LOCUS       NM_031357               2460 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus tripeptidyl peptidase 1 (Tpp1), mRNA.
ACCESSION   NM_031357
VERSION     NM_031357.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2460)
  AUTHORS   Min,S., Kwon,S.M., Hong,J., Lee,Y.K., Park,T.J., Lim,S.B. and
            Yoon,G.
  TITLE     Mitoribosomal Deregulation Drives Senescence via TPP1-Mediated
            Telomere Deprotection
  JOURNAL   Cells 11 (13), 2079 (2022)
   PUBMED   35805162
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2460)
  AUTHORS   Shlevkov,E., Basu,H., Bray,M.A., Sun,Z., Wei,W., Apaydin,K.,
            Karhohs,K., Chen,P.F., Smith,J.L.M., Wiskow,O., Roet,K., Huang,X.,
            Eggan,K., Carpenter,A.E., Kleiman,R.J. and Schwarz,T.L.
  TITLE     A High-Content Screen Identifies TPP1 and Aurora B as Regulators of
            Axonal Mitochondrial Transport
  JOURNAL   Cell Rep 28 (12), 3224-3237 (2019)
   PUBMED   31533043
  REMARK    GeneRIF: A High-Content Screen Identifies TPP1 and Aurora B as
            Regulators of Axonal Mitochondrial Transport.
REFERENCE   3  (bases 1 to 2460)
  AUTHORS   Petrova,E.B., Dimitrova,M.B., Ivanov,I.P., Pavlova,V.G.,
            Dimitrova,S.G. and Kadiysky,D.S.
  TITLE     Effect of acute hypoxic shock on the rat brain morphology and
            tripeptidyl peptidase I activity
  JOURNAL   Acta Histochem 118 (5), 496-504 (2016)
   PUBMED   27263093
  REMARK    GeneRIF: TPPI activity was strictly regulated following hypoxic
            stress in the rat brain.
REFERENCE   4  (bases 1 to 2460)
  AUTHORS   Atanasova,D. and Lazarov,N.
  TITLE     Histochemical demonstration of tripeptidyl aminopeptidase I in the
            rat carotid body
  JOURNAL   Acta Histochem 117 (2), 219-222 (2015)
   PUBMED   25636608
  REMARK    GeneRIF: These findings also suggest that TPP I is involved in the
            general turnover of chemotransmitters between glomus cells and
            sensory nerve endings which emphasizes its importance for
            chemoreception under hypoxic conditions.
REFERENCE   5  (bases 1 to 2460)
  AUTHORS   Muslimov,I.A., Tuzhilin,A., Tang,T.H., Wong,R.K., Bianchi,R. and
            Tiedge,H.
  TITLE     Interactions of noncanonical motifs with hnRNP A2 promote
            activity-dependent RNA transport in neurons
  JOURNAL   J Cell Biol 205 (4), 493-510 (2014)
   PUBMED   24841565
  REMARK    GeneRIF: We describe a molecular mechanism in which inducible
            interactions of noncanonical RNA motif structures with targeting
            factor heterogeneous nuclear ribonucleoprotein (hnRNP) A2 form the
            basis for activity-dependent dendritic RNA targeting with CLN2.
REFERENCE   6  (bases 1 to 2460)
  AUTHORS   Vines,D.J. and Warburton,M.J.
  TITLE     Classical late infantile neuronal ceroid lipofuscinosis fibroblasts
            are deficient in lysosomal tripeptidyl peptidase I
  JOURNAL   FEBS Lett 443 (2), 131-135 (1999)
   PUBMED   9989590
REFERENCE   7  (bases 1 to 2460)
  AUTHORS   Vines,D. and Warburton,M.J.
  TITLE     Purification and characterisation of a tripeptidyl aminopeptidase I
            from rat spleen
  JOURNAL   Biochim Biophys Acta 1384 (2), 233-242 (1998)
   PUBMED   9659384
REFERENCE   8  (bases 1 to 2460)
  AUTHORS   Sleat,D.E., Donnelly,R.J., Lackland,H., Liu,C.G., Sohar,I.,
            Pullarkat,R.K. and Lobel,P.
  TITLE     Association of mutations in a lysosomal protein with classical
            late-infantile neuronal ceroid lipofuscinosis
  JOURNAL   Science 277 (5333), 1802-1805 (1997)
   PUBMED   9295267
REFERENCE   9  (bases 1 to 2460)
  AUTHORS   Page,A.E., Fuller,K., Chambers,T.J. and Warburton,M.J.
  TITLE     Purification and characterization of a tripeptidyl peptidase I from
            human osteoclastomas: evidence for its role in bone resorption
  JOURNAL   Arch Biochem Biophys 306 (2), 354-359 (1993)
   PUBMED   8215436
REFERENCE   10 (bases 1 to 2460)
  AUTHORS   Maekawa,R., Yamada,J. and Nikaido,H.
  TITLE     Genetical studies of low plasma alkaline phosphatase (ALP) activity
            in the IS strain of rats
  JOURNAL   Jikken Dobutsu 31 (1), 13-19 (1982)
   PUBMED   6951716
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031357.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB043870.1, BC081775.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMN12840105 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                JAXUCZ010000001.1  169515918-169515939 c
            23-94               JAXUCZ010000001.1  169515728-169515799 c
            95-234              JAXUCZ010000001.1  169515321-169515460 c
            235-385             JAXUCZ010000001.1  169513929-169514079 c
            386-513             JAXUCZ010000001.1  169513609-169513736 c
            514-692             JAXUCZ010000001.1  169513277-169513455 c
            693-891             JAXUCZ010000001.1  169512965-169513163 c
            892-1080            JAXUCZ010000001.1  169512644-169512832 c
            1081-1150           JAXUCZ010000001.1  169512346-169512415 c
            1151-1271           JAXUCZ010000001.1  169511477-169511597 c
            1272-1430           JAXUCZ010000001.1  169511196-169511354 c
            1431-1556           JAXUCZ010000001.1  169510893-169511018 c
            1557-2460           JAXUCZ010000001.1  169509816-169510719 c
FEATURES             Location/Qualifiers
     source          1..2460
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..2460
                     /gene="Tpp1"
                     /gene_synonym="Cln2"
                     /note="tripeptidyl peptidase 1"
                     /db_xref="GeneID:83534"
                     /db_xref="RGD:621296"
     exon            1..22
                     /gene="Tpp1"
                     /gene_synonym="Cln2"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..1697
                     /gene="Tpp1"
                     /gene_synonym="Cln2"
                     /EC_number="3.4.14.9"
                     /note="TPP-1; TPP-I; tripeptidyl-peptidase I; tripeptidyl
                     aminopeptidase; ceroid-lipofuscinosis, neuronal 2"
                     /codon_start=1
                     /product="tripeptidyl-peptidase 1 precursor"
                     /protein_id="NP_112647.2"
                     /db_xref="GeneID:83534"
                     /db_xref="RGD:621296"
                     /translation="MGLQARFLGLLALVIAGKCTHSPEPDQRWMLPPGWVSLGRVDPE
                     EELSLTFALKQQNLDRLSELVQAVSDPSSPRYGKYLTLEDVAELVQPSPLTLCTVQKW
                     LLAAGARDCHSVTTQDFLTCWLSVRQAELLLPGAEFHRYVGGPAKTHIIRSPHPYQLP
                     QALAPHVDFVAGLHRFPPLSSPRQRPEPQGVGPVGLHLGVTPSVLRQRYNLTARDVGS
                     GTTNNSQACAQFLEQYFHNSDLTEFMRLFGSSFAHQASVARVVGKQGRGRAGIEASLD
                     VEYLMSAGANISTWVYSSPGRHEAQEPFLQWLLLLSNESSLPHVHTVSYGDDEDSLSS
                     VYIQRVNTEFMKAAARGLTLLFASGDTGAGCWSVSGRHKFRPSFPASSPYVTTVGGTS
                     FKNPFLVTNEVVDYISGGGFSNVFPQPSYQEEAVAQFLKSSSHLPPSSYFNASGRAYP
                     DVAALSDGYWVVSNMVPIPWVSGTSASTPVFGGILSLINEHRLLNGRPPLGFLNPRLY
                     QQHGAGLFDVTHGCHESCLNEEVEGQGFCSGPGWDPVTGWGTPNFPALLKTLLNP"
     exon            23..94
                     /gene="Tpp1"
                     /gene_synonym="Cln2"
                     /inference="alignment:Splign:2.1.0"
     exon            95..234
                     /gene="Tpp1"
                     /gene_synonym="Cln2"
                     /inference="alignment:Splign:2.1.0"
     exon            235..385
                     /gene="Tpp1"
                     /gene_synonym="Cln2"
                     /inference="alignment:Splign:2.1.0"
     exon            386..513
                     /gene="Tpp1"
                     /gene_synonym="Cln2"
                     /inference="alignment:Splign:2.1.0"
     exon            514..692
                     /gene="Tpp1"
                     /gene_synonym="Cln2"
                     /inference="alignment:Splign:2.1.0"
     exon            693..891
                     /gene="Tpp1"
                     /gene_synonym="Cln2"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1080
                     /gene="Tpp1"
                     /gene_synonym="Cln2"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1150
                     /gene="Tpp1"
                     /gene_synonym="Cln2"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1271
                     /gene="Tpp1"
                     /gene_synonym="Cln2"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1430
                     /gene="Tpp1"
                     /gene_synonym="Cln2"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1556
                     /gene="Tpp1"
                     /gene_synonym="Cln2"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..2460
                     /gene="Tpp1"
                     /gene_synonym="Cln2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccaaaatggg actccaagcc cgcttcctag gactccttgc tctcgtcatc gccggcaaat
       61 gcactcacag ccccgagccg gaccaacggt ggatgctgcc tccaggctgg gtgtcactgg
      121 gccgagtgga tcccgaggaa gagctgagtc ttacttttgc gctgaaacag cagaacctgg
      181 acagactctc ggagctggtg caggctgtgt cggatcccag ctctcctcga tatggaaagt
      241 acctcaccct agaggatgta gctgagctgg tccaaccatc accactgacc ctctgcactg
      301 tccaaaagtg gctcttggca gctggagccc gggactgcca ttcagtgacc acccaggact
      361 ttctgacttg ctggctgagt gtccggcagg ctgagctgct gcttcctggg gctgagtttc
      421 atcgctatgt agggggacct gcaaagaccc acattataag gtccccacat ccctatcagc
      481 tcccccaggc cttggcccct catgtggact ttgtggcggg gctgcaccgt ttcccccctt
      541 tatcatctcc gagacaacgt ccagagccac aaggagtggg acctgttggc ctgcacctgg
      601 gagtgactcc atctgtgctt cgtcagcgat ataacctgac agcccgagat gtgggctctg
      661 gcaccaccaa caatagccag gcctgtgccc agttcctgga acagtacttc cataactcgg
      721 atctgactga gttcatgcgc ctgtttggta gcagttttgc acaccaggcc tcagtagcaa
      781 gagtggttgg aaagcagggg cgaggccgag cgggcatcga ggccagtcta gatgtggaat
      841 acctgatgag tgctggtgcc aatatctcca cttgggtcta cagtagccct ggccgccatg
      901 aggcacagga gcccttctta caatggctcc tgcttcttag caatgagtca tccttgccgc
      961 atgtacatac tgtgagttac ggagacgatg aagactccct cagcagtgtc tacatccaga
     1021 gagtcaacac tgagttcatg aaggctgctg ctcggggtct caccctcctt tttgcctcag
     1081 gtgacactgg agctgggtgt tggtctgtct ccggaagaca caagttccgt cctagcttcc
     1141 ctgcttctag cccctatgtc actacagtag gaggaacctc cttcaagaat cctttccttg
     1201 tcacaaatga agtagttgac tatatcagtg gtggaggctt cagcaatgtt ttcccacagc
     1261 cttcatacca ggaggaagca gtagcccagt tcttgaagtc cagctctcat ctaccaccat
     1321 ctagttactt caatgctagt ggccgtgctt acccagatgt tgccgcgctt tctgatggct
     1381 actgggtggt cagcaacatg gtccccattc cgtgggtatc tggaacctcg gcctctactc
     1441 cagtgtttgg gggaatttta tccttgataa atgagcacag actcctcaat ggccgccccc
     1501 ctctaggctt tctcaatccc aggctctatc agcagcatgg ggcaggactc tttgatgtaa
     1561 cccatggctg ccatgagtcc tgtctgaatg aagaagtgga gggtcagggt ttctgctctg
     1621 gtcctggctg ggatcctgtg acaggttggg gaacacccaa cttcccagcc ctactgaaga
     1681 ctctactcaa cccttgaccc ttccctgccc tgacgagaaa gcagaactgt ttcctgtact
     1741 acaagggaag gctcagtttc tcgttattcc tcaatggaag ccctgatgaa ctcttaactg
     1801 ttgcctgctg cagatagctt ctccctaacc ctcaaatgct gtgagcagga ctggactccc
     1861 aaccctgtga gccatcaaac tcaggtctcc aaacttctac ttcgagatcc ccaacaagat
     1921 gctataacca gcattttgtc tcaccccaac cccatctctc cttcctcttt ccagcttgag
     1981 atgtgaaagc agggcgagaa gattcagtct gcattactga caccagcagt cccacctaat
     2041 gcttaccacc tctgcactga ccgtatgctc tttctcttcc agctgcttct tcgttcactg
     2101 aaatgagacc tttgtgctaa tcgtttagtc tttcttcccc tggcactgaa gtgcaatggt
     2161 ctccctgaca ttctatccag ttatacactt ctcagtgttt tatgggcttt cttgtttaag
     2221 aacaggttgg tgatgggttg gggatttagc tcagtggtag agcgcttgcc taggaagcgc
     2281 aaggccctgg gttcggtccc cagctccgaa aaaaagaacc aaaaaaaaaa aaaagaacag
     2341 gttggtgaca atctatataa ctattctaag gaaagttcaa gtttgaaaat tttaaatgtt
     2401 ttaaatgttc ttattggcaa agctcctcaa caaaataaat aggtgttaca aattttgctt
//
