LOCUS       NM_001100634            3899 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus tryptophan hydroxylase 1 (Tph1), mRNA.
ACCESSION   NM_001100634 XM_001080805 XM_341862
VERSION     NM_001100634.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3899)
  AUTHORS   Makizaki,Y., Uemoto,T., Yokota,H., Yamamoto,M., Tanaka,Y. and
            Ohno,H.
  TITLE     Improvement of loperamide-induced slow transit constipation by
            Bifidobacterium bifidum G9-1 is mediated by the correction of
            butyrate production and neurotransmitter profile due to improvement
            in dysbiosis
  JOURNAL   PLoS One 16 (3), e0248584 (2021)
   PUBMED   33750988
  REMARK    GeneRIF: Improvement of loperamide-induced slow transit
            constipation by Bifidobacterium bifidum G9-1 is mediated by the
            correction of butyrate production and neurotransmitter profile due
            to improvement in dysbiosis.
            Erratum:[PLoS One. 2022 Apr 27;17(4):e0267927. PMID: 35476793]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3899)
  AUTHORS   Zhang,Y., Wang,S., Zhang,L., Zhou,F., Zhu,K., Zhu,Q., Liu,Q.,
            Liu,Y., Jiang,L., Ning,G., Bi,Y., Zhou,L. and Wang,X.
  TITLE     Protein acetylation derepresses Serotonin Synthesis to potentiate
            Pancreatic Beta-Cell Function through HDAC1-PKA-Tph1 signaling
  JOURNAL   Theranostics 10 (16), 7351-7368 (2020)
   PUBMED   32641996
  REMARK    GeneRIF: Protein acetylation derepresses Serotonin Synthesis to
            potentiate Pancreatic Beta-Cell Function through HDAC1-PKA-Tph1
            signaling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3899)
  AUTHORS   Hagiwara,A., Nakamura,Y., Nishimoto,R., Ueno,S. and Miyagi,Y.
  TITLE     Induction of tryptophan hydroxylase in the liver of s.c. tumor
            model of prostate cancer
  JOURNAL   Cancer Sci 111 (4), 1218-1227 (2020)
   PUBMED   31997472
  REMARK    GeneRIF: tryptophan hydroxylase-1 (TPH1), an enzyme that catalyzes
            the reaction of Trp to serotonin, was significantly increased in
            liver and spleen of AT-2 engrafted rats. Further histochemical
            analysis revealed that the induction of TPH1 in the liver could be
            attributed to infiltration of mast cells.
REFERENCE   4  (bases 1 to 3899)
  AUTHORS   Coelho,L.A., Andrade-Silva,J., Motta-Teixeira,L.C., Amaral,F.G.,
            Reiter,R.J. and Cipolla-Neto,J.
  TITLE     The Absence of Pineal Melatonin Abolishes the Daily Rhythm of Tph1
            (Tryptophan Hydroxylase 1), Asmt (Acetylserotonin
            O-Methyltransferase), and Aanat (Aralkylamine N-Acetyltransferase)
            mRNA Expressions in Rat Testes
  JOURNAL   Mol Neurobiol 56 (11), 7800-7809 (2019)
   PUBMED   31124080
  REMARK    GeneRIF: The testes of control animals express the Tph1, Aanat, and
            Asmt and Per2 genes with 24-h rhythms in mRNA, reaching the maximal
            values during the dark phase.
REFERENCE   5  (bases 1 to 3899)
  AUTHORS   Fu,H.J., Zhao,Y., Zhou,Y.R., Bao,B.H., Du,Y. and Li,J.X.
  TITLE     Ursolic acid derivatives as bone anabolic agents targeted to
            tryptophan hydroxylase 1 (Tph-1)
  JOURNAL   Eur J Pharm Sci 76, 33-47 (2015)
   PUBMED   25930119
  REMARK    GeneRIF: Ursolic acid derivatives targeted to tryptophan
            hydroxylase 1 prevented bone loss by suppressing serotonin
            biosynthesis without estrogenic side-effects in ovariectomized
            rats.
REFERENCE   6  (bases 1 to 3899)
  AUTHORS   Kim,K.S., Wessel,T.C., Stone,D.M., Carver,C.H., Joh,T.H. and
            Park,D.H.
  TITLE     Molecular cloning and characterization of cDNA encoding tryptophan
            hydroxylase from rat central serotonergic neurons
  JOURNAL   Brain Res Mol Brain Res 9 (4), 277-283 (1991)
   PUBMED   1645430
REFERENCE   7  (bases 1 to 3899)
  AUTHORS   Stoll,J., Kozak,C.A. and Goldman,D.
  TITLE     Characterization and chromosomal mapping of a cDNA encoding
            tryptophan hydroxylase from a mouse mastocytoma cell line
  JOURNAL   Genomics 7 (1), 88-96 (1990)
   PUBMED   2110547
REFERENCE   8  (bases 1 to 3899)
  AUTHORS   Delort,J., Dumas,J.B., Darmon,M.C. and Mallet,J.
  TITLE     An efficient strategy for cloning 5' extremities of rare
            transcripts permits isolation of multiple 5'-untranslated regions
            of rat tryptophan hydroxylase mRNA
  JOURNAL   Nucleic Acids Res 17 (16), 6439-6448 (1989)
   PUBMED   2780283
REFERENCE   9  (bases 1 to 3899)
  AUTHORS   Darmon,M.C., Guibert,B., Leviel,V., Ehret,M., Maitre,M. and
            Mallet,J.
  TITLE     Sequence of two mRNAs encoding active rat tryptophan hydroxylase
  JOURNAL   J Neurochem 51 (1), 312-316 (1988)
   PUBMED   3379411
REFERENCE   10 (bases 1 to 3899)
  AUTHORS   Darmon,M.C., Grima,B., Cash,C.D., Maitre,M. and Mallet,J.
  TITLE     Isolation of a rat pineal gland cDNA clone homologous to tyrosine
            and phenylalanine hydroxylases
  JOURNAL   FEBS Lett 206 (1), 43-46 (1986)
   PUBMED   2875901
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000033.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001100634.4.
            
            On Feb 10, 2021 this sequence version replaced NM_001100634.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on the TPH-2 nucleotide sequence provided in
            PubMed ID 3379411. The 5' and 3' ends of the transcript are derived
            directly from Figure 2 of that publication.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN16676788
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                JACYVU010000033.1  21055234-21055298   c
            66-113              JACYVU010000033.1  21054006-21054053   c
            114-237             JACYVU010000033.1  21053031-21053154   c
            238-421             JACYVU010000033.1  21050005-21050188   c
            422-522             JACYVU010000033.1  21048523-21048623   c
            523-590             JACYVU010000033.1  21045297-21045364   c
            591-787             JACYVU010000033.1  21044951-21045147   c
            788-923             JACYVU010000033.1  21042722-21042857   c
            924-1050            JACYVU010000033.1  21041928-21042054   c
            1051-1146           JACYVU010000033.1  21040235-21040330   c
            1147-1280           JACYVU010000033.1  21039053-21039186   c
            1281-3899           JACYVU010000033.1  21034363-21036981   c
FEATURES             Location/Qualifiers
     source          1..3899
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..3899
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /note="tryptophan hydroxylase 1"
                     /db_xref="GeneID:24848"
                     /db_xref="RGD:3895"
     exon            1..65
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /inference="alignment:Splign:2.1.0"
     exon            66..113
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /inference="alignment:Splign:2.1.0"
     exon            114..237
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..1455
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /EC_number="1.14.16.4"
                     /note="tryptophan 5-monooxygenase 1"
                     /codon_start=1
                     /product="tryptophan 5-hydroxylase 1"
                     /protein_id="NP_001094104.1"
                     /db_xref="GeneID:24848"
                     /db_xref="RGD:3895"
                     /translation="MIEDNKENKDHSSERGRVTLIFSLKNEVGGLIKALKIFQENHVN
                     LLHIESRKSKRRNSEFEIFVDCDINREQLNDIFPLLKSHTTVLSVDSPDQLPEKEDVM
                     ETVPWFPKKISDLDFCANRVLLYGSELDADHPGFKDNVYRRRRKYFAELAMNYKHGDP
                     IPKIEFTEEEIKTWGTIFRELNKLYPTHACREYLRNLPLLSKYCGYREDNVPQLEDVS
                     NFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPLYTPEPDTCHELLG
                     HVPLLAEPSFAQFSQEIGLASLGASEETVQKLATCYFFTVEFGLCKQDGQLRVFGAGL
                     LSSISELRHALSGHAKVKPFDPKVACKQECLITSFQDVYFVSESFEDAKEKMREFAKT
                     VKRPFGVKYNPYTQSIQVLRDSKSITSAMNELRHDLDVVNDALARVSRWPSV"
     exon            238..421
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /inference="alignment:Splign:2.1.0"
     exon            422..522
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /inference="alignment:Splign:2.1.0"
     exon            523..590
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /inference="alignment:Splign:2.1.0"
     exon            591..787
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /inference="alignment:Splign:2.1.0"
     exon            788..923
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1050
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1146
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1280
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..3899
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttctccta taagaggcgg cagctcccgt ccgcaggtga ccctctgaac tccagtggct
       61 ttgaggtcct ctttccagtg ccggatcctg cccactgggt catcttcatt cagattcacc
      121 atgattgaag acaacaagga gaacaaagac cattcctcag aaagggggag agtgactctc
      181 atcttttcct tgaagaatga agttggagga ctcataaaag cactgaaaat cttccaggag
      241 aaccacgtga acctgttaca tattgagtcc cggaaatcga agcgaagaaa ctcagaattt
      301 gagatttttg tggactgcga catcaaccga gaacagctga atgacatctt tcccctgctg
      361 aagtcccaca ccacggtcct ctctgtggac tcgcccgatc agctccctga aaaggaagat
      421 gttatggaga ctgtcccttg gttcccaaag aagatttctg acctggactt ctgcgccaac
      481 agagtgctgt tgtacggatc cgaactcgac gcggaccatc ctggcttcaa agacaatgtc
      541 taccgtagaa gacgaaagta tttcgcagag ctggctatga actacaaaca tggggacccc
      601 attcccaaga ttgaattcac ggaagaggag attaagacct gggggaccat cttccgagag
      661 ctgaacaaac tctacccaac ccacgcctgc agggagtacc tcagaaacct tcctctgctc
      721 tcaaaatact gtggctatcg ggaagacaac gtcccgcaac tggaagatgt ctccaacttt
      781 ttaaaagaac gcacagggtt ttccatccgt cctgtggctg gttacctctc accgagagat
      841 ttcctgtcag ggttagcctt tcgagtcttt cactgcactc agtatgtgag acacagttcg
      901 gatcctctct ataccccaga gccagacacc tgccacgaac tcttaggcca cgtccctctc
      961 ttggctgaac ccagttttgc tcaattctcc caagaaattg gcctggcttc tcttggagct
     1021 tcagaggaga cggttcagaa actggcaacg tgctacttct tcactgtgga gtttggactg
     1081 tgcaagcaag atgggcagct gagagtcttt ggtgccggcc tgctttcttc catcagtgag
     1141 ctcagacatg cactttctgg acatgccaag gttaagccct ttgatcccaa ggttgcctgc
     1201 aaacaggaat gtctcatcac aagcttccag gatgtctact ttgtatcgga gagctttgaa
     1261 gatgcaaagg agaagatgag agaatttgcc aaaaccgtga agcgcccgtt tggagtgaag
     1321 tacaatccgt acacacagag cattcaggtt ctgagagaca gcaagagcat aaccagcgcc
     1381 atgaatgagt tgcggcatga cctcgatgtc gtcaatgatg cccttgctag agtcagcagg
     1441 tggcccagtg tgtgaaggtt tccagtgcag aaagcctttg agcatcagtc cagagccagg
     1501 gccagttctt gcttccccta aagacctcct tggggaggga cagcagctcc cagcttagca
     1561 atgtctctca cctctctgta accaatcact cactgtctct gaaaacgcat acctggatgc
     1621 tctagtactg cttgtcttct acttctgttt tgatttctgt cacctgctta gggaaatata
     1681 attcacatgc cacatgactc acaggatgca catttaaaat attttatttc attaaaatat
     1741 aattatatcg ttctccccct tccctctctt ctctccaatc cctccctctc aaattcatgg
     1801 cttacttttg atgggtgagt tgcctgacac tggccagagc tggactcatg gtgatgccgt
     1861 tttttcccag tcagccatta gcagatggtc agtctggatg ctatgatgag tgtttctgta
     1921 tctgttacca gcaccgactt tgtgacagcc caggcatagt cacacactag acttcaagga
     1981 gacaagctga aacagaagtg cagatggctt tgctctagag cacagctagt aaagagtaag
     2041 ctggcttcac gtgcagtgtc tgacagggac atagaaatca ccagggcaca gccaggcatg
     2101 aggatgccta tgatagcagt gcttcctagc actttattcc aaagtgtcac aaggtgtggg
     2161 gcacagaggg taggaaacgg ggctgggaat ggagaagggc caaggagagc agtttgtatc
     2221 agattgtaac tctgtgaggg ctgtaaggat tggagcacgt gtggtgtcag cagtgtagcc
     2281 ttggcataag cagttgtata aacttttcat tactgtaaca aagtgtcagg gacaatcagc
     2341 ttataaagag gaaaagtttg ttttgggtgt tatggtccat tagacgtcgt tcctgtggtt
     2401 taagccagtg gtgaaacaag gcatgatgag agaatgtggc agagcaaact tcataaagga
     2461 tggaaagaga aaaagtgaag ggtttagaga aagaagaaga gagagatgga atgagagagg
     2521 gagaacacac acatgggtac gcgcacacac acacacacac acacacacac acacacacac
     2581 acacacacac acacacacgg ggtgagagag agtcagagac agacagaaag atcctacagt
     2641 acagtttaag agttcattac cagggtaaga gagagggctc agcagttaag agtactcgct
     2701 gctcttccag aggaccctgc tttgattccc agcacccaca ctgtggctca caaccatccg
     2761 tcactccagt tccagagggt ccaatgtttt ctggcctcca cagatagcat gcaagtggtg
     2821 cacagataga aatacagcga cacattcaaa cacagaaaat aaacattgaa agaccccacc
     2881 tctgcctttc acattaatag taaaattata taccattgat catgcttctt ttcaagccca
     2941 ctagatgtat gtttatgcta gatttgtaaa agacaccttt taagaattca gaggaaacta
     3001 ctgaaaactg tatttcatcc tgtgcttctc aaggaagccg gtcgagagag tgtaataaag
     3061 ccatctcaga actttataaa cacattagct gccattgagc atgcacacat cagtaagtaa
     3121 atacgttcgt tctgaaatca cgccaagtat ggaccagcta gttcccagtc tgcttgatca
     3181 ccaggagagc actataaaga agccctatag ataacaaaca tgggagagca gtctgctctc
     3241 tctggttatt tccgcaagac tctggtgatg ctggagaatc agtcactggc ttttaaaaat
     3301 ggttgtgccc tgactaaagc actttaaaat aaacagtaaa gccacaacct taccaagtgt
     3361 aacttcaaga taatagaaat agtaggtgat agacttgacc ttgccttggc tctggttctg
     3421 cgatatttgg cagatcaggg ttccaagagc ctcagagttt tcaaaacacc taagaacctt
     3481 ttaataatta tgcaaacacc aggacagact caaaccaaaa gcatggcctg taattctttc
     3541 ccagagagag ccattccttg acagtagcag tatgcgtgac tttttgaaga agacacaaat
     3601 gctaatcttc agaatgcctg cattccttaa tctcatgctt ggcatttaga attacataag
     3661 tagcaagata cagcaaaatg cacaggatta ctgctcattt taaagttggc ttccaaacca
     3721 gagaaagaaa aaaaagcact caaaacactc aataacagag accgtatgtt aatttccagg
     3781 acgtggatag agataactgt gatctgtttc actctcgtct tcgtgttact gtggtgtata
     3841 catgtataat ttaaacgttt gttattccac tgggtaataa actcaaagtt catgatctt
//
