LOCUS       NP_001094104             444 aa            linear   ROD 14-FEB-2025
DEFINITION  tryptophan 5-hydroxylase 1 [Rattus norvegicus].
ACCESSION   NP_001094104 XP_001080805 XP_341863
VERSION     NP_001094104.1
DBSOURCE    REFSEQ: accession NM_001100634.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 444)
  AUTHORS   Makizaki,Y., Uemoto,T., Yokota,H., Yamamoto,M., Tanaka,Y. and
            Ohno,H.
  TITLE     Improvement of loperamide-induced slow transit constipation by
            Bifidobacterium bifidum G9-1 is mediated by the correction of
            butyrate production and neurotransmitter profile due to improvement
            in dysbiosis
  JOURNAL   PLoS One 16 (3), e0248584 (2021)
   PUBMED   33750988
  REMARK    GeneRIF: Improvement of loperamide-induced slow transit
            constipation by Bifidobacterium bifidum G9-1 is mediated by the
            correction of butyrate production and neurotransmitter profile due
            to improvement in dysbiosis.
            Erratum:[PLoS One. 2022 Apr 27;17(4):e0267927. doi:
            10.1371/journal.pone.0267927.. PMID: 35476793]
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 444)
  AUTHORS   Zhang,Y., Wang,S., Zhang,L., Zhou,F., Zhu,K., Zhu,Q., Liu,Q.,
            Liu,Y., Jiang,L., Ning,G., Bi,Y., Zhou,L. and Wang,X.
  TITLE     Protein acetylation derepresses Serotonin Synthesis to potentiate
            Pancreatic Beta-Cell Function through HDAC1-PKA-Tph1 signaling
  JOURNAL   Theranostics 10 (16), 7351-7368 (2020)
   PUBMED   32641996
  REMARK    GeneRIF: Protein acetylation derepresses Serotonin Synthesis to
            potentiate Pancreatic Beta-Cell Function through HDAC1-PKA-Tph1
            signaling.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 444)
  AUTHORS   Hagiwara,A., Nakamura,Y., Nishimoto,R., Ueno,S. and Miyagi,Y.
  TITLE     Induction of tryptophan hydroxylase in the liver of s.c. tumor
            model of prostate cancer
  JOURNAL   Cancer Sci 111 (4), 1218-1227 (2020)
   PUBMED   31997472
  REMARK    GeneRIF: tryptophan hydroxylase-1 (TPH1), an enzyme that catalyzes
            the reaction of Trp to serotonin, was significantly increased in
            liver and spleen of AT-2 engrafted rats. Further histochemical
            analysis revealed that the induction of TPH1 in the liver could be
            attributed to infiltration of mast cells.
REFERENCE   4  (residues 1 to 444)
  AUTHORS   Coelho,L.A., Andrade-Silva,J., Motta-Teixeira,L.C., Amaral,F.G.,
            Reiter,R.J. and Cipolla-Neto,J.
  TITLE     The Absence of Pineal Melatonin Abolishes the Daily Rhythm of Tph1
            (Tryptophan Hydroxylase 1), Asmt (Acetylserotonin
            O-Methyltransferase), and Aanat (Aralkylamine N-Acetyltransferase)
            mRNA Expressions in Rat Testes
  JOURNAL   Mol Neurobiol 56 (11), 7800-7809 (2019)
   PUBMED   31124080
  REMARK    GeneRIF: The testes of control animals express the Tph1, Aanat, and
            Asmt and Per2 genes with 24-h rhythms in mRNA, reaching the maximal
            values during the dark phase.
REFERENCE   5  (residues 1 to 444)
  AUTHORS   Fu,H.J., Zhao,Y., Zhou,Y.R., Bao,B.H., Du,Y. and Li,J.X.
  TITLE     Ursolic acid derivatives as bone anabolic agents targeted to
            tryptophan hydroxylase 1 (Tph-1)
  JOURNAL   Eur J Pharm Sci 76, 33-47 (2015)
   PUBMED   25930119
  REMARK    GeneRIF: Ursolic acid derivatives targeted to tryptophan
            hydroxylase 1 prevented bone loss by suppressing serotonin
            biosynthesis without estrogenic side-effects in ovariectomized
            rats.
REFERENCE   6  (residues 1 to 444)
  AUTHORS   Kim,K.S., Wessel,T.C., Stone,D.M., Carver,C.H., Joh,T.H. and
            Park,D.H.
  TITLE     Molecular cloning and characterization of cDNA encoding tryptophan
            hydroxylase from rat central serotonergic neurons
  JOURNAL   Brain Res Mol Brain Res 9 (4), 277-283 (1991)
   PUBMED   1645430
REFERENCE   7  (residues 1 to 444)
  AUTHORS   Stoll,J., Kozak,C.A. and Goldman,D.
  TITLE     Characterization and chromosomal mapping of a cDNA encoding
            tryptophan hydroxylase from a mouse mastocytoma cell line
  JOURNAL   Genomics 7 (1), 88-96 (1990)
   PUBMED   2110547
REFERENCE   8  (residues 1 to 444)
  AUTHORS   Delort,J., Dumas,J.B., Darmon,M.C. and Mallet,J.
  TITLE     An efficient strategy for cloning 5' extremities of rare
            transcripts permits isolation of multiple 5'-untranslated regions
            of rat tryptophan hydroxylase mRNA
  JOURNAL   Nucleic Acids Res 17 (16), 6439-6448 (1989)
   PUBMED   2780283
REFERENCE   9  (residues 1 to 444)
  AUTHORS   Darmon,M.C., Guibert,B., Leviel,V., Ehret,M., Maitre,M. and
            Mallet,J.
  TITLE     Sequence of two mRNAs encoding active rat tryptophan hydroxylase
  JOURNAL   J Neurochem 51 (1), 312-316 (1988)
   PUBMED   3379411
REFERENCE   10 (residues 1 to 444)
  AUTHORS   Darmon,M.C., Grima,B., Cash,C.D., Maitre,M. and Mallet,J.
  TITLE     Isolation of a rat pineal gland cDNA clone homologous to tyrosine
            and phenylalanine hydroxylases
  JOURNAL   FEBS Lett 206 (1), 43-46 (1986)
   PUBMED   2875901
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Oct 13, 2007 this sequence version replaced
            XP_341863.2, XP_001080805.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on the TPH-2 nucleotide sequence provided in
            PubMed ID 3379411. The 5' and 3' ends of the transcript are derived
            directly from Figure 2 of that publication.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.2539.1,
                                           SRR26360186.2277286.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676788 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..444
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     Protein         1..444
                     /product="tryptophan 5-hydroxylase 1"
                     /EC_number="1.14.16.4"
                     /note="tryptophan 5-monooxygenase 1"
                     /calculated_mol_wt=50937
     Region          3..439
                     /region_name="Trp_5_monoox"
                     /note="tryptophan 5-monooxygenase, tetrameric; TIGR01270"
                     /db_xref="CDD:130337"
     Site            58
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKA. /evidence=ECO:0000255;
                     propagated from UniProtKB/Swiss-Prot (P09810.2)"
     CDS             1..444
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /coded_by="NM_001100634.4:121..1455"
                     /db_xref="GeneID:24848"
                     /db_xref="RGD:3895"
ORIGIN      
        1 miednkenkd hssergrvtl ifslknevgg likalkifqe nhvnllhies rkskrrnsef
       61 eifvdcdinr eqlndifpll kshttvlsvd spdqlpeked vmetvpwfpk kisdldfcan
      121 rvllygseld adhpgfkdnv yrrrrkyfae lamnykhgdp ipkiefteee iktwgtifre
      181 lnklypthac reylrnlpll skycgyredn vpqledvsnf lkertgfsir pvagylsprd
      241 flsglafrvf hctqyvrhss dplytpepdt chellghvpl laepsfaqfs qeiglaslga
      301 seetvqklat cyfftvefgl ckqdgqlrvf gagllssise lrhalsghak vkpfdpkvac
      361 kqeclitsfq dvyfvsesfe dakekmrefa ktvkrpfgvk ynpytqsiqv lrdsksitsa
      421 mnelrhdldv vndalarvsr wpsv
//
