LOCUS       NM_031137               4564 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus tripeptidyl peptidase 2 (Tpp2), mRNA.
ACCESSION   NM_031137 XM_003750693
VERSION     NM_031137.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4564)
  AUTHORS   Pashevin,D.O., Honcharov,S.V., Tumanovs'ka,L.V., Dosenko,V.Ie. and
            Moibenko,O.O.
  TITLE     [The changes in the activity of tripeptidyl peptidase II in
            experimental atherosclerosis and hypertension]
  JOURNAL   Fiziol Zh (1994) 60 (3), 27-31 (2014)
   PUBMED   25095668
  REMARK    GeneRIF: Changes in the activity of TPP II play an important role
            in the pathogenesis of blood vessels wall in atherosclerosis and
            arterial hypertension.
REFERENCE   2  (bases 1 to 4564)
  AUTHORS   Schonegge,A.M., Villa,E., Forster,F., Hegerl,R., Peters,J.,
            Baumeister,W. and Rockel,B.
  TITLE     The structure of human tripeptidyl peptidase II as determined by a
            hybrid approach
  JOURNAL   Structure 20 (4), 593-603 (2012)
   PUBMED   22483107
REFERENCE   3  (bases 1 to 4564)
  AUTHORS   Wray,C.J., Tomkinson,B., Robb,B.W. and Hasselgren,P.O.
  TITLE     Tripeptidyl-peptidase II expression and activity are increased in
            skeletal muscle during sepsis
  JOURNAL   Biochem Biophys Res Commun 296 (1), 41-47 (2002)
   PUBMED   12147224
  REMARK    GeneRIF: increase of expression and activity in skeletal muscle
            during sepsis
REFERENCE   4  (bases 1 to 4564)
  AUTHORS   Stoltze,L., Schirle,M., Schwarz,G., Schroter,C., Thompson,M.W.,
            Hersh,L.B., Kalbacher,H., Stevanovic,S., Rammensee,H.G. and
            Schild,H.
  TITLE     Two new proteases in the MHC class I processing pathway
  JOURNAL   Nat Immunol 1 (5), 413-418 (2000)
   PUBMED   11062501
REFERENCE   5  (bases 1 to 4564)
  AUTHORS   Beninga,J., Rock,K.L. and Goldberg,A.L.
  TITLE     Interferon-gamma can stimulate post-proteasomal trimming of the N
            terminus of an antigenic peptide by inducing leucine aminopeptidase
  JOURNAL   J Biol Chem 273 (30), 18734-18742 (1998)
   PUBMED   9668046
REFERENCE   6  (bases 1 to 4564)
  AUTHORS   Rose,C., Vargas,F., Facchinetti,P., Bourgeat,P., Bambal,R.B.,
            Bishop,P.B., Chan,S.M., Moore,A.N., Ganellin,C.R. and Schwartz,J.C.
  TITLE     Characterization and inhibition of a cholecystokinin-inactivating
            serine peptidase
  JOURNAL   Nature 380 (6573), 403-409 (1996)
   PUBMED   8602240
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031137.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U50194.1, SRR26360172.1303098.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-178               JAXUCZ010000009.1  53538892-53539069
            179-307             JAXUCZ010000009.1  53545961-53546089
            308-403             JAXUCZ010000009.1  53564532-53564627
            404-508             JAXUCZ010000009.1  53566307-53566411
            509-633             JAXUCZ010000009.1  53568380-53568504
            634-797             JAXUCZ010000009.1  53569865-53570028
            798-952             JAXUCZ010000009.1  53571521-53571675
            953-1029            JAXUCZ010000009.1  53572577-53572653
            1030-1157           JAXUCZ010000009.1  53575251-53575378
            1158-1257           JAXUCZ010000009.1  53576663-53576762
            1258-1406           JAXUCZ010000009.1  53580124-53580272
            1407-1522           JAXUCZ010000009.1  53581547-53581662
            1523-1691           JAXUCZ010000009.1  53582310-53582478
            1692-1849           JAXUCZ010000009.1  53583288-53583445
            1850-1926           JAXUCZ010000009.1  53584092-53584168
            1927-2033           JAXUCZ010000009.1  53586080-53586186
            2034-2188           JAXUCZ010000009.1  53593821-53593975
            2189-2305           JAXUCZ010000009.1  53595230-53595346
            2306-2406           JAXUCZ010000009.1  53595545-53595645
            2407-2503           JAXUCZ010000009.1  53596641-53596737
            2504-2641           JAXUCZ010000009.1  53597884-53598021
            2642-2886           JAXUCZ010000009.1  53599304-53599548
            2887-2965           JAXUCZ010000009.1  53599768-53599846
            2966-3117           JAXUCZ010000009.1  53606540-53606691
            3118-3214           JAXUCZ010000009.1  53609181-53609277
            3215-3345           JAXUCZ010000009.1  53610231-53610361
            3346-3553           JAXUCZ010000009.1  53615083-53615290
            3554-3673           JAXUCZ010000009.1  53618472-53618591
            3674-4564           JAXUCZ010000009.1  53619363-53620253
FEATURES             Location/Qualifiers
     source          1..4564
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q22"
     gene            1..4564
                     /gene="Tpp2"
                     /gene_synonym="TPP-2"
                     /note="tripeptidyl peptidase 2"
                     /db_xref="GeneID:81815"
                     /db_xref="RGD:621584"
     exon            1..178
                     /gene="Tpp2"
                     /gene_synonym="TPP-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..3763
                     /gene="Tpp2"
                     /gene_synonym="TPP-2"
                     /EC_number="3.4.14.10"
                     /note="TPP-II; tripeptidyl-peptidase II; tripeptidyl
                     aminopeptidase"
                     /codon_start=1
                     /product="tripeptidyl-peptidase 2"
                     /protein_id="NP_112399.1"
                     /db_xref="GeneID:81815"
                     /db_xref="RGD:621584"
                     /translation="MATAATEEPFPFHGLLPKKETGASSFLCRYPEYDGRGVLIAVLD
                     TGVDPGAPGMQVTTDGKPKIIDIIDTTGSGDVNTATEVEPKDGEITGLSGRVLKIPAN
                     WTNPSGKYHIGIKNGYDFYPKALKERIQKERKEKIWDPIHRVALAEACRKQEEFDIAN
                     NGSSQANKLIKEELQSQVELLNSFEKKYSDPGPVYDCLVWHDGETWRACVDSNENGDL
                     GKSTVLRNYKEAQEYGSFGTAEMLNYSVNIYDDGNLLSIVTSGGAHGTHVASIAAGHF
                     PEEPERNGVAPGAQILSIKIGDTRLSTMETGTGLIRAMIEVINHKCDLVNYSYGEATH
                     WPNSGRICEVINEAVWKHNTIYVSSAGNNGPCLSTVGCPGGTTSSVIGVGAYVSPDMM
                     VAEYSLREKLPANQYTWSSRGPSADGALGVSISAPGGAIASVPNWTLRGTQLMNGTSM
                     SSPNACGGIALVLSGLKANNVDYTVHSVRRALENTAIKADNIEVFAQGHGIIQVDKAY
                     DYLIQNTSFANRLGFTVTVGNNRGIYLRDPVQVAAPSDHGVGIEPVFPENTENSEKIS
                     FQLHLALTSNSSWVQCPSHLELMNQCRHINIRVDPRGLREGLHYTEVCGYDIASPNAG
                     PLFRVPITAVIAAKVNESSHYDLAFTDVHFKPGQIRRHFVEVPEGATWAEVTVCSCSS
                     EVSAKFVLHAVQLVKQRAYRSHEFYKFCSLPEKGTLIEAFPVLGGKAIEFCIARWWAS
                     LSDVNIDYTISFHGIVCTAPQLNIHASEGINRFDVQSSLKYEDLAPCITLKSWVQTLR
                     PVNAKTRPLGSRDVLPNNRQLYEMVLTYSFHQPKSGEVTPSCPLLCELLYESEFDSQL
                     WIIFDQNKRQMGSGDAYPHQYSLKLEKGDYTIRLQIRHEQISDLDRLKDLPFIVSHRL
                     SNTLSLDIHENHSLALLGKKKSSSLTLPPKYNQPFFVTSLPDDKIPKGAGPGCYLAGS
                     LTLSKTELGKKADVIPVHYYLIPPPTKTKNGSKDKEKDSEKEKDLKEEFTEALRDLKI
                     QWMTKLDSTDIYNELKETYPAYLPLYVARLHQLDAEKERMKRLNEIVDAANAVISHID
                     QTALAVYIAMKTDPRPDAATIKNDMDKQKSTLVDALCRKGCALADHLLHAQPHDGAAA
                     GDAEAKEEEGESTLESLSETYWETTKWTDLFDTKVLTFAYKHALVNKMYGRGLKFATK
                     LVEEKPTKENWKNCIQLMKLLGWTHCASFTENWLPIMYPPDYCVF"
     exon            179..307
                     /gene="Tpp2"
                     /gene_synonym="TPP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            308..403
                     /gene="Tpp2"
                     /gene_synonym="TPP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            404..508
                     /gene="Tpp2"
                     /gene_synonym="TPP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            509..633
                     /gene="Tpp2"
                     /gene_synonym="TPP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            634..797
                     /gene="Tpp2"
                     /gene_synonym="TPP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            798..952
                     /gene="Tpp2"
                     /gene_synonym="TPP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1029
                     /gene="Tpp2"
                     /gene_synonym="TPP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1157
                     /gene="Tpp2"
                     /gene_synonym="TPP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1257
                     /gene="Tpp2"
                     /gene_synonym="TPP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1406
                     /gene="Tpp2"
                     /gene_synonym="TPP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1522
                     /gene="Tpp2"
                     /gene_synonym="TPP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1691
                     /gene="Tpp2"
                     /gene_synonym="TPP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1849
                     /gene="Tpp2"
                     /gene_synonym="TPP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1926
                     /gene="Tpp2"
                     /gene_synonym="TPP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..2033
                     /gene="Tpp2"
                     /gene_synonym="TPP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2188
                     /gene="Tpp2"
                     /gene_synonym="TPP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2305
                     /gene="Tpp2"
                     /gene_synonym="TPP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2406
                     /gene="Tpp2"
                     /gene_synonym="TPP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2407..2503
                     /gene="Tpp2"
                     /gene_synonym="TPP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2504..2641
                     /gene="Tpp2"
                     /gene_synonym="TPP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2642..2886
                     /gene="Tpp2"
                     /gene_synonym="TPP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2887..2965
                     /gene="Tpp2"
                     /gene_synonym="TPP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2966..3117
                     /gene="Tpp2"
                     /gene_synonym="TPP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3118..3214
                     /gene="Tpp2"
                     /gene_synonym="TPP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3215..3345
                     /gene="Tpp2"
                     /gene_synonym="TPP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3346..3553
                     /gene="Tpp2"
                     /gene_synonym="TPP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3554..3673
                     /gene="Tpp2"
                     /gene_synonym="TPP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3674..4564
                     /gene="Tpp2"
                     /gene_synonym="TPP-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccagcttgcg tccatggcca ccgctgcgac cgaggagcct ttccctttcc atggtcttct
       61 accaaagaaa gagactgggg cctcctcctt cctgtgccgc tacccggagt atgacggacg
      121 cggggtgctc atcgccgtcc tggacacagg ggttgatccc ggggccccgg gcatgcaggt
      181 cacgactgat gggaaaccaa aaatcattga tatcattgat acaacaggaa gtggtgatgt
      241 gaatactgct acagaagtag aaccaaaaga tggcgaaatc actggtcttt ctggaagagt
      301 gcttaagatt cctgcaaact ggacaaatcc ttcaggaaaa tatcatattg gcattaaaaa
      361 tggttatgac ttctatccaa aggctctcaa ggaaaggata cagaaagaac ggaaggaaaa
      421 aatctgggat ccaattcaca gagttgcgct tgcagaagct tgtagaaaac aagaagaatt
      481 tgatattgcc aataatggct cttcccaagc caataaacta atcaaggaag agttgcagag
      541 tcaagtggaa ttacttaatt cttttgagaa aaagtatagt gatccaggcc ctgtgtatga
      601 ctgcttggtg tggcatgatg gtgagacctg gagagcctgt gttgattcga atgaaaatgg
      661 ggacttgggt aaatctactg tattgagaaa ctacaaagag gctcaagaat atggttcttt
      721 tggcacagct gagatgctga attactctgt taatatttat gatgatggaa acctgctctc
      781 cattgtgacc agtggaggag ctcatggaac ccatgtagcg agtatagctg ctgggcattt
      841 tccagaagag cctgaacgga atggagttgc tcctggtgct caaattctat ccattaagat
      901 tggtgataca aggctaagca ccatggaaac aggcacaggc ctcatcagag ctatgataga
      961 agttataaat cataagtgtg atcttgtcaa ctacagttat ggagaagcaa ctcattggcc
     1021 aaattctggg agaatttgtg aagtaattaa tgaagcagta tggaaacata atacaattta
     1081 tgtttcaagt gctggaaata atggtccatg cctttctaca gtgggttgtc caggaggaac
     1141 tacttccagc gtgataggtg ttggagctta tgtttctcct gatatgatgg ttgcagagta
     1201 ttcactgaga gagaaactac ctgcaaatca atatacatgg tcttctagag gcccaagtgc
     1261 tgatggggcc cttggtgtga gcatcagtgc accaggaggt gctattgctt ctgtgcctaa
     1321 ctggacattg agggggactc agctaatgaa tgggacatca atgtcttccc ccaatgcctg
     1381 tggtggcatt gccctggtac tttcaggact gaaagcaaat aatgttgact atactgttca
     1441 ctcagtcaga agagctctag aaaacactgc aataaaagct gacaatatag aagtatttgc
     1501 ccaaggacat ggaattattc aggttgacaa agcttatgac tacctcattc agaatacatc
     1561 atttgctaac agattaggtt ttacagttac agttggaaat aaccgtggca tctacctccg
     1621 agatcctgtt caggtggctg ctccttcaga tcatggtgtt ggcattgagc ctgtatttcc
     1681 agagaacaca gaaaactctg aaaaaatatc cttccagctt catttagctt taacttcaaa
     1741 ttcatcttgg gttcaatgtc ccagccattt ggaactcatg aatcaatgtc ggcacataaa
     1801 catacgtgtg gaccccaggg gcttaagaga agggttacat tatacagagg tatgtgggta
     1861 tgatatagca tcccccaatg caggtccttt attcagagtt ccaatcactg cagttatagc
     1921 agcaaaagta aatgaatcat cacattatga tctagccttt acagatgtac attttaaacc
     1981 tggtcagatt cgaagacatt ttgttgaggt tcctgagggg gcaacttggg ctgaagttac
     2041 cgtgtgttcg tgttcttctg aggtatcagc aaaatttgtt cttcatgcag tacagcttgt
     2101 gaagcagaga gcatatcgaa gtcatgaatt ttataagttt tgttcccttc cagaaaaagg
     2161 aacactcatt gaagcctttc ctgttctggg tgggaaagca attgaatttt gtattgctcg
     2221 ttggtgggca agtctcagtg atgtcaatat tgattatacc atatcattcc atggcatagt
     2281 gtgtactgca ccacagttaa acattcatgc atctgaagga atcaatcgtt ttgatgtcca
     2341 gtcctcttta aaatatgaag atctggctcc ttgcataact ttgaagagct gggtgcaaac
     2401 actacgccca gtaaatgcaa aaaccagacc tttaggatca agagatgttt tgccaaataa
     2461 tcgccagctt tatgagatgg tcctgacata cagctttcat cagcccaaga gcggagaagt
     2521 aacacctagt tgtccactcc tttgtgaatt attatatgag tcagaatttg acagtcagtt
     2581 gtggattatt tttgaccaga acaaaagaca gatgggctca ggcgatgcct atccacatca
     2641 gtattctttg aaattggaga aaggagatta tacgattcga ttacagattc gtcatgagca
     2701 aatcagtgat ttggatcgtc tcaaagatct tccgtttatt gtttcgcata ggttgtctaa
     2761 taccttgagc ttagatattc atgaaaatca tagccttgca cttctaggaa agaagaaatc
     2821 aagcagtttg acattaccac ccaaatataa tcagccattc tttgttactt ccttacctga
     2881 tgataaaata cctaaggggg caggacccgg atgctacctt gcaggctcct tgacattgtc
     2941 aaagactgag cttggaaaga aagctgatgt gatccctgtt cattactatc taatacctcc
     3001 accaacaaag actaagaatg gcagcaaaga taaagaaaag gattcagaaa aagagaaaga
     3061 tttgaaagaa gagtttactg aagctttacg agatcttaaa attcagtgga tgaccaagct
     3121 ggattctact gacatttaca atgaattgaa agaaacatat cctgcttacc ttcctttgta
     3181 tgttgcacgt cttcatcaat tagatgctga aaaggagcgg atgaaaagac ttaatgaaat
     3241 tgttgatgct gccaatgctg ttatttctca catcgatcag accgctctcg ctgtttacat
     3301 tgccatgaag actgacccca ggcctgatgc agctactata aaaaatgata tggacaagca
     3361 gaaatctacc ctggtagatg ccctctgcag gaaaggatgt gctctggcag accaccttct
     3421 tcatgcacag ccccacgatg gggcagcagc tggagatgca gaagcaaaag aagaggaagg
     3481 agaaagtacc ttggaatctc tatcagaaac ctattgggaa actacaaagt ggacagatct
     3541 ttttgacact aaggttttga catttgcata caagcatgca ttagtaaata agatgtacgg
     3601 gagaggcctt aagtttgcaa ccaaactcgt agaagaaaaa ccaacaaaag aaaactggaa
     3661 aaattgtatt caactaatga aattactcgg atggacccat tgtgcgtctt ttactgaaaa
     3721 ctggctcccc atcatgtatc ctcctgatta ttgtgtattc taaaatggga accaaaacgt
     3781 taaatttcga aacagaaaat tttatagtga acaaatatat gaacaaatgt gtggcatttc
     3841 tagtctaact aatgcatgtc ttcatccact atcgaatact gatcattaaa actctatgta
     3901 tttatcagag aactcaatgg tgtgtggctt catacatgta atgtagacag acctctgaca
     3961 tcatgctgct ttcctgctgc ctcccacact tggctaggga gggcagagcc tgcctgccag
     4021 ccccaacctg ggtgggatgc agctgctcac tgcaggagag gttttcatct cttaattttt
     4081 aactgtaaaa cgtcatccag tttttatttt ataaatcaaa aaggttaaaa catgctaaat
     4141 ttttccaatt atatagaggc cttaaaaatg ctacattggg tgtagctaaa ttatttattt
     4201 gactaaaaat tacgagaaca taatttccag acttctaaaa ataaattcaa ttaatgggta
     4261 tggtggggag gtataaatac atggcaactg ggaaaagaaa cgtgttaatg taatcttcac
     4321 tccggagtca caacaagcaa gttgttttta cagcatcctc aagtacacag catcagaata
     4381 agttaaaatt tcatgtgttg gtgccaggca gttgaatcta tctggttttg taaagatata
     4441 cacagtatgt ttataacatt gaaatcatgt aaaatacatg aataaatgtg caaaacaaca
     4501 ggcacagcac accatatgca ctctgatacc tgttttttat aaataaaagt aaatattgaa
     4561 gcta
//
