LOCUS       NM_057208               1078 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus tropomyosin 3 (Tpm3), transcript variant Tpm3.4,
            mRNA.
ACCESSION   NM_057208 XM_346626
VERSION     NM_057208.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1078)
  AUTHORS   Tian,H. and Hu,H.
  TITLE     [Effects of tropomyosin 3 on pyroptosis of cardiomyocytes and
            fibroblast activation induced by hypoxia/reoxygenation in rats]
  JOURNAL   Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 35 (1), 93-98 (2023)
   PUBMED   36880246
  REMARK    GeneRIF: [Effects of tropomyosin 3 on pyroptosis of cardiomyocytes
            and fibroblast activation induced by hypoxia/reoxygenation in
            rats].
REFERENCE   2  (bases 1 to 1078)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 1078)
  AUTHORS   Xu,F., Zhu,J., Chen,Y., He,K., Guo,J., Bai,S., Zhao,R., Du,J. and
            Shen,B.
  TITLE     Physical interaction of tropomyosin 3 and STIM1 regulates vascular
            smooth muscle contractility and contributes to hypertension
  JOURNAL   Biomed Pharmacother 134, 111126 (2021)
   PUBMED   33341060
  REMARK    GeneRIF: Physical interaction of tropomyosin 3 and STIM1 regulates
            vascular smooth muscle contractility and contributes to
            hypertension.
REFERENCE   4  (bases 1 to 1078)
  AUTHORS   Dong,T., Zhang,Z., Zhou,W., Zhou,X., Geng,C., Chang,L.K., Tian,X.
            and Liu,S.
  TITLE     WNT10A/beta-catenin pathway in tumorigenesis of papillary thyroid
            carcinoma
  JOURNAL   Oncol Rep 38 (2), 1287-1294 (2017)
   PUBMED   28677753
REFERENCE   5  (bases 1 to 1078)
  AUTHORS   Geeves,M.A., Hitchcock-DeGregori,S.E. and Gunning,P.W.
  TITLE     A systematic nomenclature for mammalian tropomyosin isoforms
  JOURNAL   J Muscle Res Cell Motil 36 (2), 147-153 (2015)
   PUBMED   25369766
  REMARK    Review article
REFERENCE   6  (bases 1 to 1078)
  AUTHORS   Robaszkiewicz,K., Dudek,E., Kasprzak,A.A. and Moraczewska,J.
  TITLE     Functional effects of congenital myopathy-related mutations in
            gamma-tropomyosin gene
  JOURNAL   Biochim Biophys Acta 1822 (10), 1562-1569 (2012)
   PUBMED   22749829
  REMARK    GeneRIF: All studied gamma-tropomyosin mutants reduced Ca-induced
            activation but had no effect on the inhibition of actomyosin
            cross-bridges.
REFERENCE   7  (bases 1 to 1078)
  AUTHORS   Clayton,L. and Johnson,M.H.
  TITLE     Tropomyosin in preimplantation mouse development: identification,
            expression, and organization during cell division and polarization
  JOURNAL   Exp Cell Res 238 (2), 450-464 (1998)
   PUBMED   9473354
REFERENCE   8  (bases 1 to 1078)
  AUTHORS   Temm-Grove,C.J., Guo,W. and Helfman,D.M.
  TITLE     Low molecular weight rat fibroblast tropomyosin 5 (TM-5): cDNA
            cloning, actin-binding, localization, and coiled-coil interactions
  JOURNAL   Cell Motil Cytoskeleton 33 (3), 223-240 (1996)
   PUBMED   8674141
REFERENCE   9  (bases 1 to 1078)
  AUTHORS   Laing,N.G., Wilton,S.D., Akkari,P.A., Dorosz,S., Boundy,K.,
            Kneebone,C., Blumbergs,P., White,S., Watkins,H., Love,D.R. et al.
  TITLE     A mutation in the alpha tropomyosin gene TPM3 associated with
            autosomal dominant nemaline myopathy
  JOURNAL   Nat Genet 9 (1), 75-79 (1995)
   PUBMED   7704029
  REMARK    Erratum:[Nat Genet. 1995 Jun;10(2):249. doi: 10.1038/ng0695-249..
            PMID: 7663526]
REFERENCE   10 (bases 1 to 1078)
  AUTHORS   Beisel,K.W. and Kennedy,J.E.
  TITLE     Identification of novel alternatively spliced isoforms of the
            tropomyosin-encoding gene, TMnm, in the rat cochlea
  JOURNAL   Gene 143 (2), 251-256 (1994)
   PUBMED   8206382
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from L24777.1.
            
            On Sep 21, 2004 this sequence version replaced NM_057208.1.
            
            Transcript Variant: This variant (Tpm3.4, also known as variant 1)
            differs in both UTR's and the coding region but maintains the
            reading frame, compared to variant Tpm3.12. This results in an
            isoform (Tpm3.4cy, also known as isoform 1) that is shorter at both
            the N- and C-termini, compared to isoform Tpm3.12st.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L24777.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132264
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1078
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1078
                     /gene="Tpm3"
                     /gene_synonym="TM30nm; Tpm5"
                     /note="tropomyosin 3"
                     /db_xref="GeneID:117557"
                     /db_xref="RGD:621546"
     exon            1..150
                     /gene="Tpm3"
                     /gene_synonym="TM30nm; Tpm5"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..762
                     /gene="Tpm3"
                     /gene_synonym="TM30nm; Tpm5"
                     /note="isoform Tpm3.4cy is encoded by transcript variant
                     Tpm3.4; tropomyosin alpha-3 chain; tropomyosin non-muscle;
                     nonmuscle tropomyosin 5; tropomyosin-5; gamma-tropomyosin;
                     tropomyosin 3, gamma"
                     /codon_start=1
                     /product="tropomyosin alpha-3 chain isoform Tpm3.4cy"
                     /protein_id="NP_476556.2"
                     /db_xref="GeneID:117557"
                     /db_xref="RGD:621546"
                     /translation="MAGSTTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQ
                     AEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDE
                     EKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEE
                     LKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTID
                     DLEERLYSQLERNRLLSNELKLTLHGLCD"
     exon            151..284
                     /gene="Tpm3"
                     /gene_synonym="TM30nm; Tpm5"
                     /inference="alignment:Splign:2.1.0"
     exon            285..402
                     /gene="Tpm3"
                     /gene_synonym="TM30nm; Tpm5"
                     /inference="alignment:Splign:2.1.0"
     exon            403..473
                     /gene="Tpm3"
                     /gene_synonym="TM30nm; Tpm5"
                     /inference="alignment:Splign:2.1.0"
     exon            474..549
                     /gene="Tpm3"
                     /gene_synonym="TM30nm; Tpm5"
                     /inference="alignment:Splign:2.1.0"
     exon            550..612
                     /gene="Tpm3"
                     /gene_synonym="TM30nm; Tpm5"
                     /inference="alignment:Splign:2.1.0"
     exon            613..682
                     /gene="Tpm3"
                     /gene_synonym="TM30nm; Tpm5"
                     /inference="alignment:Splign:2.1.0"
     exon            683..1078
                     /gene="Tpm3"
                     /gene_synonym="TM30nm; Tpm5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcagctggg taggcaccat ggccgggagc accaccatcg aggcggtaaa gcgcaagatc
       61 caggttctgc agcagcaggc tgatgatgcg gaggagaggg ctgagcgcct ccagcgggaa
      121 gtggagggag aaaggcgggc ccgggagcag gctgaagctg aggtggcttc cttgaaccgt
      181 aggatccagc tggttgaaga ggagctggac cgcgcccagg agcgccttgc cactgctttg
      241 cagaagctgg aggaagcgga gaaggctgct gatgagagtg agagaggtat gaaggtgatt
      301 gaaaaccggg ctctaaaaga tgaagaaaag atggagctcc aggaaatcca gctgaaggaa
      361 gcaaagcaca ttgcagaaga ggcagacagg aagtatgaag aggtggctcg taagttggtg
      421 atcattgaag gagacttgga acgcacggag gaacgcgccg agctggcaga gtctaagtgt
      481 tctgagctgg aggaggagct gaagaatgtc accaacaacc tcaaatctct tgaggctcag
      541 gcggagaagt actctcaaaa agaagacaag tatgaagaag aaataaagat tcttactgat
      601 aaactcaagg aggcggagac ccgggctgag tttgctgaaa gatcggtagc caagctggaa
      661 aagaccattg atgacttgga agagcgtctc tacagccaac ttgagcgaaa ccgcctgctt
      721 tctaatgagc tgaagctaac gctgcatggt ctttgtgact gacgggccgg gctccctgat
      781 gcccagtaaa cccacaccac tgacctggac ccagccaaaa gctgactgcc ttttaaaaag
      841 tcactgttcg ccctaagcaa gttgcttttt aatgagggca gctagactac tgttgatttc
      901 ctggcagccc ccttcaagtt gcaatggcta tttctattct agaagagatt gtgggtgatg
      961 aagatggggc ctgggaggtt tagtgcagaa cttgaaaacc gttagctgca gccctctcac
     1021 ctgtatactg actgtagggt ttgctcacct gcatggttat tttctaacaa taaaaaca
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