LOCUS       NM_022922               1471 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus triosephosphate isomerase 1 (Tpi1), mRNA.
ACCESSION   NM_022922
VERSION     NM_022922.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1471)
  AUTHORS   Lei,M., Tao,M.Q., Wu,Y.J., Xu,L., Yang,Z., Li,Y., Olatunji,O.J.,
            Wang,X.W. and Zuo,J.
  TITLE     Metabolic Enzyme Triosephosphate Isomerase 1 and Nicotinamide
            Phosphoribosyltransferase, Two Independent Inflammatory Indicators
            in Rheumatoid Arthritis: Evidences From Collagen-Induced Arthritis
            and Clinical Samples
  JOURNAL   Front Immunol 12, 795626 (2022)
   PUBMED   35111160
  REMARK    GeneRIF: Metabolic Enzyme Triosephosphate Isomerase 1 and
            Nicotinamide Phosphoribosyltransferase, Two Independent
            Inflammatory Indicators in Rheumatoid Arthritis: Evidences From
            Collagen-Induced Arthritis and Clinical Samples.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1471)
  AUTHORS   Pieragostino,D., Agnifili,L., Fasanella,V., D'Aguanno,S.,
            Mastropasqua,R., Di Ilio,C., Sacchetta,P., Urbani,A. and Del
            Boccio,P.
  TITLE     Shotgun proteomics reveals specific modulated protein patterns in
            tears of patients with primary open angle glaucoma naive to therapy
  JOURNAL   Mol Biosyst 9 (6), 1108-1116 (2013)
   PUBMED   23580065
REFERENCE   3  (bases 1 to 1471)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   4  (bases 1 to 1471)
  AUTHORS   Martins-de-Souza,D., Alsaif,M., Ernst,A., Harris,L.W., Aerts,N.,
            Lenaerts,I., Peeters,P.J., Amess,B., Rahmoune,H., Bahn,S. and
            Guest,P.C.
  TITLE     The application of selective reaction monitoring confirms
            dysregulation of glycolysis in a preclinical model of schizophrenia
  JOURNAL   BMC Res Notes 5, 146 (2012)
   PUBMED   22420779
  REMARK    GeneRIF: Data show statistically significant altered levels of Tpi1
            and alteration of Hk1, Aldoc, Pgam1 and Gapdh with borderline
            significance in phencyclidine (PCP) rats compared to controls.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1471)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   6  (bases 1 to 1471)
  AUTHORS   Brand,I.A. and Heinickel,A.
  TITLE     Key enzymes of carbohydrate metabolism as targets of the 11.5-kDa
            Zn(2+)-binding protein (parathymosin)
  JOURNAL   J Biol Chem 266 (31), 20984-20989 (1991)
   PUBMED   1834654
REFERENCE   7  (bases 1 to 1471)
  AUTHORS   Merkle,S. and Pretsch,W.
  TITLE     Characterization of triosephosphate isomerase mutants with reduced
            enzyme activity in Mus musculus
  JOURNAL   Genetics 123 (4), 837-844 (1989)
   PUBMED   2693209
REFERENCE   8  (bases 1 to 1471)
  AUTHORS   Minna,J.D., Bruns,G.A., Krinsky,A.H., Lalley,P.A., Francke,U. and
            Gerald,P.S.
  TITLE     Assignment of a Mus musculus gene for triosephosphate isomerase to
            chromosome 6 and for glyoxalase-I to chromosome 17 using somatic
            cell hybrids
  JOURNAL   Somatic Cell Genet 4 (2), 241-252 (1978)
   PUBMED   566476
REFERENCE   9  (bases 1 to 1471)
  AUTHORS   Leinwand,L.A., Kozak,C.A. and Ruddle,F.H.
  TITLE     Assignment of the genes for triose phosphate isomerase to
            chromosome 6 and tripeptidase-1 to chromosome 10 in Mus musculus by
            somatic cell hybridization
  JOURNAL   Somatic Cell Genet 4 (2), 233-240 (1978)
   PUBMED   566475
REFERENCE   10 (bases 1 to 1471)
  AUTHORS   Kozak,C.A. and Ruddle,F.H.
  TITLE     Assignment of the genes for thymidine kinase and galactokinase to
            Mus musculus chromosome 11 and the preferential segregation of this
            chromosome in Chinese hamster/mouse somatic cell hybrids
  JOURNAL   Somatic Cell Genet 3 (2), 121-133 (1977)
   PUBMED   204065
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC126087.1.
            
            On Nov 13, 2006 this sequence version replaced NM_022922.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK356973.1, FQ212675.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1471
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1471
                     /gene="Tpi1"
                     /gene_synonym="Tpi"
                     /note="triosephosphate isomerase 1"
                     /db_xref="GeneID:24849"
                     /db_xref="RGD:3896"
     exon            1..139
                     /gene="Tpi1"
                     /gene_synonym="Tpi"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..774
                     /gene="Tpi1"
                     /gene_synonym="Tpi"
                     /EC_number="5.3.1.1"
                     /EC_number="4.2.3.3"
                     /note="TIM; triose-phosphate isomerase; methylglyoxal
                     synthase; triosephosphate isomerase-like"
                     /codon_start=1
                     /product="triosephosphate isomerase"
                     /protein_id="NP_075211.2"
                     /db_xref="GeneID:24849"
                     /db_xref="RGD:3896"
                     /translation="MAPSRKFFVGGNWKMNGRKKCLGELICTLNAAKLPADTEVVCAP
                     PTAYIDFARQKLDPKIAVAAQNCYKVTNGAFTGEISPGMIKDLGATWVVLGHSERRHI
                     FGESDELIGQKVNHALSEGLGVIACIGEKLDEREAGITEKVVFEQTKAIADNVKDWCK
                     VVLAYEPVWAIGTGKTATPQQAQEVHEKLRGWLKCNVSEGVAQCTRIIYGGSVTGATC
                     KELASQPDVDGFLVGGASLKPEFVDIINAKQ"
     exon            140..263
                     /gene="Tpi1"
                     /gene_synonym="Tpi"
                     /inference="alignment:Splign:2.1.0"
     exon            264..348
                     /gene="Tpi1"
                     /gene_synonym="Tpi"
                     /inference="alignment:Splign:2.1.0"
     exon            349..481
                     /gene="Tpi1"
                     /gene_synonym="Tpi"
                     /inference="alignment:Splign:2.1.0"
     exon            482..567
                     /gene="Tpi1"
                     /gene_synonym="Tpi"
                     /inference="alignment:Splign:2.1.0"
     exon            568..655
                     /gene="Tpi1"
                     /gene_synonym="Tpi"
                     /inference="alignment:Splign:2.1.0"
     exon            656..1448
                     /gene="Tpi1"
                     /gene_synonym="Tpi"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttcagagag ttgatccttg tgcaatggcg ccttccagga agttcttcgt cgggggcaac
       61 tggaagatga acgggaggaa gaaatgcctg ggagaactca tctgcactct gaacgcagcc
      121 aagctgccgg cagacaccga ggtggtttgt gcaccgccaa ccgcctacat cgactttgcc
      181 aggcagaagc tggatcccaa aattgctgtg gctgcacaga actgctacaa agtgaccaat
      241 ggggccttca ctggggaaat cagtcctggc atgatcaagg acttaggagc tacctgggtg
      301 gtgctgggac actctgaaag aagacacatc tttggggaat cagacgagtt gattgggcag
      361 aaagtgaacc atgccctatc cgagggactc ggagtgatcg cctgcattgg ggagaagtta
      421 gacgaaaggg aagctggcat cactgagaag gttgtttttg agcaaaccaa ggccatcgca
      481 gataatgtga aggactggtg caaggtggtc ctggcctatg aaccagtatg ggccattggg
      541 actggcaaga ctgcaacccc tcaacaggcc caggaagtac acgagaagct ccggggatgg
      601 ctgaaatgca acgtctctga gggggtggct cagtgcactc ggatcattta tggaggttct
      661 gtgactggag cgacttgcaa agagctggca agccagcctg atgtggatgg cttcctcgtg
      721 ggcggtgcat ctctcaagcc tgaattcgtg gacattatca atgccaaaca atgagcactg
      781 ctcatccccc taccttcctg cgtagcctgg accaggttgc ccagaagttt agtaactgct
      841 cctgccagtc acatgcttct gataacatca tcaactccat cttgtgacct aatccatact
      901 gtaccttcct gagcctctta cctccccata atagttggga ccaggccaat ccctttacca
      961 cttacaatgg gtaaaatcaa atatgtcacc aagatggctt cctgaggagg ggaaggagta
     1021 gaactagctg tccctttggg ccctaatggg tgaaaacggc cttccattgg tttgggatgg
     1081 aaactcacag ctggaccaca ggaagtaggc ttcttgtcac tttggcctgt cacttagatg
     1141 gccttggctc tagcttcact cccaagccct actggatgtg tgatgcagag attcagagtc
     1201 ttcgggtctg aatttcagtg tacattaagg ccaagatcct tttactctta gaggcctggg
     1261 atatcccctc cctgtagtgc cgaagccctt gtattgtgtt tgtgaaccat cctacatata
     1321 agggaaataa acacctgggc ctaaacatgg tttgtcataa ttttaagaca gtgagggggc
     1381 tctagcctcg aggggggggg gcaagtggaa tgtaaaaaga accaataatg aaacacgttc
     1441 tgtgacaaaa aaaaaaaaaa aaaaaaaaaa a
//
