LOCUS       NM_001106421            2240 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus tumor protein D52 (Tpd52), transcript variant 1,
            mRNA.
ACCESSION   NM_001106421 XM_001054008 XM_215524
VERSION     NM_001106421.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2240)
  AUTHORS   Biesemann C, Gronborg M, Luquet E, Wichert SP, Bernard V, Bungers
            SR, Cooper B, Varoqueaux F, Li L, Byrne JA, Urlaub H, Jahn O, Brose
            N and Herzog E.
  TITLE     Proteomic screening of glutamatergic mouse brain synaptosomes
            isolated by fluorescence activated sorting
  JOURNAL   EMBO J 33 (2), 157-170 (2014)
   PUBMED   24413018
REFERENCE   2  (bases 1 to 2240)
  AUTHORS   Messenger SW, Thomas DD, Falkowski MA, Byrne JA, Gorelick FS and
            Groblewski GE.
  TITLE     Tumor protein D52 controls trafficking of an apical endolysosomal
            secretory pathway in pancreatic acinar cells
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 305 (6), G439-G452 (2013)
   PUBMED   23868405
  REMARK    GeneRIF: D52 regulates apical endolysosomal secretion in pancreatic
            acinar cells.
REFERENCE   3  (bases 1 to 2240)
  AUTHORS   Thomas DD, Martin CL, Weng N, Byrne JA and Groblewski GE.
  TITLE     Tumor protein D52 expression and Ca2+-dependent phosphorylation
            modulates lysosomal membrane protein trafficking to the plasma
            membrane
  JOURNAL   Am J Physiol Cell Physiol 298 (3), C725-C739 (2010)
   PUBMED   20032513
  REMARK    GeneRIF: Implicate both D52 expression and Ca(2+)-dependent
            phosphorylation at serine 136 in lysosomal membrane trafficking to
            and from the plasma membrane providing a novel Ca(2+)-sensitive
            pathway modulating the lysosome-like secretory pathway.
REFERENCE   4  (bases 1 to 2240)
  AUTHORS   Wang R, He H, Sun X, Xu J, Marshall FF, Zhau H, Chung LW, Fu H and
            He D.
  TITLE     Transcription variants of the prostate-specific PrLZ gene and their
            interaction with 14-3-3 proteins
  JOURNAL   Biochem Biophys Res Commun 389 (3), 455-460 (2009)
   PUBMED   19732746
REFERENCE   5  (bases 1 to 2240)
  AUTHORS   Lewis JD, Payton LA, Whitford JG, Byrne JA, Smith DI, Yang L and
            Bright RK.
  TITLE     Induction of tumorigenesis and metastasis by the murine orthologue
            of tumor protein D52
  JOURNAL   Mol Cancer Res 5 (2), 133-144 (2007)
   PUBMED   17314271
REFERENCE   6  (bases 1 to 2240)
  AUTHORS   Kaspar KM, Thomas DD, Weng N and Groblewski GE.
  TITLE     Dietary and hormonal stimulation of rat exocrine pancreatic
            function regulates CRHSP-28 phosphorylation in vivo
  JOURNAL   J Nutr 133 (10), 3072-3075 (2003)
   PUBMED   14519786
  REMARK    GeneRIF: data demonstrate that calcium-responsive heat stable
            protein-28(CRHSP-28 )phosphorylation occurs in vivo and can be used
            as a functional indicator of nutrient-driven pancreatic acinar cell
            activation
REFERENCE   7  (bases 1 to 2240)
  AUTHORS   Thomas DD, Kaspar KM, Taft WB, Weng N, Rodenkirch LA and Groblewski
            GE.
  TITLE     Identification of annexin VI as a Ca2+-sensitive CRHSP-28-binding
            protein in pancreatic acinar cells
  JOURNAL   J Biol Chem 277 (38), 35496-35502 (2002)
   PUBMED   12105190
  REMARK    GeneRIF: binding of CRHSP-28 and annexin VI, together with their
            colocalization in the apical cytoplasm, is consistent with a role
            for these molecules in acinar cell membrane trafficking events that
            are essential for digestive enzyme secretion.
REFERENCE   8  (bases 1 to 2240)
  AUTHORS   Hoja MR, Wahlestedt C and Hoog C.
  TITLE     A visual intracellular classification strategy for uncharacterized
            human proteins
  JOURNAL   Exp Cell Res 259 (1), 239-246 (2000)
   PUBMED   10942595
REFERENCE   9  (bases 1 to 2240)
  AUTHORS   Byrne JA, Nourse CR, Basset P and Gunning P.
  TITLE     Identification of homo- and heteromeric interactions between
            members of the breast carcinoma-associated D52 protein family using
            the yeast two-hybrid system
  JOURNAL   Oncogene 16 (7), 873-881 (1998)
   PUBMED   9484778
REFERENCE   10 (bases 1 to 2240)
  AUTHORS   Groblewski GE, Wishart MJ, Yoshida M and Williams JA.
  TITLE     Purification and identification of a 28-kDa calcium-regulated
            heat-stable protein. A novel secretagogue-regulated phosphoprotein
            in exocrine pancreas
  JOURNAL   J Biol Chem 271 (49), 31502-31507 (1996)
   PUBMED   8940165
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000067.1.
            
            [WARNING] On Mar 25, 2024 this sequence was replaced by
            NM_001106421.3.
            
            On Feb 25, 2022 this sequence version replaced NM_001106421.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: GQ499323.1, DN933414.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132281, SAMD00132294
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-238               JACYVU010000067.1  7851611-7851848
            239-354             JACYVU010000067.1  7864183-7864298
            355-503             JACYVU010000067.1  7869100-7869248
            504-605             JACYVU010000067.1  7872171-7872272
            606-654             JACYVU010000067.1  7880563-7880611
            655-2240            JACYVU010000067.1  7881957-7883542
FEATURES             Location/Qualifiers
     source          1..2240
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q23"
     gene            1..2240
                     /gene="Tpd52"
                     /gene_synonym="Crhsp-28; PrLZ"
                     /note="tumor protein D52"
                     /db_xref="GeneID:294900"
                     /db_xref="RGD:1306767"
     exon            1..238
                     /gene="Tpd52"
                     /gene_synonym="Crhsp-28; PrLZ"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..777
                     /gene="Tpd52"
                     /gene_synonym="Crhsp-28; PrLZ"
                     /EC_number="2.7.1.21"
                     /note="isoform 1 is encoded by transcript variant 1;
                     calcium regulated heat stable protein-28"
                     /codon_start=1
                     /product="tumor protein D52 isoform 1"
                     /protein_id="NP_001099891.2"
                     /db_xref="GeneID:294900"
                     /db_xref="RGD:1306767"
                     /translation="MDCRDMELSDDYQSPFDFDSGVNKNYLYLSPSGNTSPPGSPTQN
                     VGLLKTEPVAEEGEDAVAMLSAPETLTEEEQEELRRELTKVEEEIQTLSQVLAAKEKH
                     LAEIKRKLGITSLQEFKQNIAKGWQDVTATNAYKKTSETLSQAGQKASAAFSSVGSVI
                     TKKLEDVKNSPTFKSFEEKVENLKSKVGGAKPCWWRLWRSPEFHSERYQYHNHGAPPE
                     QTTESP"
     exon            239..354
                     /gene="Tpd52"
                     /gene_synonym="Crhsp-28; PrLZ"
                     /inference="alignment:Splign:2.1.0"
     exon            355..503
                     /gene="Tpd52"
                     /gene_synonym="Crhsp-28; PrLZ"
                     /inference="alignment:Splign:2.1.0"
     exon            504..605
                     /gene="Tpd52"
                     /gene_synonym="Crhsp-28; PrLZ"
                     /inference="alignment:Splign:2.1.0"
     exon            606..654
                     /gene="Tpd52"
                     /gene_synonym="Crhsp-28; PrLZ"
                     /inference="alignment:Splign:2.1.0"
     exon            655..2240
                     /gene="Tpd52"
                     /gene_synonym="Crhsp-28; PrLZ"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagcaccagt tcctttcctc agccgggcct tggcccagga gtcccaggcc tgaggagcaa
       61 ttgcaggctg ctgtagcgcc atgctctctg ccatcacctg gcatggattg tagagatatg
      121 gagctgtctg atgattacca gtccccgttc gatttcgatt ccggagtgaa caagaactat
      181 ctctacctct ctccgagcgg gaacacgtcg ccgcctggct cacctacaca gaacgttggt
      241 ctgctgaaga cagagccagt ggctgaggaa ggagaggatg ctgttgccat gctcagtgcc
      301 ccagagacac tcacagagga ggagcaagag gagctgagac gggaacttac taaggtggaa
      361 gaagaaatcc agactctgtc ccaagtgttg gctgcaaaag agaagcatct tgcggagatc
      421 aagcggaaac ttgggatcac ctcgcttcag gaattcaagc agaatatcgc caaagggtgg
      481 caagatgtga cagcaaccaa cgcatacaag aagacatcgg aaaccctatc gcaggccgga
      541 cagaaggcct ctgctgcatt ttcatcggtt ggctcagtca tcaccaaaaa gctggaagac
      601 gtaaaaaact ctccaacttt caagtcattt gaagaaaaag ttgaaaactt aaagtctaaa
      661 gtaggaggag ccaagccctg ctggtggcga ctttggagaa gtcctgaatt ccacagcgaa
      721 cgctaccagt accacaacca cggagcccct ccagaacaga cgacagagag cccctgagct
      781 gccgacctgt gtcctgctgc ccactgccag gtgctgcgag agccaagcac atcttgacaa
      841 cgctcacgac tgcagatttc taccagatgt gctttcattt agctttactt atttctttga
      901 ccaaatagtt tgtgaatgaa accaagtgaa accaccttcc cctccactcc agggaaacgc
      961 ccgttagctt gcggaaggcc cctttgtaaa ggagacagca ccatagcctc tggtagtccc
     1021 tgcaggcaac cactgtgctc ttcaaatcac tttccatctg gagtctacgt cgatctttct
     1081 ttgctatgct tgaatcattc tttttggatc tctgtacact taatcaattt ctaacgaata
     1141 ctgtcctttt ctaaattctg gttattaaaa gtcttggagt tatttcatta ctttcaaagg
     1201 agagactact agctacatct tttttttttc ttttggataa acagttataa gaggaccata
     1261 tcttgggttt ctgaagacac cagagtaaag tagacaggtg tgtgtgcatg tcagtagttc
     1321 tgtaagtgca caacatgcag acactcaaac tgccactgtc gtgagtgtgg gcacaccacc
     1381 cccaccccct tggtaactgt cacttgtagc tgcgtctact tcagtgtatc ggttatttat
     1441 tataccattc ttatgcattt tttacaagtt taaaatttaa ttttaggtaa attaacagaa
     1501 tagcattgtg agtcaagtgt gtgatattac agtaagttgg agtgttccca tactctcact
     1561 cataatctga aagtctaaaa agtctttagg tctgtacaac tatagaatcc acaaggctat
     1621 acaactacag aaatgctaaa ataattcacc ttaggggaaa ctactcccct ccattaactc
     1681 catttaacac cctccaggaa gcacagacag ttgtatgaga aatgcaactt gaatgttttt
     1741 tatactgagg tggtgttgat aactcggaag gctgtgacgc gctgacacgg atgagctgct
     1801 catgctgtac ttctcggtgt gtttgtgact gtgaactgca ctgtagacat tgttcccact
     1861 ttgagaactg tcgggcttgt gaatcgaagc ttccagatgt ctctgctgag ttcctctatt
     1921 agctgtggtt actactgacc cactaccgtt tcctttgcgt gtgtgggttt atggcctgtg
     1981 aggttgtgtc tgttctctat tgtgctggtt ttacccttgt tcattgccaa atgttaattg
     2041 ccaagcttgg agtgacctaa agcatttctt aaaagcatga ctagatttaa ctgaggatag
     2101 gtttctgcaa accagaatcg aaaagccaca gtgacagttg ttacaaaatg acatgctgcc
     2161 atccctgatt gctccttgga tgcaatggaa actatgctct attatatgtg aaaatcttaa
     2221 taaagtctga ggtctcagta
//
