LOCUS       NP_001288214             285 aa            linear   ROD 09-FEB-2025
DEFINITION  tropomyosin alpha-3 chain isoform Tpm3.12st [Rattus norvegicus].
ACCESSION   NP_001288214 XP_006232636
VERSION     NP_001288214.1
DBSOURCE    REFSEQ: accession NM_001301285.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 285)
  AUTHORS   Tian,H. and Hu,H.
  TITLE     [Effects of tropomyosin 3 on pyroptosis of cardiomyocytes and
            fibroblast activation induced by hypoxia/reoxygenation in rats]
  JOURNAL   Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 35 (1), 93-98 (2023)
   PUBMED   36880246
  REMARK    GeneRIF: [Effects of tropomyosin 3 on pyroptosis of cardiomyocytes
            and fibroblast activation induced by hypoxia/reoxygenation in
            rats].
REFERENCE   2  (residues 1 to 285)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (residues 1 to 285)
  AUTHORS   Xu,F., Zhu,J., Chen,Y., He,K., Guo,J., Bai,S., Zhao,R., Du,J. and
            Shen,B.
  TITLE     Physical interaction of tropomyosin 3 and STIM1 regulates vascular
            smooth muscle contractility and contributes to hypertension
  JOURNAL   Biomed Pharmacother 134, 111126 (2021)
   PUBMED   33341060
  REMARK    GeneRIF: Physical interaction of tropomyosin 3 and STIM1 regulates
            vascular smooth muscle contractility and contributes to
            hypertension.
REFERENCE   4  (residues 1 to 285)
  AUTHORS   Dong,T., Zhang,Z., Zhou,W., Zhou,X., Geng,C., Chang,L.K., Tian,X.
            and Liu,S.
  TITLE     WNT10A/beta-catenin pathway in tumorigenesis of papillary thyroid
            carcinoma
  JOURNAL   Oncol Rep 38 (2), 1287-1294 (2017)
   PUBMED   28677753
REFERENCE   5  (residues 1 to 285)
  AUTHORS   Geeves,M.A., Hitchcock-DeGregori,S.E. and Gunning,P.W.
  TITLE     A systematic nomenclature for mammalian tropomyosin isoforms
  JOURNAL   J Muscle Res Cell Motil 36 (2), 147-153 (2015)
   PUBMED   25369766
  REMARK    Review article
REFERENCE   6  (residues 1 to 285)
  AUTHORS   Robaszkiewicz,K., Dudek,E., Kasprzak,A.A. and Moraczewska,J.
  TITLE     Functional effects of congenital myopathy-related mutations in
            gamma-tropomyosin gene
  JOURNAL   Biochim Biophys Acta 1822 (10), 1562-1569 (2012)
   PUBMED   22749829
  REMARK    GeneRIF: All studied gamma-tropomyosin mutants reduced Ca-induced
            activation but had no effect on the inhibition of actomyosin
            cross-bridges.
REFERENCE   7  (residues 1 to 285)
  AUTHORS   Clayton,L. and Johnson,M.H.
  TITLE     Tropomyosin in preimplantation mouse development: identification,
            expression, and organization during cell division and polarization
  JOURNAL   Exp Cell Res 238 (2), 450-464 (1998)
   PUBMED   9473354
REFERENCE   8  (residues 1 to 285)
  AUTHORS   Temm-Grove,C.J., Guo,W. and Helfman,D.M.
  TITLE     Low molecular weight rat fibroblast tropomyosin 5 (TM-5): cDNA
            cloning, actin-binding, localization, and coiled-coil interactions
  JOURNAL   Cell Motil Cytoskeleton 33 (3), 223-240 (1996)
   PUBMED   8674141
REFERENCE   9  (residues 1 to 285)
  AUTHORS   Laing,N.G., Wilton,S.D., Akkari,P.A., Dorosz,S., Boundy,K.,
            Kneebone,C., Blumbergs,P., White,S., Watkins,H., Love,D.R. et al.
  TITLE     A mutation in the alpha tropomyosin gene TPM3 associated with
            autosomal dominant nemaline myopathy
  JOURNAL   Nat Genet 9 (1), 75-79 (1995)
   PUBMED   7704029
  REMARK    Erratum:[Nat Genet. 1995 Jun;10(2):249. doi: 10.1038/ng0695-249..
            PMID: 7663526]
REFERENCE   10 (residues 1 to 285)
  AUTHORS   Beisel,K.W. and Kennedy,J.E.
  TITLE     Identification of novel alternatively spliced isoforms of the
            tropomyosin-encoding gene, TMnm, in the rat cochlea
  JOURNAL   Gene 143 (2), 251-256 (1994)
   PUBMED   8206382
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from FQ215580.1.
            
            On Aug 24, 2014 this sequence version replaced XP_006232636.1.
            
            Transcript Variant: This variant (Tpm3.12, also known as variant 3)
            encodes the longest isoform (Tpm3.12st, also known as isoform 3).
            The encoded protein is a fast skeletal muscle isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ215580.1, FQ215752.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..285
                     /organism="Rattus norvegicus"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     Protein         1..285
                     /product="tropomyosin alpha-3 chain isoform Tpm3.12st"
                     /note="tropomyosin alpha-3 chain; tropomyosin non-muscle;
                     nonmuscle tropomyosin 5; tropomyosin-5; gamma-tropomyosin;
                     tropomyosin 3, gamma"
                     /calculated_mol_wt=32838
     Region          49..283
                     /region_name="Tropomyosin"
                     /note="pfam00261"
                     /db_xref="CDD:459736"
     CDS             1..285
                     /gene="Tpm3"
                     /gene_synonym="TM30nm; Tpm5"
                     /coded_by="NM_001301285.1:84..941"
                     /note="isoform Tpm3.12st is encoded by transcript variant
                     Tpm3.12"
                     /db_xref="GeneID:117557"
                     /db_xref="RGD:621546"
ORIGIN      
        1 mmeaikkkmq mlkldkenvl draeqaeaeq kqaeerskql edelatmqkk lkgtedeldk
       61 ysealkdaqe klelaekkaa daeaevasln rriqlveeel draqerlata lqkleeaeka
      121 adesergmkv ienralkdee kmelqeiqlk eakriaeead rkyeevarkl viiegdlert
      181 eeraelaesk cseleeelkn vtnnlkslea qaekysqked kyeeeikilt dklkeaetra
      241 efaersvakl ektiddlede lyaqklkyka isdgldhvln dmtsi
//
