LOCUS       NM_012678                895 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus tropomyosin 4 (Tpm4), mRNA.
ACCESSION   NM_012678
VERSION     NM_012678.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 895)
  AUTHORS   Geeves,M.A., Hitchcock-DeGregori,S.E. and Gunning,P.W.
  TITLE     A systematic nomenclature for mammalian tropomyosin isoforms
  JOURNAL   J Muscle Res Cell Motil 36 (2), 147-153 (2015)
   PUBMED   25369766
  REMARK    Review article
REFERENCE   2  (bases 1 to 895)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   3  (bases 1 to 895)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   4  (bases 1 to 895)
  AUTHORS   McMichael,B.K., Kotadiya,P., Singh,T., Holliday,L.S. and Lee,B.S.
  TITLE     Tropomyosin isoforms localize to distinct microfilament populations
            in osteoclasts
  JOURNAL   Bone 39 (4), 694-705 (2006)
   PUBMED   16765662
REFERENCE   5  (bases 1 to 895)
  AUTHORS   Hossain,M.M., Crish,J.F., Eckert,R.L., Lin,J.J. and Jin,J.P.
  TITLE     h2-Calponin is regulated by mechanical tension and modifies the
            function of actin cytoskeleton
  JOURNAL   J Biol Chem 280 (51), 42442-42453 (2005)
   PUBMED   16236705
REFERENCE   6  (bases 1 to 895)
  AUTHORS   Foster,L.J., Zeemann,P.A., Li,C., Mann,M., Jensen,O.N. and
            Kassem,M.
  TITLE     Differential expression profiling of membrane proteins by
            quantitative proteomics in a human mesenchymal stem cell line
            undergoing osteoblast differentiation
  JOURNAL   Stem Cells 23 (9), 1367-1377 (2005)
   PUBMED   16210410
REFERENCE   7  (bases 1 to 895)
  AUTHORS   Gimona,M., Watakabe,A. and Helfman,D.M.
  TITLE     Specificity of dimer formation in tropomyosins: influence of
            alternatively spliced exons on homodimer and heterodimer assembly
  JOURNAL   Proc Natl Acad Sci U S A 92 (21), 9776-9780 (1995)
   PUBMED   7568216
REFERENCE   8  (bases 1 to 895)
  AUTHORS   Lees-Miller,J.P., Yan,A. and Helfman,D.M.
  TITLE     Structure and complete nucleotide sequence of the gene encoding rat
            fibroblast tropomyosin 4
  JOURNAL   J Mol Biol 213 (3), 399-405 (1990)
   PUBMED   2112608
REFERENCE   9  (bases 1 to 895)
  AUTHORS   Yamawaki-Kataoka,Y. and Helfman,D.M.
  TITLE     Isolation and characterization of cDNA clones encoding a low
            molecular weight nonmuscle tropomyosin isoform
  JOURNAL   J Biol Chem 262 (22), 10791-10800 (1987)
   PUBMED   3611091
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from J02780.1.
            
            On Aug 31, 2012 this sequence version replaced NM_012678.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J02780.1, FQ225054.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680453, SAMN11044071
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-895               J02780.1           4-898
FEATURES             Location/Qualifiers
     source          1..895
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..895
                     /gene="Tpm4"
                     /gene_synonym="Tpm4.2; Tpm4.2cy"
                     /note="tropomyosin 4"
                     /db_xref="GeneID:24852"
                     /db_xref="RGD:3899"
     exon            1..155
                     /gene="Tpm4"
                     /gene_synonym="Tpm4.2; Tpm4.2cy"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..770
                     /gene="Tpm4"
                     /gene_synonym="Tpm4.2; Tpm4.2cy"
                     /note="tropomycin 4; TM-4"
                     /codon_start=1
                     /product="tropomyosin alpha-4 chain"
                     /protein_id="NP_036810.1"
                     /db_xref="GeneID:24852"
                     /db_xref="RGD:3899"
                     /translation="MAGLNSLEAVKRKIQALQQQADDAEDRAQGLQRELDGERERREK
                     AEGDAAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDE
                     EKMEIQEMQLKEAKHIAEEADRKYEEVARKLVILEGELERAEERAEVSELKSSDLEEE
                     LKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAERTVSKLEKTID
                     DLEEKLAQAKEENVGLHQTLDQTLNELNCI"
     exon            156..289
                     /gene="Tpm4"
                     /gene_synonym="Tpm4.2; Tpm4.2cy"
                     /inference="alignment:Splign:2.1.0"
     exon            290..407
                     /gene="Tpm4"
                     /gene_synonym="Tpm4.2; Tpm4.2cy"
                     /inference="alignment:Splign:2.1.0"
     exon            408..478
                     /gene="Tpm4"
                     /gene_synonym="Tpm4.2; Tpm4.2cy"
                     /inference="alignment:Splign:2.1.0"
     exon            479..554
                     /gene="Tpm4"
                     /gene_synonym="Tpm4.2; Tpm4.2cy"
                     /inference="alignment:Splign:2.1.0"
     exon            555..617
                     /gene="Tpm4"
                     /gene_synonym="Tpm4.2; Tpm4.2cy"
                     /inference="alignment:Splign:2.1.0"
     exon            618..687
                     /gene="Tpm4"
                     /gene_synonym="Tpm4.2; Tpm4.2cy"
                     /inference="alignment:Splign:2.1.0"
     exon            688..895
                     /gene="Tpm4"
                     /gene_synonym="Tpm4.2; Tpm4.2cy"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcccagtg gagcgagtga gctatggccg gcctcaactc actggaggcg gtgaagcgca
       61 agatccaggc cctgcagcag caggcggacg acgcagagga ccgtgcgcag ggcctgcagc
      121 gcgagctgga tggcgagcgc gaacggcgcg agaaagctga aggagatgcg gccgctctca
      181 accgtcgcat ccagctggtg gaggaagagc tggaccgggc tcaggagcga ctggccacag
      241 ccctgcagaa gctggaggag gcagagaagg ctgctgacga gagtgagaga ggcatgaagg
      301 tgatagagaa ccgagccatg aaagacgagg agaagatgga gatccaggag atgcagctca
      361 aagaagccaa gcacatcgct gaggaggctg accggaagta tgaggaggtt gctcgtaagt
      421 tggtcatcct ggagggtgag ctggagagag cagaggagcg ggcggaggtg tctgaactaa
      481 agagtagcga cctggaagag gagctcaaga acgtaactaa caatctgaaa tcactggagg
      541 ctgcttctga aaagtactct gaaaaggagg ataaatatga agaagaaatc aagcttctgt
      601 ctgacaaact gaaagaggct gagacccgag ctgagtttgc ggaaaggaca gtttctaaac
      661 tggagaagac aatcgatgac ctggaagaaa aacttgccca ggccaaagaa gagaacgtgg
      721 gcttgcatca gacactggac cagacactaa acgaacttaa ctgtatataa accaaaccag
      781 aagagtcctg tcttgatacc aactccactc cagagagtgc accctgtctt cctctcttat
      841 aagaagttcc gcttactacc atgtctccac cttgctggaa aggccaagca gaaaa
//
