LOCUS       NM_001108696            4749 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus tumor protein p73 (Tp73), mRNA.
ACCESSION   NM_001108696 XM_001077013 XM_342992
VERSION     NM_001108696.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4749)
  AUTHORS   Liu,J., Jin,Y. and Chen,L.
  TITLE     Association between p73 gene G4C14-to-A4T14 polymorphism and risk
            of lung cancer: A meta-analysis
  JOURNAL   J Pak Med Assoc 70 (2), 313-319 (2020)
   PUBMED   32063627
REFERENCE   2  (bases 1 to 4749)
  AUTHORS   Jin,Y., Lee,W.Y., Toh,S.T., Tennakoon,C., Toh,H.C., Chow,P.K.,
            Chung,A.Y., Chong,S.S., Ooi,L.L., Sung,W.K. and Lee,C.G.
  TITLE     Comprehensive analysis of transcriptome profiles in hepatocellular
            carcinoma
  JOURNAL   J Transl Med 17 (1), 273 (2019)
   PUBMED   31429776
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4749)
  AUTHORS   Zhang,K., Meng,Y., Cao,X., Xu,Y., Du,M., Wu,Y. and Liu,L.
  TITLE     Genetic variants in p53 signaling pathway genes predict
            chemotherapy efficacy in colorectal cancer
  JOURNAL   Cancer Med 8 (7), 3428-3436 (2019)
   PUBMED   31090204
REFERENCE   4  (bases 1 to 4749)
  AUTHORS   Abul,M., Al-Bader,M.D. and Mouihate,A.
  TITLE     Exposure to synthetic glucocorticoids during pregnancy alters the
            expression of p73 gene variants in fetal brains in a sex-specific
            manner
  JOURNAL   Brain Res 1707, 117-123 (2019)
   PUBMED   30476470
  REMARK    GeneRIF: Dexamethasone induced a sex-dependent effect on the
            expression of p73 gene variants. DEX-induced growth restriction in
            the brain of female fetuses is independent of p73 gene.
REFERENCE   5  (bases 1 to 4749)
  AUTHORS   Meng,J., Wang,S., Zhang,M., Fan,S., Zhang,L. and Liang,C.
  TITLE     TP73 G4C14-A4T14 polymorphism and cancer susceptibility: evidence
            from 36 case-control studies
  JOURNAL   Biosci Rep 38 (6) (2018)
   PUBMED   30420492
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4749)
  AUTHORS   Schwartz,D.I., Lindor,N.M., Walsh-Vockley,C., Roche,P.C., Mai,M.,
            Smith,D.I., Liu,W. and Couch,F.J.
  TITLE     p73 mutations are not detected in sporadic and hereditary breast
            cancer
  JOURNAL   Breast Cancer Res Treat 58 (1), 25-29 (1999)
   PUBMED   10634515
REFERENCE   7  (bases 1 to 4749)
  AUTHORS   Davison,T.S., Vagner,C., Kaghad,M., Ayed,A., Caput,D. and
            Arrowsmith,C.H.
  TITLE     p73 and p63 are homotetramers capable of weak heterotypic
            interactions with each other but not with p53
  JOURNAL   J Biol Chem 274 (26), 18709-18714 (1999)
   PUBMED   10373484
REFERENCE   8  (bases 1 to 4749)
  AUTHORS   Chi,S.G., Chang,S.G., Lee,S.J., Lee,C.H., Kim,J.I. and Park,J.H.
  TITLE     Elevated and biallelic expression of p73 is associated
            withprogression of human bladder cancer
  JOURNAL   Cancer Res 59 (12), 2791-2793 (1999)
   PUBMED   10383132
REFERENCE   9  (bases 1 to 4749)
  AUTHORS   Mai,M., Qian,C., Yokomizo,A., Tindall,D.J., Bostwick,D.,
            Polychronakos,C., Smith,D.I. and Liu,W.
  TITLE     Loss of imprinting and allele switching of p73 in renal cell
            carcinoma
  JOURNAL   Oncogene 17 (13), 1739-1741 (1998)
   PUBMED   9796703
REFERENCE   10 (bases 1 to 4749)
  AUTHORS   Kaghad,M., Bonnet,H., Yang,A., Creancier,L., Biscan,J.C.,
            Valent,A., Minty,A., Chalon,P., Lelias,J.M., Dumont,X., Ferrara,P.,
            McKeon,F. and Caput,D.
  TITLE     Monoallelically expressed gene related to p53 at 1p36, a region
            frequently deleted in neuroblastoma and other human cancers
  JOURNAL   Cell 90 (4), 809-819 (1997)
   PUBMED   9288759
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473968.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_342992.3, XM_001077013.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN12840111
                              [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4749
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..4749
                     /gene="Tp73"
                     /gene_synonym="P73; Trp73"
                     /note="tumor protein p73"
                     /db_xref="GeneID:362675"
                     /db_xref="RGD:1307083"
     exon            1..119
                     /gene="Tp73"
                     /gene_synonym="P73; Trp73"
                     /inference="alignment:Splign:2.1.0"
     CDS             4..2058
                     /gene="Tp73"
                     /gene_synonym="P73; Trp73"
                     /note="transformation related protein 73"
                     /codon_start=1
                     /product="tumor protein p73"
                     /protein_id="NP_001102166.1"
                     /db_xref="GeneID:362675"
                     /db_xref="RGD:1307083"
                     /translation="MSSPRQLDAYATALPLQATGPPAPLPKSTDPSRAQVQPRMSNGV
                     GEMAQSSSSSSSSSTFEHLWSSLEPDSTYFDLPQPSQGNSEATGSEESNMDVFHLQGM
                     TSSVMAQFNLLSSAMDQMGSRAAPASPYTPEHAASAPTHSPYAQPSSTFDTMSPAPVI
                     PSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGT
                     AIRAMPVYKKAEHVTDIVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVT
                     GRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVGGMNRRPILVIITLETRDGQVLGRRS
                     FEGRICACPGRDRKADEDHYREQQALNESTTKNGAASKRAFKQSPPAIPALGTNVKKR
                     RHGDEDMFYMHVRGRENFEILMKVKESLELMELVPQPLVDSYRQQQQQQLLQRPSHLQ
                     PPSYGPVLSPMNKVHGGVNKLPSVNQLVGQPPPHSSAAGPNLGSMGSGILNSHSHSMP
                     ANGEMNGGHSSQTMVSGSHCTPPPPYHADPSLVSFLTGLGCPNCIECFTSQGLQSIYH
                     LQNLTIEDLGALKIPDQYRMTIWRGLQDLKQSHDCGQQLLRSSSNAATISIGGSGELQ
                     RQRVMEAVHFRVRHTITIPNRGGAGGVTGPDEWADFGFDLPDCKSRKQPIKEEFTETE
                     SH"
     exon            120..203
                     /gene="Tp73"
                     /gene_synonym="P73; Trp73"
                     /inference="alignment:Splign:2.1.0"
     exon            204..324
                     /gene="Tp73"
                     /gene_synonym="P73; Trp73"
                     /inference="alignment:Splign:2.1.0"
     exon            325..567
                     /gene="Tp73"
                     /gene_synonym="P73; Trp73"
                     /inference="alignment:Splign:2.1.0"
     exon            568..754
                     /gene="Tp73"
                     /gene_synonym="P73; Trp73"
                     /inference="alignment:Splign:2.1.0"
     exon            755..870
                     /gene="Tp73"
                     /gene_synonym="P73; Trp73"
                     /inference="alignment:Splign:2.1.0"
     exon            871..980
                     /gene="Tp73"
                     /gene_synonym="P73; Trp73"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1123
                     /gene="Tp73"
                     /gene_synonym="P73; Trp73"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1212
                     /gene="Tp73"
                     /gene_synonym="P73; Trp73"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1340
                     /gene="Tp73"
                     /gene_synonym="P73; Trp73"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1489
                     /gene="Tp73"
                     /gene_synonym="P73; Trp73"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1628
                     /gene="Tp73"
                     /gene_synonym="P73; Trp73"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1722
                     /gene="Tp73"
                     /gene_synonym="P73; Trp73"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..4749
                     /gene="Tp73"
                     /gene_synonym="P73; Trp73"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccaatgtcat cacctaggca actggacgct tatgccactg ccctgccact gcaagccaca
       61 ggacctccag cacctctgcc caagtctacg gacccatcca gggcccaggt tcagccaaga
      121 atgagcaacg gcgtcgggga gatggcccag tcctcttcct cctcctcttc ctcctccacc
      181 ttcgagcacc tgtggagttc tctggagcca gacagtacct actttgacct tccccagccc
      241 agccaaggga atagcgaggc aacgggcagc gaggagtcca acatggatgt cttccacctg
      301 caaggcatga cctcctccgt catggcccag ttcaatttgc tcagcagcgc catggaccag
      361 atgggcagcc gcgcggcccc ggccagcccc tacaccccgg agcacgccgc cagcgcaccc
      421 acccactcgc cctacgcgca gcccagctcc accttcgaca ccatgtctcc agcgcctgtc
      481 atcccttcca acaccgacta ccctggtccc caccacttcg aggtcacctt ccagcagtcg
      541 agcacagcca agtcggccac ctggacatac tccccacttt tgaagaagtt gtactgtcag
      601 attgccaaga catgccccat ccagatcaaa gtgtccacac caccacctcc gggcacggcc
      661 atccgggcca tgcccgtcta caagaaggca gagcatgtga ccgacattgt taagcgctgt
      721 cccaaccacg agcttggaag ggacttcaat gaaggacagt ctgctccggc tagtcacctc
      781 atccgtgtgg aaggcaacaa cctctcccaa tatgtggatg accctgtcac cggcaggcag
      841 agtgtggttg tgccatatga acccccacag gtaggaacag aattcaccac catcttgtac
      901 aacttcatgt gtaacagcag ctgcgtaggg ggcatgaatc ggagacccat cctcgtcatc
      961 atcaccctgg agacccggga tggacaggta ctgggccggc ggtctttcga gggccgcatc
     1021 tgcgcctgtc ctggccgtga ccgaaaggcc gatgaagacc attaccggga gcaacaggct
     1081 ctgaatgaaa gcaccaccaa gaacggggct gccagcaaac gtgcgttcaa gcagagcccc
     1141 cctgccatcc ctgccctggg taccaacgta aagaagagac gccatggtga cgaggacatg
     1201 ttctacatgc atgttcgagg ccgggagaac tttgagatct tgatgaaagt caaggagagc
     1261 ctagagctga tggagcttgt gccgcagcct ttggttgact cctaccgaca gcaacagcag
     1321 cagcagctcc tacagaggcc gagtcacctg cagcctccct cctatgggcc cgtgctgtcc
     1381 ccaatgaaca aggtacacgg tggtgtcaac aaactgccct ctgtcaacca gctggtaggc
     1441 cagcctcccc cacacagctc tgcagctggg cccaacctgg ggtccatggg ttccgggata
     1501 ctcaacagcc acagccacag catgccagcc aatggagaga tgaatggagg ccacagctcc
     1561 cagaccatgg tttccggatc ccactgcacc ccgccacccc cgtaccatgc cgaccccagc
     1621 ctcgtcagtt ttttgacagg gttggggtgt ccgaactgta tcgagtgctt cacttcccaa
     1681 gggttacaga gcatctacca cctgcagaac ctcaccatcg aggaccttgg ggccctgaag
     1741 atccctgacc agtaccgtat gaccatctgg aggggcctac aggacctgaa gcagagccat
     1801 gactgcggtc agcagcttct acgctccagc agcaacgcgg ccaccatctc catcggcggc
     1861 tctggcgagc tgcagcggca gcgggtcatg gaagccgtgc atttccgcgt gcgccacacc
     1921 atcacgatcc ccaaccgcgg aggcgcgggt ggcgtgacgg gccccgacga gtgggcagac
     1981 tttggctttg acctgcctga ctgcaagtcc cgtaagcagc ccatcaaaga ggagttcaca
     2041 gagacagaga gccactgagg ggcgtcgtac cttctccttc ctgccttcct ctgtgagaaa
     2101 ctgcccttgg aagcgggacc cctctgttgt gcccacggaa acagcaaggg ccttctgcca
     2161 gacgccattc ctgaagggaa gtcgttcatg aactaagtcc tcccaggaaa cttctggaac
     2221 tgcccttaac tacacataca caagggcagg ttgtgggcca agtgcttaga cagggactgt
     2281 ccctttgtgg gtaggtacac catatccatt ccctcctccc ctctattgag gactctgcca
     2341 actccaggac agagcagcat ccttcgctcg ataaccctct gccacgaagt attccagcgt
     2401 cttctgttcc cgatagccac acgcagccag ccgggcctcc ctgtcttctg cactttacgt
     2461 gcgggttgat tccactgtgt tttgaaggtg aagtcagggc cggagacatc ctctgcagga
     2521 ggtggggaca catctgtccc tgatgtaggt tattccaccg ttcctccctg tctcccgagg
     2581 cttggttgct ggggttaggg aaagctagac ggtggcagag cagaggaaga ggctggcctc
     2641 aagcctccag ccagcaccct gaacatgctg gccacagcag cctcgatgaa gctctccccc
     2701 ggcagacaga gggacagaat gagtctcaga ggactgaaaa ttgaattgtc aatatttgat
     2761 aaaaaaaaac aaaacaacaa acattactct tctacttggt gggtcagctt gctttttgcc
     2821 cccctctggc tcttttcagc atttccttct gagatcaacc tagcgtgtcc accacacgag
     2881 cttctcaaca agtctttaaa aaaaaataaa gaaaagagtg tcaagccagg aagggttgga
     2941 tgggagtgcg ggttagaccc cagctgtgag gaacatcggt tctgccctcg ctaagtgctc
     3001 agagtctagg ctctgtgccc aagtgccagc ccatccttgt gggctggaac tggggtgact
     3061 gctggaggcc ctggtcttcc tatgcacccc caaggagtca gtagacttga gagagagctc
     3121 ctttgtgcac tcagccactg aggccttgta cctgccagaa actctgtgaa cttctacaat
     3181 gagagccccc ggcagtcgct gctaggagtg gaaggagctc ttgcctcagg aaagcccaac
     3241 tgcctgctga ggttctgtgg agccgtttct cttaggcctg gctctcatta gcatggccca
     3301 acagctgcag tgaaggccgt ggactggtca cagagtcagc actaccagga ctggcttcag
     3361 accagggctg cctcctagaa gcacaggagc aaatgtcgcc aaccttatca agctctgcaa
     3421 agttaggtgg ctaccaccca caccgtgctt catgagtctc tgaggggcag gattcgggtg
     3481 cacttagggt tggtgcaaac atcacattgg cagagaacag agctggccat gccggccctt
     3541 ccaacttgac agcttagcct ctgggggtcc tgcacccaga agggccataa cagctgcagc
     3601 atcaggctta gagcttccag ggtgcagggc atggccatcc cagtaagcgg tgacacacct
     3661 cacagagcct gaggttgaac acatgcttgt tgatgaggaa gaggaagctg aggctggatg
     3721 gaactgagtt ccccgctgca ggcatcagct cactgcagag gcatgttctc actcctgagg
     3781 tacacgctgc cccatgctac ctcggggact aggcagcaca tgctcactcc taggcctgtg
     3841 agccccactg tgagacgtgc ttgagttctg gggtgtcacg tacgtatgcc tcaggcactg
     3901 tccaggaggg gccatcctaa gcgccccacc acatgctcct gaaaagactt cagaggagtg
     3961 gctgtcacca ggcatctgag gaatgaagac cctatctctg gtgaggacct agggctgtgt
     4021 gtctccccag acccctgcct caagtgccaa agctgtctca tgagcttctg agatcctgac
     4081 aggcctggag ggaactgcaa agggccatct gccaggaaac aaatgtcaca gaggcaaggc
     4141 ttgctgtgac tgattagctc tcctccggga aatggccttt gggtctgaaa caaactttgt
     4201 tctgcaaaag acagaaagca agaggaagaa attttccagt caccaggttt cccaggaaca
     4261 ctgaagtgct agtctggaag cgagtttggg ggtggcctgg aacacatctg ttgagcaagg
     4321 gcgggtacct caaggctcta caagccactc cagcctcagc ctgtacaacc cgtacggtcc
     4381 cagggagctt tgagcatcca gttaacagcc actcccatgc cccttcccgg ccctgctgac
     4441 catgccttgg gctgctttga gctttgagct tacagcacca gcacttgttc cctgggcaag
     4501 aaccctgtgt gagtcaacag ttgctactta gaacagcatt tcagactgga ggcaaaaacc
     4561 aaaaccaaac tgtccacgtt tcaatggatg aaatgcttct ccaagcagta ttgatggata
     4621 cagtccaatg actctatgaa ctgttttggg tgatgtcatc ttaggaaaaa aatgtgttat
     4681 ttttttagct gtgtttcagt gggatttttt gtttttgtaa tataataaaa atcacatgtt
     4741 cccacggtt
//
