LOCUS       NM_001301285            1149 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus tropomyosin 3 (Tpm3), transcript variant Tpm3.12,
            mRNA.
ACCESSION   NM_001301285 XM_006232574
VERSION     NM_001301285.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1149)
  AUTHORS   Tian,H. and Hu,H.
  TITLE     [Effects of tropomyosin 3 on pyroptosis of cardiomyocytes and
            fibroblast activation induced by hypoxia/reoxygenation in rats]
  JOURNAL   Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 35 (1), 93-98 (2023)
   PUBMED   36880246
  REMARK    GeneRIF: [Effects of tropomyosin 3 on pyroptosis of cardiomyocytes
            and fibroblast activation induced by hypoxia/reoxygenation in
            rats].
REFERENCE   2  (bases 1 to 1149)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 1149)
  AUTHORS   Xu,F., Zhu,J., Chen,Y., He,K., Guo,J., Bai,S., Zhao,R., Du,J. and
            Shen,B.
  TITLE     Physical interaction of tropomyosin 3 and STIM1 regulates vascular
            smooth muscle contractility and contributes to hypertension
  JOURNAL   Biomed Pharmacother 134, 111126 (2021)
   PUBMED   33341060
  REMARK    GeneRIF: Physical interaction of tropomyosin 3 and STIM1 regulates
            vascular smooth muscle contractility and contributes to
            hypertension.
REFERENCE   4  (bases 1 to 1149)
  AUTHORS   Dong,T., Zhang,Z., Zhou,W., Zhou,X., Geng,C., Chang,L.K., Tian,X.
            and Liu,S.
  TITLE     WNT10A/beta-catenin pathway in tumorigenesis of papillary thyroid
            carcinoma
  JOURNAL   Oncol Rep 38 (2), 1287-1294 (2017)
   PUBMED   28677753
REFERENCE   5  (bases 1 to 1149)
  AUTHORS   Geeves,M.A., Hitchcock-DeGregori,S.E. and Gunning,P.W.
  TITLE     A systematic nomenclature for mammalian tropomyosin isoforms
  JOURNAL   J Muscle Res Cell Motil 36 (2), 147-153 (2015)
   PUBMED   25369766
  REMARK    Review article
REFERENCE   6  (bases 1 to 1149)
  AUTHORS   Robaszkiewicz,K., Dudek,E., Kasprzak,A.A. and Moraczewska,J.
  TITLE     Functional effects of congenital myopathy-related mutations in
            gamma-tropomyosin gene
  JOURNAL   Biochim Biophys Acta 1822 (10), 1562-1569 (2012)
   PUBMED   22749829
  REMARK    GeneRIF: All studied gamma-tropomyosin mutants reduced Ca-induced
            activation but had no effect on the inhibition of actomyosin
            cross-bridges.
REFERENCE   7  (bases 1 to 1149)
  AUTHORS   Clayton,L. and Johnson,M.H.
  TITLE     Tropomyosin in preimplantation mouse development: identification,
            expression, and organization during cell division and polarization
  JOURNAL   Exp Cell Res 238 (2), 450-464 (1998)
   PUBMED   9473354
REFERENCE   8  (bases 1 to 1149)
  AUTHORS   Temm-Grove,C.J., Guo,W. and Helfman,D.M.
  TITLE     Low molecular weight rat fibroblast tropomyosin 5 (TM-5): cDNA
            cloning, actin-binding, localization, and coiled-coil interactions
  JOURNAL   Cell Motil Cytoskeleton 33 (3), 223-240 (1996)
   PUBMED   8674141
REFERENCE   9  (bases 1 to 1149)
  AUTHORS   Laing,N.G., Wilton,S.D., Akkari,P.A., Dorosz,S., Boundy,K.,
            Kneebone,C., Blumbergs,P., White,S., Watkins,H., Love,D.R. et al.
  TITLE     A mutation in the alpha tropomyosin gene TPM3 associated with
            autosomal dominant nemaline myopathy
  JOURNAL   Nat Genet 9 (1), 75-79 (1995)
   PUBMED   7704029
  REMARK    Erratum:[Nat Genet. 1995 Jun;10(2):249. doi: 10.1038/ng0695-249..
            PMID: 7663526]
REFERENCE   10 (bases 1 to 1149)
  AUTHORS   Beisel,K.W. and Kennedy,J.E.
  TITLE     Identification of novel alternatively spliced isoforms of the
            tropomyosin-encoding gene, TMnm, in the rat cochlea
  JOURNAL   Gene 143 (2), 251-256 (1994)
   PUBMED   8206382
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from FQ215580.1.
            
            On Aug 24, 2014 this sequence version replaced XM_006232574.2.
            
            Transcript Variant: This variant (Tpm3.12, also known as variant 3)
            encodes the longest isoform (Tpm3.12st, also known as isoform 3).
            The encoded protein is a fast skeletal muscle isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ215580.1, FQ215752.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1149
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1149
                     /gene="Tpm3"
                     /gene_synonym="TM30nm; Tpm5"
                     /note="tropomyosin 3"
                     /db_xref="GeneID:117557"
                     /db_xref="RGD:621546"
     exon            1..200
                     /gene="Tpm3"
                     /gene_synonym="TM30nm; Tpm5"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..941
                     /gene="Tpm3"
                     /gene_synonym="TM30nm; Tpm5"
                     /note="isoform Tpm3.12st is encoded by transcript variant
                     Tpm3.12; tropomyosin alpha-3 chain; tropomyosin
                     non-muscle; nonmuscle tropomyosin 5; tropomyosin-5;
                     gamma-tropomyosin; tropomyosin 3, gamma"
                     /codon_start=1
                     /product="tropomyosin alpha-3 chain isoform Tpm3.12st"
                     /protein_id="NP_001288214.1"
                     /db_xref="GeneID:117557"
                     /db_xref="RGD:621546"
                     /translation="MMEAIKKKMQMLKLDKENVLDRAEQAEAEQKQAEERSKQLEDEL
                     ATMQKKLKGTEDELDKYSEALKDAQEKLELAEKKAADAEAEVASLNRRIQLVEEELDR
                     AQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKRIAEEAD
                     RKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQK
                     EDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDELYAQKLKYKAISDGLD
                     HVLNDMTSI"
     exon            201..326
                     /gene="Tpm3"
                     /gene_synonym="TM30nm; Tpm5"
                     /inference="alignment:Splign:2.1.0"
     exon            327..460
                     /gene="Tpm3"
                     /gene_synonym="TM30nm; Tpm5"
                     /inference="alignment:Splign:2.1.0"
     exon            461..578
                     /gene="Tpm3"
                     /gene_synonym="TM30nm; Tpm5"
                     /inference="alignment:Splign:2.1.0"
     exon            579..649
                     /gene="Tpm3"
                     /gene_synonym="TM30nm; Tpm5"
                     /inference="alignment:Splign:2.1.0"
     exon            650..725
                     /gene="Tpm3"
                     /gene_synonym="TM30nm; Tpm5"
                     /inference="alignment:Splign:2.1.0"
     exon            726..788
                     /gene="Tpm3"
                     /gene_synonym="TM30nm; Tpm5"
                     /inference="alignment:Splign:2.1.0"
     exon            789..858
                     /gene="Tpm3"
                     /gene_synonym="TM30nm; Tpm5"
                     /inference="alignment:Splign:2.1.0"
     exon            859..937
                     /gene="Tpm3"
                     /gene_synonym="TM30nm; Tpm5"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1134
                     /gene="Tpm3"
                     /gene_synonym="TM30nm; Tpm5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacccaggca gcagcccttc ctttctggct ctagcctcca gttctccagt gttcacaggt
       61 gaacccacca acagtcacag ctcatgatgg aggccatcaa gaaaaaaatg cagatgctga
      121 agttagacaa agagaatgtc ctggaccgag ctgagcaagc tgaagctgag cagaagcagg
      181 cagaagaaag aagcaaacag ctagaggatg aactagcaac catgcagaag aagctgaaag
      241 ggacagagga tgagctggac aagtattctg aggctttaaa ggatgcccag gagaagctgg
      301 agctagcaga gaagaaggca gcggatgctg aagctgaggt ggcctccttg aaccgcagga
      361 tccagctggt tgaagaggag ctggaccgcg cccaggagcg cctcgccact gctttgcaga
      421 agctggagga agcggagaag gctgctgatg agagtgagag aggtatgaag gtgattgaaa
      481 accgggctct aaaagatgaa gaaaagatgg agctccagga aatccagctg aaggaagcaa
      541 agcgcattgc agaagaggca gacaggaagt atgaagaggt ggctcgtaag ttggtgatta
      601 ttgaaggaga cttggaacgc acggaggaac gcgccgagct ggcagagtct aagtgttctg
      661 agctggagga ggagctgaag aatgtcacca acaacctcaa atctcttgag gctcaggcgg
      721 agaagtactc tcaaaaagaa gacaagtatg aagaagaaat aaagattctt actgataaac
      781 tcaaggaggc ggagacccgg gctgagtttg ctgaaagatc ggtagccaaa ctggaaaaga
      841 ccattgatga cttggaagat gagctctatg cccagaaact gaagtacaag gccattagcg
      901 acgggctgga ccacgtcctc aatgacatga cctctatata aactgtcacc gtttctgctc
      961 tgttctggat ctacccccct ttccttgggg aacccaacac cccactcgct ctggattcca
     1021 tttgggtcag cctggctggt tcccacagcc ttaggactga agggcctggg gcggggcaca
     1081 aagcaattta catatttgct ttcaccccca tattaaaatg ttaagctgcc aaaaaaaaaa
     1141 aaaaaaaaa
//
