LOCUS       NM_001270947            4035 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus tumor protein p53 inducible nuclear protein 2
            (Tp53inp2), mRNA.
ACCESSION   NM_001270947 XM_001074013
VERSION     NM_001270947.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4035)
  AUTHORS   Shi,J., Qin,S., Wang,R., Zhang,Z., Li,H. and Hao,C.
  TITLE     MicroRNA-362-3p Implicated in Cardioprotection Against
            Hypoxia/Reoxygenation-Induced Cardiomyocyte Apoptosis by Repressing
            TP53INP2 and Regulating SDF-1/CXCR4 Pathway
  JOURNAL   Altern Ther Health Med 29 (3), 254-261 (2023)
   PUBMED   36933242
  REMARK    GeneRIF: MicroRNA-362-3p Implicated in Cardioprotection Against
            Hypoxia/Reoxygenation-Induced Cardiomyocyte Apoptosis by Repressing
            TP53INP2 and Regulating SDF-1/CXCR4 Pathway.
REFERENCE   2  (bases 1 to 4035)
  AUTHORS   Crerar,H., Scott-Solomon,E., Bodkin-Clarke,C., Andreassi,C.,
            Hazbon,M., Logie,E., Cano-Jaimez,M., Gaspari,M., Kuruvilla,R. and
            Riccio,A.
  TITLE     Regulation of NGF Signaling by an Axonal Untranslated mRNA
  JOURNAL   Neuron 102 (3), 553-563 (2019)
   PUBMED   30853298
  REMARK    GeneRIF: Tp53inp2 is an atypical mRNA that regulates axon growth by
            enhancing NGF-TrkA signaling in a translation-independent manner.
REFERENCE   3  (bases 1 to 4035)
  AUTHORS   Seldin,M.M., Kim,E.D., Romay,M.C., Li,S., Rau,C.D., Wang,J.J.,
            Krishnan,K.C., Wang,Y., Deb,A. and Lusis,A.J.
  TITLE     A systems genetics approach identifies Trp53inp2 as a link between
            cardiomyocyte glucose utilization and hypertrophic response
  JOURNAL   Am J Physiol Heart Circ Physiol 312 (4), H728-H741 (2017)
   PUBMED   28235788
  REMARK    GeneRIF: Trp53inp2 gene knockdown in rat cardiomyocytes reduced
            expression and protein abundance of key glycolytic enzymes
REFERENCE   4  (bases 1 to 4035)
  AUTHORS   Sala,D., Ivanova,S., Plana,N., Ribas,V., Duran,J., Bach,D.,
            Turkseven,S., Laville,M., Vidal,H., Karczewska-Kupczewska,M.,
            Kowalska,I., Straczkowski,M., Testar,X., Palacin,M., Sandri,M.,
            Serrano,A.L. and Zorzano,A.
  TITLE     Autophagy-regulating TP53INP2 mediates muscle wasting and is
            repressed in diabetes
  JOURNAL   J Clin Invest 124 (5), 1914-1927 (2014)
   PUBMED   24713655
REFERENCE   5  (bases 1 to 4035)
  AUTHORS   Yasin,S.A., Ali,A.M., Tata,M., Picker,S.R., Anderson,G.W.,
            Latimer-Bowman,E., Nicholson,S.L., Harkness,W., Cross,J.H.,
            Paine,S.M. and Jacques,T.S.
  TITLE     mTOR-dependent abnormalities in autophagy characterize human
            malformations of cortical development: evidence from focal cortical
            dysplasia and tuberous sclerosis
  JOURNAL   Acta Neuropathol 126 (2), 207-218 (2013)
   PUBMED   23728790
REFERENCE   6  (bases 1 to 4035)
  AUTHORS   Sancho,A., Duran,J., Garcia-Espana,A., Mauvezin,C., Alemu,E.A.,
            Lamark,T., Macias,M.J., DeSalle,R., Royo,M., Sala,D., Chicote,J.U.,
            Palacin,M., Johansen,T. and Zorzano,A.
  TITLE     DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family
            encoding dual regulators of autophagy and transcription
  JOURNAL   PLoS One 7 (3), e34034 (2012)
   PUBMED   22470510
  REMARK    Erratum:[PLoS One. 2012 May;7(5):
            doi/10.1371/annotation/f2e121d7-0878-44b1-a5c2-994231626fe1]
REFERENCE   7  (bases 1 to 4035)
  AUTHORS   Linares,G.R., Xing,W., Burghardt,H., Baumgartner,B., Chen,S.T.,
            Ricart,W., Fernandez-Real,J.M., Zorzano,A. and Mohan,S.
  TITLE     Role of diabetes- and obesity-related protein in the regulation of
            osteoblast differentiation
  JOURNAL   Am J Physiol Endocrinol Metab 301 (1), E40-E48 (2011)
   PUBMED   21467300
REFERENCE   8  (bases 1 to 4035)
  AUTHORS   Nowak,J., Archange,C., Tardivel-Lacombe,J., Pontarotti,P.,
            Pebusque,M.J., Vaccaro,M.I., Velasco,G., Dagorn,J.C. and
            Iovanna,J.L.
  TITLE     The TP53INP2 protein is required for autophagy in mammalian cells
  JOURNAL   Mol Biol Cell 20 (3), 870-881 (2009)
   PUBMED   19056683
REFERENCE   9  (bases 1 to 4035)
  AUTHORS   Guo,Z., Linn,J.F., Wu,G., Anzick,S.L., Eisenberger,C.F.,
            Halachmi,S., Cohen,Y., Fomenkov,A., Hoque,M.O., Okami,K.,
            Steiner,G., Engles,J.M., Osada,M., Moon,C., Ratovitski,E.,
            Trent,J.M., Meltzer,P.S., Westra,W.H., Kiemeney,L.A.,
            Schoenberg,M.P., Sidransky,D. and Trink,B.
  TITLE     CDC91L1 (PIG-U) is a newly discovered oncogene in human bladder
            cancer
  JOURNAL   Nat Med 10 (4), 374-381 (2004)
   PUBMED   15034568
  REMARK    Erratum:[Nat Med. 2004 Oct;10(10):1139]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Aug 14, 2012 this sequence version replaced XM_001074013.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.15116.1,
                                           SRR26360194.2076124.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               JAXUCZ010000003.1  164342137-164342333
            198-372             JAXUCZ010000003.1  164345592-164345766
            373-661             JAXUCZ010000003.1  164346197-164346485
            662-4035            JAXUCZ010000003.1  164346897-164350270
FEATURES             Location/Qualifiers
     source          1..4035
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..4035
                     /gene="Tp53inp2"
                     /gene_synonym="Trp53inp2"
                     /note="tumor protein p53 inducible nuclear protein 2"
                     /db_xref="GeneID:362246"
                     /db_xref="RGD:735085"
     exon            1..197
                     /gene="Tp53inp2"
                     /gene_synonym="Trp53inp2"
                     /inference="alignment:Splign:2.1.0"
     exon            198..372
                     /gene="Tp53inp2"
                     /gene_synonym="Trp53inp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..914
                     /gene="Tp53inp2"
                     /gene_synonym="Trp53inp2"
                     /note="diabetes and obesity-regulated"
                     /codon_start=1
                     /product="tumor protein p53-inducible nuclear protein 2"
                     /protein_id="NP_001257876.1"
                     /db_xref="GeneID:362246"
                     /db_xref="RGD:735085"
                     /translation="MFQRFTSLFFSTPAPPEDSNCPGAFVSEEDEVDGWLIIDLQDSY
                     TAPPDPRASPAPAGRPPPAPSLMDESWFVTPPACFTAEGPGLGPARLQSNPLEDLLIE
                     HPSMSVYVTGSTIVLESGPPSPHPEAALPDQDLSDGELAPARREPRALHHAAAPMPAR
                     AVLLEKAGQVRRLQRARQRAERHTLSAKVLQRQNRARESRSRRPKHQGSFIYQPCQRQ
                     FNY"
     exon            373..661
                     /gene="Tp53inp2"
                     /gene_synonym="Trp53inp2"
                     /inference="alignment:Splign:2.1.0"
     exon            662..4035
                     /gene="Tp53inp2"
                     /gene_synonym="Trp53inp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acaatcagct gttgaagcgt tcggatttgt gccctgagcc ccggctgcag cggccgcagc
       61 agctccgggc gtccgttcgc gagccccgcc gtctctcggc ctgtccccgg tatgcagctc
      121 cggttgtgag caccggcgac ccggggacgc ccggccgcac aactacctca gcgcagcggt
      181 tgctgcagcg gccccaggtc tttgaactgc catagggcgc ccccttgagg ttgcttcacc
      241 cgctgaccat gttccagcgc ttcaccagcc ttttctttag cacccccgca cctcctgaag
      301 actccaactg tccgggggcc tttgtctctg aggaggatga agtggacggc tggctcatca
      361 ttgacctaca ggacagctat acagctccac ccgaccccag ggcctctcct gctcctgcag
      421 gccgcccccc acccgcgccc tccttgatgg acgagagctg gtttgttacc cctcccgcct
      481 gttttactgc agaggggccc ggccttgggc ctgcccgcct ccagagcaat cccctggagg
      541 acctcctcat tgagcatccc agcatgtccg tttatgtcac cggcagcacc atagtgctgg
      601 agtctgggcc accttcccct caccctgaag ctgccttgcc tgatcaggac ctcagcgatg
      661 gagagctggc gcctgcccgc cgggagccta gggccctgca ccacgcagct gcccctatgc
      721 cggctcgagc tgtgctgctg gagaaggctg gccaggtgcg gaggctgcag agagcccgac
      781 agcgcgccga gcgccacaca ctgagtgcta aagtgttgca acggcagaat cgcgcccggg
      841 agagccgttc gcgccggccc aagcaccagg gcagcttcat ttaccagccg tgccagcgcc
      901 agttcaacta ctgagcgccc ccgctgcacc gcgaatccct cgtcgtctct tggtcccttc
      961 tgcctcctct gtagcagcca gtgtgctgct caaggggtat tcagggtccg cccgcctcca
     1021 tccggatacc acaacctccc tccttcctaa gttttgaggt gggatgatgg ccctctactt
     1081 ccctgtttct gatctaactc acctattaac ctctctcatc ctcgtcctcc ctccccaagt
     1141 gtctgactca cactccccac gcctcgtctc ccatgcttcc ttttcagacc cctatttctg
     1201 tctctcgctc cttcactttt tccctcttag cccaccggat ttctaagagc ctctcacacc
     1261 ctgacctggc gcattctcca ctttcagctc ctactttcca agacttactc ttctctgttt
     1321 gggatcgctc ccactcctgt tccttttttt tttttcattc ctggcaattc cctcccaatc
     1381 ctgcaggtac agcctgccag gcctgggcca ttgtccttac cctgcagtca gggatcaggc
     1441 acggttttga tttcagcttt ccccttttct ctgccctggg ggctgggctc cttcttgctg
     1501 cttaggccta gaaagtttaa gtatgtggaa gaggacggtg agttgtaagt tagataaggt
     1561 gaagggaatg gagggaaaaa agcagcctat tgggagactc aggcaggggc agatgggttg
     1621 agaagcagaa gggagcaggg catcttgaga gctggcattg tgcttggtca gaggagctaa
     1681 gccctggtct taggcctgag cctggagtct gcccccattt ccttttccta taatcctgcc
     1741 ttccaggttt ttttcctgaa gtctgtccct cttcaggagt aacccctacc catccccacc
     1801 cctgtgagtc tggagtccga agggcttgta ccttgtcacc ttaccttgac atgccacccc
     1861 aggagtagaa gctgggtaag gccccaatat cctggccatc tctgttcata tgcccaaggt
     1921 gctagaatta gcttaggaga gatgcaggcc agagggtttg caggcaggga gaaggacacc
     1981 ttaccccaag gcaagaatgc agagaggcat gatgctaagg aggaattaat gatgctaagg
     2041 agggattatg gggtaaagcc gtccccagac tgacagtccc ctgccttcat cttgcctctg
     2101 gccttatatt tcatactctg ttcaatatgg ctggggaata aacactcctg ggtagaggag
     2161 gtcaggagcc tcagtgtcca gattcccaaa tttttcttac agagattcag ggccttcaag
     2221 agtcttctta atgttctccc acagggctct ttctttgagt gccctatgat ccctcttccc
     2281 tttctagtta aatatcagga gtaaggaatt tcttggttag gacacaggga tggggtagcc
     2341 agcttctccc ttcttgtggt ggggctcaga caccagcaac agcctcttgg gatgccccaa
     2401 gttgtctcca gttctttcta gctgtccttt tttaagtgtg tgctcttcct tccttaaaac
     2461 ccctagattt cctgttacat actaacacag gtcttccctt tcactccaac cccaggtttc
     2521 aggcctcaga gccatgctgg ggttggagaa aactgcattc ctatgagggt aaaaagtagc
     2581 tgccctctct gaccctttct tgctaggctt catgcgggat gggagagggt atccccagga
     2641 tggggacaga ggaagcctgg ctagggcctt ctagcccaat aagccaaaca ggaactataa
     2701 gcagatcaaa atcctacact agcttattag ggccctgtta gttgaaaacc ttgttgctgt
     2761 cccaagttct tcagttacaa ccgagtacac ttactcttcc aactgtccta agggtcacta
     2821 cccagccagc tttggatctt cagcactttt aaaagctgaa actccctctt gcccttcttg
     2881 tctattcctc actgccagtt ggggcctagg ctcagtcctg ggcaaatgcc catgatcctg
     2941 ctgctgtggg aagtttgata gggcatttgg ctcaaatttc aaaaggcctc gctcctgacc
     3001 tgatttctcg aagctccagt agttctagac ccctccaatc tctcatctga ctggttgcaa
     3061 ggcttatttt tcttttgtac tttcctatag agcatttctg tagcatttga gtgtggcgat
     3121 atttttgttg tgtgtagatt tctaagaacc aacactactc agtctcctgc tagtctgact
     3181 cctgaagcat cagacctcgt catacggtat tgactgtgta tgtgcctttc accttgagca
     3241 tgcttcagga ttttttttct taaaccacag aacttgaata cacaagggaa ccagaattca
     3301 caaagtccta tgcaacccta gacaggagga ggttagagag tctgtcttga ttggtgattt
     3361 cagagaccct agagaaattt gtaccagttt gtattaatgt cagtactacc agcactttgc
     3421 caaaactaag gatgtcagag ggacctgttt ctagagtgag tcccaattac atcaaagggc
     3481 aacttacagc tttctccagt aagtctgagt ggttctcttg agctggtgtc actttctaac
     3541 ctttgccagt ctagcccagc agggccctgt gtgtgtgagt gcagtttggt gctgttttgg
     3601 agtatgcctg ctccccagcc tggaaccctc tcagcaactt gctgggacct ataatgtctt
     3661 aggtgcaaca aggaccctac cagagctcct gggtggcttt caagatccac gtagctttgt
     3721 gtgaggggac tgaatgcaga caaaccacag cctgcttcaa ataccttctt tccctaccac
     3781 ctagttccaa atggaaccaa caagttgagt gcatctctgt tgggtgtttt gtgttgagac
     3841 tggctgaagt gaaaactctt tgactgacca tgttgtgatg tgtcgacaga ctcaaggaca
     3901 caaccacctc gacctggtca tgtggcatgc ctgtgtatgt gtgtaacagg attctgaatg
     3961 ttaggttgta atgctattcc tgtatgggag aaaaaaataa tataaacaaa taaaaatcta
     4021 tttaaagcac attaa
//
