LOCUS       NM_001109621            1555 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus tubulin polyglutamylase complex subunit 1
            (Tpgs1), mRNA.
ACCESSION   NM_001109621 XM_001076820
VERSION     NM_001109621.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1555)
  AUTHORS   Jakobsen L, Vanselow K, Skogs M, Toyoda Y, Lundberg E, Poser I,
            Falkenby LG, Bennetzen M, Westendorf J, Nigg EA, Uhlen M, Hyman AA
            and Andersen JS.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   2  (bases 1 to 1555)
  AUTHORS   Ikegami K, Heier RL, Taruishi M, Takagi H, Mukai M, Shimma S, Taira
            S, Hatanaka K, Morone N, Yao I, Campbell PK, Yuasa S, Janke C,
            Macgregor GR and Setou M.
  TITLE     Loss of alpha-tubulin polyglutamylation in ROSA22 mice is
            associated with abnormal targeting of KIF1A and modulated synaptic
            function
  JOURNAL   Proc Natl Acad Sci U S A 104 (9), 3213-3218 (2007)
   PUBMED   17360631
REFERENCE   3  (bases 1 to 1555)
  AUTHORS   Regnard C, Fesquet D, Janke C, Boucher D, Desbruyeres E, Koulakoff
            A, Insina C, Travo P and Edde B.
  TITLE     Characterisation of PGs1, a subunit of a protein complex
            co-purifying with tubulin polyglutamylase
  JOURNAL   J Cell Sci 116 (Pt 20), 4181-4190 (2003)
   PUBMED   12972506
  REMARK    GeneRIF: Isolation and functional characterization of the mouse
            PGs1 ortholog, and comparison to the rat protein.
REFERENCE   4  (bases 1 to 1555)
  AUTHORS   Campbell PK, Waymire KG, Heier RL, Sharer C, Day DE, Reimann H,
            Jaje JM, Friedrich GA, Burmeister M, Bartness TJ, Russell LD, Young
            LJ, Zimmer M, Jenne DE and MacGregor GR.
  TITLE     Mutation of a novel gene results in abnormal development of
            spermatid flagella, loss of intermale aggression and reduced body
            fat in mice
  JOURNAL   Genetics 162 (1), 307-320 (2002)
   PUBMED   12242242
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474029.1.
            
            On Oct 4, 2007 this sequence version replaced XM_001076820.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ212876.1, BF420090.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1555
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..1555
                     /gene="Tpgs1"
                     /gene_synonym="Gtrgeo22; PGs1"
                     /note="tubulin polyglutamylase complex subunit 1"
                     /db_xref="GeneID:691093"
                     /db_xref="RGD:1588613"
     exon            1..814
                     /gene="Tpgs1"
                     /gene_synonym="Gtrgeo22; PGs1"
                     /inference="alignment:Splign:2.1.0"
     CDS             441..1352
                     /gene="Tpgs1"
                     /gene_synonym="Gtrgeo22; PGs1"
                     /note="gene trap ROSA b-geo 22"
                     /codon_start=1
                     /product="tubulin polyglutamylase complex subunit 1"
                     /protein_id="NP_001103091.1"
                     /db_xref="GeneID:691093"
                     /db_xref="RGD:1588613"
                     /translation="MAALPVPLPPAKMAAVEKRRPAVAPAANFPDSGRTSVSQAVAAA
                     ESEEDFLRQVGVTEMLRAALLKVLETRPEEPIAFLAHYFENMGLRSPANGGAGEPPGQ
                     LLLQQQRLGRALWHLRLAHHSQRTAFNNNVSVAYECLSASGRKKKPGLDGRTYSELLK
                     RVCRDGGAPEEVVAPLLRKIQCRDHEAVPLGIFRTGMLSCFVLLEFVARASALFQLLE
                     DPGLAVADRRVGQAVLDTLEGALSAGDLATAPTHYLEAGSRLGPDNLARALDRAAAGR
                     RPSAPMAREEFLEKAAALFIAKVKPVG"
     exon            815..1555
                     /gene="Tpgs1"
                     /gene_synonym="Gtrgeo22; PGs1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acaaagtgag gccaaaagcc cgggagagcc caggccgagt ctaagagcaa acacagaaaa
       61 cggtctgaac cccgctctta gccctagatt cccggtgggc tttctggggt ttctctggta
      121 cccagggtgc ctggttgcta ggagaccatg cttaggaaga tttgcccact accaagatgg
      181 caaggtgtcg cgcttcaagc cagaaaccaa gtccttcctg ggggaccatt ttgaagtctg
      241 gcaagctcac gattcctgac tgaagctaga agatgcagtc atggagtagc aggagagatg
      301 caaacagaaa acgccagtta gggtataagg ggaaaggaag cctgcgcttg tcactatcga
      361 gactctcaga aagggcgcag ctgcctctgc ccttaacaaa aatggccgtt ctcggagggt
      421 gcctcgtcgc gccgtgaatt atggcggcgc ttccggtccc gctgccccca gcaaagatgg
      481 cggcagtgga gaaacgacgg ccggcagtag caccagcggc caatttccca gacagtggcc
      541 ggacgtcggt gtctcaggcg gtggcggcgg ctgagagcga ggaggatttc ctacggcagg
      601 ttggcgtgac ggagatgctg cgcgcagccc tcctgaaggt gctggagacc cggcccgaag
      661 agcccatcgc cttcttggcg cattacttcg agaacatggg tttgcgctcg ccggccaacg
      721 gaggcgccgg ggagcccccg ggccagctcc tcctgcagca acagcgcctg ggtcgcgcgc
      781 tgtggcacct tcgcctggct caccactcgc agaggacggc cttcaacaac aacgtgagcg
      841 tggcctatga gtgcctgagt gcgagcggcc gcaagaagaa gccaggcctg gatgggcgca
      901 catacagcga gctgctgaag cgagtttgca gggacggcgg ggcgcctgag gaagtggtgg
      961 caccgctgct gcgcaagatc cagtgccgag accatgaggc tgtgcctctg ggcatcttca
     1021 gaaccggcat gctgtcctgc tttgtgctgc tggaattcgt ggcgcgcgcc agcgccctct
     1081 tccagctgct ggaggaccct ggcctagcgg tggctgatcg gcgtgtgggt caggctgtgc
     1141 tggacacgct cgagggtgcg ctgagcgcag gagacctggc aacggcgccc acgcactacc
     1201 tggaggccgg ttcccgcctg ggccccgaca acctggcgcg tgccctggac agggcagcag
     1261 ccgggcgacg acccagtgca cccatggccc gcgaggagtt cttggagaag gctgcagccc
     1321 tcttcattgc caaggtcaag ccagtgggct aaacccacaa tgcacccaca ccctgtcacc
     1381 tgcccaggaa ggcgtgaact tgggacctgc aaaccgatgt cccggcatcc tgcacagggt
     1441 catcaaccag gaagggggag ccacttggac cctgcaggac aagcacctgc agatcaatcc
     1501 cctctgtact ggcctgccta ccccactcac agaaataaaa tctaaaaaga tccgg
//
