2941 agctagatac agaaataaat cttcatctta acacaaaaga gctgttaaaa aatgctcaga
     3001 aggatattgc tacactgaaa cagcacctta ataatatgga agcccagctt gcttctcagt
     3061 ccacacagag aaccggtaaa ggtcagcctg gtgacagaga tgatgttgat gatcttaaaa
     3121 gtcagctaag gcaggctgaa gaacaggtca atgacttgaa ggagagactc aagacaagtg
     3181 ctagtaacgt agagcagtat agagccatgg tgaccagctt agaagactcc ctgaacaagg
     3241 agaaacaggt gactgaggag gtacataaga acattgaagt gcgtttgaaa gagtcagcag
     3301 agtttcagac acagttggag aaaaagctga tggaagtaga gaaggagaag caagaacttc
     3361 aggatgacaa gaggaaagcc atcgaaagca tggaacagca attaactgaa ttgaagaaaa
     3421 cactgtctag tgttcagagt gaagtacaag aagctcttca gagagcaagc acagctttaa
     3481 gtaatgaaca gcaagccagg cgtgactgtc aggaacaagc taaaatagcg gtggaagctc
     3541 agaataagta tgagcgagaa ttgatgctac atgctgctga tgtcgaagct ctgcaagctg
     3601 ccaaggaaca ggtttcaaaa atggcatcag tccgtcagca tttggaagaa acaactcaga
     3661 aagcagaatc acagttgttg gaatgtaaag cttcttggga agaaagagag agagtgttga
     3721 aggatgaagt ttccaagagt gtgtctcgct gtgaagatct agagaaacaa aacagactac
     3781 ttcatgatca gatcgaaaag ttaagtgaca aggtggtcac ctctatgaag gaggttgtgc
     3841 aatcaccatt aaatatatct ctcaatgaag aaggaaaatc tcaagaacaa attttagaaa
     3901 ttcttagatt tattcgacga gaaaaagaaa ttgctgaaac taggtttgag gtggctcagg
     3961 ttgaaagtct gcgatatcga caaagagttg aacttctgga acgggagttg caggaactgc
     4021 aggatagcct gaacgcagaa agggaaaagg tgcaggtaac tgcaaaaaca atggctcaac
     4081 atgaagaact gatgaagaaa accgaaacaa tgaatgtagt tatggagacc aataagatgc
     4141 taagggagga aaaggaaagg ctcgaacaga acctacaaca aatgcaagcc aaggtgagga
     4201 aactggaatt ggacatttta cccttacaag aagccaatgc tgagctgagt gagaaaagtg
     4261 gcatgctcca ggcagaaaag aagctactag aagaggatgt caaacgttgg aaagcgcgga
     4321 accagcatct aataaatcag cagaaagatc cagatacaga agaatatcga aagttgcttt
     4381 ctgaaaagga aattcacact aagagaattc agcagctaaa tgaagaagtt ggaagactta
     4441 aggctgaaat tgcaagatca aatgcatcct tgactaacaa ccagaattta atccagagtc
     4501 taaaggaaga tttaagtaaa gtaagaactg aaaaggaaag cattcagaaa gatttagatg
     4561 ccaaaataat tgatatacag gaaaaagtga aaacaatcac tcaagtcaag aagatcggac
     4621 gcaggtacaa gactcagttt gaagaactta aagcacagca gaaggccatg gagacttcca
     4681 ctcagtcttc aggagaccat caggaacagc acatctctgt ccaggaaatg caagagctca
     4741 aagataacct cagccaatct gaaacaaaga caaagtcact tgagggtcaa gtagagaatc
     4801 tgcagaagac cttatctgaa aaagagacag aagcaagaag cctccaggag cagacagcgc
     4861 agcttcagtc tgagctgtcc cgcctccgcc aggaactcca ggataaaacc acaaaggagg
     4921 agcagctccg acagcaaatg aatgaaaagg atgagaaaac atggaaggcc attacagtgg
     4981 ccagatcaaa aattgcacac ctatctggtg tgaaagatca gttaactaaa gaaaatgaag
     5041 agcttaaaca aaggaatgga gctttagatc agcagaaaga tgaactcgat gtccgaatga
     5101 ctgctctgaa gtcccagtat gaaggtcgca tcagtcgctt agagagagag ctcagagagc
     5161 atcaagagag acaccttgag cagagagatg aacctcagga acccactaat aaggctccag
     5221 aacagcagag acaaatcaca ctgaaaacca ctccagcttc tggtgaaaga ggaattgcca
     5281 gtacatcaga cccaccaaca gccaatatca agccaactcc tgttgtttct actccaagta
     5341 aagtgacagc tgcagctatg gctgggaata agtcgacacc cagggcaagt atccgcccaa
     5401 tggttacacc tgcaactgtc acaaacccaa ccactacccc aacagcaacc gtaatgccta
     5461 ctacacaggt ggagtcacag gaagctatgc agtcagaagg gcctgtggag cacgttccag
     5521 tgttcggaag cacaagtgga tctgtccgtt ctactagtcc taacgtccag ccctccattt
     5581 ctcaacccct cctgactgta cagcagcaaa cacaggctac agcttttgta cagcccactc
     5641 agcagagtca ccctcagatt gaacctgcaa atcaagagtt gtccccaaac atagttgagg
     5701 tggtacagag ttcaccagtg gaacgaccat ctacctccac agcagtattt ggcactgttt
     5761 cagctacccc aagctcctcc ttgccaaagc gcgctcggga ggaagaggag gacagcacaa
     5821 tagaagcagg agaccaagtc tctgatgaca cagtggaaat gcctctccca aagaagctga
     5881 agacggtcac acctgtagga actgaggaag aagttatggc ggaagaaagt actgatggag
     5941 aggcagaaac tcagacctat aatcaggatt ctcaagattc cattggagaa ggagtcaccc
     6001 agggagatta tacaccaatg gaagacagtg aagaaacatc acaatctcta caaattgatc
     6061 ttgggccact tcaatcagat cagcagacaa cttcctctca ggatggtcaa ggcaaaggag
     6121 atgatgtaat tgtaattgac agtgatgatg aagatgatga tgaagaaaat gatggagaac
     6181 atgaagatta tgaggaagat gaggatgagg acgacgatga ggaagatgac acggggatgg
     6241 gagatgaggg tgaagacagc aatgagggaa ctggcagtgc agatggtaat gatggatacg
     6301 aagctgatga cgccgagggt ggtgatggaa ctgatccagg cacagagaca gaagaaagta
     6361 tgggtggagc tgaaagtaat cagagagctg ctgattctca gaacagtggt gaaggaaata
     6421 caagtgcagc agagtcttct ttctctcagg aggttgccag agaacagcag cccacgtcag
     6481 cttctgagag acagaccccc caagcgccac agtcaccaag gcgcccacca catcctcttc
     6541 ccccacgcct gaccatccat gccccgcctc aggagttggg gccaccagtt cagagaattc
     6601 agatgacccg gaggcagtct gtagggcgtg gtcttcagtt aaccccagga ataggtggca
     6661 tgcaacaaca ctttttcgat gacgaagaca gaacagttcc gagtacccca acccttgtgg
     6721 tgccacatcg cactgatggg tttgctgaag ctattcattc tccacaggtt gccggtgttc
     6781 ctagattccg gtttgggcca cctgaagaca tgccacagac aagttccagt cactctgatc
     6841 ttggccaact tgcttctcaa ggaggtttgg gaatgtatga aacacccctc ttcctggctc
     6901 atgaagaaga gtctggtggc cgcagtgttc ccactacgcc tctccaagta gcagccccag
     6961 tgaccgtgtt tactgagagt accacctctg atgcttcaga acatgcctct cagtctgttc
     7021 caatggtgac aacatctaca ggcaccttat ccacgacaaa tgaaacccca gccggtgatg
     7081 acggagatga agtatttgta gagacggagt ctgaaggtat tagttcagag gcaggcctag
     7141 aaattgacag ccagcaggaa gaggagcctg tccaggcatc tgatgaatca gacctcccct
     7201 caaccagcca agacccccct tccagctcct ccgtagatac cagtagtagt cagccaaagc
     7261 ctttcagacg agtaagactt cagacaacct tgagacaggg tgttcgtggt cgtcagttta
     7321 accgacaaag aggtataagc catgcaatgg gaggaagagg aggaataaat agagggaata
     7381 ttaattaagg gatctatgaa ctgtgacact tgtgaataag attggcgaat ctgttttaat
     7441 ataattgtca agttgagaag tgttttgtat ttaaataggt atgctcattt caacattctt
     7501 tattaataaa atgtatttca atgtcaa
//
