LOCUS       NM_019221               4968 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus tumor protein p63 (Tp63), transcript variant 1,
            mRNA.
ACCESSION   NM_019221
VERSION     NM_019221.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4968)
  AUTHORS   Wang,Y., Wu,W., Zhu,M., Wang,C., Shen,W., Cheng,Y., Geng,L., Li,Z.,
            Zhang,J., Dai,J., Ma,H., Chen,L., Hu,Z., Jin,G. and Shen,H.
  TITLE     Integrating expression-related SNPs into genome-wide gene- and
            pathway-based analyses identified novel lung cancer susceptibility
            genes
  JOURNAL   Int J Cancer 142 (8), 1602-1610 (2018)
   PUBMED   29193083
REFERENCE   2  (bases 1 to 4968)
  AUTHORS   Liao,W., Liu,H., Zhang,Y., Jung,J.H., Chen,J., Su,X., Kim,Y.C.,
            Flores,E.R., Wang,S.M., Czarny-Ratajczak,M., Li,W., Zeng,S.X. and
            Lu,H.
  TITLE     Ccdc3: A New P63 Target Involved in Regulation Of Liver Lipid
            Metabolism
  JOURNAL   Sci Rep 7 (1), 9020 (2017)
   PUBMED   28827783
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4968)
  AUTHORS   Alves,L.U., Pardono,E., Otto,P.A. and Mingroni Netto,R.C.
  TITLE     A novel c.1037C > G (p.Ala346Gly) mutation in TP63 as cause of the
            ectrodactyly-ectodermal dysplasia and cleft lip/palate (EEC)
            syndrome
  JOURNAL   Genet Mol Biol 38 (1), 37-41 (2015)
   PUBMED   25983622
REFERENCE   4  (bases 1 to 4968)
  AUTHORS   Eisenkraft,A., Pode-Shakked,B., Goldstein,N., Shpirer,Z., van
            Bokhoven,H. and Anikster,Y.
  TITLE     Clinical Variability in a Family with an Ectodermal Dysplasia
            Syndrome and a Nonsense Mutation in the TP63 Gene
  JOURNAL   Fetal Pediatr Pathol 34 (6), 400-406 (2015)
   PUBMED   26470833
REFERENCE   5  (bases 1 to 4968)
  AUTHORS   Bamberger,C. and Schmale,H.
  TITLE     Identification and tissue distribution of novel KET/p63 splice
            variants
  JOURNAL   FEBS Lett 501 (2-3), 121-126 (2001)
   PUBMED   11470269
REFERENCE   6  (bases 1 to 4968)
  AUTHORS   Davison,T.S., Vagner,C., Kaghad,M., Ayed,A., Caput,D. and
            Arrowsmith,C.H.
  TITLE     p73 and p63 are homotetramers capable of weak heterotypic
            interactions with each other but not with p53
  JOURNAL   J Biol Chem 274 (26), 18709-18714 (1999)
   PUBMED   10373484
REFERENCE   7  (bases 1 to 4968)
  AUTHORS   Yang,A., Schweitzer,R., Sun,D., Kaghad,M., Walker,N., Bronson,R.T.,
            Tabin,C., Sharpe,A., Caput,D., Crum,C. and McKeon,F.
  TITLE     p63 is essential for regenerative proliferation in limb,
            craniofacial and epithelial development
  JOURNAL   Nature 398 (6729), 714-718 (1999)
   PUBMED   10227294
REFERENCE   8  (bases 1 to 4968)
  AUTHORS   Mills,A.A., Zheng,B., Wang,X.J., Vogel,H., Roop,D.R. and Bradley,A.
  TITLE     p63 is a p53 homologue required for limb and epidermal
            morphogenesis
  JOURNAL   Nature 398 (6729), 708-713 (1999)
   PUBMED   10227293
REFERENCE   9  (bases 1 to 4968)
  AUTHORS   Yang,A., Kaghad,M., Wang,Y., Gillett,E., Fleming,M.D., Dotsch,V.,
            Andrews,N.C., Caput,D. and McKeon,F.
  TITLE     p63, a p53 homolog at 3q27-29, encodes multiple products with
            transactivating, death-inducing, and dominant-negative activities
  JOURNAL   Mol Cell 2 (3), 305-316 (1998)
   PUBMED   9774969
REFERENCE   10 (bases 1 to 4968)
  AUTHORS   Schmale,H. and Bamberger,C.
  TITLE     A novel protein with strong homology to the tumor suppressor p53
  JOURNAL   Oncogene 15 (11), 1363-1367 (1997)
   PUBMED   9315105
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from JAXUCZ010000011.1.
            
            On Nov 27, 2020 this sequence version replaced NM_019221.3.
            
            Summary: This gene encodes tumor protein p63, a member of the p53
            family of transcription factors involved in cellular responses to
            stress and development. The family members include p53, p63, and
            p73, which have high sequence similarity to one another. This
            similarity allows p63 and p73 to transactivate p53-responsive genes
            causing cell cycle arrest and apoptosis. The family members can
            interact with each other in many ways, including direct and
            indirect protein interactions. This results in mutual regulation of
            target gene promoters. Both alternative splicing and the use of
            alternative promoters result in multiple transcript variants
            encoding different protein isoforms.[provided by RefSeq, Dec 2009].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a, also known as TA2KETalpha).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y10258.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-209               JAXUCZ010000011.1  88553969-88554177   c
            210-338             JAXUCZ010000011.1  88480615-88480743   c
            339-471             JAXUCZ010000011.1  88479746-88479878   c
            472-726             JAXUCZ010000011.1  88417771-88418025   c
            727-913             JAXUCZ010000011.1  88373669-88373855   c
            914-1029            JAXUCZ010000011.1  88371839-88371954   c
            1030-1139           JAXUCZ010000011.1  88370402-88370511   c
            1140-1276           JAXUCZ010000011.1  88369598-88369734   c
            1277-1359           JAXUCZ010000011.1  88367591-88367673   c
            1360-1496           JAXUCZ010000011.1  88364831-88364967   c
            1497-1654           JAXUCZ010000011.1  88353084-88353241   c
            1655-1799           JAXUCZ010000011.1  88350700-88350844   c
            1800-1893           JAXUCZ010000011.1  88349375-88349468   c
            1894-4968           JAXUCZ010000011.1  88343651-88346725   c
FEATURES             Location/Qualifiers
     source          1..4968
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q22"
     gene            1..4968
                     /gene="Tp63"
                     /gene_synonym="Ket; P73l; Tp73l; Trp63"
                     /note="tumor protein p63"
                     /db_xref="GeneID:246334"
                     /db_xref="RGD:620863"
     exon            1..209
                     /gene="Tp63"
                     /gene_synonym="Ket; P73l; Tp73l; Trp63"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..2190
                     /gene="Tp63"
                     /gene_synonym="Ket; P73l; Tp73l; Trp63"
                     /note="isoform a is encoded by transcript variant 1; tumor
                     protein 63 kDa; transformation related protein 63;
                     keratinocyte transcription factor KET"
                     /codon_start=1
                     /product="tumor protein 63 isoform a"
                     /protein_id="NP_062094.1"
                     /db_xref="GeneID:246334"
                     /db_xref="RGD:620863"
                     /translation="MNFETSRCATLQYCPDPYIQRFIETPSHFSWKESYYRSAMSQST
                     QTSEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEPSENGATNKIEISMDCIRMQDSD
                     LSDPMWPQYTNLGLLNGMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALS
                     PSPAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTP
                     PPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYV
                     EDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQV
                     LGRRCFEARICACPGRDRKADEDSIRKQQVSDSAKNGDGTKRPFRQNTHGIQMTSIKK
                     RRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQ
                     TSMQSQSSYGNSSPPLNKMNSMNKLPSVSQLINPQQRNALTPTTMPEGMGANIPMMGT
                     HMPMAGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCLDYFT
                     TQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQLHDFSSPPHLLRTPSGAS
                     TVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWNDFNFDMDSRRNKQQRIKEEGE"
     exon            210..338
                     /gene="Tp63"
                     /gene_synonym="Ket; P73l; Tp73l; Trp63"
                     /inference="alignment:Splign:2.1.0"
     exon            339..471
                     /gene="Tp63"
                     /gene_synonym="Ket; P73l; Tp73l; Trp63"
                     /inference="alignment:Splign:2.1.0"
     exon            472..726
                     /gene="Tp63"
                     /gene_synonym="Ket; P73l; Tp73l; Trp63"
                     /inference="alignment:Splign:2.1.0"
     exon            727..913
                     /gene="Tp63"
                     /gene_synonym="Ket; P73l; Tp73l; Trp63"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1029
                     /gene="Tp63"
                     /gene_synonym="Ket; P73l; Tp73l; Trp63"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1139
                     /gene="Tp63"
                     /gene_synonym="Ket; P73l; Tp73l; Trp63"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1276
                     /gene="Tp63"
                     /gene_synonym="Ket; P73l; Tp73l; Trp63"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1359
                     /gene="Tp63"
                     /gene_synonym="Ket; P73l; Tp73l; Trp63"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1496
                     /gene="Tp63"
                     /gene_synonym="Ket; P73l; Tp73l; Trp63"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1654
                     /gene="Tp63"
                     /gene_synonym="Ket; P73l; Tp73l; Trp63"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1799
                     /gene="Tp63"
                     /gene_synonym="Ket; P73l; Tp73l; Trp63"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1893
                     /gene="Tp63"
                     /gene_synonym="Ket; P73l; Tp73l; Trp63"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..4968
                     /gene="Tp63"
                     /gene_synonym="Ket; P73l; Tp73l; Trp63"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggggaagt gtctaaactt ctatgtctga tggcatttga ccctattgct ttcagcctcc
       61 tggctatata cctagatatt ctcaggtgta tatgtatatt ttatagaatt gttccccatc
      121 tgttggtatc aaagagagtt gaaggaaatg aattttgaaa cttcacggtg tgctacccta
      181 cagtactgcc ctgaccctta catccagcgt ttcatagaaa ccccatctca tttctcctgg
      241 aaagaaagtt attaccggtc cgccatgtcg cagagcaccc agacaagtga gttcctcagc
      301 ccagaggtgt tccagcatat ctgggatttt ctggaacagc ctatatgctc agtacagccc
      361 atcgacttga actttgtgga cgaaccatca gaaaatggtg caacaaacaa gattgagatt
      421 agcatggatt gtatccgcat gcaagactca gacctcagtg accccatgtg gccacagtac
      481 acgaacctgg ggctcctgaa cggcatggac cagcagattc agaacggctc ctcatctacc
      541 agcccctata acacagacca tgcacagaac agcgtgacgg caccctcgcc ctatgcacag
      601 cccagctcaa ccttcgatgc cctttctcca tcccctgcca ttccctccaa cacagattac
      661 ccaggcccac acagcttcga tgtgtccttc cagcagtcaa gcaccgccaa gtcagctacc
      721 tggacgtatt ccaccgaact gaagaaactc tactgccaga ttgcaaagac ctgccccatc
      781 cagatcaagg tgatgacccc acccccacag ggcgccgtca ttcgtgccat gcctgtctac
      841 aagaaagccg agcatgtcac cgaggttgtg aaacgatgtc ctaaccacga gctgagccgc
      901 gagttcaatg agggacagat tgcccctccc agtcatctga ttcgagtaga agggaacagc
      961 catgcccagt atgtagaaga tcctatcaca ggaaggcaga gcgtgctggt cccttatgag
     1021 ccaccacagg ttggcactga attcacaaca gtcctgtaca atttcatgtg caacagcagc
     1081 tgtgtcggag gaatgaaccg ccgtccaatt ttaatcatcg ttactctgga aaccagagat
     1141 gggcaagtcc tgggccgacg ttgctttgag gcccggatct gcgcttgccc aggaagagac
     1201 cggaaggccg atgaagacag catcagaaag cagcaagtat cagacagcgc aaagaacggc
     1261 gatggtacga agcgcccttt ccgtcagaat acccacggaa tccagatgac ttccatcaag
     1321 aaacggagat ccccagatga tgagctgctg tacctaccag tgagaggccg tgagacttat
     1381 gaaatgctgc tcaagatcaa ggagtcgctc gagctcatgc agtatctccc tcagcacacg
     1441 atcgagacgt acaggcagca gcagcagcag cagcaccaac acctacttca gaaacagacc
     1501 tcgatgcagt ctcagtcttc atacggtaac agctcaccac ctctgaacaa aatgaacagc
     1561 atgaacaagc tgccgtctgt gagccagctt atcaacccac agcagcgcaa cgccctgact
     1621 cccaccacca tgcctgaggg catgggagcc aacattccta tgatgggcac tcacatgcca
     1681 atggctggag acatgaatgg actcagcccc acccaagctc ttcctcctcc actctccatg
     1741 ccctccacct cccactgcac ccccccacct ccgtacccaa cagactgcag cattgtcagt
     1801 ttcttagcaa ggttgggctg ttcatcatgt ctggactatt tcacgaccca ggggctgacc
     1861 accatctatc agattgagca ttactccatg gatgatttgg caagtctgaa gatccctgag
     1921 cagttccgac atgccatctg gaaggggatc ctggaccaca ggcagctgca tgacttctcc
     1981 tcacctccgc atctcctgag aacccccagt ggtgcctcta cagtcagtgt gggctccagt
     2041 gagacccgtg gagaacgtgt gattgatgcc gtgcgcttta ctctccgcca gaccatctct
     2101 ttcccacccc gtgatgagtg gaacgatttc aactttgaca tggattcccg tcgcaacaag
     2161 cagcagcgca tcaaagagga aggagaatga acgtccgtcg ccgggttctt cctgttttct
     2221 tcctcctccc agctcccaca gggcacgcct gcttgatcct caaagccttc tcgctagctc
     2281 tcctcctcct ccttctcagt ctggtttcta aagggacgga gaattaagag gctacctgtt
     2341 acctaaagtc tgacctgtca cctgattctg atcctggctt taagccttca atactcttgc
     2401 ttgcaagatg cgttgacatt gctagataga cgttagcaga gaagcagtgg gtctctctaa
     2461 gcactggaga tcgctcattg acttttataa agcattttca gccttatagt ctaagactat
     2521 atatataaat atataaatat acaatatata tttcgggtgg gggtattgag tattgtttaa
     2581 atgtaattta atggaaatcg agttgcactt atcaaccttc tttggaattt gcttgttttg
     2641 gttggctgat ctgtacccct ttctcagggg tatcatgtat ggtgacagat atttagagtt
     2701 gaatggtcta tgtgagtaac agtgatatat aggtcctctc ctttctttgg atgattgccg
     2761 tttagcacat caaacctgtg gatgcgtcca gtctgtttac cattgctcct tatgaggtaa
     2821 aactgcatat actgtcagtc tattttatgt tactggtgtc cattccagtt aggctggttc
     2881 actctgtggc cattccaagc aaaattttat gtttgctttg tcacacacta gaagacaggg
     2941 catcatctct tgcttttgtt tgagaatgag gagtactttt ttttttttct ggaaaatctt
     3001 aaatggtcca aatcagccat tccaaatggc tgatgaaatg tagccaatat agcagttagc
     3061 tctctaaaat ttaagaccca acaccctcgt atttattagt aaaacaaaaa tgaaacattt
     3121 gctgtcatta gagtagcctt aaaattaaat ttcaatacca gattgactga gtaaactatg
     3181 cattcaatgt tgttgtgaga attggggcta attagtcagg atgattggaa tttgtgtagt
     3241 tttttatggt gagttgcaat atctatttag gaaggttcag gaataataag aatgactcag
     3301 aaatactcaa tctccgtgac aacagaaagc aatctcacca aactctgaat ttaaacccct
     3361 tttgaaacat ggagtgaggc ttgggaaatg taccttttaa agactttcct atctataaga
     3421 cactgcatgc aggggcaagt ttaatctctc atcaaggtgg aaaataagaa tagtagctcg
     3481 gaaactacaa acttgctagt gtagctttca catggcatga gctcaactat tgttattttc
     3541 ctctttatca tcaaagctcc attgctgtag aaagcagagg tgaagaccca gttttccacc
     3601 tgacactttc cgggcaaggc atagaccaag aactgtctac aaaaccaggg caaagctctt
     3661 cagtgaagct gtttaattca catggagaaa cacttgtttc ccactttggg aaagcatgca
     3721 acagtgttcc ccctagatgt tttggaaaca ttttgagtca aatatatttt tcccagacta
     3781 aaccaggcta atgagctcta caatcctcct gcacattttg gtaaagggct gtcattgcac
     3841 aggagctccc atttttatct taaagtgcaa atgggctaat acgcctacga aatgtaatgt
     3901 atgggttttg ccagaaaata gtatattgtg tacacgtgtc tgtgtgtgag tgtgagagtg
     3961 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgaaattgca tactatgctg gttttgtttg
     4021 ttactctttc tcttggggat agttgggttt tccagaacca cagacgaaac ttttttttgt
     4081 tgctgttttt atatttttgc agaaacacca tttagtgaga attcaatgtc aaattagaca
     4141 tgacacctta attgtaagaa ggggggagag ggaaagttgg ttttttttaa ttttttaaaa
     4201 ttttgtatac taaagagaat gagtccttaa tttcaacatt ctgttgcatt taaataatga
     4261 taagcatcat taacttctgt aacaacttcc cagcttggca aattcaatgc atggagaaca
     4321 aagctgggcc ttagccatgt tagggagaaa aatggcttct tgggggttgt gagcatttgg
     4381 gttgctttag caccgttgag gtggcacagg ggactcctga ggcatttcag cactacttac
     4441 gtagcactag ggactcggaa attcctgtac tgtagctaat gattttggcg ttcaccatta
     4501 gcagtagata ggccgtttct ctcctcacac cagtgttaag cgtgtgagta gccagagctg
     4561 tggggaagag catggagaac agacgtctgc tggatgcctc tcaccggaga atgagattcc
     4621 ttcgcgtggt ggtgaagtag gataggaagc aggagtctcc ttgttagtcc agttagctat
     4681 tgttttcttg atattccccc ccaaaacatt gactatgaga gatatgtggg gcttttttat
     4741 ttttataatt gtacaaaatt aaacaaatat gaaatgtttt atatacttta ttaatgtttt
     4801 ttttcaaaag gtactttctt atagacatga tccttttttt acaggttcag ttgcttgtcc
     4861 cttggtattt ttgtgttatg ggctatggtg agcctgaggc aaatctataa gccatttttg
     4921 tttgccagga catgcaataa aatttaaaaa taaatgaaaa tacactga
//
