LOCUS       XM_039096088             793 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus thiopurine S-methyltransferase (Tpmt),
            transcript variant X3, mRNA.
ACCESSION   XM_039096088
VERSION     XM_039096088.1
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051352.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_039096088.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..793
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..793
                     /gene="Tpmt"
                     /note="thiopurine S-methyltransferase; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 3 ESTs, and 100% coverage of the annotated genomic
                     feature by RNAseq alignments, including 102 samples with
                     support for all annotated introns"
                     /db_xref="GeneID:690050"
                     /db_xref="RGD:1585162"
     CDS             208..651
                     /gene="Tpmt"
                     /codon_start=1
                     /product="thiopurine S-methyltransferase isoform X3"
                     /protein_id="XP_038952016.1"
                     /db_xref="GeneID:690050"
                     /db_xref="RGD:1585162"
                     /translation="MSLGIKEHPDAEVQKNRVLTLDDWQDKWVTRHIAFHQEQGHQLL
                     KKHFDTFLKGQSGLRVFFPLCGKAIEMKWFADRGHTVVGVEISEIGIREFFAEQNLSY
                     TEEPLTEIAGAKVFKSSSGNISLYCCSIFDLPRIRSPALLSSAIG"
ORIGIN      
        1 ggccgggcct ataggatggg agcctggata atcttttccg gagcgggatc tgcctacagt
       61 gggcggggcc ttcgcccttg gggcggggtc tgtccgtcct tgcacgttac cggtctctca
      121 aaggcgcgct agagtctgag gcacgcagct gggtgcagct gaggcaccgg gagacaccaa
      181 cctcggagac aagccacgga tggcaccatg tcactcggta tcaaagagca ccctgatgct
      241 gaggtacaaa agaaccgggt actaaccctg gacgactggc aagacaagtg ggtgacccgt
      301 cacatcgcat tccatcagga gcaagggcat cagctattaa agaagcattt cgatacattt
      361 cttaaagggc agagtggact gagagtgttt ttcccgctct gtggaaaagc cattgagatg
      421 aaatggttcg cagaccgggg ccacactgta gttggtgtag aaatcagtga aattgggatt
      481 cgggaatttt ttgcagaaca gaatctgtca tacacagaag aaccgctcac cgaaattgct
      541 ggtgccaaag tgtttaagag ttcttccggg aacatttcct tatactgttg cagcattttc
      601 gaccttccca gaatcagaag tccagctctt ctctcctcag ctattggttg attggctttt
      661 cttgacaaat cagagaatag acggagagca aagttcacac aacattccag caggagatac
      721 ttagaatcct caccccagtg aacgtgattg ttggggggag ggcggtaata ggggtagaat
      781 ggggagggga aca
//
