LOCUS       NM_181084               5433 bp    mRNA    linear   ROD 18-DEC-2020
DEFINITION  Rattus norvegicus tumor protein p53 inducible nuclear protein 1
            (Tp53inp1), mRNA.
ACCESSION   NM_181084 XM_006237868
VERSION     NM_181084.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5433)
  AUTHORS   Li XQ, Yu Q, Tan WF, Zhang ZL and Ma H.
  TITLE     MicroRNA-125b mimic inhibits ischemia reperfusion-induced
            neuroinflammation and aberrant p53 apoptotic signalling activation
            through targeting TP53INP1
  JOURNAL   Brain Behav Immun 74, 154-165 (2018)
   PUBMED   30193876
  REMARK    GeneRIF: IR-induced alterations in hind-limb motor function were
            closely related to the temporal changes in miR-125b and TP53INP1
            expression. The miR-125b/TP53INP1 gene pair was confirmed by
            luciferase assay.
REFERENCE   2  (bases 1 to 5433)
  AUTHORS   He W, Huang H, Xie Q, Wang Z, Fan Y, Kong B, Huang D and Xiao Y.
  TITLE     MiR-155 Knockout in Fibroblasts Improves Cardiac Remodeling by
            Targeting Tumor Protein p53-Inducible Nuclear Protein 1
  JOURNAL   J Cardiovasc Pharmacol Ther 21 (4), 423-435 (2016)
   PUBMED   26589288
REFERENCE   3  (bases 1 to 5433)
  AUTHORS   Chen Q, Zhou Y, Richards AM and Wang P.
  TITLE     Up-regulation of miRNA-221 inhibits hypoxia/reoxygenation-induced
            autophagy through the DDIT4/mTORC1 and Tp53inp1/p62 pathways
  JOURNAL   Biochem Biophys Res Commun 474 (1), 168-174 (2016)
   PUBMED   27105917
  REMARK    GeneRIF: In conclusion, miRNA-221 exerts cytoprotective effects in
            hypoxia-reoxygenation injury in association with alterations in
            autophagic cell injury. Mir-221 may constitute is a novel
            therapeutic target in the treatment of cardiac I/R injury.
REFERENCE   4  (bases 1 to 5433)
  AUTHORS   Seillier M, Peuget S, Gayet O, Gauthier C, N'Guessan P, Monte M,
            Carrier A, Iovanna JL and Dusetti NJ.
  TITLE     TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family
            proteins through the LC3-interacting region (LIR) and promotes
            autophagy-dependent cell death
  JOURNAL   Cell Death Differ 19 (9), 1525-1535 (2012)
   PUBMED   22421968
REFERENCE   5  (bases 1 to 5433)
  AUTHORS   Sancho A, Duran J, Garcia-Espana A, Mauvezin C, Alemu EA, Lamark T,
            Macias MJ, DeSalle R, Royo M, Sala D, Chicote JU, Palacin M,
            Johansen T and Zorzano A.
  TITLE     DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family
            encoding dual regulators of autophagy and transcription
  JOURNAL   PLoS One 7 (3), e34034 (2012)
   PUBMED   22470510
  REMARK    Erratum:[PLoS One. 2012 May;7(5):
            doi/10.1371/annotation/f2e121d7-0878-44b1-a5c2-994231626fe1]
REFERENCE   6  (bases 1 to 5433)
  AUTHORS   Seux M, Peuget S, Montero MP, Siret C, Rigot V, Clerc P, Gigoux V,
            Pellegrino E, Pouyet L, N'Guessan P, Garcia S, Dufresne M, Iovanna
            JL, Carrier A, Andre F and Dusetti NJ.
  TITLE     TP53INP1 decreases pancreatic cancer cell migration by regulating
            SPARC expression
  JOURNAL   Oncogene 30 (27), 3049-3061 (2011)
   PUBMED   21339733
REFERENCE   7  (bases 1 to 5433)
  AUTHORS   Cano CE, Gommeaux J, Pietri S, Culcasi M, Garcia S, Seux M,
            Barelier S, Vasseur S, Spoto RP, Pebusque MJ, Dusetti NJ, Iovanna
            JL and Carrier A.
  TITLE     Tumor protein 53-induced nuclear protein 1 is a major mediator of
            p53 antioxidant function
  JOURNAL   Cancer Res 69 (1), 219-226 (2009)
   PUBMED   19118006
REFERENCE   8  (bases 1 to 5433)
  AUTHORS   Tomasini R, Seux M, Nowak J, Bontemps C, Carrier A, Dagorn JC,
            Pebusque MJ, Iovanna JL and Dusetti NJ.
  TITLE     TP53INP1 is a novel p73 target gene that induces cell cycle arrest
            and cell death by modulating p73 transcriptional activity
  JOURNAL   Oncogene 24 (55), 8093-8104 (2005)
   PUBMED   16044147
REFERENCE   9  (bases 1 to 5433)
  AUTHORS   Tomasini R, Samir AA, Carrier A, Isnardon D, Cecchinelli B, Soddu
            S, Malissen B, Dagorn JC, Iovanna JL and Dusetti NJ.
  TITLE     TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are
            partners in regulating p53 activity
  JOURNAL   J Biol Chem 278 (39), 37722-37729 (2003)
   PUBMED   12851404
REFERENCE   10 (bases 1 to 5433)
  AUTHORS   Tomasini R, Samir AA, Vaccaro MI, Pebusque MJ, Dagorn JC, Iovanna
            JL and Dusetti NJ.
  TITLE     Molecular and functional characterization of the stress-induced
            protein (SIP) gene and its two transcripts generated by alternative
            splicing. SIP induced by stress and promotes cell death
  JOURNAL   J Biol Chem 276 (47), 44185-44192 (2001)
   PUBMED   11557757
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AABR07047217.1.
            
            [WARNING] On Jun 29, 2023 this sequence was replaced by
            NM_181084.4.
            
            On or before Dec 2, 2020 this sequence version replaced
            XM_006237868.2, NM_181084.2.
            
            Summary: displays increased expression in response to stress [RGD,
            Feb 2006].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ141284.1, FQ133399.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00052296, SAMD00052297
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               AABR07047217.1     11290-11398
            110-367             AABR07047217.1     19242-19499
            368-725             AABR07047217.1     20012-20369
            726-5433            AABR07047217.1     24866-29573
FEATURES             Location/Qualifiers
     source          1..5433
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="mixed"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q13"
     gene            1..5433
                     /gene="Tp53inp1"
                     /gene_synonym="Stinp; Trp53inp1"
                     /note="tumor protein p53 inducible nuclear protein 1"
                     /db_xref="GeneID:297822"
                     /db_xref="RGD:631423"
     exon            1..109
                     /gene="Tp53inp1"
                     /gene_synonym="Stinp; Trp53inp1"
                     /inference="alignment:Splign:2.1.0"
     exon            110..367
                     /gene="Tp53inp1"
                     /gene_synonym="Stinp; Trp53inp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..975
                     /gene="Tp53inp1"
                     /gene_synonym="Stinp; Trp53inp1"
                     /note="TEAP; transformation related protein 53 inducible
                     nuclear protein 1; p53DINP1; stress-induced protein;
                     thymus-expressed acidic protein; p53-dependent
                     damage-inducible nuclear protein 1"
                     /codon_start=1
                     /product="tumor protein p53-inducible nuclear protein 1"
                     /protein_id="NP_851598.2"
                     /db_xref="GeneID:297822"
                     /db_xref="RGD:631423"
                     /translation="MFQRLNKMFVGEVTTSSSHEPEFSEKEDDEWILVDFIDTCTGFS
                     AEEEEEDEDIGEESSAEHTSVFSCLPTSLECLADTSDSCFLQFESCPMEESWFITPPP
                     CFTAGGLTTIKVETSPMENLLIEHPSMSVYAVHNSCPGLSEASCGNDDYNSSGPRMEA
                     QSELGTHIHCCVAALAAQATFLEQPKSFRPSQWIKGHSERQSLNRNGLRRQNLTRDYH
                     TRQMKHSGWVVHQPCPRQYNY"
     exon            368..725
                     /gene="Tp53inp1"
                     /gene_synonym="Stinp; Trp53inp1"
                     /inference="alignment:Splign:2.1.0"
     exon            726..5433
                     /gene="Tp53inp1"
                     /gene_synonym="Stinp; Trp53inp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acaacaacaa aaggacccgg acgggccggc ggccgccagg gcagcgaccg cagcgcagga
       61 gcccggcccg ccgcagctac ctcagcgccc gccgcgccgc tcggctcacg gatgatgact
      121 cttcctgctc ctcacctaag ctgaaaaaac actgtgcact ttaatttccc gcctgtaacc
      181 ttgggccagc tggagacagg gttttgaaat ctcagctata aagataccca gccaaagtct
      241 catcttgcct taacaatgtt tcagagactg aataaaatgt ttgtaggtga agtcactact
      301 tcttccagcc acgagccaga atttagtgag aaagaagatg atgagtggat tcttgttgac
      361 ttcatagata cctgcactgg tttctcagca gaagaagagg aggaagatga agacattggt
      421 gaagagtcct cagcagagca cacttctgtc ttctcctgtt tacctacatc tttggagtgc
      481 ttggctgaca ccagcgattc ctgcttcctt cagtttgagt cctgtccaat ggaggagagc
      541 tggttcatca ctcctccccc atgttttaca gcagggggat taaccactat caaagtggaa
      601 acaagtccta tggaaaacct tctcattgaa catcccagca tgtctgtcta tgctgtgcac
      661 aactcctgtc ctggtctcag tgaagctagc tgtgggaacg atgactataa ctcaagtggt
      721 cccagaatgg aagcccagag tgaactgggg acgcacattc actgctgtgt tgcagcgctt
      781 gctgctcagg caaccttttt ggaacaaccc aagagttttc gcccttccca gtggataaaa
      841 ggacacagtg aaagacagtc tctgaacaga aatggcctcc gtcgccagaa ccttaccagg
      901 gattaccaca ctcgacaaat gaagcacagt ggctgggtgg ttcaccagcc ctgcccacgc
      961 cagtacaatt actgagaagg ctgagttatg ttggttggct tccttaggtt ttgtgcatat
     1021 gtattggatg tatgtgcata caatcaaagt gctgcctctt tccagccaac tgaagaccaa
     1081 tcgcttagtg tatcggtgtg tttagacact atcacaacca gatttttgtg ctgtgtatca
     1141 caaaatgcct tgctcctgac aattactttt aaaaaacctt ttcagaatat ttttggaaac
     1201 atatcaatac agtgacagtg tttggggttg tctttaagta caataaggta tatatatata
     1261 tgagttagca tcttaaggac atttctcacc ccaagtataa gaataggcat cttctcaatt
     1321 tcctttattt tgtattattt aatcttttgt gtaagcaaaa atttattctc agggtcagcc
     1381 atatacttta ttgaccagta cttgttagtc ttttctgtat ataatgagta catttttaca
     1441 ctaacacgag cattaacagg tgattttttt ttttttgcca tggatataat ggaattaatg
     1501 gctgaactta cctttgaaag aaaacttgac atatttctgt atgtatggtt cctccccccc
     1561 cccccagatt aagtcattgc agttcattgt ggaattcagg tacattaact ttggtgaaca
     1621 acattattca gtaattctga tgtgactcca tgatatggta caaatactac agatgttgtg
     1681 gagtaaagca cttgtttcat atgcaaaggg gaaaatcaga cccaggagat agtgtttgga
     1741 atctgtttgt agataatgag aagagcagtc agtatttgga gatgtctaga gttttaactg
     1801 ccagcttagt tgaaaatgca caagtgtgtg cccaagcact cagtgactag atgctcatgt
     1861 ctgccacaag acagggaggg acacagtgat aactcctcag acatggactc tgtcctccca
     1921 agggatttct ggtggcatct gtttatagca cccaagtgaa gactgatggg ttcatttcta
     1981 caagctttca tttttcaact tcacaatatc tttaaccact ttggcctctg tttcctccac
     2041 agcaggggag taataatact tacctccctc acagagttgt gaggattata tactgatggg
     2101 aggtggggct gtcagaactg aactctgtga acttccaggg tctttctact gaacctagtt
     2161 gtgggaagcc tgacagtttc ctgccatgat tattcttcag ggttggtgct aatgaggcta
     2221 gagtgcaggg ctccactcat atataccagt taacggcatg tagaggaaag tccattttct
     2281 taacctctat ctggtcagtt ctttttaaaa gcagttttgg tggattttga tgagccagct
     2341 ataatttctg gaaaattaaa ctcatataca gcttgaagcg cattctactg aggacagtac
     2401 cattgcctat atattcaaac tgctcatttc cctagcccct ctgcaaccat aactaaacat
     2461 ttgtttatta aataatttca aggaaaaaag atactgttat gtgaaggatt atccttgaag
     2521 cagcttgatg cagggagccc tgagagactt tcaggaagga acagtgctcc cctctgacaa
     2581 ggctggcgtt tagagctgca gttagatgtt gaagggtatt ctgaacaaac actggctgtg
     2641 attaggtgcc cggatgtctc tttagaacaa ggatctagat ttcttcttcc ttaatccttt
     2701 tccatactga ctcccccttt tatttattgg ttttctaatt aagggccaag tcggtaaagt
     2761 ttgttaaact gagaagttgt ttctatctgt tctcatggag gtgtgcacat tttatactac
     2821 agctgttata gggtcatatg ttggtaactt gaagtggacc agctaagtgt cttctggaca
     2881 tgctctgaaa acatgtagct ttccccctac ttccttacat cacatgcaag ccgtgtctca
     2941 caaatcagaa tctgtttggc cagtatgaat tggtttgtgt attaaaatac agtgggtttt
     3001 tttttcccac cacatttatt catcccttaa gtacacttac atctctgtta gttactgact
     3061 tttcatttgc tttgtgtatg cttggggttt tttcctgaaa accagcaaac aaatcaatta
     3121 ttgggatttt ttttcccctt tgggggtaag attaccacac cacatatcat aagtaggtaa
     3181 cacactggtt tttgtctgag aatctaaagt ttatgtctaa acttggcact tataagaact
     3241 gaagaaaaag gttacgtatc tcatttgaag ttcttagtca ttaggtgttt tgttaggcaa
     3301 ttactgtgtg ttagctacaa gtctaataac accacgatat taacctgtta agcatttttt
     3361 ggaaacatgg ccaaaattac attttgagtt gattactcat tatccccatc accatcattt
     3421 tgctgttata cctgctagtg gtttacagtg ttcttcaatg cgctgaaagt acaagcagta
     3481 aaaagatccc aagagttgag gatgtagctt agtggtagag gatttgccta gcatgtgcaa
     3541 ggtcctgagt tccatcccca gcactgtaag acaaaaacaa aaagaagcaa gactccagta
     3601 tttagtagca ctgaccattt ctaaactgat agctttcaaa gtctggaata catggtgtgc
     3661 atcagctatc tggggtcttt ttagctttta ccacattccc caaagtttgt gttttatgtt
     3721 aaacattata gaatgtgtat tctgttaatt acgatttcct gggttatatt ccgcactgta
     3781 tataggtact tagctcgcca tatttatctt tgtgataatc tgtatttgta tggttggata
     3841 ggtggggaat tttttgcaga aatgcacaaa gattggattt tacttcccac tgcaggaagt
     3901 tcaaaacaaa acagaacatt agctttctgt atatttttcc aatttccagc agactgttct
     3961 tttttattag ttctttggtt ttagcaaaga gtgcttactt aaaagttgcg agggctcata
     4021 tgcctggcta ttgtttttgc ttctcaaatc tgcacaggtt tacagtcttt gcttttgtta
     4081 aaagtctgaa ttgctttgct atttgctccg tcctcacaga ggcattcagt ctctgtatac
     4141 tcttaaaaga aggaaaagca agggagggta tcttctttat tctcattttc tttgagttgt
     4201 taacaaaaat aagtatgaag gactacaact agaagataga catttaaatg aatttaaata
     4261 gactaatgga aagtttttac ctttttcttt ctgttttaga gacagttaaa agactgctcc
     4321 ttgttctagg agatactagt gtaagctatg gttgccttga aattatcctt tattttttta
     4381 aggcctatag atactattac ctttaaattc tttaaagtag gtaggttcat gccatcagcc
     4441 tctgatgtat tataaatggc aacctacctt cttattctgt taaaattgta tgaacacctg
     4501 tctacttaac aaacttacat gtatgacagt gttgtctact ttgtcatagg ccagttttct
     4561 tttgaatgtg acagcaattc aagtggctta ggtgcaggac ctgatacgcc aagaatagaa
     4621 ttgcagaagg agtaatagtg cagagtcaca ggaagttgtt tttttctttt taaaaaactg
     4681 gcaagggtat ctcctttatg tgagaaaagt tactattcag aaagaagggc agcttaaatg
     4741 gatgatttct gtgtatcatt gataaatttc ccttatatta aaaaaatgtt ctctaattgt
     4801 tattacgcca tttgggcttc tatactagcc tgtcgtttta gtattgtttt ctagatggac
     4861 ttattaaaac caaacagtgt tgtacgaggt aagaggtgtg cattgggtgt ctcaggtgtg
     4921 ctgtgtggtt tgttttcccc agaagttttg aactttactc agattatggt gatgtatatt
     4981 tttaagaagt gctttattag ttttctagta aaattgtgaa catttgcttg tgaggggatc
     5041 gaggtatgag ttatggattc tgaaatttgt aggttgtact atgtgccttc ttaatgtgtt
     5101 tatgggcaca atattttctc tcatcaactt gaaacttaaa agggacattt tggttagaat
     5161 atatactgta catcaatcta tgcataaatg gcagcttgtt ttcttgagcc actatctgtt
     5221 tttctttttt ttataaattt tttatactga ttgggtcaga gatggtcagt tttatacaga
     5281 atgaacagca cagcactttg ccaaaaaaca tgtagcattg cttaaacatt gtgtaataac
     5341 cccagttctt tgtaatgggt ttggtagtac attttgcact gcccagagtt acagtttttt
     5401 aatctgtcag taaataaaat gtcctttaac tta
//
