LOCUS       NM_001301336            1235 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus tropomyosin 1 (Tpm1), transcript variant Tpm1.1,
            mRNA.
ACCESSION   NM_001301336 XM_006243387
VERSION     NM_001301336.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1235)
  AUTHORS   Ji,M., Su,L., Liu,L., Zhuang,M., Xiao,J., Guan,Y., Zhu,S., Ma,L.
            and Pu,H.
  TITLE     CaMKII regulates the proteins TPM1 and MYOM2 and promotes
            diacetylmorphine-induced abnormal cardiac rhythms
  JOURNAL   Sci Rep 13 (1), 5827 (2023)
   PUBMED   37037889
  REMARK    GeneRIF: CaMKII regulates the proteins TPM1 and MYOM2 and promotes
            diacetylmorphine-induced abnormal cardiac rhythms.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1235)
  AUTHORS   Ly,T., Pappas,C.T., Johnson,D., Schlecht,W., Colpan,M.,
            Galkin,V.E., Gregorio,C.C., Dong,W.J. and Kostyukova,A.S.
  TITLE     Effects of cardiomyopathy-linked mutations K15N and R21H in
            tropomyosin on thin-filament regulation and pointed-end dynamics
  JOURNAL   Mol Biol Cell 30 (2), 268-281 (2019)
   PUBMED   30462572
  REMARK    GeneRIF: the R21H mutation causes a twofold decrease in
            tropomyosin's affinity for F-actin and affects leiomodin's
            function.
REFERENCE   3  (bases 1 to 1235)
  AUTHORS   Chen,C.C., Hsia,C.W., Ho,C.W., Liang,C.M., Chen,C.M., Huang,K.L.,
            Kang,B.H. and Chen,Y.H.
  TITLE     Hypoxia and hyperoxia differentially control proliferation of rat
            neural crest stem cells via distinct regulatory pathways of the
            HIF1alpha-CXCR4 and TP53-TPM1 proteins
  JOURNAL   Dev Dyn 246 (3), 162-185 (2017)
   PUBMED   28002632
  REMARK    GeneRIF: Hypoxia and hyperoxia differentially control proliferation
            of rat neural crest stem cells via distinct regulatory pathways of
            the HIF1alpha-CXCR4 and TP53-TPM1 proteins
REFERENCE   4  (bases 1 to 1235)
  AUTHORS   Geeves,M.A., Hitchcock-DeGregori,S.E. and Gunning,P.W.
  TITLE     A systematic nomenclature for mammalian tropomyosin isoforms
  JOURNAL   J Muscle Res Cell Motil 36 (2), 147-153 (2015)
   PUBMED   25369766
  REMARK    Review article
REFERENCE   5  (bases 1 to 1235)
  AUTHORS   Kirwan,J.P. and Hodges,R.S.
  TITLE     Transmission of stability information through the N-domain of
            tropomyosin is interrupted by a stabilizing mutation (A109L) in the
            hydrophobic core of the stability control region (residues 97-118)
  JOURNAL   J Biol Chem 289 (7), 4356-4366 (2014)
   PUBMED   24362038
  REMARK    GeneRIF: Transmission of stability information through the N-domain
            of tropomyosin is interrupted by a stabilizing mutation (A109L) in
            the hydrophobic core of the stability control region (residues
            97-118).
REFERENCE   6  (bases 1 to 1235)
  AUTHORS   Yar,S., Chowdhury,S.A.K., Davis,R.T. 3rd, Kobayashi,M.,
            Monasky,M.M., Rajan,S., Wolska,B.M., Gaponenko,V., Kobayashi,T.,
            Wieczorek,D.F. and Solaro,R.J.
  TITLE     Conserved Asp-137 is important for both structure and regulatory
            functions of cardiac alpha-tropomyosin (alpha-TM) in a novel
            transgenic mouse model expressing alpha-TM-D137L
  JOURNAL   J Biol Chem 288 (23), 16235-16246 (2013)
   PUBMED   23609439
  REMARK    GeneRIF: the link between flexibility of TM and its function in
            ejecting hearts.
REFERENCE   7  (bases 1 to 1235)
  AUTHORS   Goodwin,L.O., Lees-Miller,J.P., Leonard,M.A., Cheley,S.B. and
            Helfman,D.M.
  TITLE     Four fibroblast tropomyosin isoforms are expressed from the rat
            alpha-tropomyosin gene via alternative RNA splicing and the use of
            two promoters
  JOURNAL   J Biol Chem 266 (13), 8408-8415 (1991)
   PUBMED   2022655
REFERENCE   8  (bases 1 to 1235)
  AUTHORS   Lees-Miller,J.P., Goodwin,L.O. and Helfman,D.M.
  TITLE     Three novel brain tropomyosin isoforms are expressed from the rat
            alpha-tropomyosin gene through the use of alternative promoters and
            alternative RNA processing
  JOURNAL   Mol Cell Biol 10 (4), 1729-1742 (1990)
   PUBMED   2320008
REFERENCE   9  (bases 1 to 1235)
  AUTHORS   Wieczorek,D.F., Smith,C.W. and Nadal-Ginard,B.
  TITLE     The rat alpha-tropomyosin gene generates a minimum of six different
            mRNAs coding for striated, smooth, and nonmuscle isoforms by
            alternative splicing
  JOURNAL   Mol Cell Biol 8 (2), 679-694 (1988)
   PUBMED   3352602
REFERENCE   10 (bases 1 to 1235)
  AUTHORS   Ruiz-Opazo,N. and Nadal-Ginard,B.
  TITLE     Alpha-tropomyosin gene organization. Alternative splicing of
            duplicated isotype-specific exons accounts for the production of
            smooth and striated muscle isoforms
  JOURNAL   J Biol Chem 262 (10), 4755-4765 (1987)
   PUBMED   3558368
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from JAXUCZ010000008.1.
            
            On Sep 4, 2014 this sequence version replaced XM_006243387.2.
            
            SUMMARY: This gene is a member of the tropomyosin family and
            encodes a protein that heterodimerizes with a beta subunit, binding
            actin in both muscle and nonmuscle cells. In both smooth and
            striated muscle cells, it plays a role in calcium
            dependent-regulation of muscle contraction. In nonmuscle cells, it
            stabilizes cytoskeleton actin filaments. Alternate transcriptional
            splice variants, encoding different isoforms, have been
            characterized. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (Tpm1.1st, also known as variant
            10) contains a alternate 3' exon compared to variant 1. The
            resulting protein (isoform Tpm1.1st) is shorter and has a distinct
            C-terminus compared to isoform a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ216683.1, FQ214868.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-220               JAXUCZ010000008.1  76543196-76543415   c
            221-346             JAXUCZ010000008.1  76541958-76542083   c
            347-480             JAXUCZ010000008.1  76530181-76530314   c
            481-598             JAXUCZ010000008.1  76528138-76528255   c
            599-669             JAXUCZ010000008.1  76526996-76527066   c
            670-745             JAXUCZ010000008.1  76526169-76526244   c
            746-808             JAXUCZ010000008.1  76525672-76525734   c
            809-878             JAXUCZ010000008.1  76525347-76525416   c
            879-957             JAXUCZ010000008.1  76523954-76524032   c
            958-1235            JAXUCZ010000008.1  76522193-76522470   c
FEATURES             Location/Qualifiers
     source          1..1235
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..1235
                     /gene="Tpm1"
                     /gene_synonym="Alpha-tm; Tma2; Tmsa"
                     /note="tropomyosin 1"
                     /db_xref="GeneID:24851"
                     /db_xref="RGD:3898"
     exon            1..220
                     /gene="Tpm1"
                     /gene_synonym="Alpha-tm; Tma2; Tmsa"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..961
                     /gene="Tpm1"
                     /gene_synonym="Alpha-tm; Tma2; Tmsa"
                     /note="isoform Tpm1.1st is encoded by transcript variant
                     Tpm1.1; smooth muscle alpha-tropomyosin; striated muscle
                     alpha-tropomyosin; hepatoma alpha tropomyosin; tropomyosin
                     1, alpha; tropomyosin 3 alpha; tropomyosin-alpha"
                     /codon_start=1
                     /product="tropomyosin alpha-1 chain isoform Tpm1.1st"
                     /protein_id="NP_001288265.1"
                     /db_xref="GeneID:24851"
                     /db_xref="RGD:3898"
                     /translation="MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELV
                     SLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRA
                     QERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADR
                     KYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKE
                     DKYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDH
                     ALNDMTSI"
     exon            221..346
                     /gene="Tpm1"
                     /gene_synonym="Alpha-tm; Tma2; Tmsa"
                     /inference="alignment:Splign:2.1.0"
     exon            347..480
                     /gene="Tpm1"
                     /gene_synonym="Alpha-tm; Tma2; Tmsa"
                     /inference="alignment:Splign:2.1.0"
     exon            481..598
                     /gene="Tpm1"
                     /gene_synonym="Alpha-tm; Tma2; Tmsa"
                     /inference="alignment:Splign:2.1.0"
     exon            599..669
                     /gene="Tpm1"
                     /gene_synonym="Alpha-tm; Tma2; Tmsa"
                     /inference="alignment:Splign:2.1.0"
     exon            670..745
                     /gene="Tpm1"
                     /gene_synonym="Alpha-tm; Tma2; Tmsa"
                     /inference="alignment:Splign:2.1.0"
     exon            746..808
                     /gene="Tpm1"
                     /gene_synonym="Alpha-tm; Tma2; Tmsa"
                     /inference="alignment:Splign:2.1.0"
     exon            809..878
                     /gene="Tpm1"
                     /gene_synonym="Alpha-tm; Tma2; Tmsa"
                     /inference="alignment:Splign:2.1.0"
     exon            879..957
                     /gene="Tpm1"
                     /gene_synonym="Alpha-tm; Tma2; Tmsa"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1235
                     /gene="Tpm1"
                     /gene_synonym="Alpha-tm; Tma2; Tmsa"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcagggagc agcaggcagc tccgcgctcg cactccggct ctgccaccct accgcgctcg
       61 cgtctcctct ggctcctctg cctaagggcc cctcgccacc gccaccatgg acgccatcaa
      121 gaagaagatg cagatgctga agctcgacaa agagaacgcc ttggatcgag cagagcaggc
      181 ggaggctgac aagaaggctg cggaagaccg gagcaagcag ctggaagatg agctggtgtc
      241 actgcaaaag aaactcaagg gcactgaaga tgaactggac aaatactccg aggctctcaa
      301 agatgcccag gagaaactgg agctggcgga gaaaaaggcc acagatgctg aagctgacgt
      361 agcatctctg aacagacgca tccagctggt tgaggaggag ttggatcgcg ctcaggagcg
      421 tctggccaca gctctacaga agctggagga ggctgagaag gctgcagatg agagtgagag
      481 aggcatgaaa gtcattgaaa gccgagccca aaaagatgaa gaaaagatgg agattcagga
      541 gatccagctg aaagaggcca agcacattgc tgaagatgct gaccgaaagt atgaagaggt
      601 ggcccgtaag ctggtcatca tcgagagcga tctggagcgt gcggaggaga gggctgagct
      661 ctcggaaggc aaatgtgccg agcttgaaga agagttgaaa acggtgacga acaacttgaa
      721 gtcactggag gctcaggctg agaagtactc tcagaaagaa gacaagtatg aagaggagat
      781 caaggttctc tctgacaagc tgaaggaggc tgagacccgg gctgagtttg cagagagatc
      841 agtaaccaaa ttggagaaaa gcattgatga cttagaagac gagctgtatg ctcagaaact
      901 gaagtacaag gccatcagcg aggagctgga ccacgctctc aacgatatga cttccatata
      961 agtttctttg cttctctcct cccaagactc cttcatcaag ccggatgtcc cacctctctg
     1021 agctctgcat ctgtctgctc tccagctgac ccaggtttct ttctagtgcc cacccaccct
     1081 agggccaggc acagaccgtg ctttctattg tacagaggtg atcctcccag tgtaaaataa
     1141 acactgtacg ctagtcctgt ttgctattcc tctgctcctt atttattgac atttttgtct
     1201 cagcgctcaa taaaactaca gttctgcttt gtgca
//
