LOCUS       NM_001371259            6113 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus tumor protein p53 binding protein 1 (Tp53bp1),
            mRNA.
ACCESSION   NM_001371259 XM_006234867
VERSION     NM_001371259.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6113)
  AUTHORS   Drane,P., Brault,M.E., Cui,G., Meghani,K., Chaubey,S., Detappe,A.,
            Parnandi,N., He,Y., Zheng,X.F., Botuyan,M.V., Kalousi,A.,
            Yewdell,W.T., Munch,C., Harper,J.W., Chaudhuri,J., Soutoglou,E.,
            Mer,G. and Chowdhury,D.
  TITLE     TIRR regulates 53BP1 by masking its histone methyl-lysine binding
            function
  JOURNAL   Nature 543 (7644), 211-216 (2017)
   PUBMED   28241136
REFERENCE   2  (bases 1 to 6113)
  AUTHORS   Meloche,J., Pflieger,A., Vaillancourt,M., Paulin,R., Potus,F.,
            Zervopoulos,S., Graydon,C., Courboulin,A., Breuils-Bonnet,S.,
            Tremblay,E., Couture,C., Michelakis,E.D., Provencher,S. and
            Bonnet,S.
  TITLE     Role for DNA damage signaling in pulmonary arterial hypertension
  JOURNAL   Circulation 129 (7), 786-797 (2014)
   PUBMED   24270264
REFERENCE   3  (bases 1 to 6113)
  AUTHORS   Panier,S. and Boulton,S.J.
  TITLE     Double-strand break repair: 53BP1 comes into focus
  JOURNAL   Nat Rev Mol Cell Biol 15 (1), 7-18 (2014)
   PUBMED   24326623
  REMARK    Review article
REFERENCE   4  (bases 1 to 6113)
  AUTHORS   Mosammaparast,N., Kim,H., Laurent,B., Zhao,Y., Lim,H.J.,
            Majid,M.C., Dango,S., Luo,Y., Hempel,K., Sowa,M.E., Gygi,S.P.,
            Steen,H., Harper,J.W., Yankner,B. and Shi,Y.
  TITLE     The histone demethylase LSD1/KDM1A promotes the DNA damage response
  JOURNAL   J Cell Biol 203 (3), 457-470 (2013)
   PUBMED   24217620
REFERENCE   5  (bases 1 to 6113)
  AUTHORS   Lu,R. and Wang,G.G.
  TITLE     Tudor: a versatile family of histone methylation 'readers'
  JOURNAL   Trends Biochem Sci 38 (11), 546-555 (2013)
   PUBMED   24035451
  REMARK    Review article
REFERENCE   6  (bases 1 to 6113)
  AUTHORS   Ding,Y., Wen,Y., Spohn,B., Wang,L., Xia,W., Kwong,K.Y., Shao,R.,
            Li,Z., Hortobagyi,G.N., Hung,M.C. and Yan,D.H.
  TITLE     Proapoptotic and antitumor activities of adenovirus-mediated p202
            gene transfer
  JOURNAL   Clin Cancer Res 8 (10), 3290-3297 (2002)
   PUBMED   12374701
REFERENCE   7  (bases 1 to 6113)
  AUTHORS   Celeste,A., Petersen,S., Romanienko,P.J., Fernandez-Capetillo,O.,
            Chen,H.T., Sedelnikova,O.A., Reina-San-Martin,B., Coppola,V.,
            Meffre,E., Difilippantonio,M.J., Redon,C., Pilch,D.R., Olaru,A.,
            Eckhaus,M., Camerini-Otero,R.D., Tessarollo,L., Livak,F.,
            Manova,K., Bonner,W.M., Nussenzweig,M.C. and Nussenzweig,A.
  TITLE     Genomic instability in mice lacking histone H2AX
  JOURNAL   Science 296 (5569), 922-927 (2002)
   PUBMED   11934988
REFERENCE   8  (bases 1 to 6113)
  AUTHORS   Jullien,D., Vagnarelli,P., Earnshaw,W.C. and Adachi,Y.
  TITLE     Kinetochore localisation of the DNA damage response component 53BP1
            during mitosis
  JOURNAL   J Cell Sci 115 (Pt 1), 71-79 (2002)
   PUBMED   11801725
REFERENCE   9  (bases 1 to 6113)
  AUTHORS   Wen,Y., Yan,D.H., Wang,B., Spohn,B., Ding,Y., Shao,R., Zou,Y.,
            Xie,K. and Hung,M.C.
  TITLE     p202, an interferon-inducible protein, mediates multiple antitumor
            activities in human pancreatic cancer xenograft models
  JOURNAL   Cancer Res 61 (19), 7142-7147 (2001)
   PUBMED   11585747
REFERENCE   10 (bases 1 to 6113)
  AUTHORS   Iwabuchi,K., Li,B., Massa,H.F., Trask,B.J., Date,T. and Fields,S.
  TITLE     Stimulation of p53-mediated transcriptional activation by the
            p53-binding proteins, 53BP1 and 53BP2
  JOURNAL   J Biol Chem 273 (40), 26061-26068 (1998)
   PUBMED   9748285
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1 and CK840114.1.
            
            On Jul 3, 2019 this sequence version replaced XM_006234867.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.13080.1,
                                           SRR26643298.17982.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               JAXUCZ010000003.1  128696612-128696747 c
            137-321             JAXUCZ010000003.1  128695864-128696048 c
            322-412             JAXUCZ010000003.1  128695505-128695595 c
            413-497             JAXUCZ010000003.1  128695206-128695290 c
            498-622             JAXUCZ010000003.1  128687039-128687163 c
            623-790             JAXUCZ010000003.1  128683957-128684124 c
            791-917             JAXUCZ010000003.1  128677889-128678015 c
            918-1084            JAXUCZ010000003.1  128676211-128676377 c
            1085-1211           JAXUCZ010000003.1  128672497-128672623 c
            1212-1306           JAXUCZ010000003.1  128671666-128671760 c
            1307-1509           JAXUCZ010000003.1  128667923-128668125 c
            1510-2827           JAXUCZ010000003.1  128660882-128662199 c
            2828-3031           JAXUCZ010000003.1  128654514-128654717 c
            3032-3089           JAXUCZ010000003.1  128651101-128651158 c
            3090-3182           JAXUCZ010000003.1  128648832-128648924 c
            3183-3669           JAXUCZ010000003.1  128643918-128644404 c
            3670-3822           JAXUCZ010000003.1  128635989-128636141 c
            3823-4094           JAXUCZ010000003.1  128633861-128634132 c
            4095-4244           JAXUCZ010000003.1  128633137-128633286 c
            4245-4675           JAXUCZ010000003.1  128632489-128632919 c
            4676-4867           JAXUCZ010000003.1  128629646-128629837 c
            4868-5083           JAXUCZ010000003.1  128629062-128629277 c
            5084-5299           JAXUCZ010000003.1  128627270-128627485 c
            5300-5394           JAXUCZ010000003.1  128625795-128625889 c
            5395-5594           JAXUCZ010000003.1  128625124-128625323 c
            5595-5740           JAXUCZ010000003.1  128624451-128624596 c
            5741-6096           JAXUCZ010000003.1  128623725-128624080 c
            6097-6113           CK840114.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..6113
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..6113
                     /gene="Tp53bp1"
                     /gene_synonym="Trp53bp1"
                     /note="tumor protein p53 binding protein 1"
                     /db_xref="GeneID:296099"
                     /db_xref="RGD:1308039"
     exon            1..136
                     /gene="Tp53bp1"
                     /gene_synonym="Trp53bp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..5928
                     /gene="Tp53bp1"
                     /gene_synonym="Trp53bp1"
                     /note="tumor suppressor p53-binding protein 1;
                     transformation related protein 53 binding protein 1"
                     /codon_start=1
                     /product="TP53-binding protein 1"
                     /protein_id="NP_001358188.1"
                     /db_xref="GeneID:296099"
                     /db_xref="RGD:1308039"
                     /translation="MPGEQMDPTGSQLDSDFSQQDTPCLIIEDSQPESQALEEDAGSH
                     FSVLSRHLPNLQMHKENPVLDIMSNPEQTVAEQGDSNSSFSEHLKEKKASDPVESSHL
                     GTSGPISQVIERLPQPNRTSSALGVTVEAASLAEEEKEEELEEEKEEVGVNAPDADPR
                     SLAEDSASSQLGFGVLELSQSQDVEEHTVPYDVKQEHLQLVTTNSGSTQLSDVDANTD
                     GKAIKCEEQSTDAISIIEPSKDIPVTVQPSKGSHVVEEQNLPLVRSEDLPSSPQVSVA
                     AVETKEQVPAQELLEGGLQVQVSSEPEVSSTQEDLFDQSSKTASDGCSTPSREEGGCS
                     PVSTPATTLQLLQLSGQKPLVQESLSTNSSDLVAPSPDAFRSTPFIVPSSPTEQGQRK
                     DEPMDMSVIPEGGEHFQKLQDDEAVDIEKPLLPSQPAVSPQASTPVSRSTPVFTPASL
                     PIPSQPEFSHDIFIPSPSLEEPSNDVEKGGGLHSSSLTVECSKTSESEPKNFTDDLGL
                     SMTGDSCKLMLSTSECSQSSKMESLGSPRTEEVGENTQVEDTEPSSPVTKSKLPAESE
                     SVLVNPTQDDQVEMSQNVDKAKEDEVEDRGDVDVLAAGCKGREDMVAEDVCIDLTCDS
                     GSQAVPSPATRSEALSSVLDQEEAMEIKEHHPEEEFSGSEVEEVPETPCGSHREESKE
                     EPMESIPLHLSLTETQSEALCLQKEAPKEECPEAMEVETSVISIDSPQKLPVLDQELE
                     HKDPETWEEATSEDSSVVIVDVKEPSPRVDISCEPVEGVGKCSDSQSLEGAAPEEEPC
                     AENRLNTPEEKRVECDGDSKAETTEKNSVTEDSPQPPLPSVRDEPVRPDQELQQPQVQ
                     EKESPVTLDAKVADDKHLGSEGSCQQLEKAPARASQSFCESSSGISNYPESTIATSDV
                     MSESMVEINDPLLGNEKGDSESAPEMDGKLSLKMKLVSPETEASEESLQFSLEKPTTA
                     ERRNGSTAIAEPVASPQKPMSVFGCIYEAQQEEEAQSGDPPSTPVRTNLLHFPSAQEE
                     DREEPDATPQLRQSEQPVKLIGPVKDAAASEDSASSVSQQRASQGSLSPQEEVMEADL
                     LEGLGANQDRPSKILMERPTQSNIGIQTMDHSLCAPETVSAATQTVKNVCEQGTSTVE
                     QNSGKQDATVQTERGSGEKPASAPVDDTESLHSQGEEEFEMPQPPHGHVLHRHTRTIR
                     EVRTLVTRVITDVYYVDGTEVERKVTEETEEPIVECQECETEVSPSQTGGSSGDLGDI
                     SSFSSKASSSHHTSSGTSLSAIHSSGSSGRGAGPLKGKTSGTEPADFALPSSRGGPGK
                     LSPRKGISQTGAPVCEEDGDAGLGIRQGGKAPVTPRGRGRRGRPPSRTTGTRETVVSG
                     PLGIEDTSPSMSPDDKSFTRIMPRVPDSTKRMDASSGALRRSDSPEIPFQAATGSSDG
                     LDSSSSGNSFVGLRVVAKWSSNGYFYSGKITRDVGAGKYKLLFDDGYECDVLGKDILL
                     CDPIPLDTEVTALSEDEYFSAGVVKGHRKESGELYYSIEKEGQRKWYKRMAVILSLEQ
                     GNRLREQYGLGPYEAVTPLTKAADISLDNLVEGKRKRRSNISSPATPTASSSSSTTPT
                     RKTTESPRASMGVPSGKRKLTTSEEERSPAKRGRKSATVKPGTVGAAELVSPCESGDN
                     TGEPSVLEEPRGPLPLNKTLFLGYAFLLTMATTSDKLASRSKLLDGPTGSSEEEEEFL
                     EIPPFNKQYTECQLRAGAGYILEDFNEAQCNTAYQCLLIADQHCRTRKYFLCLASGIP
                     CVSHVWVHDSCHANQLQNYRNYLLPAGYSLEEQRILDWQPRENPFQNLKVLLVSDQQQ
                     NFLELWSEILMTGGAASVKQHHSSAHNKDIALGVFDVVVTDPSCPASVLKCAEALQLP
                     VVSQEWVIQCLIVGERIGFQQHPKYKHDYVSH"
     exon            137..321
                     /gene="Tp53bp1"
                     /gene_synonym="Trp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            322..412
                     /gene="Tp53bp1"
                     /gene_synonym="Trp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            413..497
                     /gene="Tp53bp1"
                     /gene_synonym="Trp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            498..622
                     /gene="Tp53bp1"
                     /gene_synonym="Trp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            623..790
                     /gene="Tp53bp1"
                     /gene_synonym="Trp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            791..917
                     /gene="Tp53bp1"
                     /gene_synonym="Trp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1084
                     /gene="Tp53bp1"
                     /gene_synonym="Trp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1211
                     /gene="Tp53bp1"
                     /gene_synonym="Trp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1306
                     /gene="Tp53bp1"
                     /gene_synonym="Trp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1509
                     /gene="Tp53bp1"
                     /gene_synonym="Trp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..2827
                     /gene="Tp53bp1"
                     /gene_synonym="Trp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2828..3031
                     /gene="Tp53bp1"
                     /gene_synonym="Trp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3032..3089
                     /gene="Tp53bp1"
                     /gene_synonym="Trp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3090..3182
                     /gene="Tp53bp1"
                     /gene_synonym="Trp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3183..3669
                     /gene="Tp53bp1"
                     /gene_synonym="Trp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3670..3822
                     /gene="Tp53bp1"
                     /gene_synonym="Trp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3823..4094
                     /gene="Tp53bp1"
                     /gene_synonym="Trp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            4095..4244
                     /gene="Tp53bp1"
                     /gene_synonym="Trp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            4245..4675
                     /gene="Tp53bp1"
                     /gene_synonym="Trp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            4676..4867
                     /gene="Tp53bp1"
                     /gene_synonym="Trp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            4868..5083
                     /gene="Tp53bp1"
                     /gene_synonym="Trp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            5084..5299
                     /gene="Tp53bp1"
                     /gene_synonym="Trp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            5300..5394
                     /gene="Tp53bp1"
                     /gene_synonym="Trp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            5395..5594
                     /gene="Tp53bp1"
                     /gene_synonym="Trp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            5595..5740
                     /gene="Tp53bp1"
                     /gene_synonym="Trp53bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            5741..6097
                     /gene="Tp53bp1"
                     /gene_synonym="Trp53bp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgacgggaa aagggggagc tcgcggccag tggcggcggt ggcgacagtg gcgacctggg
       61 gatcgacctg gaggggcctg ggcagcgtgc agagacctct agatccagcg cgagggacct
      121 cccgccggga tgccagggga gcagatggac cctactggaa gtcaattgga ttcagatttc
      181 tctcagcaag acactccttg cctgataata gaagattctc agcctgaaag ccaggctctg
      241 gaagaagatg caggttctca cttcagcgtg ctatctcgac accttcctaa tctgcagatg
      301 cacaaagaga acccggtgtt ggatattatg tcaaatccgg aacaaactgt tgcagaacaa
      361 ggagacagta acagctcatt cagtgaacat ctgaaagaaa agaaagcgtc agaccctgtg
      421 gagtcttctc atttgggtac gagtggtccc atcagtcagg tcatagaacg gttacctcag
      481 cccaacagga caagcagtgc tctgggagtg acagtagaag ctgcttctct tgcagaggag
      541 gagaaggagg aagagttgga agaggagaag gaagaggtgg gagtgaacgc tcctgatgct
      601 gacccacgct cccttgctga agattctgct tcatcccagt tgggctttgg agttctggaa
      661 ttgtcccaga gccaggatgt tgaagagcat acagtgccat atgatgtcaa acaagagcat
      721 ctgcagttgg tgaccactaa ctcgggttct acccagctat cggatgtgga tgcaaatact
      781 gatgggaaag caattaaatg tgaagaacag tccactgacg ccatctctat aatagaaccc
      841 agcaaagaca tccctgttac agtgcagccc agcaaaggct cccatgtggt agaagaacaa
      901 aatctaccac ttgtaaggtc tgaagacctg ccttccagtc ctcaagtttc tgttgctgct
      961 gtggaaacaa aggagcaggt acctgcccaa gagctgctgg aaggggggct gcaggttcag
     1021 gtgtcatcag agcctgaggt ttcctcaact caggaagact tgtttgacca gagcagtaaa
     1081 acagcttctg atggttgttc tactccttca agggaggaag gcgggtgctc tccggtttcc
     1141 acacctgcta ccaccctgca gctcctgcag ctctctggtc agaagcccct tgttcaggag
     1201 agtctttcca cgaattcctc agatcttgtt gctccttccc ctgatgcttt ccgatctacc
     1261 ccttttatcg ttcctagcag tcccacagag caaggacaga gaaaagatga gcccatggat
     1321 atgtcagtga tacctgaagg aggggagcat ttccaaaagc ttcaggatga cgaagcagtg
     1381 gacatagaga aaccccttct cccatctcag cctgctgtat caccgcaagc gtccacacca
     1441 gtgtctcgga gcacgccagt tttcactcct gcctcacttc ccatcccgtc ccagcccgag
     1501 ttctctcatg acatctttat tccatcacca agtttggaag aaccatcgaa tgatgtggag
     1561 aaaggtggag gtttgcatag ctcgtctctc actgttgagt gttctaagac gtcagagagt
     1621 gaaccaaaga atttcactga tgaccttggg ctctccatga cgggggattc gtgcaagctg
     1681 atgctttcta caagtgagtg tagtcagtcc tcaaagatgg agagcttggg ttctcccagg
     1741 actgaggaag tcggagagaa cacacaggtt gaggatactg aaccttcatc cccagttact
     1801 aagtctaaac ttcctgccga aagtgaaagt gtcctggtga atccaacaca ggacgaccag
     1861 gtagaaatga gtcagaatgt agataaagca aaggaagatg aagtggagga tagaggtgac
     1921 gttgacgttt tagctgctgg ctgtaaaggc agagaagaca tggttgctga agatgtttgc
     1981 atcgacctca cttgtgattc tgggagtcag gcagttcctt ctccagctac ccgctctgag
     2041 gcactttcca gtgtcttaga tcaggaggaa gctatggaaa ttaaagaaca ccatccagag
     2101 gaagagtttt cgggatctga ggtagaagaa gtccctgaga ctccctgtgg aagtcacaga
     2161 gaggagtcca aagaggaacc gatggaaagt attccactgc acctttctct gactgaaact
     2221 cagtctgagg cgttgtgtct tcagaaggaa gcccctaaag aggaatgccc agaagctatg
     2281 gaagttgaaa ccagtgtgat tagtattgac tccccccaga agttgccagt acttgaccag
     2341 gaattggagc ataaggatcc agaaacttgg gaagaagcta cttctgagga ctccagtgtt
     2401 gttatcgttg atgtaaagga gccctctcct agagttgaca tttcctgtga accggtggag
     2461 ggagtgggaa aatgctcaga ctcccagtcc ttggagggtg cggctccaga ggaagaaccc
     2521 tgtgctgaga atagattaaa tactccagag gaaaagagag ttgagtgtga tggagattca
     2581 aaagcagaga ccacagagaa gaactctgta acagaagact ctccacaacc tcctttgcct
     2641 tcagtgagag acgaacctgt cagacctgac caggagttgc agcagcccca ggttcaagag
     2701 aaagagagcc ccgtgactct agatgcaaag gtggctgatg acaagcatct ggggtcagag
     2761 ggctcatgcc agcagcttga gaaggcccct gcccgagcct cccagagttt ctgtgaaagt
     2821 tctagtggga ttagcaacta tccagaaagc accatagcaa ccagtgatgt catgtctgaa
     2881 agcatggtgg agatcaacga tcctctactt gggaatgaaa aaggggattc tgagtctgcc
     2941 ccagaaatgg atggaaaact atctctgaaa atgaaacttg ttagtcctga gacagaggcc
     3001 agtgaagaat ctttacagtt tagcctggaa aagcctacaa ctgctgagag aagaaatgga
     3061 tctactgcca ttgctgagcc tgttgccagt ccccagaagc ccatgtctgt gtttggctgc
     3121 atctatgaag cccagcaaga ggaggaggct cagagtgggg atcctccttc cacacctgtc
     3181 aggacgaact tgctccattt tccaagtgct caagaagaag acagagaaga accggatgct
     3241 accccacagc tcaggcagag tgaacagcct gtgaagctga ttgggcctgt caaggatgcg
     3301 gctgcttctg aggactctgc ctcttctgtt tcccagcaga gggcctcaca gggatcattg
     3361 agtcctcaag aggaagtgat ggaagcagac ctgcttgaag gactgggtgc taaccaggac
     3421 agacctagta agatcttgat ggaaaggccc acccagagta acataggaat ccagaccatg
     3481 gaccattccc tatgtgcacc agagaccgtt tcagcagcca cccagactgt gaagaatgta
     3541 tgtgagcagg ggaccagtac agtggagcag aactctggga aacaagatgc cactgtgcag
     3601 actgagcggg ggagtggaga gaaacctgcc agtgctcctg tggatgacac agagtccctc
     3661 cacagccagg gagaagaaga atttgaaatg cctcagcctc cacatggcca tgtcttgcat
     3721 cgtcacacga gaacgattcg agaagtccgt acacttgtca cccgtgtcat cacagatgtt
     3781 tattatgtgg atggaacaga agtggaaagg aaagtaacgg aggagactga agaaccaatc
     3841 gtagaatgtc aggaatgtga aacagaagtt tccccttcac agactggcgg ttcctctggg
     3901 gacctggggg acatcagctc cttctcctcc aaagcctcca gctcacacca cacatccagt
     3961 ggaacaagtc tctcagccat acacagcagt ggcagctcag ggcgaggagc tgggccactc
     4021 aaaggaaaaa ccagtgggac agaacctgca gattttgcct tacccagttc ccgaggaggc
     4081 ccaggaaaac tgagtcctag aaaagggatc agtcagacag gggcaccagt gtgtgaggaa
     4141 gatggtgatg caggccttgg catcagacaa ggagggaagg ctccagttac acctcgtggt
     4201 cgtgggcgaa ggggccgccc accttctcgg accactggaa ccagagaaac agttgtgtct
     4261 ggtccattgg gcatagaaga cacttcacct agcatgtcac ccgatgacaa gtccttcacc
     4321 cgcattatgc cccgtgtgcc agactctacc aaacggatgg atgccagttc tggtgctttg
     4381 cggcggagtg attctccaga gattcctttt caggctgcta ctggttcctc tgatggcttg
     4441 gattcctcat cttctggaaa cagctttgtg gggctccggg ttgtagccaa gtggtcgtcc
     4501 aatggctact tttactctgg gaaaatcaca cgagatgtcg gagctgggaa gtataagctg
     4561 ctctttgatg acgggtatga gtgtgacgtg ctgggcaagg acattctcct gtgtgacccc
     4621 atacccctgg acactgaagt gaccgccctc tcagaagatg agtatttcag tgcaggagtg
     4681 gtgaaaggac acaggaagga gtctggggag ctgtattaca gcattgaaaa agaaggccaa
     4741 aggaagtggt ataaacggat ggcagtcatt ctgtccttgg agcaaggaaa cagactgaga
     4801 gaacaatatg ggcttggccc atatgaagct gtcacaccac tcacaaaggc agcagatatc
     4861 agcttagaca atttggtgga aggaaagagg aaacggcgca gtaacatcag ctccccagcc
     4921 acccccactg cctccagtag cagcagcaca acacccacac gtaaaaccac agagagtccc
     4981 cgtgcttcca tgggagttcc gtcaggcaaa aggaaactta cgacttctga agaggaacgg
     5041 tcccctgcta agcgaggccg aaagtctgct actgtgaaac ctggaacagt gggggcagca
     5101 gagcttgtga gcccctgtga gagtggagac aacacaggtg agccttctgt cctggaagag
     5161 ccaagagggc ctttgcccct caacaagacc ttgtttctgg gctatgcctt tctcctcacc
     5221 atggctacaa ctagtgacaa gctggccagc cgctctaagc tgctagatgg tcctacagga
     5281 agcagcgaag aagaggagga atttttagaa attcctcctt tcaacaagca gtatacagaa
     5341 tgccagcttc gagcaggagc tgggtatatc ctggaagact tcaatgaagc ccagtgtaac
     5401 acagcctacc agtgtctcct aattgcggac cagcactgtc gaacccggaa gtacttcctg
     5461 tgccttgcca gtggcattcc ttgtgtgtct catgtctggg tccatgacag ctgccatgcc
     5521 aaccagcttc aaaactaccg taattatctg ctgcctgctg ggtatagcct tgaggagcaa
     5581 cgaattctgg actggcaacc ccgtgaaaac cctttccaga atctgaaggt cctcttggtg
     5641 tcagatcaac agcagaactt cctggagctc tggtctgaga tccttatgac tggaggggca
     5701 gcctctgtga agcagcatca ttcaagtgcc cataacaaag acattgcttt aggggtattt
     5761 gatgtggtgg tgacagaccc ctcatgccca gcctcggtgc tcaagtgtgc tgaagccttg
     5821 cagctgcctg tggtatcaca agaatgggtg atccagtgcc tcattgttgg ggagagaatt
     5881 ggattccagc agcatccaaa atacaaacat gattatgttt ctcactaaag atacttggtc
     5941 ttactggttt tattccctgc tattgtggag attgtgtttt aatcaggttt taagtgtgtc
     6001 ttgtgtgtaa ttgtattctt tgcatggacc ttgtacatag ttttatttgt tggactttta
     6061 tgataaaata aatgttgaat ctctttggtt gtagtaaaaa aaaaaaaaaa aaa
//
