LOCUS       NM_001108654            3093 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus thymocyte selection-associated high mobility
            group box (Tox), mRNA.
ACCESSION   NM_001108654 XM_001063218 XM_342800
VERSION     NM_001108654.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3093)
  AUTHORS   Artegiani,B., de Jesus Domingues,A.M., Bragado Alonso,S.,
            Brandl,E., Massalini,S., Dahl,A. and Calegari,F.
  TITLE     Tox: a multifunctional transcription factor and novel regulator of
            mammalian corticogenesis
  JOURNAL   EMBO J 34 (7), 896-910 (2015)
   PUBMED   25527292
REFERENCE   2  (bases 1 to 3093)
  AUTHORS   Yun,S., Lee,S.H., Yoon,S.R., Kim,M.S., Piao,Z.H., Myung,P.K.,
            Kim,T.D., Jung,H. and Choi,I.
  TITLE     TOX regulates the differentiation of human natural killer cells
            from hematopoietic stem cells in vitro
  JOURNAL   Immunol Lett 136 (1), 29-36 (2011)
   PUBMED   21126536
REFERENCE   3  (bases 1 to 3093)
  AUTHORS   Aliahmad,P., de la Torre,B. and Kaye,J.
  TITLE     Shared dependence on the DNA-binding factor TOX for the development
            of lymphoid tissue-inducer cell and NK cell lineages
  JOURNAL   Nat Immunol 11 (10), 945-952 (2010)
   PUBMED   20818394
REFERENCE   4  (bases 1 to 3093)
  AUTHORS   Aliahmad,P. and Kaye,J.
  TITLE     Development of all CD4 T lineages requires nuclear factor TOX
  JOURNAL   J Exp Med 205 (1), 245-256 (2008)
   PUBMED   18195075
REFERENCE   5  (bases 1 to 3093)
  AUTHORS   Aliahmad,P., O'Flaherty,E., Han,P., Goularte,O.D., Wilkinson,B.,
            Satake,M., Molkentin,J.D. and Kaye,J.
  TITLE     TOX provides a link between calcineurin activation and CD8 lineage
            commitment
  JOURNAL   J Exp Med 199 (8), 1089-1099 (2004)
   PUBMED   15078895
REFERENCE   6  (bases 1 to 3093)
  AUTHORS   Wilkinson,B., Chen,J.Y., Han,P., Rufner,K.M., Goularte,O.D. and
            Kaye,J.
  TITLE     TOX: an HMG box protein implicated in the regulation of thymocyte
            selection
  JOURNAL   Nat Immunol 3 (3), 272-280 (2002)
   PUBMED   11850626
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473984.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_342800.3, XM_001063218.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3093
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q12"
     gene            1..3093
                     /gene="Tox"
                     /note="thymocyte selection-associated high mobility group
                     box"
                     /db_xref="GeneID:362481"
                     /db_xref="RGD:1310455"
     exon            1..176
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
     exon            177..312
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..1788
                     /gene="Tox"
                     /note="thymocyte selection-associated HMG box"
                     /codon_start=1
                     /product="thymocyte selection-associated high mobility
                     group box protein TOX"
                     /protein_id="NP_001102124.1"
                     /db_xref="GeneID:362481"
                     /db_xref="RGD:1310455"
                     /translation="MDVRFYPPPAQPAAAPAAPCLGPSPCLDPYYCNKFDGENMYMSM
                     TEPSQDYVPVSQSYPGPSLESEDFNIPPITPPSLPDHSLVHLNEVESGYHSLCHPMNH
                     NGLLPFHPQNMDLPEITVSNMLGQDGTLLSNSISVMQEIGNAEGAQYSSHPQLAAMRP
                     RGQPTDLRQQASMMQHGQLTTINQSQLSAQLGLNMGGTNVPHNSPSPPGSKSATPSPS
                     SSVHEDECEDTSKINGGEKRPASDMGKKPKTPKKKKKKDPNEPQKPVSAYALFFRDTQ
                     AAIKGQNPNATFGEVSKIVASMWDGLGEEQKQVYKKKTEAAKKEYLKQLAAYRASLVS
                     KSYNDPVDVKTSQPPQLVNSKPSVFHGPSQAHSALYLSSHYHQQPGMTPQLTAMHPSL
                     PRNIAPKPNNQMPVTVSIANMAVSPPPPLQISPPLHQHLSMQQHQPLVQQPLASQLPM
                     QVQTALHSPTMQQGFTLQPDYQTIINPTSTAAQVVTQAMEYVRSGCRNPPPQPVDWST
                     DYCSSGGMQRDKALYLT"
     exon            313..378
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
     exon            379..621
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
     exon            622..903
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1134
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1215
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1599
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1751
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..3093
                     /gene="Tox"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 taactccagg agcactgctc atcgcactgc gatcagctgg ggtcccttgg tcagttgccc
       61 actagcatga agcagaggtt gcgctccctg caggctccgg agcagcgcta cgggacaccc
      121 tctcctctac ctcccgcgtg gtacagaggt tggcagtgca gctactccag gcgggagaaa
      181 agaaaaggag ttgcttgatg tgagagtgaa atggacgtaa gattttatcc acctccagcc
      241 cagcccgctg ctgcgcccgc cgctccctgt ctgggacctt ctccctgcct ggacccctac
      301 tattgcaaca agtttgacgg tgagaacatg tatatgagca tgacagagcc gagccaggac
      361 tatgtgccag tcagccagtc ctaccctggc ccaagtctgg aaagtgaaga ctttaacatc
      421 ccacccatta ctcctccctc actccctgac cactctctgg tgcacctgaa tgaggtggag
      481 tccggttacc actctctgtg tcaccccatg aaccacaatg gcctgcttcc attccatcca
      541 caaaacatgg acctgccaga gatcaccgtg tccaacatgc tgggccagga tggcacactg
      601 ctctccaatt ccatctctgt gatgcaagag attggaaatg ctgaaggagc tcagtacagt
      661 tcccatcctc agctggcagc catgaggccg agaggccagc ctacagacct cagacagcag
      721 gcaagcatga tgcagcacgg ccagctgacc accatcaacc agtcacagct gagcgcacag
      781 ttgggcttga acatgggagg aaccaacgtc ccacacaact ccccttctcc acctgggagc
      841 aagtctgcaa ccccttcgcc ttccagctcg gtgcatgagg atgagtgtga ggatacctcc
      901 aagatcaatg gaggagagaa gcggcctgcc tctgatatgg gaaaaaaacc aaaaactcct
      961 aaaaagaaga agaagaagga tcctaatgag ccccagaagc ctgtgtctgc ctatgctttg
     1021 ttctttcgtg atacccaggc tgccatcaag ggccaaaatc caaatgctac ttttggtgaa
     1081 gtctctaaga ttgtggcatc catgtgggat ggcctaggag aagagcagaa acaggtctac
     1141 aagaagaaaa ctgaggctgc aaaaaaggaa tacctgaagc agctagcagc atacagagcc
     1201 agccttgtat ccaagagcta caatgaccct gtggatgtta agacatctca gccaccccag
     1261 ctggtcaact ccaagccgtc agtgttccat gggcccagcc aggcccactc agctctgtac
     1321 ctaagttctc actatcacca acaaccagga atgactcctc agctcaccgc catgcatccg
     1381 agcctcccca gaaacatagc acctaagccc aataaccaaa tgccagtgac tgtctccata
     1441 gccaacatgg ctgtgtcccc accaccgccc ctccaaatca gcccacctct tcatcagcat
     1501 ctcagcatgc agcagcatca gccacttgtg cagcagcctc ttgcgagtca gctccccatg
     1561 caggtccaga ccgccttaca ctcgcccacc atgcagcaag gatttactct ccaacccgac
     1621 tatcagacta ttatcaaccc tacatctaca gccgcacaag ttgtcaccca agcgatggag
     1681 tacgtgcgtt ctgggtgcag aaatcctccc ccacagccgg tggactggag taccgactac
     1741 tgcagtagtg ggggcatgca gagggacaaa gcgctgtacc tcacctgaaa atctcaacac
     1801 ctctcctttc cactgaggaa ttcagggaaa ccttttcacc acggattgct ttggccgctc
     1861 aaagcagttc ttcattttat tagaaaatac aagttgctaa gcacttagga ccatgtgagc
     1921 ttgtgggtca cccacgctgg aagaaatagt catgcttctt tattattttt ttaatctttt
     1981 atggacattg tccctcttcc ctgaaggaag tatgggccat tcagatttct gttggttttg
     2041 ctgtgaagtg ctgccgctct agtaactgcc ttagcaacgg tagatgtctg gggtaaaacg
     2101 gtcctgggtt ttccattggt tttcataatg ggtgtttata tgaaactact aaagactttt
     2161 taaatggctt gatgtagcag tcatagcaag tttgtaaata gcatatatgt tacactctcc
     2221 tagagtataa aatgtgaatg tttttgtagc taaattgtaa tttgaaactg gctcacccca
     2281 gtttgttgat ttcagagggg ttaaattggc aaacattcat atttttactt catttttaaa
     2341 aagaaaaaaa acaactgact gatagttcta tattttcaaa agacttgaaa actattccca
     2401 aatcatttta atttaaaaac aaattggctt tgtcttattg atcagacaaa aggaagctct
     2461 cgtgtggagg gaagcgcaaa cacatttatt ttgtattgca ggaaaaaaat tcttttttgt
     2521 atcacttttg tgtaatggtt agtaagcgtc atctaagtcc ttttatgtat aaaactgcca
     2581 aatgctcgcc tggtatctta gctgcagaaa caggtcaaac agcgctaagt gatcaccgtt
     2641 acctgtggct ctgtgttact gttccctcat ccgtgtctgt atttaatcgt tttcttctct
     2701 ttttttttta atgaaacttg tttcgcttat ttatgaaata ataaatatag gtgtttgtaa
     2761 gtaaatttgt tagtatttga aagaggtttt gttgatgctt taatttttgc tggcaaaaaa
     2821 gaaaaaaaat ccatgcttgg tgtgaatatt tagtttttac agtgacatga ataaaaccaa
     2881 aactgctttt catttagtag caaaatagag tgacgaatct gtatttttgc atatcttttg
     2941 ttgacataaa tgaaaaacaa ttctacttag ccatcttctt ctcttgaaca atacaacaga
     3001 aaattgccct ggagatctca cacttgccaa gcctaagcaa acaccagtgc atcccgttcc
     3061 taaaaagata cgaagagcta tttttcactt ctc
//
