LOCUS       NM_019353               3250 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Rattus norvegicus thyroid peroxidase (Tpo), mRNA.
ACCESSION   NM_019353
VERSION     NM_019353.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3250)
  AUTHORS   Panda,S., Sikdar,M., Biswas,S., Sharma,R. and Kar,A.
  TITLE     Allylpyrocatechol, isolated from betel leaf ameliorates
            thyrotoxicosis in rats by altering thyroid peroxidase and
            thyrotropin receptors
  JOURNAL   Sci Rep 9 (1), 12276 (2019)
   PUBMED   31439949
  REMARK    GeneRIF: Allylpyrocatechol, isolated from betel leaf ameliorates
            thyrotoxicosis in rats by altering thyroid peroxidase and
            thyrotropin receptors.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3250)
  AUTHORS   Montesinos Mdel,M., Nicola,J.P., Nazar,M., Peyret,V., Lucero,A.M.,
            Pellizas,C.G. and Masini-Repiso,A.M.
  TITLE     Nitric oxide-repressed Forkhead factor FoxE1 expression is involved
            in the inhibition of TSH-induced thyroid peroxidase levels
  JOURNAL   Mol Cell Endocrinol 420, 105-115 (2016)
   PUBMED   26610751
  REMARK    GeneRIF: Nitric oxide decreases TSH-induced FoxE1 expression, thus
            repressing the transcripcional activation of TPO gene.
REFERENCE   3  (bases 1 to 3250)
  AUTHORS   Rauer,C., Ringseis,R., Rothe,S., Wen,G. and Eder,K.
  TITLE     Sterol regulatory element-binding proteins are regulators of the
            rat thyroid peroxidase gene in thyroid cells
  JOURNAL   PLoS One 9 (3), e91265 (2014)
   PUBMED   24625548
  REMARK    GeneRIF: SREBP-1c and SREBP-2 are regulators of the rat thyroid
            peroxidase gene in thyroid cells
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3250)
  AUTHORS   Nazar,M., Nicola,J.P., Velez,M.L., Pellizas,C.G. and
            Masini-Repiso,A.M.
  TITLE     Thyroid peroxidase gene expression is induced by lipopolysaccharide
            involving nuclear factor (NF)-kappaB p65 subunit phosphorylation
  JOURNAL   Endocrinology 153 (12), 6114-6125 (2012)
   PUBMED   23064013
  REMARK    GeneRIF: Thyroid peroxidase gene expression is induced by
            lipopolysaccharide involving nuclear factor (NF)-kappaB p65 subunit
            phosphorylation
REFERENCE   5  (bases 1 to 3250)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   6  (bases 1 to 3250)
  AUTHORS   Bikker,H., Vulsma,T., Baas,F. and de Vijlder,J.J.
  TITLE     Identification of five novel inactivating mutations in the human
            thyroid peroxidase gene by denaturing gradient gel electrophoresis
  JOURNAL   Hum Mutat 6 (1), 9-16 (1995)
   PUBMED   7550241
REFERENCE   7  (bases 1 to 3250)
  AUTHORS   Westman,K.W., Erfurth,E.M., Hagmar,L., Bygren,P.G., Ericsson,U.B.
            and Landin-Olsson,M.
  TITLE     Increased prevalence of thyroid peroxidase antibodies (TPO-Ab) in
            women with glomerulonephritis
  JOURNAL   Nephrol Dial Transplant 8 (5), 402-406 (1993)
   PUBMED   8393543
REFERENCE   8  (bases 1 to 3250)
  AUTHORS   Derwahl,M., Seto,P. and Rapoport,B.
  TITLE     An abnormal splice donor site in one allele of the thyroid
            peroxidase gene in FRTL5 rat thyroid cells introduces a premature
            stop codon: association with the absence of functional enzymatic
            activity
  JOURNAL   Mol Endocrinol 4 (6), 793-799 (1990)
   PUBMED   2233737
REFERENCE   9  (bases 1 to 3250)
  AUTHORS   Isozaki,O., Kohn,L.D., Kozak,C.A. and Kimura,S.
  TITLE     Thyroid peroxidase: rat cDNA sequence, chromosomal localization in
            mouse, and regulation of gene expression by comparison to
            thyroglobulin in rat FRTL-5 cells
  JOURNAL   Mol Endocrinol 3 (11), 1681-1692 (1989)
   PUBMED   2691880
REFERENCE   10 (bases 1 to 3250)
  AUTHORS   Derwahl,M., Seto,P. and Rapoport,B.
  TITLE     Complete nucleotide sequence of the cDNA for thyroid peroxidase in
            FRTL5 rat thyroid cells
  JOURNAL   Nucleic Acids Res 17 (20), 8380 (1989)
   PUBMED   2813071
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Aug 31, 2012 this sequence version replaced NM_019353.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X17396.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                JAXUCZ010000006.1  52495753-52495793   c
            42-136              JAXUCZ010000006.1  52495003-52495097   c
            137-221             JAXUCZ010000006.1  52488354-52488438   c
            222-373             JAXUCZ010000006.1  52482602-52482753   c
            374-506             JAXUCZ010000006.1  52480099-52480231   c
            507-636             JAXUCZ010000006.1  52468519-52468648   c
            637-843             JAXUCZ010000006.1  52466910-52467116   c
            844-1344            JAXUCZ010000006.1  52466051-52466551   c
            1345-1603           JAXUCZ010000006.1  52464494-52464752   c
            1604-1774           JAXUCZ010000006.1  52462761-52462931   c
            1775-2012           JAXUCZ010000006.1  52458943-52459180   c
            2013-2221           JAXUCZ010000006.1  52456920-52457128   c
            2222-2392           JAXUCZ010000006.1  52455486-52455656   c
            2393-2524           JAXUCZ010000006.1  52448950-52449081   c
            2525-2624           JAXUCZ010000006.1  52446954-52447053   c
            2625-2748           JAXUCZ010000006.1  52445292-52445415   c
            2749-3250           JAXUCZ010000006.1  52425998-52426499   c
FEATURES             Location/Qualifiers
     source          1..3250
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q16"
     gene            1..3250
                     /gene="Tpo"
                     /note="thyroid peroxidase"
                     /db_xref="GeneID:54314"
                     /db_xref="RGD:3900"
     exon            1..41
                     /gene="Tpo"
                     /inference="alignment:Splign:2.1.0"
     exon            42..136
                     /gene="Tpo"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..2787
                     /gene="Tpo"
                     /EC_number="1.11.1.8"
                     /codon_start=1
                     /product="thyroid peroxidase precursor"
                     /protein_id="NP_062226.2"
                     /db_xref="GeneID:54314"
                     /db_xref="RGD:3900"
                     /translation="MRTLGAMAVMLVVMGTAIFLPFLLRSRDILGGKTMTSHVINVVE
                     TSQLLVDNAVYNTMKRNLKKRGVLSPAQLLSFSKLPESTSGAISRAAEIMETSIQVMK
                     REQSQFSTDALSADILATIANLSGCLPFMLPPRCPDTCLANKYRPITGVCNNRDHPRW
                     GASNTALARWLPPVYEDGFSQPRGWNPNFLYHGFPLPPVREVTRHLIQVSNEAVTEDD
                     QYSDFLPVWGQYIDHDIALTPQSTSTAAFWGGVDCQLTCENQNPCFPIQLPSNSSRTT
                     ACLPFYRSSAACGTGDQGALFGNLSAANPRQQMNGLTSFLDASTVYGSSPGVEKQLRN
                     WSSSAGLLRVNTLHLDSGRAYLPFASAACAPEPGAPHANRTPCFLAGDGRASEVPALA
                     AVHTLWLREHNRLATAFKAINTHWSANTAYQEARKVVGALHQIITMRDYIPKILGPDA
                     FRQYVGPYEGYNPTVNPTVSNVFSTAAFRFGHATVHPLVRRLNTDFQDHTELPRLQLH
                     DVFFRPWRLIQEGGLDPIVRGLLARPAKLQVQEQLMNEELTERLFVLSNVGTLDLASL
                     NLQRGRDHGLPGYNEWREFCGLSRLETPAELNKAIANRSMVNKIMELYKHADNIDVWL
                     GGLAEKFLPGARTGPLFACIIGKQMKALRDGDRFWWENSHVFTDAQRQELEKHSLPRV
                     ICDNTGLTRVPVDAFRIGKFPQDFESCEEIPSMDLRLWRETFPQDDKCVFPEKVDNGN
                     FVHCEESGKLVLVYSCFHGYKLQGQEQVTCTQNGWDSEPPVCKDVNECADLTHPPCHS
                     SAKCKNTKGSFQCVCTDPYVLGEDEKTCIDSGRLPRASWVSIALGALLIGGLASLSWT
                     VICRWTHADKKSTLLITERVTTESGFRKSQESGISPQKAEVQDAEQEPAYGSRVLLCE
                     "
     exon            137..221
                     /gene="Tpo"
                     /inference="alignment:Splign:2.1.0"
     exon            222..373
                     /gene="Tpo"
                     /inference="alignment:Splign:2.1.0"
     exon            374..506
                     /gene="Tpo"
                     /inference="alignment:Splign:2.1.0"
     exon            507..636
                     /gene="Tpo"
                     /inference="alignment:Splign:2.1.0"
     exon            637..843
                     /gene="Tpo"
                     /inference="alignment:Splign:2.1.0"
     exon            844..1344
                     /gene="Tpo"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1603
                     /gene="Tpo"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1774
                     /gene="Tpo"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..2012
                     /gene="Tpo"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2221
                     /gene="Tpo"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2392
                     /gene="Tpo"
                     /inference="alignment:Splign:2.1.0"
     exon            2393..2524
                     /gene="Tpo"
                     /inference="alignment:Splign:2.1.0"
     exon            2525..2624
                     /gene="Tpo"
                     /inference="alignment:Splign:2.1.0"
     exon            2625..2748
                     /gene="Tpo"
                     /inference="alignment:Splign:2.1.0"
     exon            2749..3250
                     /gene="Tpo"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcacagcctg cttcttcagt ggaggaaaag aaaatggtca gaatgagaac acttggagct
       61 atggcagtaa tgctggttgt gatgggaact gcaattttcc tccctttcct cctgagaagc
      121 agagacatct tgggggggaa gactatgaca tcccatgtta tcaatgttgt agaaacgagc
      181 cagcttctgg tggacaatgc agtctacaac accatgaaaa gaaacctcaa gaaaagggga
      241 gtcctttctc cagcccagct tctctctttc tccaagctgc cagagtccac cagtggagct
      301 atttcccgag cagcagagat catggaaaca tcaatacaag tcatgaaacg tgaacaatca
      361 cagttctcca cggatgcact atcagcagac atcctggcca caattgccaa cctgtcagga
      421 tgcttgcctt tcatgctgcc accgagatgt cctgacacct gcctggcaaa caagtaccgg
      481 cccatcacag gggtgtgcaa caacagagat caccccagat ggggagcctc caacacagcc
      541 ctagcaagat ggctgcctcc tgtctacgaa gatggtttca gtcagcccag aggctggaac
      601 cctaatttct tataccatgg cttcccactg cccccggtac gggaggtgac aagacacctc
      661 attcaagttt caaatgaggc tgtgactgaa gatgaccagt actctgattt tctgccggtg
      721 tggggacagt acatcgatca tgacattgct ctcacaccac agagcaccag cacagcagcc
      781 ttctggggag gtgtcgactg ccagttgacc tgtgagaacc aaaacccctg cttccccata
      841 cagcttccct caaactcctc acggaccact gcatgcctac ctttctaccg ctcctcagcc
      901 gcctgtggca ctggggacca aggagcactc tttggcaacc tgtctgcagc caatccgagg
      961 cagcagatga atggcttgac ctccttcctt gatgcttcca cggtgtatgg cagctcccca
     1021 ggtgttgaga agcagttgcg caactggagc agctctgcag ggctgctgcg tgtcaacacc
     1081 ctccacctag actctggccg tgcctacctg cccttcgcat cagccgcctg tgctccagag
     1141 cctggtgctc cacacgccaa ccgcacgccc tgcttcctgg ctggtgatgg ccgcgccagc
     1201 gaggtccccg ccctggcagc agtgcacacc ttgtggctgc gcgagcacaa ccgcctggct
     1261 acagctttca aagccatcaa cacacattgg agcgccaaca ctgcctacca ggaggcacgc
     1321 aaggtggtag gggcattgca ccagatcatc accatgaggg attatatccc caagatcctg
     1381 ggtcccgatg ccttcaggca gtatgtgggc ccctatgaag gctataaccc cacggtgaac
     1441 cctactgtgt ccaacgtctt ctctactgct gccttccgct ttggccatgc cacagtccat
     1501 ccactggtga gacgactaaa cacagacttc caggaccaca cagagctccc caggctgcag
     1561 ctgcacgacg tcttcttcag gccctggagg cttatccagg aaggtggttt ggatccaata
     1621 gtaagaggcc tcctggcaag accagccaag ctgcaagtac aggagcaact gatgaatgag
     1681 gaactgaccg agaggctctt tgtgttgtct aatgtgggca ccttggatct ggcatcactg
     1741 aacttgcaga ggggccggga ccacggctta ccaggctaca atgagtggag agagttctgt
     1801 ggcttgtcac gcctggagac accagctgag ctgaacaagg ccattgccaa cagaagcatg
     1861 gtcaacaaga taatggagtt atacaagcat gctgacaaca ttgatgtctg gttgggaggc
     1921 ctggctgaaa agttcttacc gggagcccgc accggtcctc tgtttgcatg tatcattggg
     1981 aagcagatga aggctctgag ggatggggac aggttttggt gggagaacag ccatgtcttc
     2041 acagacgctc agaggcagga actggaaaag cattcactac ctcgggtcat ctgtgacaac
     2101 accggcctca ccagagtacc tgtggatgcc ttccgtattg gaaagttccc ccaggacttt
     2161 gaatcctgtg aggaaatccc tagcatggac ctcagactgt ggagggagac cttcccacaa
     2221 gacgacaagt gtgtcttccc agagaaggtg gacaatggga actttgtgca ctgtgaagaa
     2281 tctgggaagc tggtactggt gtattcctgt ttccatggat acaagctgca aggccaggag
     2341 caggtcacat gtacccagaa tggatgggac tcagagcctc ctgtctgtaa agatgttaat
     2401 gagtgtgcag atctgacaca cccaccttgc cactcctccg caaagtgcaa gaacaccaag
     2461 ggaagcttcc agtgtgtgtg cacagacccc tacgtgctag gtgaggatga gaagacctgc
     2521 atagattctg gcaggctacc tcgggcatcc tgggtctcca ttgcattggg tgcacttctc
     2581 attggtggtt tggccagtct cagctggact gtaatttgca ggtggacaca tgctgataag
     2641 aagtccacat tgctgatcac cgagagagtg accacggagt caggattcag aaagagtcag
     2701 gagagtggga tttcaccaca aaaggccgag gttcaagatg ctgaacagga accggcttat
     2761 ggatccagag tcctcctgtg tgaatagaag tcctcactgc tttggagcca gacattggct
     2821 aattcaagtc tcaagctgcc tgggcaaaga aagacatgat acatgttgaa gtcagaggct
     2881 tgaggacacc agatggttaa tcttatcagt ccaaggctgc atagctgagt tccatctcat
     2941 gtttttccac aggagcaggc caggccagac tgtgctaatg cctctcctac acagtaaggc
     3001 taatggataa gtaggtggaa ggataggaga attgcataag cctgaaaggc ttgagagaag
     3061 ctagcataga ctccagatcc ttccagacaa ttccacgttc attcagaatc agaatgtatc
     3121 tcttccagat acattcagtt ctctcattat gttccagtca ccacaaagca cagacgaata
     3181 aatgccacag cccttctctg gtctagctca gatatcctct tcctctaggc ttgcattaaa
     3241 aaattacata
//
