LOCUS       NP_001128466             243 aa            linear   ROD 26-FEB-2024
DEFINITION  thiamin pyrophosphokinase 1 [Rattus norvegicus].
ACCESSION   NP_001128466 XP_001058258 XP_001073146
VERSION     NP_001128466.1
DBSOURCE    REFSEQ: accession NM_001134994.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 243)
  AUTHORS   Fragoza R, Das J, Wierbowski SD, Liang J, Tran TN, Liang S, Beltran
            JF, Rivera-Erick CA, Ye K, Wang TY, Yao L, Mort M, Stenson PD,
            Cooper DN, Wei X, Keinan A, Schimenti JC, Clark AG and Yu H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 243)
  AUTHORS   Chen S, Fragoza R, Klei L, Liu Y, Wang J, Roeder K, Devlin B and Yu
            H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   3  (residues 1 to 243)
  AUTHORS   Wei X, Das J, Fragoza R, Liang J, Bastos de Oliveira FM, Lee HR,
            Wang X, Mort M, Stenson PD, Cooper DN, Lipkin SM, Smolka MB and Yu
            H.
  TITLE     A massively parallel pipeline to clone DNA variants and examine
            molecular phenotypes of human disease mutations
  JOURNAL   PLoS Genet 10 (12), e1004819 (2014)
   PUBMED   25502805
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 243)
  AUTHORS   Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M,
            Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail
            S, Li P and Sutton G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   5  (residues 1 to 243)
  AUTHORS   Nosaka K, Onozuka M, Nishino H, Nishimura H, Kawasaki Y and Ueyama
            H.
  TITLE     Molecular cloning and expression of a mouse thiamin
            pyrophosphokinase cDNA
  JOURNAL   J Biol Chem 274 (48), 34129-34133 (1999)
   PUBMED   10567383
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473959.1.
            
            On or before Sep 17, 2008 this sequence version replaced
            XP_001073146.1, XP_001058258.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132262, SAMD00132265
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..243
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     Protein         1..243
                     /product="thiamin pyrophosphokinase 1"
                     /EC_number="2.7.6.2"
                     /note="thiamine pyrophosphokinase"
                     /calculated_mol_wt=27076
     Region          21..241
                     /region_name="PLN02714"
                     /note="thiamin pyrophosphokinase"
                     /db_xref="CDD:178316"
     CDS             1..243
                     /gene="Tpk1"
                     /coded_by="NM_001134994.1:161..892"
                     /db_xref="GeneID:680668"
                     /db_xref="RGD:1589408"
ORIGIN      
        1 mehvftplep llptgdlkfc lvvlnqtldp hfrhlwrkal lracadggan hlydlteger
       61 esflpefing dfdsirpevk eyytkkgcdl istpdqdhtd ftkclqvlqr kieekelqvd
      121 vivtlgglgg rfdqimasvn tlfqatdiip vpiiiiqkes liyllqpgkh rlrvdtgmeg
      181 swcglipvgq pcnhvtttgl kwnltndvlg fgtlvstsnt ydgsglvtve tdhpllwtma
      241 ikt
//
