LOCUS       NM_001007744            1470 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Rattus norvegicus torsin family 2, member A (Tor2a), mRNA.
ACCESSION   NM_001007744 XM_342415
VERSION     NM_001007744.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1470)
  AUTHORS   Xu,Y., Fei,X., Fu,H., Chen,A., Zhu,X., Zhang,F. and Han,Y.
  TITLE     Upregulated expression of a TOR2A gene product-salusin-beta in the
            paraventricular nucleus enhances sympathetic activity and cardiac
            sympathetic afferent reflex in rats with chronic heart failure
            induced by coronary artery ligation
  JOURNAL   Acta Physiol (Oxf) 238 (4), e13987 (2023)
   PUBMED   37183727
  REMARK    GeneRIF: Upregulated expression of a TOR2A gene
            product-salusin-beta in the paraventricular nucleus enhances
            sympathetic activity and cardiac sympathetic afferent reflex in
            rats with chronic heart failure induced by coronary artery
            ligation.
REFERENCE   2  (bases 1 to 1470)
  AUTHORS   Chen,S., Hu,Y., Zhang,J. and Zhang,P.
  TITLE     Anti-inflammatory effect of salusin-beta knockdown on LPS-activated
            alveolar macrophages via NF-kappaB inhibition and HO-1 activation
  JOURNAL   Mol Med Rep 23 (2) (2021)
   PUBMED   33300078
  REMARK    GeneRIF: Antiinflammatory effect of salusinbeta knockdown on
            LPSactivated alveolar macrophages via NFkappaB inhibition and HO1
            activation.
REFERENCE   3  (bases 1 to 1470)
  AUTHORS   Shichiri,M., Nonaka,D., Lee,L.J. and Tanaka,K.
  TITLE     Identification of the salusin-beta receptor using proteoliposomes
            embedded with endogenous membrane proteins
  JOURNAL   Sci Rep 8 (1), 17865 (2018)
   PUBMED   30552345
  REMARK    GeneRIF: Here, the authors show that the beta-chain of ATP synthase
            is a cell surface receptor for salusin-beta
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1470)
  AUTHORS   Ren,X.S., Ling,L., Zhou,B., Han,Y., Zhou,Y.B., Chen,Q., Li,Y.H.,
            Kang,Y.M. and Zhu,G.Q.
  TITLE     Silencing salusin-beta attenuates cardiovascular remodeling and
            hypertension in spontaneously hypertensive rats
  JOURNAL   Sci Rep 7, 43259 (2017)
   PUBMED   28230187
  REMARK    GeneRIF: These results indicate that silencing salusin-beta
            attenuates hypertension and cardiovascular remodeling in
            spontaneously hypertensive rats.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1470)
  AUTHORS   Sun,H.J., Zhao,M.X., Ren,X.S., Liu,T.Y., Chen,Q., Li,Y.H.,
            Kang,Y.M., Wang,J.J. and Zhu,G.Q.
  TITLE     Salusin-beta Promotes Vascular Smooth Muscle Cell Migration and
            Intimal Hyperplasia After Vascular Injury via ROS/NFkappaB/MMP-9
            Pathway
  JOURNAL   Antioxid Redox Signal 24 (18), 1045-1057 (2016)
   PUBMED   26952533
  REMARK    GeneRIF: salusin-beta may be important in the vascular smooth
            muscle cell migration and neointima of some vascular diseases.
REFERENCE   6  (bases 1 to 1470)
  AUTHORS   Chen,W.W., Sun,H.J., Zhang,F., Zhou,Y.B., Xiong,X.Q., Wang,J.J. and
            Zhu,G.Q.
  TITLE     Salusin-beta in paraventricular nucleus increases blood pressure
            and sympathetic outflow via vasopressin in hypertensive rats
  JOURNAL   Cardiovasc Res 98 (3), 344-351 (2013)
   PUBMED   23400761
  REMARK    GeneRIF: Salusin-beta in the paraventricular nucleus increases
            blood pressure, heart rate, and sympathetic outflow via both
            circulating AVP and AVP in the rostral ventrolateral medulla in
            hypertensive rats.
REFERENCE   7  (bases 1 to 1470)
  AUTHORS   Jungwirth,M., Dear,M.L., Brown,P., Holbrook,K. and Goodchild,R.
  TITLE     Relative tissue expression of homologous torsinB correlates with
            the neuronal specific importance of DYT1 dystonia-associated
            torsinA
  JOURNAL   Hum Mol Genet 19 (5), 888-900 (2010)
   PUBMED   20015956
REFERENCE   8  (bases 1 to 1470)
  AUTHORS   Saito,T., Dayanithi,G., Saito,J., Onaka,T., Urabe,T.,
            Watanabe,T.X., Hashimoto,H., Yokoyama,T., Fujihara,H., Yokota,A.,
            Nishizawa,S., Hirata,Y. and Ueta,Y.
  TITLE     Chronic osmotic stimuli increase salusin-beta-like immunoreactivity
            in the rat hypothalamo-neurohypophyseal system: possible
            involvement of salusin-beta on [Ca2+]i increase and
            neurohypophyseal hormone release from the axon terminals
  JOURNAL   J Neuroendocrinol 20 (2), 207-219 (2008)
   PUBMED   18047553
  REMARK    GeneRIF: Salusin-beta may be involved in the regulation of body
            fluid balance by stimulating neurohypophyseal hormone release from
            nerve endings by an autocrine/paracrine mechanism.
REFERENCE   9  (bases 1 to 1470)
  AUTHORS   Suzuki,N., Shichiri,M., Akashi,T., Sato,K., Sakurada,M., Hirono,Y.,
            Yoshimoto,T., Koyama,T. and Hirata,Y.
  TITLE     Systemic distribution of salusin expression in the rat
  JOURNAL   Hypertens Res 30 (12), 1255-1262 (2007)
   PUBMED   18344632
  REMARK    GeneRIF: rat salusin is immunologically similar to human
            salusin-beta and widely expressed, especially in the immune,
            gastrointestinal, and central nervous systems and mainly in
            endocrine- and hematopoietic-derived cells
REFERENCE   10 (bases 1 to 1470)
  AUTHORS   Shichiri,M., Ishimaru,S., Ota,T., Nishikawa,T., Isogai,T. and
            Hirata,Y.
  TITLE     Salusins: newly identified bioactive peptides with hemodynamic and
            mitogenic activities
  JOURNAL   Nat Med 9 (9), 1166-1172 (2003)
   PUBMED   12910263
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC078943.1.
            
            On Aug 3, 2022 this sequence version replaced NM_001007744.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078943.1, EV779984.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1470              BC078943.1         26-1495
FEATURES             Location/Qualifiers
     source          1..1470
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p11"
     gene            1..1470
                     /gene="Tor2a"
                     /note="torsin family 2, member A"
                     /db_xref="GeneID:362112"
                     /db_xref="RGD:1359111"
     exon            1..176
                     /gene="Tor2a"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..991
                     /gene="Tor2a"
                     /note="torsin-2A; prosalusin"
                     /codon_start=1
                     /product="torsin-2A precursor"
                     /protein_id="NP_001007745.3"
                     /db_xref="GeneID:362112"
                     /db_xref="RGD:1359111"
                     /translation="MAVARHGCPPWGSILGLLVLALAAAAAWDVSFLRCSLGSFCECD
                     FWPDLPGLECDLARHLAGQHLAKALVVKSLKAFVQDPAPSKPLVLSLHGWTGTGKSYV
                     SSLLAQYLFRGGLRSPHVHHFSPIIHFPHPSHTEQYKNELKSWVQGNLTACGRSLFLF
                     DEMDKLPPGLMEVLKPFLGPSWVVYGTNYRKAIFIFISNTGGEQINQVALEAWRSRRD
                     REEISLQEVEPAVSQAVLDNPHHGFWRSGIMEEQLLDAVVPFLPLQRHHVRHCVLNEL
                     AQLGLEPREEVVQAVLDSTTYFPEEEQLFSSNGCKTVASRITFFL"
     exon            177..442
                     /gene="Tor2a"
                     /inference="alignment:Splign:2.1.0"
     exon            443..618
                     /gene="Tor2a"
                     /inference="alignment:Splign:2.1.0"
     exon            619..746
                     /gene="Tor2a"
                     /inference="alignment:Splign:2.1.0"
     exon            747..1470
                     /gene="Tor2a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgactgaaa tagggcctca accggatggc ggtggctagg cacggctgcc cgccctgggg
       61 ctcgatcctc gggctgctcg tgctggcctt ggctgccgcc gccgcctggg acgtgtcttt
      121 tctgcgatgc agtttagggt ccttctgcga atgtgacttc tggcccgact tgcctggtct
      181 ggaatgtgac ctggctcgac acctagctgg ccagcatttg gccaaggccc tggtggtgaa
      241 gtcattgaag gcctttgtac aggacccagc ccccagcaag ccattggtcc tttccctgca
      301 cggctggaca ggcactggga agtcctatgt gagctccctg ctggcgcagt atctcttccg
      361 gggtggcctt cgcagccctc atgtccatca cttctctcct atcatccact tcccacatcc
      421 cagccacact gagcagtaca agaatgagct caagagctgg gtccagggga acctcactgc
      481 ctgtggccgg tctcttttcc tcttcgatga gatggacaag ctgccccctg gcctgatgga
      541 agtcctgaag cccttcctgg gcccttcttg ggttgtgtat gggaccaact atcgcaaagc
      601 cattttcatc tttatcagca atactggagg tgagcagatc aaccaggtgg ccctggaggc
      661 atggcgcagc cgtagggaca gggaagaaat cagcctacag gaggtggagc cagcagtgtc
      721 ccaagctgtg ttggacaacc ctcaccatgg cttctggcgg tctggcatca tggaggagca
      781 gctgctggat gctgtggtcc ccttcctccc cctccagcgg catcatgtgc gccactgtgt
      841 gctcaatgag ctggctcagc tgggtttgga gccccgagag gaggtggttc aggctgtgct
      901 ggacagtacc acctacttcc ctgaggagga gcagctcttc tcctccaatg gctgcaagac
      961 agtggcatcc cgaatcacat ttttcctctg agaaccccgg gggcatcatt gcctcctctg
     1021 cctagacaga tcaaacagac gcctgggcgt ctcctggaag aattcttccc taagctggct
     1081 ggcaagtggg acccagagca cagagttacg atgaagaaag gagttggcag gccaaggaag
     1141 aaaggtctag aagcatcttt gctgggaaat tcctgggcac cccagaacct cacagcctcg
     1201 ccattgctct gcggtctgag ccttctcaat gtgaacggca actcagggac aaagtggcta
     1261 ctccagctgg gggcttttac tggcacgcct tgtctggtcc cttctccaga tctcagccta
     1321 tggctggacc tggcaatcca gctaggccag gcaagcatct cagttttacc aaatgaaagg
     1381 actcaagctg ccacctgggc ctggctttca aagtttttaa ttttgtatga gaagagagca
     1441 gagataataa acttagccat ggtattggaa
//
