LOCUS       NM_001399200            3415 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus TOX high mobility group box family member 3
            (Tox3), mRNA.
ACCESSION   NM_001399200 XM_006255187
VERSION     NM_001399200.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3415)
  AUTHORS   Dittmer,S., Kovacs,Z., Yuan,S.H., Siszler,G., Kogl,M., Summer,H.,
            Geerts,A., Golz,S., Shioda,T. and Methner,A.
  TITLE     TOX3 is a neuronal survival factor that induces transcription
            depending on the presence of CITED1 or phosphorylated CREB in the
            transcriptionally active complex
  JOURNAL   J Cell Sci 124 (Pt 2), 252-260 (2011)
   PUBMED   21172805
REFERENCE   2  (bases 1 to 3415)
  AUTHORS   Yuan,S.H., Qiu,Z. and Ghosh,A.
  TITLE     TOX3 regulates calcium-dependent transcription in neurons
  JOURNAL   Proc Natl Acad Sci U S A 106 (8), 2909-2914 (2009)
   PUBMED   19196971
  REMARK    GeneRIF: observations identify TOX3 as an important regulator of
            calcium-dependent transcription and suggest that TOX3 exerts its
            effect on CRE-mediated transcription via its association with the
            CREB-CBP complex
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Jan 4, 2022 this sequence version replaced XM_006255187.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU194254.1, SRR26360194.965840.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-510               JAXUCZ010000019.1  32820977-32821486
            511-573             JAXUCZ010000019.1  32899587-32899649
            574-828             JAXUCZ010000019.1  32903772-32904026
            829-1098            JAXUCZ010000019.1  32918019-32918288
            1099-1326           JAXUCZ010000019.1  32922232-32922459
            1327-1407           JAXUCZ010000019.1  32924100-32924180
            1408-3415           JAXUCZ010000019.1  32927769-32929776
FEATURES             Location/Qualifiers
     source          1..3415
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p11"
     gene            1..3415
                     /gene="Tox3"
                     /gene_synonym="Tnrc9"
                     /note="TOX high mobility group box family member 3"
                     /db_xref="GeneID:291908"
                     /db_xref="RGD:1311529"
     exon            1..510
                     /gene="Tox3"
                     /gene_synonym="Tnrc9"
                     /inference="alignment:Splign:2.1.0"
     CDS             424..2163
                     /gene="Tox3"
                     /gene_synonym="Tnrc9"
                     /note="trinucleotide repeat-containing gene 9 protein;
                     trinucleotide repeat containing 9"
                     /codon_start=1
                     /product="TOX high mobility group box family member 3"
                     /protein_id="NP_001386129.1"
                     /db_xref="GeneID:291908"
                     /db_xref="RGD:1311529"
                     /translation="MDVRFYPAAAGDPAGLDFAQCLGYYGYSKLGNNNYMNMAEANNA
                     FFAASEQTFHTPSLGDEEFEIPPITPPPESDPTLGMPDVLLPFQTLSDPLPSQGNEFT
                     PQFPPQSLDLPSITISRNLVEQDGVLHSNGLHMDQSHTQVSQYRQDPSLVMRSIVHMT
                     DAARSGIMPPAQLTTINQSQLSAQLGLNLGGASVPHTSPSPPASKSATPSPSSSINEE
                     DADETNRAVGEKRTAPDSGKKPKTPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQN
                     PNATFGEVSKIVASMWDSLGEEQKQVYKRKTEAAKKEYLKALAAYRASLVSKAAAESA
                     EAQTIRSVQQTLASTNLTSSLLLNTSLSQHGTVPASPQTLPQSLPRSIAPKPLTMRLP
                     MSQIVTSVTIAANMPSNIGAPLISSMGTTMVGSVSSTQVSPSVQTQQHQLQLQQQQQQ
                     QQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQHFQHHMQQHLQQQQQQHLQQQISQQQL
                     QQQLQQHLQLQQQLQHMQHQSQPSPRQHSPVTSQITSPIPAIGSPQPASQQHQPQIQS
                     QTQTQVLPQVSIF"
     exon            511..573
                     /gene="Tox3"
                     /gene_synonym="Tnrc9"
                     /inference="alignment:Splign:2.1.0"
     exon            574..828
                     /gene="Tox3"
                     /gene_synonym="Tnrc9"
                     /inference="alignment:Splign:2.1.0"
     exon            829..1098
                     /gene="Tox3"
                     /gene_synonym="Tnrc9"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1326
                     /gene="Tox3"
                     /gene_synonym="Tnrc9"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1407
                     /gene="Tox3"
                     /gene_synonym="Tnrc9"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..3415
                     /gene="Tox3"
                     /gene_synonym="Tnrc9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctccgcgg ctcctcggct cagtccgccc ggggaggagg agcggggcca gccgccgccg
       61 ccgtcccagc ttcgccgcgc acctgagctc gccggccgcc ccgggcccac gcgctgcgcc
      121 ccgcgccccg cgccccgggc gcccggcccg cgcgcaggca gcttcagtgt cccggtgggg
      181 cgcgtccccc gggccgcctc ccgctctccc gcggctcgcg tggccgcgcc tttgtgtgcc
      241 gcggccgcag ctcccgggct cgtcggctgc ccccgcgcga cgcccctcaa gccccacggc
      301 cagtgcgctg tccctgggcg cccccggccg ggcgtcctcg acggtggatc gtgcggccgc
      361 aagacgggta gctgcccagg cgagctccaa ccccggcccc tagcccccgg ccccggcccc
      421 ggcatggatg tgaggttcta ccccgcggcg gccggggatc ccgccggcct ggacttcgcg
      481 cagtgcctgg ggtactacgg ctacagcaag ttgggaaata ataactacat gaacatggct
      541 gaggcaaaca acgccttctt tgctgccagt gagcagacat tccacacgcc aagccttggg
      601 gatgaagagt ttgaaattcc gccgatcacg cctcctccag agtcagaccc caccctgggc
      661 atgcccgatg tactgctacc ctttcagaca ctcagcgatc cgttgccttc ccagggaaat
      721 gagttcacac cccagtttcc ccctcagagc ctggatcttc cttccatcac aatctcaagg
      781 aatctggtgg aacaagatgg tgtgcttcat agcaacgggc tgcatatgga tcagagccac
      841 acacaagtgt cgcagtaccg ccaggatcct tctttggtca tgaggtcaat tgtccacatg
      901 acagatgctg ctcgctctgg gatcatgcct cctgcccaac tgaccaccat caaccagtct
      961 cagctcagtg cacagttggg cttgaatctg ggaggagcca gtgtgcccca cacgtctcct
     1021 tcacctccag caagcaaatc agccactccc tccccttcca gctctatcaa cgaagaggat
     1081 gctgatgaaa caaacagagc cgttggagag aaaagaacag ccccagattc tggcaagaag
     1141 cccaagactc caaagaaaaa gaaaaagaaa gatcccaacg agcctcagaa gccagtgtca
     1201 gcatacgccc tgtttttcag agatacacag gctgcaatta aaggtcaaaa ccccaatgcg
     1261 acctttggag aagtctcaaa aattgtagca tctatgtggg acagccttgg agaggagcaa
     1321 aagcaggtat ataaaaggaa aacagaagct gccaagaaag aatatttgaa ggccctggct
     1381 gcctaccggg ccagcctcgt ttctaaggct gctgctgagt ccgcagaagc ccagactatc
     1441 cgctctgtcc agcagactct ggcatcaacc aacctgacat cctctctcct tctgaacacg
     1501 tcactgtctc aacatgggac agtcccggct tcacctcaga ctctcccgca gtcactccct
     1561 aggtcgattg cccccaaacc cttaaccatg agactaccca tgagccagat tgtcacatca
     1621 gtcaccattg cagccaacat gccctcgaac attggggctc cacttatcag ctccatggga
     1681 acgaccatgg ttggctcagt atcctccacg caggtgagcc cttcggtaca aacccagcaa
     1741 catcagctgc agctgcagca gcagcagcaa caacagcagc agcagcagca gatgcagcag
     1801 atgcaacagc agcagctgca gcagcaccag atgcatcagc agattcagca gcagatgcag
     1861 caacagcatt tccagcacca catgcaacag cacctgcagc agcagcaaca gcagcacctc
     1921 cagcagcaga tcagccaaca gcagctgcag cagcagctgc agcagcatct ccagctgcag
     1981 cagcagctgc agcacatgca gcaccagtct cagccttctc cccggcagca ctcgcccgtc
     2041 acctcacaga tcacgtcccc catccccgcc attggcagcc cccagccagc ctctcagcag
     2101 caccagcctc aaatccagtc gcagacacag actcaagtgt taccgcaggt cagtattttt
     2161 taaggtgcac gaggcatgcg gatctgagtg aggcgcagga gggaaggtat acggaccgga
     2221 agttgtcagt tgactctggt tatgcaggaa tgcgtaacag atcaaaagat cctctcaagt
     2281 gtctattaga taggcaataa gaactgcagt gtagctggga agcgtcttta gccaactgtc
     2341 catcactttg tttttaaacg agaaagctgc gctctgtcat gtgctgcctt ttttatttat
     2401 tcaggctata cctacaatat gtgaatcaac ctgtttaatg actcctggga cacaccgatg
     2461 actgtagact ggcctttccg agtcatagaa aaaaaaaaca aaacaaaaaa gatggcctta
     2521 tttctccaga agtgagcgac ccacacttcc aggctatttg aacttccgaa gccctaagat
     2581 aaataagtac aaagcacagt cataactacc tgaaatctgc agatccagtt tcatacaaac
     2641 gtttgtatga tgggaatagt tgatggcatt tttttgtcat gaagaaaaat aatgtaaatc
     2701 acagactttt gccaaagctc ttattttttt tcctaaatct gtccagaaaa aaaattgcaa
     2761 gcgattagat tcaatgattg atttatttac atacttctac tttgtatcca tgacttctct
     2821 gaatcaaacc acggcatacg ttgtgacaat atctatagcc accgttagcc cttcatgtcc
     2881 attccgatta gaagaaatgt gaatactata ttacgtgttt tgagtgatga gtttggggaa
     2941 aattaaaaac actgtatttt taaaagggaa aaatgcactt aaatgaaagc agttattaca
     3001 aaagttaaga tttaaaaaag aaaaagcgag agtttttatt atgatgtaat accggtagaa
     3061 tattgaatat ttaaaaggca cactacatct gaaataatca atgtaaatat tttctttcca
     3121 agttgtaagt tttcctatca tgtgttgtaa agttttccta aacgaggctt taacgtaaac
     3181 actggtgaca tgaaccattc attgctacct tgttcattgt gtttttatgc tgttttatac
     3241 ttttttatga gttatgatag cagcaattaa gttgtttgta ttttgcttaa ctaaaacaaa
     3301 aatgctttta tcttgctata gaataaacac atttcagtaa aatccgtgga ctgtattttg
     3361 atgctacagc aaggacattg ttcactttgc aaataaaatg gaatgtcaaa tttta
//
