LOCUS       NM_001108606            1806 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus tumor protein p53 regulating kinase B (Tp53rkb),
            mRNA.
ACCESSION   NM_001108606 XM_342580
VERSION     NM_001108606.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1806)
  AUTHORS   Braun,D.A., Rao,J., Mollet,G., Schapiro,D., Daugeron,M.C., Tan,W.,
            Gribouval,O., Boyer,O., Revy,P., Jobst-Schwan,T., Schmidt,J.M.,
            Lawson,J.A., Schanze,D., Ashraf,S., Ullmann,J.F.P.,
            Hoogstraten,C.A., Boddaert,N., Collinet,B., Martin,G., Liger,D.,
            Lovric,S., Furlano,M., Guerrera,I.C., Sanchez-Ferras,O., Hu,J.F.,
            Boschat,A.C., Sanquer,S., Menten,B., Vergult,S., De Rocker,N.,
            Airik,M., Hermle,T., Shril,S., Widmeier,E., Gee,H.Y., Choi,W.I.,
            Sadowski,C.E., Pabst,W.L., Warejko,J.K., Daga,A., Basta,T.,
            Matejas,V., Scharmann,K., Kienast,S.D., Behnam,B., Beeson,B.,
            Begtrup,A., Bruce,M., Ch'ng,G.S., Lin,S.P., Chang,J.H., Chen,C.H.,
            Cho,M.T., Gaffney,P.M., Gipson,P.E., Hsu,C.H., Kari,J.A., Ke,Y.Y.,
            Kiraly-Borri,C., Lai,W.M., Lemyre,E., Littlejohn,R.O., Masri,A.,
            Moghtaderi,M., Nakamura,K., Ozaltin,F., Praet,M., Prasad,C.,
            Prytula,A., Roeder,E.R., Rump,P., Schnur,R.E., Shiihara,T.,
            Sinha,M.D., Soliman,N.A., Soulami,K., Sweetser,D.A., Tsai,W.H.,
            Tsai,J.D., Topaloglu,R., Vester,U., Viskochil,D.H.,
            Vatanavicharn,N., Waxler,J.L., Wierenga,K.J., Wolf,M.T.F.,
            Wong,S.N., Leidel,S.A., Truglio,G., Dedon,P.C., Poduri,A., Mane,S.,
            Lifton,R.P., Bouchard,M., Kannu,P., Chitayat,D., Magen,D.,
            Callewaert,B., van Tilbeurgh,H., Zenker,M., Antignac,C. and
            Hildebrandt,F.
  TITLE     Mutations in KEOPS-complex genes cause nephrotic syndrome with
            primary microcephaly
  JOURNAL   Nat Genet 49 (10), 1529-1538 (2017)
   PUBMED   28805828
REFERENCE   2  (bases 1 to 1806)
  AUTHORS   Wan,L.C., Maisonneuve,P., Szilard,R.K., Lambert,J.P., Ng,T.F.,
            Manczyk,N., Huang,H., Laister,R., Caudy,A.A., Gingras,A.C.,
            Durocher,D. and Sicheri,F.
  TITLE     Proteomic analysis of the human KEOPS complex identifies C14ORF142
            as a core subunit homologous to yeast Gon7
  JOURNAL   Nucleic Acids Res 45 (2), 805-817 (2017)
   PUBMED   27903914
REFERENCE   3  (bases 1 to 1806)
  AUTHORS   Abe,Y., Matsumoto,S., Wei,S., Nezu,K., Miyoshi,A., Kito,K.,
            Ueda,N., Shigemoto,K., Hitsumoto,Y., Nikawa,J. and Enomoto,Y.
  TITLE     Cloning and characterization of a p53-related protein kinase
            expressed in interleukin-2-activated cytotoxic T-cells, epithelial
            tumor cell lines, and the testes
  JOURNAL   J Biol Chem 276 (47), 44003-44011 (2001)
   PUBMED   11546806
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Dec 8, 2020 this sequence version replaced NM_001108606.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.1453920.1,
                                           SRR26360186.2280118.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-888               JAXUCZ010000003.1  175948368-175949255
            889-1806            JAXUCZ010000003.1  175950815-175951732
FEATURES             Location/Qualifiers
     source          1..1806
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..1806
                     /gene="Tp53rkb"
                     /gene_synonym="Tp53rk; Trp53rk; Trp53rkb"
                     /note="tumor protein p53 regulating kinase B"
                     /db_xref="GeneID:362272"
                     /db_xref="RGD:1304911"
     exon            1..888
                     /gene="Tp53rkb"
                     /gene_synonym="Tp53rk; Trp53rk; Trp53rkb"
                     /inference="alignment:Splign:2.1.0"
     CDS             633..1367
                     /gene="Tp53rkb"
                     /gene_synonym="Tp53rk; Trp53rk; Trp53rkb"
                     /EC_number="2.7.11.1"
                     /note="TP53 regulating kinase; TP53 regulating kinase B;
                     transformation related protein 53 regulating kinase B"
                     /codon_start=1
                     /product="TP53-regulating kinase"
                     /protein_id="NP_001102076.1"
                     /db_xref="GeneID:362272"
                     /db_xref="RGD:1304911"
                     /translation="MAGASSEAEAEALAAARERSRLFLSGLELVQQGAEARVFRGRFQ
                     GRAAVVKHRFPKGYRHPELEARLGRRRTVQEARALLRCRRAGIAAPVVFFVDYASNCL
                     YMEEIEDSVTVRDYIQSTMETKQDPQCLLDLARKIGQVLARLHDEDLIHGDLTTSNML
                     LTRPLEQLHIVLIDFGLSFVSGLPEDKGVDLYVLEKAFLSTHPHTETVFEAFLKSYGA
                     SSKKSDPVLKKLDEVRLRGRKRSMVG"
     exon            889..1806
                     /gene="Tp53rkb"
                     /gene_synonym="Tp53rk; Trp53rk; Trp53rkb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcatgtgaag aaagtctcta tccaccggca ccttgtaacc agcctcttat ttaattcggt
       61 taagccctta ccccagcaga accaggcaac atcattctga agagtaggaa accggaacca
      121 ggatggtagc ggctactgac gtcagatgct attggcgtca tcaagtagaa agctttgcct
      181 agtctgtctt tccctcttgg attatacagt gtgtttccgt ggtttgatgc gtgaggatca
      241 tgagttcaaa gctaacctga gatacacagt gagtttctgt ctttaaaaag taaaggattt
      301 ttctatgcta gtagaaagga gcagagtatc cccaccagaa aggatcccaa actcagcatc
      361 gccaacgagc ttcctgagag agccaaagag agagaagctg ttgagtaaaa gttgcagagc
      421 gctcacggag atagaaaaag aacttcagga agggccaagt cgtcagatcc gagaggctcc
      481 gcagagcgcg gaagggtcgc gaggcggaac cactcttgca gggtaaagtt gttggggggc
      541 gggggggggc ggcggtgttc atagcggaag aagccggagg atttccgaag cgagcggaag
      601 cggcgcggtc cgggtccaaa ccagccgaaa gcatggctgg cgcgtcttcg gaggcggagg
      661 cggaggcgct ggccgcggcg cgcgagcgga gccgcctctt cctgagcggc ctggagctgg
      721 tgcagcaggg cgccgaggct cgagtgttcc gtggccgctt ccagggccga gcggccgtgg
      781 tgaagcaccg cttccctaag ggctaccggc acccggagct ggaggcgcgg ctcggccggc
      841 ggcggacggt tcaggaggct cgcgcgctgt tgcgctgccg ccgtgcggga atagctgccc
      901 ccgtcgtctt ctttgtggac tatgcttcta actgcctata tatggaagaa atcgaagact
      961 cggtgactgt tcgagattat attcaatcca ctatggagac taaacaagac ccccaatgcc
     1021 tcttggactt ggccaggaag atcgggcagg ttctggccag actgcatgac gaggacctca
     1081 ttcacgggga cctcaccacc tccaacatgc tcctgacacg gcccctggag cagctgcaca
     1141 tcgtgctcat cgacttcggg ctgagttttg tctcaggact gccagaagac aaaggcgtag
     1201 acctctatgt cctggagaaa gccttcctca gcacgcaccc ccacactgag actgtgtttg
     1261 aagcctttct gaagagttac ggtgcctcat ccaagaagtc cgatccagtg ctgaagaagt
     1321 tagatgaggt gcgcctgaga gggcgaaagc ggtccatggt tgggtagcgg agctgtggtg
     1381 actggctcac agtgaaggat gatgtagacg aggctggacc tcagcaaagc gtggggtcgt
     1441 taagtggtct gtgatcatac tgggacacca ccatccttgg ctcactgttc tcaggggctt
     1501 cgtgttcatg agatttattc taggcagaac tgggtgggta gcccaggcta gccttgaatt
     1561 tgtggcagca tcttgcctca gcttgctggg aggaggttat aaaccaccat acctgacttt
     1621 gcactgattc tgtaagaaac aaaacatcta tgattacatt tatttttata tctttttata
     1681 tttatttcgt gtgcctgtgc aaatgtgtac atggaggtca gagagtcaga tctctggttc
     1741 tgcattgtag aatctgtcat atggattcca gggtgattaa attaaattaa aattaaatcc
     1801 aggtga
//
