LOCUS       NM_001039197            2991 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus torsin family 1, member B (Tor1b), mRNA.
ACCESSION   NM_001039197 XM_231146
VERSION     NM_001039197.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2991)
  AUTHORS   Rose,A.E., Zhao,C., Turner,E.M., Steyer,A.M. and Schlieker,C.
  TITLE     Arresting a Torsin ATPase reshapes the endoplasmic reticulum
  JOURNAL   J Biol Chem 289 (1), 552-564 (2014)
   PUBMED   24275647
REFERENCE   2  (bases 1 to 2991)
  AUTHORS   Zhao,C., Brown,R.S., Chase,A.R., Eisele,M.R. and Schlieker,C.
  TITLE     Regulation of Torsin ATPases by LAP1 and LULL1
  JOURNAL   Proc Natl Acad Sci U S A 110 (17), E1545-E1554 (2013)
   PUBMED   23569223
REFERENCE   3  (bases 1 to 2991)
  AUTHORS   Kim,C.E., Perez,A., Perkins,G., Ellisman,M.H. and Dauer,W.T.
  TITLE     A molecular mechanism underlying the neural-specific defect in
            torsinA mutant mice
  JOURNAL   Proc Natl Acad Sci U S A 107 (21), 9861-9866 (2010)
   PUBMED   20457914
REFERENCE   4  (bases 1 to 2991)
  AUTHORS   Jungwirth,M., Dear,M.L., Brown,P., Holbrook,K. and Goodchild,R.
  TITLE     Relative tissue expression of homologous torsinB correlates with
            the neuronal specific importance of DYT1 dystonia-associated
            torsinA
  JOURNAL   Hum Mol Genet 19 (5), 888-900 (2010)
   PUBMED   20015956
REFERENCE   5  (bases 1 to 2991)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   6  (bases 1 to 2991)
  AUTHORS   Hewett,J.W., Kamm,C., Boston,H., Beauchamp,R., Naismith,T.,
            Ozelius,L., Hanson,P.I., Breakefield,X.O. and Ramesh,V.
  TITLE     TorsinB--perinuclear location and association with torsinA
  JOURNAL   J Neurochem 89 (5), 1186-1194 (2004)
   PUBMED   15147511
REFERENCE   7  (bases 1 to 2991)
  AUTHORS   Konakova,M. and Pulst,S.M.
  TITLE     Immunocytochemical characterization of torsin proteins in mouse
            brain
  JOURNAL   Brain Res 922 (1), 1-8 (2001)
   PUBMED   11730696
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC111704.1.
            
            On Jan 29, 2006 this sequence version replaced XM_231146.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC111704.1, FQ222570.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2991
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p12"
     gene            1..2991
                     /gene="Tor1b"
                     /note="torsin family 1, member B"
                     /db_xref="GeneID:311854"
                     /db_xref="RGD:1308431"
     exon            1..213
                     /gene="Tor1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..1025
                     /gene="Tor1b"
                     /note="torsin-1B"
                     /codon_start=1
                     /product="torsin-1B precursor"
                     /protein_id="NP_001034286.1"
                     /db_xref="GeneID:311854"
                     /db_xref="RGD:1308431"
                     /translation="MRRVGAFGGSTALWVLLAAHVAAAFEPVSVGIAIGAVSALTGYL
                     SYSDFYCRFTECCHEERPLNTSALKLDLEEKLFGQHLATEVILKALTGFRNNKNPKKP
                     LTLSLHGWAGTGKNFVSQIVAENLYPKGLKSNFVHLFVSTLHFPHEQKIKLYQDQLQK
                     WIRGNVSACGSSVFIFDEMDKLHPGIIDAIKPFLDYYEQVDGISYRKAIFIFLSNAGG
                     DLITKTTLDFWRAGRKREEIQLKDLEPVLSVGVFNNKHSGLWHSGLIDKNLIDYFIPF
                     LPLEYKHVKMCVRAEMRARGAAVDEDIVTSVADEMTFFPKDEKIYSDKGCKTVQSRLD
                     FH"
     exon            214..479
                     /gene="Tor1b"
                     /inference="alignment:Splign:2.1.0"
     exon            480..655
                     /gene="Tor1b"
                     /inference="alignment:Splign:2.1.0"
     exon            656..783
                     /gene="Tor1b"
                     /inference="alignment:Splign:2.1.0"
     exon            784..2923
                     /gene="Tor1b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttcgttgag tgcgatgaga cgagtcgggg cgtttggggg ctccacggcc ctgtgggtgc
       61 tcctggccgc ccacgtggcg gcggcgttcg agcccgtgag cgtgggcatc gccatcgggg
      121 ctgtgtcagc gctcaccggc tacctgtcct atagcgactt ttactgccgc ttcaccgagt
      181 gctgccatga ggaacggccc ctcaacacgt cggccctcaa gctggacttg gaagagaagc
      241 tgttcggaca gcaccttgcc accgaagtga ttctcaaggc attgactggc ttcaggaaca
      301 acaaaaatcc caagaaacca ctgactctat ccttgcacgg ctgggctggc acgggcaaga
      361 attttgtcag ccagattgtg gctgaaaacc tttatccaaa aggcctgaag agtaactttg
      421 tccacctgtt cgtctctact ctgcacttcc ctcatgagca gaagataaaa ctgtaccagg
      481 accagctcca gaagtggatc cgaggcaacg tgagcgcgtg cggcagctcc gttttcatct
      541 ttgacgagat ggataagttg catcctggaa tcattgatgc aatcaagccc ttcctggact
      601 attatgagca ggtggatggg atttcctacc gcaaagccat cttcatcttc ctcagcaatg
      661 caggagggga cctgataacc aagacgaccc tggacttctg gcgggcagga agaaaaaggg
      721 aggagatcca gctgaaggac ctggagcctg tgctgtctgt gggtgtcttc aacaacaagc
      781 acagtggcct gtggcacagt gggctaatag acaagaacct catcgactac ttcatcccct
      841 tcctgccctt ggagtataaa cacgtgaaaa tgtgtgtgcg ggcagagatg agggcccgag
      901 gggctgctgt ggatgaagac attgtcacca gtgtggcaga tgaaatgacc tttttcccca
      961 aggatgagaa gatctactcg gacaagggct gcaagacagt gcagtcacgg ctggatttcc
     1021 actgagctct tccctcagtg aggtgggatg accagggcct tgccatggag aagcactttg
     1081 aaagcccccc acttggggct ttgcacattt gcacctgtgg acttgggacg ttgtccatgt
     1141 attgtctgaa gatgaacttt tagaacattc actcttactg tgaatcaagt gcctaaaaaa
     1201 cgtctgaacg caggccaagg tcctgtgtgg ccaacaatgc ccatgcctca gataccacta
     1261 agagcctgca gcgcctgctg cagtcttggg gaagcagggt ttcctgacag gggcgcccac
     1321 tgtgctgttt tctttttcgc cttgagctgg aactcagtag ctggtggtac tgacagatgc
     1381 tcgctgttgg aggggagcat gtaggcctga ccttggctga agtgtcagcg tgagcagtgg
     1441 gggctccctc tgaggcccct ggagcactgg gacactacct tgctcgctgc tgctcacagc
     1501 cctggctgtg gaattctctc ctgtttccta ctgtgtgtgc cttgtacttt ccctatcatc
     1561 tgttagattc accccagcct catgcctgct ccaatcagga tgagctgtca ttttaaaggg
     1621 aggtctttgg ttctgtttgc ctgttacacc tgctctgaag gtcaagcgct gctgtgcaga
     1681 accagtaacc acataggaag agctctaggc cggagctgcc ctggccaaac cccatcggaa
     1741 ggagtgtctg ccgcacacca gagatgctgg ttttttaaaa ggacatgcac atatttaaaa
     1801 gttatgtctt tacctctaaa gcttaggtaa tataagatgc catgcatttt aaaacctagg
     1861 aagtgccatg agtgcaacct ttaatcccag cactcaggag acagaggcgg gtgcatctct
     1921 gagttcaagg ccagcctggt ctacacagtg agttccaggg cagccaaggc aacacagagt
     1981 aacctttttt tttttttttt ttgaaaaaaa aaaaaaaacc caaaaaacct aggagggaca
     2041 taaagtagaa taaggccaat tctcaggttt ttattgtggc tgggtccagg ggcacaatgc
     2101 ccatgatccc acaggaaggt cagggttcag ggctcctcag ctatcttggg atgagaataa
     2161 cctgagctac acacaactct caaaagaaag gctttattgc taaatgtgta gagtgtagaa
     2221 ctatatgggc gcaactgtag ctcccacaaa gtcctccgtt tgtgagttct gtgtacaacc
     2281 tcaggatgac gccttgagct gctctgactg tagggaaccg agcctgcagt cactctgccc
     2341 tgcagtcgca gacagggaaa cactgccatg tatgtataga acgtggggga atgacttttt
     2401 ataacatgga aatgcctcat agagaaccac atctagtctt ttgaaaatgt caaggtgagc
     2461 tgggcgtggt ggtgctcacc tttagtcccc ctacctggga ggccatggca cgactgtccc
     2521 aagtttgaag ccagcctgga ccagacaagc ggacactagg cggtggtgtg catgcctgta
     2581 atgccagccc ttaggaagaa gagcttaaag ttaactatgc ccagagaccc tgtctcaaag
     2641 caggaagcac acaaaactca ccaaggtgag gctgactcct atgccatatt cttggacctg
     2701 agccaagtta ctgtttctaa cctgttgggc tcctggtcaa gaaacaagct tttctgttta
     2761 cagtgatgta atactcggac acgtgttggc cacctttgga ctgctgttac tgatctccaa
     2821 ctttgaaagg cctggtgtga actgccccag cctccccagc ctgcccatga gaagtcatga
     2881 acagagctgg acacaaaaca ataaaagtgg tgcactggtg agaaaaaaaa aaaaaaaaaa
     2941 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
