LOCUS       NM_199392               2022 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus TOX high mobility group box family member 2
            (Tox2), mRNA.
ACCESSION   NM_199392 XM_230852
VERSION     NM_199392.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2022)
  AUTHORS   Vong,Q.P., Leung,W.H., Houston,J., Li,Y., Rooney,B., Holladay,M.,
            Oostendorp,R.A. and Leung,W.
  TITLE     TOX2 regulates human natural killer cell development by controlling
            T-BET expression
  JOURNAL   Blood 124 (26), 3905-3913 (2014)
   PUBMED   25352127
REFERENCE   2  (bases 1 to 2022)
  AUTHORS   Kajitani,T., Mizutani,T., Yamada,K., Yazawa,T., Sekiguchi,T.,
            Yoshino,M., Kawata,H. and Miyamoto,K.
  TITLE     Cloning and characterization of granulosa cell high-mobility group
            (HMG)-box protein-1, a novel HMG-box transcriptional regulator
            strongly expressed in rat ovarian granulosa cells
  JOURNAL   Endocrinology 145 (5), 2307-2318 (2004)
   PUBMED   14764631
  REMARK    GeneRIF: data strongly suggest that granulosa cell HMG-box
            protein-1(GCX-1) is a novel transcriptional activator that is
            expressed in reproductive tissues involving the
            hypothalamo-pituitary-gonadal axis, and functions as a regulator of
            follicular development
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB096685.1.
            
            On Jun 22, 2007 this sequence version replaced NM_199392.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB096685.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2022              AB096685.1         2-2023
FEATURES             Location/Qualifiers
     source          1..2022
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..2022
                     /gene="Tox2"
                     /gene_synonym="GCX-1; Gcx1"
                     /note="TOX high mobility group box family member 2"
                     /db_xref="GeneID:311615"
                     /db_xref="RGD:735184"
     exon            1..132
                     /gene="Tox2"
                     /gene_synonym="GCX-1; Gcx1"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..1581
                     /gene="Tox2"
                     /gene_synonym="GCX-1; Gcx1"
                     /note="granulosa cell HMG box protein 1"
                     /codon_start=1
                     /product="TOX high mobility group box family member 2"
                     /protein_id="NP_955424.2"
                     /db_xref="GeneID:311615"
                     /db_xref="RGD:735184"
                     /translation="MDVRLYPSAPAVGARPGAEPAGLAHLDYYHCGKFDGDSAYVGMS
                     DGNPELLSTSQTYNSQGESNEDYEIPPITPPNLPEPSLLHLGDHEAGYHSLCHGLAPN
                     GLLPAYSYQAMDLPAIMVSNMLAQDGHLLSGQLPTIQEMVHSEVAAYDSGRPGPLLGR
                     PAMLASHMSALSQSQLISQMGLRSGIAHSSPSPPGSKSATPSPSSSTQEEESDAHFKI
                     SGEKRPSTDPGKKAKNPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPSATFGDV
                     SKIVASMWDSLGEEQKQAYKRKTEAAKKEYLKALAAYRASLVSKSPPDQGEAKNAQAN
                     PPAKMLPPKQPMYAMPGLASFLTPSDLQAFRSAASPASLARTLGSKALLPGLSTSPPP
                     PSFPLSPSLHQQLPLPPHAQGTLLSPPLSMSPAPQPPVLPAPMALQVQLAMSPSPPGP
                     QDFPHISDFPSGSGSRSPGPSNPSSSGDWDGSYPSGERGLGTCRLCRSSPPPTTSPKN
                     LQEPSAR"
     exon            133..198
                     /gene="Tox2"
                     /gene_synonym="GCX-1; Gcx1"
                     /inference="alignment:Splign:2.1.0"
     exon            199..444
                     /gene="Tox2"
                     /gene_synonym="GCX-1; Gcx1"
                     /inference="alignment:Splign:2.1.0"
     exon            445..684
                     /gene="Tox2"
                     /gene_synonym="GCX-1; Gcx1"
                     /inference="alignment:Splign:2.1.0"
     exon            685..912
                     /gene="Tox2"
                     /gene_synonym="GCX-1; Gcx1"
                     /inference="alignment:Splign:2.1.0"
     exon            913..993
                     /gene="Tox2"
                     /gene_synonym="GCX-1; Gcx1"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1386
                     /gene="Tox2"
                     /gene_synonym="GCX-1; Gcx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1514
                     /gene="Tox2"
                     /gene_synonym="GCX-1; Gcx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..2022
                     /gene="Tox2"
                     /gene_synonym="GCX-1; Gcx1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgctgccg ccgccgccgc cgccgcgccc gccatggacg tccgcctgta tccctcggcg
       61 cccgcggtag gtgcgcggcc cggggccgag ccggccggcc tggcgcacct ggactactac
      121 cactgcggca agtttgatgg tgacagtgcc tacgtgggga tgagtgacgg aaatccagag
      181 ctcctgtcaa ccagccagac ctataacagc cagggcgaga gcaacgaaga ctatgagatc
      241 cctcctataa cacctcccaa tctccctgag ccatccctcc tgcacctggg ggaccacgaa
      301 gccggttacc actcactgtg tcacggcctt gcgcccaacg gtctgctccc cgcctactcg
      361 taccaggcaa tggatctccc ggccatcatg gtgtccaaca tgctggccca ggatggccac
      421 ctgctgtcag gacagctgcc cacgatccag gaaatggtcc actcggaggt agctgcctat
      481 gactcaggcc ggccagggcc cctgctgggc cgccctgcga tgctggccag ccacatgagt
      541 gccctcagtc aatcccagct catctcccag atgggcctcc ggagtggcat tgcccacagc
      601 tccccatcac ccccagggag caagtcagca accccgtctc catccagctc cacccaggag
      661 gaggagtcag atgcccattt caagatttca ggagagaaga gaccctcaac agacccaggc
      721 aaaaaggcca aaaatccaaa gaagaagaag aagaaggatc ccaatgagcc acagaagcca
      781 gtgtcggcct acgctctctt cttcagagac actcaggctg ccatcaaggg gcagaacccc
      841 agtgccacct ttggggatgt ttccaaaatt gtggcctcca tgtgggacag cctgggagaa
      901 gagcagaaac aggcgtataa gaggaagacc gaagctgcca agaaggagta cctgaaagcc
      961 ttggcggcct acagagctag cctcgtgtcc aagagccccc cggaccaagg cgaggccaag
     1021 aacgctcagg caaacccacc agccaaaatg cttccaccca agcagcccat gtacgccatg
     1081 cccggcctgg cttccttcct gacgccctcc gacctgcagg ctttccgcag cgcagcctct
     1141 cctgccagcc tcgccagaac gctgggctcc aaggccctgc tgccaggcct cagcacctcc
     1201 ccaccaccac cctccttccc tctcagcccc tccttgcacc agcagctgcc actgccaccc
     1261 cacgcgcagg gtaccctcct cagcccgcct ctcagcatgt ccccagcccc gcagcctcct
     1321 gtcctgcctg cccccatggc actccaggtg cagctggcga tgagcccctc gcctccaggg
     1381 ccacaggact ttccacacat ctctgacttc cccagtggct ctggctcccg ctcacctggc
     1441 ccatccaacc cttccagcag cggggactgg gatgggagtt accccagtgg ggagcgcggc
     1501 ctcggcacct gcagactctg cagaagcagc ccaccgccca ccaccagccc aaagaacctg
     1561 caggaacctt ctgcccgctg acctgcttgc tccagggtag ctgtggatcc cgctccttgg
     1621 cctgcacaca gtcccctgcg tctggacttc cggccccagc ccaagctcac caggctgccc
     1681 ccttcgaggt tgcttagcaa cagacaccca cccctgatgc tgggccagcc acaggtgtgc
     1741 tctcagtgta cacaaagatg ctgaaactca tgctgtgggt tccgtgtaag tagttcactg
     1801 ttttagaact gtgctgaaga catctgtaag attattctgt ggggagaagg aaactttcct
     1861 ttaaggttaa aaaaactttt ataatacctt tggcccattg tttttttaag ttttatctta
     1921 agggagacat gtgcacaagc aactgtcaaa ctgattctaa tctgcacaca gagagagaat
     1981 gggaactttt aagccacacc gaggggcatt cctcctcctc ct
//
