LOCUS       NM_001108461            1020 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus tubulin polymerization promoting protein (Tppp),
            mRNA.
ACCESSION   NM_001108461 XM_001060230 XM_341746
VERSION     NM_001108461.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1020)
  AUTHORS   Fu,M.M., McAlear,T.S., Nguyen,H., Oses-Prieto,J.A., Valenzuela,A.,
            Shi,R.D., Perrino,J.J., Huang,T.T., Burlingame,A.L., Bechstedt,S.
            and Barres,B.A.
  TITLE     The Golgi Outpost Protein TPPP Nucleates Microtubules and Is
            Critical for Myelination
  JOURNAL   Cell 179 (1), 132-146 (2019)
   PUBMED   31522887
  REMARK    GeneRIF: These results demonstrate that TPPP on Golgi outposts are
            important for local microtubule nucleation and myelin sheath
            elongation.
REFERENCE   2  (bases 1 to 1020)
  AUTHORS   DeBonis,S., Neumann,E. and Skoufias,D.A.
  TITLE     Self protein-protein interactions are involved in TPPP/p25 mediated
            microtubule bundling
  JOURNAL   Sci Rep 5, 13242 (2015)
   PUBMED   26289831
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1020)
  AUTHORS   Ejlerskov,P., Rasmussen,I., Nielsen,T.T., Bergstrom,A.L.,
            Tohyama,Y., Jensen,P.H. and Vilhardt,F.
  TITLE     Tubulin polymerization-promoting protein (TPPP/p25alpha) promotes
            unconventional secretion of alpha-synuclein through exophagy by
            impairing autophagosome-lysosome fusion
  JOURNAL   J Biol Chem 288 (24), 17313-17335 (2013)
   PUBMED   23629650
  REMARK    GeneRIF: Exophagy, with or without expression of TPPP, may be an
            important physiological mechanism for unconventional secretion of
            alpha-synuclein from dopaminergic neurons.
REFERENCE   4  (bases 1 to 1020)
  AUTHORS   Schofield,A.V., Steel,R. and Bernard,O.
  TITLE     Rho-associated coiled-coil kinase (ROCK) protein controls
            microtubule dynamics in a novel signaling pathway that regulates
            cell migration
  JOURNAL   J Biol Chem 287 (52), 43620-43629 (2012)
   PUBMED   23093407
REFERENCE   5  (bases 1 to 1020)
  AUTHORS   Heng,Y.W., Lim,H.H., Mina,T., Utomo,P., Zhong,S., Lim,C.T. and
            Koh,C.G.
  TITLE     TPPP acts downstream of RhoA-ROCK-LIMK2 to regulate astral
            microtubule organization and spindle orientation
  JOURNAL   J Cell Sci 125 (Pt 6), 1579-1590 (2012)
   PUBMED   22328514
REFERENCE   6  (bases 1 to 1020)
  AUTHORS   Goldbaum,O., Jensen,P.H. and Richter-Landsberg,C.
  TITLE     The expression of tubulin polymerization promoting protein
            TPPP/p25alpha is developmentally regulated in cultured rat brain
            oligodendrocytes and affected by proteolytic stress
  JOURNAL   Glia 56 (16), 1736-1746 (2008)
   PUBMED   18563798
  REMARK    GeneRIF: Malfunction of the proteasomal system, leading to the
            accumulation of aggregation prone proteins and the pro-aggregatory
            protein TPPP/p25alpha, is causally related to the protein
            aggregation process in a variety of neurodegenerative diseases.
REFERENCE   7  (bases 1 to 1020)
  AUTHORS   Acevedo,K., Li,R., Soo,P., Suryadinata,R., Sarcevic,B.,
            Valova,V.A., Graham,M.E., Robinson,P.J. and Bernard,O.
  TITLE     The phosphorylation of p25/TPPP by LIM kinase 1 inhibits its
            ability to assemble microtubules
  JOURNAL   Exp Cell Res 313 (20), 4091-4106 (2007)
   PUBMED   18028908
REFERENCE   8  (bases 1 to 1020)
  AUTHORS   Werner,H.B., Kuhlmann,K., Shen,S., Uecker,M., Schardt,A.,
            Dimova,K., Orfaniotou,F., Dhaunchak,A., Brinkmann,B.G., Mobius,W.,
            Guarente,L., Casaccia-Bonnefil,P., Jahn,O. and Nave,K.A.
  TITLE     Proteolipid protein is required for transport of sirtuin 2 into CNS
            myelin
  JOURNAL   J Neurosci 27 (29), 7717-7730 (2007)
   PUBMED   17634366
REFERENCE   9  (bases 1 to 1020)
  AUTHORS   Vincze,O., Tokesi,N., Olah,J., Hlavanda,E., Zotter,A., Horvath,I.,
            Lehotzky,A., Tirian,L., Medzihradszky,K.F., Kovacs,J., Orosz,F. and
            Ovadi,J.
  TITLE     Tubulin polymerization promoting proteins (TPPPs): members of a new
            family with distinct structures and functions
  JOURNAL   Biochemistry 45 (46), 13818-13826 (2006)
   PUBMED   17105200
REFERENCE   10 (bases 1 to 1020)
  AUTHORS   Lindersson,E., Lundvig,D., Petersen,C., Madsen,P., Nyengaard,J.R.,
            Hojrup,P., Moos,T., Otzen,D., Gai,W.P., Blumbergs,P.C. and
            Jensen,P.H.
  TITLE     p25alpha Stimulates alpha-synuclein aggregation and is co-localized
            with aggregated alpha-synuclein in alpha-synucleinopathies
  JOURNAL   J Biol Chem 280 (7), 5703-5715 (2005)
   PUBMED   15590652
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474002.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_341746.3, XM_001060230.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK600925.1, CK357749.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00155336,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1020
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p11"
     gene            1..1020
                     /gene="Tppp"
                     /gene_synonym="RGD1310121; TPPP/p25"
                     /note="tubulin polymerization promoting protein"
                     /db_xref="GeneID:361466"
                     /db_xref="RGD:1310121"
     exon            1..76
                     /gene="Tppp"
                     /gene_synonym="RGD1310121; TPPP/p25"
                     /inference="alignment:Splign:2.1.0"
     exon            77..388
                     /gene="Tppp"
                     /gene_synonym="RGD1310121; TPPP/p25"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..737
                     /gene="Tppp"
                     /gene_synonym="RGD1310121; TPPP/p25"
                     /note="p25-alpha; 25 kDa brain-specific protein"
                     /codon_start=1
                     /product="tubulin polymerization-promoting protein"
                     /protein_id="NP_001101931.1"
                     /db_xref="GeneID:361466"
                     /db_xref="RGD:1310121"
                     /translation="MADSKAKPTKAANKTPPKSPGDPAKAAKRLSLESEGANEGAAAA
                     PELSALEEAFRRFAVHGDTRATGKEMHGKNWSKLCKDCHVIDGKNVTVTDVDIVFSKI
                     KGKSCRTITFEQFQEALEELAKKRFKDKSSEEAVREVHRLIEGRAPVISGVTKAVSSP
                     TVSRLTDTSKFTGSHKERFDQSGKGKGKAGRVDLVDESGYVPGYKHAGTYDQKVQGGK
                     "
     exon            389..542
                     /gene="Tppp"
                     /gene_synonym="RGD1310121; TPPP/p25"
                     /inference="alignment:Splign:2.1.0"
     exon            543..1020
                     /gene="Tppp"
                     /gene_synonym="RGD1310121; TPPP/p25"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggactgct cagggagctc agcgcccccg ggctcgcgtc tagtcgcgga ggcgcagcag
       61 tggacgcgtt ttggagcaac atggctgaca gcaaggccaa gcccaccaaa gctgccaaca
      121 agacaccacc caagtcccca ggagacccag ccaaggctgc taagaggttg tcgctggagt
      181 cagagggggc caatgagggt gcagctgcag cccctgagct cagtgccctg gaggaggcct
      241 tccggcggtt tgcagtacac ggggacacca gggccacagg aaaggagatg cacggcaaga
      301 actggtcaaa actgtgcaag gactgccacg tgatcgacgg gaagaacgtg accgtcaccg
      361 acgtggacat cgtcttcagc aagatcaaag ggaagtcctg caggaccatc acctttgagc
      421 agttccagga ggcactggag gaactggcca agaagcggtt caaggataag agcagcgagg
      481 aagccgtgcg tgaggtgcac cgactcatcg agggccgagc accagtcatc tctggcgtca
      541 cgaaagctgt gtcctcaccc acagtgtcac ggctcacgga taccagcaag ttcacaggct
      601 cccacaaaga gcgcttcgac caatcaggaa agggcaaggg caaagctggc cgcgtggacc
      661 tggtggatga gtcaggctac gtgcctggtt acaagcatgc gggcacctat gaccagaagg
      721 tgcagggggg caagtagcct tacgggctgg agctccggac actacaggtg gcaggcacag
      781 gacttacacc cattgcactt cattacattc ctatgttaac tgggcagaac tcagaatgca
      841 cctccactag gcgatggtgg gggcgatgcc caggcctcct cctgctgggt gcttcgacac
      901 ttctccctca gaccccaggt ttgggccgtg attcattgtc ctgtcctaac atacctgccc
      961 tgtccacagc tgggaagtgg actgctcttt ccaaactgtc tcccaggatc ataccacact
//
