LOCUS       NM_173839               2580 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus tryptophan hydroxylase 2 (Tph2), mRNA.
ACCESSION   NM_173839
VERSION     NM_173839.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2580)
  AUTHORS   Alonso,L., Peeva,P., Fernandez-Del Valle Alquicira,T., Erdelyi,N.,
            Gil Nolskog,A., Bader,M., Winter,Y., Alenina,N. and Rivalan,M.
  TITLE     Poor Decision Making and Sociability Impairment Following Central
            Serotonin Reduction in Inducible TPH2-Knockdown Rats
  JOURNAL   Int J Mol Sci 25 (9), 5003 (2024)
   PUBMED   38732220
  REMARK    GeneRIF: Poor Decision Making and Sociability Impairment Following
            Central Serotonin Reduction in Inducible TPH2-Knockdown Rats.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2580)
  AUTHORS   Haduch,A., Bromek,E., Kuban,W., Basinska-Ziobron,A., Danek,P.J.,
            Alenina,N., Bader,M. and Daniel,W.A.
  TITLE     The effect of brain serotonin deficit (TPH2-KO) on the expression
            and activity of liver cytochrome P450 enzymes in aging male Dark
            Agouti rats
  JOURNAL   Pharmacol Rep 75 (6), 1522-1532 (2023)
   PUBMED   37848703
  REMARK    GeneRIF: The effect of brain serotonin deficit (TPH2-KO) on the
            expression and activity of liver cytochrome P450 enzymes in aging
            male Dark Agouti rats.
REFERENCE   3  (bases 1 to 2580)
  AUTHORS   Wang,Y., Huang,Y., Zhao,M., Yang,L., Su,K., Wu,H., Wang,Y.,
            Chang,Q. and Liu,W.
  TITLE     Zuojin pill improves chronic unpredictable stress-induced
            depression-like behavior and gastrointestinal dysfunction in mice
            via the theTPH2/5-HT pathway
  JOURNAL   Phytomedicine 120, 155067 (2023)
   PUBMED   37716030
REFERENCE   4  (bases 1 to 2580)
  AUTHORS   Cheng,S., Zhu,Z., Li,H., Wang,W., Jiang,Z., Pan,F., Liu,D.,
            Ho,R.C.M. and Ho,C.S.H.
  TITLE     Rifaximin ameliorates depression-like behaviour in chronic
            unpredictable mild stress rats by regulating intestinal microbiota
            and hippocampal tryptophan metabolism
  JOURNAL   J Affect Disord 329, 30-41 (2023)
   PUBMED   36842645
REFERENCE   5  (bases 1 to 2580)
  AUTHORS   Liu,Y., Shan,L., Liu,T., Li,J., Chen,Y., Sun,C., Yang,C., Bian,X.,
            Niu,Y., Zhang,C., Xi,J. and Rao,Y.
  TITLE     Molecular and cellular mechanisms of the first social relationship:
            A conserved role of 5-HT from mice to monkeys, upstream of oxytocin
  JOURNAL   Neuron 111 (9), 1468-1485 (2023)
   PUBMED   36868221
  REMARK    GeneRIF: Molecular and cellular mechanisms of the first social
            relationship: A conserved role of 5-HT from mice to monkeys,
            upstream of oxytocin.
REFERENCE   6  (bases 1 to 2580)
  AUTHORS   Malek,Z.S., Dardente,H., Pevet,P. and Raison,S.
  TITLE     Tissue-specific expression of tryptophan hydroxylase mRNAs in the
            rat midbrain: anatomical evidence and daily profiles
  JOURNAL   Eur J Neurosci 22 (4), 895-901 (2005)
   PUBMED   16115212
  REMARK    GeneRIF: The circadian 5-HT synthesis within the serotonergic
            neurons projecting to the circadian system might be explained by
            the rhythmic transcription of the tph2 gene in raphe nuclei.
REFERENCE   7  (bases 1 to 2580)
  AUTHORS   Coon,H., Dunn,D., Lainhart,J., Miller,J., Hamil,C., Battaglia,A.,
            Tancredi,R., Leppert,M.F., Weiss,R. and McMahon,W.
  TITLE     Possible association between autism and variants in the
            brain-expressed tryptophan hydroxylase gene (TPH2)
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 135B (1), 42-46 (2005)
   PUBMED   15768392
REFERENCE   8  (bases 1 to 2580)
  AUTHORS   Liang,J., Wessel,J.H. 3rd, Iuvone,P.M., Tosini,G. and Fukuhara,C.
  TITLE     Diurnal rhythms of tryptophan hydroxylase 1 and 2 mRNA expression
            in the rat retina
  JOURNAL   Neuroreport 15 (9), 1497-1500 (2004)
   PUBMED   15194882
  REMARK    GeneRIF: Tph1 and Tph2 transcripts showed robust diurnal rhythms of
            abundance, with highest levels at night.
REFERENCE   9  (bases 1 to 2580)
  AUTHORS   Sugden,D.
  TITLE     Comparison of circadian expression of tryptophan hydroxylase
            isoform mRNAs in the rat pineal gland using real-time PCR
  JOURNAL   J Neurochem 86 (5), 1308-1311 (2003)
   PUBMED   12911638
  REMARK    GeneRIF: TPH1 mRNA expression was 105-fold more abundant in rat
            pineal than TPH2; TPH2 expression within the gland showed no
            significant variation with time of day and was very low.
REFERENCE   10 (bases 1 to 2580)
  AUTHORS   Walther,D.J., Peter,J.U., Bashammakh,S., Hortnagl,H., Voits,M.,
            Fink,H. and Bader,M.
  TITLE     Synthesis of serotonin by a second tryptophan hydroxylase isoform
  JOURNAL   Science 299 (5603), 76 (2003)
   PUBMED   12511643
  REMARK    GeneRIF: a second tryptophan hydroxylase isoform detected in the
            brain
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 27, 2020 this sequence version replaced NM_173839.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY098915.1, SRR26643298.39021.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-222               JAXUCZ010000007.1  52675418-52675639   c
            223-357             JAXUCZ010000007.1  52673461-52673595   c
            358-541             JAXUCZ010000007.1  52670695-52670878   c
            542-642             JAXUCZ010000007.1  52670493-52670593   c
            643-710             JAXUCZ010000007.1  52665964-52666031   c
            711-907             JAXUCZ010000007.1  52644046-52644242   c
            908-1043            JAXUCZ010000007.1  52639208-52639343   c
            1044-1170           JAXUCZ010000007.1  52613519-52613645   c
            1171-1266           JAXUCZ010000007.1  52585891-52585986   c
            1267-1400           JAXUCZ010000007.1  52573216-52573349   c
            1401-2580           JAXUCZ010000007.1  52571911-52573090   c
FEATURES             Location/Qualifiers
     source          1..2580
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..2580
                     /gene="Tph2"
                     /gene_synonym="Ntph"
                     /note="tryptophan hydroxylase 2"
                     /db_xref="GeneID:317675"
                     /db_xref="RGD:631332"
     exon            1..222
                     /gene="Tph2"
                     /gene_synonym="Ntph"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..1575
                     /gene="Tph2"
                     /gene_synonym="Ntph"
                     /EC_number="1.14.16.4"
                     /note="tryptophan 5-monooxygenase 2; neuronal tryptophan
                     hydroxylase"
                     /codon_start=1
                     /product="tryptophan 5-hydroxylase 2"
                     /protein_id="NP_776211.1"
                     /db_xref="GeneID:317675"
                     /db_xref="RGD:631332"
                     /translation="MQPAMMMFSSKYWARRGLSLDSAVPEEHQILGGLTQNKATASKS
                     EDKRSGKDTSESSKTAVVFSLKNEVGGLVRALRLFQEKHVNMLHIESRRSRRRSSEVE
                     IFVDCECGKTEFNELIQLLKFQTTIVTLNPPDNIWTEEEELEDVPWFPRKISELDRCS
                     HRVLMYGTELDADHPGFKDNVYRQRRKYFVDVAMGYKYGQPIPRVEYTEEETKTWGVV
                     FRELSKLYPTHACREYLKNFPLLTKYCGYREDNVPQLEDVSMFLKERSGFTVRPVAGY
                     LSPRDFLAGLAYRVFHCTQYVRHGSDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEI
                     GLASLGASDEDVQKLATCYFFTIEFGLCKQEGQLRAYGAGLLSSIGELKHALSDKACV
                     KAFDPKTTCLQECLITTFQDAYFVSESFEEAKEKMRDFAKSITRPFSVYFNPYTQSIE
                     ILKDTRSIENVVQDLRSDLNTVCDALNKMNQYLGI"
     exon            223..357
                     /gene="Tph2"
                     /gene_synonym="Ntph"
                     /inference="alignment:Splign:2.1.0"
     exon            358..541
                     /gene="Tph2"
                     /gene_synonym="Ntph"
                     /inference="alignment:Splign:2.1.0"
     exon            542..642
                     /gene="Tph2"
                     /gene_synonym="Ntph"
                     /inference="alignment:Splign:2.1.0"
     exon            643..710
                     /gene="Tph2"
                     /gene_synonym="Ntph"
                     /inference="alignment:Splign:2.1.0"
     exon            711..907
                     /gene="Tph2"
                     /gene_synonym="Ntph"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1043
                     /gene="Tph2"
                     /gene_synonym="Ntph"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1170
                     /gene="Tph2"
                     /gene_synonym="Ntph"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1266
                     /gene="Tph2"
                     /gene_synonym="Ntph"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1400
                     /gene="Tph2"
                     /gene_synonym="Ntph"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..2580
                     /gene="Tph2"
                     /gene_synonym="Ntph"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagggttctg gacagcgcct cgagcagcca gctgccgctc accttcctcc tacatctctg
       61 ccaaggctgc ccctctggtc ccccctgctg ctgagaaaga aaattacatc gggatccatg
      121 cagcccgcaa tgatgatgtt ttccagtaaa tactgggcca ggagagggtt gtccttggat
      181 tcagcggtgc cagaagagca tcagatactt ggcggcttaa cacaaaataa ggctaccgct
      241 agcaaaagcg aggacaagag aagcggcaaa gacacttcgg agagcagcaa gactgcggtt
      301 gtgttctccc tgaagaatga agttggcggg ctggtgagag cactgagact cttccaggaa
      361 aaacacgtca acatgctcca tattgaatcc aggaggtccc ggcgaagaag ttctgaagtc
      421 gaaatcttcg tggactgtga atgtggcaaa acagaattca acgagctcat tcagttgctc
      481 aagtttcaga ccaccattgt gacgctgaat ccacctgaca acatttggac ggaggaagaa
      541 gaactagagg atgtgccgtg gttccctcgg aagatctctg agttagacag atgctctcac
      601 agagtcctca tgtacggcac cgagcttgac gccgaccacc caggattcaa ggacaacgtc
      661 tatcgacaga ggaggaagta ttttgtggat gtggccatgg gttataaata tggccagccc
      721 attcccaggg tggaatacac agaagaagag actaaaactt ggggtgttgt gtttcgggag
      781 ctctccaaac tctaccccac tcatgcttgc cgagagtacc tgaaaaactt ccccctgctg
      841 accaagtact gcggctacag ggaagacaac gtcccgcagc tggaagacgt ctccatgttt
      901 ctgaaagagc gatctggctt cacagtgaga ccagtggctg gctacctgag cccaagagac
      961 ttcctggctg ggctggccta cagagtattc cactgcactc agtacgtgcg gcatggctcc
     1021 gaccccctct acaccccgga accagacaca tgccatgagc tcctgggaca tgtgccactg
     1081 ctggcggatc ccaagttcgc tcagttttct caagaaatag gcttagcctc tctgggagcc
     1141 tcagatgaag acgttcagaa actggccacg tgctatttct tcacaatcga gttcggcctt
     1201 tgcaagcaag aaggtcaact gcgggcgtac ggagcagggt tactttcctc catcggagaa
     1261 ttgaagcatg ctctttctga caaggcgtgt gtaaaagcct ttgacccgaa gacaacctgc
     1321 ttgcaggaat gcctaatcac caccttccaa gatgcttact ttgtttctga aagttttgaa
     1381 gaagccaaag agaagatgag ggattttgca aagtcaatta cccgtccttt ctcagtatat
     1441 ttcaacccct acacacagag cattgaaatt ctgaaagaca ccagaagtat tgagaatgtg
     1501 gtgcaggacc tgcgcagtga tttgaacacc gtgtgcgacg ccttgaataa aatgaaccaa
     1561 tatttgggga tttgagccta ttgtcagcac gagctcttgg gggcttagca acaatgcagt
     1621 caatgttatc caacatcaac aactttctgt gtcatggctg gctagtaagc atgcaattcc
     1681 atgtgtctat acctctatgt aacttaacat acaaaaatga tctaagaaac ccaggcagat
     1741 gaccattcag cattttaaag attgtgatct atttgaacat ctcaagtaga tttgacattt
     1801 ctgattagtg agcaaactgt aacttaagca aactgtgtct ttaaaatttg tagccaacat
     1861 tcctcacaca attccagctg ctgagtcctt gaccttttct tccttggacc tgagtctttc
     1921 ctctgtgttc attagataaa atgaaaacag ttgggaggtg gtttctactt tcaatagtat
     1981 tggtgttctc tgagataaac tagagttgct ccaagcttcg catcacagta acaaaagatt
     2041 taatatttta cttcagaagc tgttcagaaa cacagcgatt ggaatgaatc tggactgagt
     2101 gtttagacaa tgcaagaaaa gaaaaatttt gataaacagg atatatagat tgcactgacc
     2161 ttgttgaaac caatttgtgg tacgcttcct gaagtgcttt tggaaggaaa cactttgaca
     2221 aagaatattt ggaaaggtta aacagaaggg aagaaaatct tggaactgtg aatgtgtcat
     2281 tagaataaag tgaattatca gtgcaggtgt gactcctttc tcttacactg agaaccccaa
     2341 atcctgcagg gatgtgagta ccatctctga ttccgaagat ttggaaaccg agtcacagag
     2401 aaacaaaggg atttgcttca gttaggtctg ttgacttgtg ctgcagtcat aatccacctc
     2461 ccttttatgt tggacttctg gcaagtctac tgtagtgtac atgcgtgttt atgtatcgac
     2521 acagaaagaa aactaatgct tataaaacta atgcttctca ataaacagaa acttgccccc
//
