LOCUS       NM_001301235            1278 bp    mRNA    linear   ROD 04-APR-2024
DEFINITION  Rattus norvegicus tropomyosin 2 (Tpm2), transcript variant Tpm2.2,
            mRNA.
ACCESSION   NM_001301235 XM_008763679
VERSION     NM_001301235.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1278)
  AUTHORS   Hsu,W.L., Ma,Y.L., Liu,Y.C. and Lee,E.H.Y.
  TITLE     Smad4 SUMOylation is essential for memory formation through
            upregulation of the skeletal myopathy gene TPM2
  JOURNAL   BMC Biol 15 (1), 112 (2017)
   PUBMED   29183317
  REMARK    GeneRIF: This study identified a novel role of Smad4 SUMOylation
            and TPM2 in learning and memory formation. These results suggest
            that patients with skeletal myopathies who carry the TPM2E122K
            mutation may also have deficits in learning and memory functions.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1278)
  AUTHORS   Geeves,M.A., Hitchcock-DeGregori,S.E. and Gunning,P.W.
  TITLE     A systematic nomenclature for mammalian tropomyosin isoforms
  JOURNAL   J Muscle Res Cell Motil 36 (2), 147-153 (2015)
   PUBMED   25369766
  REMARK    Review article
REFERENCE   3  (bases 1 to 1278)
  AUTHORS   Kalyva,A., Schmidtmann,A. and Geeves,M.A.
  TITLE     In vitro formation and characterization of the skeletal muscle
            alpha.beta tropomyosin heterodimers
  JOURNAL   Biochemistry 51 (32), 6388-6399 (2012)
   PUBMED   22812662
REFERENCE   4  (bases 1 to 1278)
  AUTHORS   Robinson,P., Lipscomb,S., Preston,L.C., Altin,E., Watkins,H.,
            Ashley,C.C. and Redwood,C.S.
  TITLE     Mutations in fast skeletal troponin I, troponin T, and
            beta-tropomyosin that cause distal arthrogryposis all increase
            contractile function
  JOURNAL   FASEB J 21 (3), 896-905 (2007)
   PUBMED   17194691
REFERENCE   5  (bases 1 to 1278)
  AUTHORS   Shultz,M.A., Zhang,L., Gu,Y.Z., Baker,G.L., Fannuchi,M.V.,
            Padua,A.M., Gurske,W.A., Morin,D., Penn,S.G., Jovanovich,S.B.,
            Plopper,C.G. and Buckpitt,A.R.
  TITLE     Gene expression analysis in response to lung toxicants: I.
            Sequencing and microarray development
  JOURNAL   Am J Respir Cell Mol Biol 30 (3), 296-310 (2004)
   PUBMED   12947022
REFERENCE   6  (bases 1 to 1278)
  AUTHORS   Gimona,M., Watakabe,A. and Helfman,D.M.
  TITLE     Specificity of dimer formation in tropomyosins: influence of
            alternatively spliced exons on homodimer and heterodimer assembly
  JOURNAL   Proc Natl Acad Sci U S A 92 (21), 9776-9780 (1995)
   PUBMED   7568216
REFERENCE   7  (bases 1 to 1278)
  AUTHORS   Helfman,D.M., Cheley,S., Kuismanen,E., Finn,L.A. and
            Yamawaki-Kataoka,Y.
  TITLE     Nonmuscle and muscle tropomyosin isoforms are expressed from a
            single gene by alternative RNA splicing and polyadenylation
  JOURNAL   Mol Cell Biol 6 (11), 3582-3595 (1986)
   PUBMED   2432392
REFERENCE   8  (bases 1 to 1278)
  AUTHORS   Yamawaki-Kataoka,Y. and Helfman,D.M.
  TITLE     Rat embryonic fibroblast tropomyosin 1. cDNA and complete primary
            amino acid sequence
  JOURNAL   J Biol Chem 260 (27), 14440-14445 (1985)
   PUBMED   3840484
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FQ223760.1, FQ217483.1 and FQ118075.1.
            
            On Aug 24, 2014 this sequence version replaced XM_008763679.1.
            
            Transcript Variant: This variant (Tpm2.2, also known as variant 1)
            represents the longer transcript and encodes isoform Tpm2.2st (also
            known as isoform 1), which has the same protein size as isoform
            Tpm2.1sm/cy.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ223760.1, FQ224893.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                FQ223760.1         1-60
            61-1255             FQ217483.1         1-1195
            1256-1278           FQ118075.1         1-23                c
FEATURES             Location/Qualifiers
     source          1..1278
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..1278
                     /gene="Tpm2"
                     /note="tropomyosin 2"
                     /db_xref="GeneID:500450"
                     /db_xref="RGD:1559479"
     exon            1..286
                     /gene="Tpm2"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..1027
                     /gene="Tpm2"
                     /note="isoform Tpm2.2st is encoded by transcript variant
                     Tpm2.2; tropomyosin beta chain; beta-tropomyosin;
                     tropomyosin 2, beta"
                     /codon_start=1
                     /product="tropomyosin beta chain isoform Tpm2.2st"
                     /protein_id="NP_001288164.1"
                     /db_xref="GeneID:500450"
                     /db_xref="RGD:1559479"
                     /translation="MDAIKKKMQMLKLDKENAIDRAEQAEADKKQAEDRCKQLEEEQQ
                     ALQKKLKGTEDEVEKYSESVKDAQEKLEQAEKKATDAEADVASLNRRIQLVEEELDRA
                     QERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMELQEMQLKEAKHIAEDSDR
                     KYEEVARKLVILEGELERSEERAEVAESKCGDLEEELKIVTNNLKSLEAQADKYSTKE
                     DKYEEEIKLLEEKLKEAETRAEFAERSVAKLEKTIDDLEDEVYAQKMKYKAISEELDN
                     ALNDITSL"
     exon            287..412
                     /gene="Tpm2"
                     /inference="alignment:Splign:2.1.0"
     exon            413..546
                     /gene="Tpm2"
                     /inference="alignment:Splign:2.1.0"
     exon            547..664
                     /gene="Tpm2"
                     /inference="alignment:Splign:2.1.0"
     exon            665..735
                     /gene="Tpm2"
                     /inference="alignment:Splign:2.1.0"
     exon            736..811
                     /gene="Tpm2"
                     /inference="alignment:Splign:2.1.0"
     exon            812..874
                     /gene="Tpm2"
                     /inference="alignment:Splign:2.1.0"
     exon            875..944
                     /gene="Tpm2"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1261
                     /gene="Tpm2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctggtcccc cggctccgcc cggcttctcc ccgcctttta ggcgcccgcg ctgctgggac
       61 atcacagtcc ctcttgatcc tcctaacctg tcccgggtgc atcagtgctc tcggctagcc
      121 cggtctacct actcttcacc gctcgcccgc cggcccactc cccaccgcag ccatggacgc
      181 catcaagaag aagatgcaga tgctgaaact ggacaaggag aatgccatcg accgcgcaga
      241 gcaggccgaa gccgacaaga agcaagctga agaccgatgc aagcagctgg aggaagagca
      301 gcaggccctc cagaagaaac tgaaggggac agaggatgag gtggaaaagt attccgagtc
      361 tgtgaaggat gcccaggaga aactggagca ggccgagaag aaggccaccg atgctgaagc
      421 agatgtggct tctctgaatc gacgcattca gctcgtagag gaggagttgg atcgggcaca
      481 ggagcgcctg gctacagcct tgcaaaagct ggaggaggct gagaaagccg ctgatgagag
      541 cgagagagga atgaaggtca ttgagaaccg ggccatgaag gatgaggaga agatggagct
      601 gcaggagatg cagctgaaag aagccaagca catcgctgag gactcagacc gcaaatacga
      661 ggaggtggcc aggaagctgg tgatcctgga aggagagctg gagcgctctg aagagagagc
      721 cgaggtggct gagagtaaat gtggggacct agaggaggag ctgaaaattg ttaccaacaa
      781 cttgaaatct ctggaagccc aagcggacaa gtattccacc aaagaggaca aatacgaaga
      841 agagatcaaa cttctggagg agaagctgaa ggaggctgag acccgagcag agtttgctga
      901 aagatctgtg gcaaagttgg agaaaaccat cgatgacctg gaagatgaag tctatgcaca
      961 gaagatgaag tacaaggcca tcagcgagga gctggacaac gcgctcaatg acatcacttc
     1021 cctctgagtt cccactgtgg ccatcgcagg cccctttctt ctttttccat tctctctgag
     1081 gggagggggc agccaggagg agcacaaact ggccatgttg cacagccagt ctgagggcag
     1141 cctgaggaac acgcctgcca cccctgccac ccactctggc actggctttc tcctgtcatc
     1201 tatccaccgt ccactgactt ccacccctcc tctacttaat aaactctgaa cttggtctcc
     1261 aaaaaaaaaa aaaaaaaa
//
