LOCUS       NM_199100               5080 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus torsin 1A interacting protein 2 (Tor1aip2),
            transcript variant 1, mRNA.
ACCESSION   NM_199100 XM_222761
VERSION     NM_199100.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5080)
  AUTHORS   Rose,A.E., Zhao,C., Turner,E.M., Steyer,A.M. and Schlieker,C.
  TITLE     Arresting a Torsin ATPase reshapes the endoplasmic reticulum
  JOURNAL   J Biol Chem 289 (1), 552-564 (2014)
   PUBMED   24275647
REFERENCE   2  (bases 1 to 5080)
  AUTHORS   Zhao,C., Brown,R.S., Chase,A.R., Eisele,M.R. and Schlieker,C.
  TITLE     Regulation of Torsin ATPases by LAP1 and LULL1
  JOURNAL   Proc Natl Acad Sci U S A 110 (17), E1545-E1554 (2013)
   PUBMED   23569223
REFERENCE   3  (bases 1 to 5080)
  AUTHORS   Vander Heyden,A.B., Naismith,T.V., Snapp,E.L., Hodzic,D. and
            Hanson,P.I.
  TITLE     LULL1 retargets TorsinA to the nuclear envelope revealing an
            activity that is impaired by the DYT1 dystonia mutation
  JOURNAL   Mol Biol Cell 20 (11), 2661-2672 (2009)
   PUBMED   19339278
REFERENCE   4  (bases 1 to 5080)
  AUTHORS   Goodchild,R.E. and Dauer,W.T.
  TITLE     The AAA+ protein torsinA interacts with a conserved domain present
            in LAP1 and a novel ER protein
  JOURNAL   J Cell Biol 168 (6), 855-862 (2005)
   PUBMED   15767459
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000243.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_199100.4.
            
            On Feb 10, 2021 this sequence version replaced NM_199100.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer protein, isoform b, referred to
            as torsin-1A-interacting protein 2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061831.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-98                JACYVU010000243.1  3086676-3086773
            99-275              JACYVU010000243.1  3104291-3104467
            276-1085            JACYVU010000243.1  3106048-3106857
            1086-1187           JACYVU010000243.1  3108233-3108334
            1188-5080           JACYVU010000243.1  3109311-3113203
FEATURES             Location/Qualifiers
     source          1..5080
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q22"
     gene            1..5080
                     /gene="Tor1aip2"
                     /note="torsin 1A interacting protein 2"
                     /db_xref="GeneID:304881"
                     /db_xref="RGD:735059"
     exon            1..98
                     /gene="Tor1aip2"
                     /inference="alignment:Splign:2.1.0"
     exon            99..275
                     /gene="Tor1aip2"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..1945
                     /gene="Tor1aip2"
                     /note="isoform b is encoded by transcript variant 1;
                     interferon alpha responsive protein; torsin A interacting
                     protein 2"
                     /codon_start=1
                     /product="torsin-1A-interacting protein 2 isoform b"
                     /protein_id="NP_954531.1"
                     /db_xref="GeneID:304881"
                     /db_xref="RGD:735059"
                     /translation="MSQTLKSQDTNMSDSGYRDPVEDSQNVLGNDPSVNSQAQDPIVT
                     PSNTVEAQTLHPTSDLKEDHHEIGAKGQEHADTGDRAESSEEPALEKPPLDKAELERS
                     PSSQDTEQRHHPYSEHVGGDTLVLDPNYSQSDLGGRADAHLESSSAAPTEGAGEGGEA
                     GAHLESSCAALPVGADEGGRANAHLESSSAAPTEGAGEGGEADVHLESSSAVPPEEAH
                     LESSSAAPSEGAGEGGEADAHLESSSAAPSEGAGEGGETAQNLLAVDSTDAQSPCHSS
                     AGPGSQDSLRRRLPVTEAERHEEETQLVTEKEEVAQETLRKTEKKSLWTYGSMFLGCL
                     IVAVVLSSVNSYYSSPAQQVPQNPALEAFLAQFSQLREKFPGQSAFLWQRGRKFLQKH
                     LNASNPSEPATVIFTAAREGKETLKCLSYHVANAYTSSQKVTAVSIDGAERALQDSDT
                     VKLLVDLELSYGFENGHKAAVVHHFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLL
                     EEETLEASVSPRETEEKVRDLLWAKFTDSGTPSSFSHMDSDKLSGLWSRISHLVLPVQ
                     PVKNIEERGCLL"
     exon            276..1085
                     /gene="Tor1aip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1187
                     /gene="Tor1aip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..5080
                     /gene="Tor1aip2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggctggggg ttgcagacca gcgctgtgga gcaggaggga cagccgagtg gcgccgctga
       61 tcctgactgt cccatatttt aaaacctggc tggaaattcc actgtcgata tcccttgctt
      121 cttgcttcca tgggaagcat gagtctattg gaacttggga caagaagaaa tcaaggtatc
      181 tctactacag agcccagaca ctaaacacat gtcccaaact ctgaagagcc aggacacaaa
      241 catgagtgac agtggctaca gggatcctgt ggaagactct caaaacgttt tgggaaatga
      301 tccatcagta aactctcaag cacaggaccc catagtcaca ccgagtaaca ctgtggaagc
      361 ccagacccta catcccacat ctgatcttaa ggaagaccat catgaaatag gggccaaagg
      421 tcaggagcat gcagacacag gtgacagggc agaaagttct gaggaaccag ctttggagaa
      481 acctccactg gataaagcag aactggagag gagcccgagt tctcaggaca cagagcaaag
      541 gcatcacccc tactcggaac atgtgggcgg agacaccctg gttctggatc ctaactactc
      601 tcaaagcgac ttgggaggaa gagcggatgc acacctggag agcagctctg cagcccccac
      661 agagggggca ggtgagggag gtgaagcagg tgcacacctg gagagcagct gtgcagccct
      721 cccagtggga gcagatgagg gaggaagagc gaatgcacac ctggagagca gctctgcagc
      781 ccccacagag ggggcaggtg agggaggtga agcagatgta cacctagaaa gcagctctgc
      841 agtcccccca gaggaggccc atctggagag cagctctgca gccccctcag agggggcagg
      901 tgagggaggt gaagcagatg cacacctgga gagcagctct gcagcccctt cagagggggc
      961 aggtgaggga ggtgaaactg ctcagaacct acttgctgta gactctaccg atgcccagag
     1021 tccctgtcac tccagtgcag gcccagggag ccaggattca ctgaggagaa gactgcctgt
     1081 gacagaggct gaaaggcatg aagaagagac acagttggtg acggaaaagg aggaggtcgc
     1141 acaggaaaca ttgagaaaga ctgagaaaaa gagtctctgg acctatggtt ccatgtttct
     1201 tggctgcctg attgtggctg tggtgctaag ctctgtcaac agctactatt cctccccagc
     1261 tcagcaggtg ccacagaacc cagctctgga ggccttcctg gctcagttta gccaactgag
     1321 ggagaaattt ccaggtcaga gtgccttcct gtggcagcga gggcgtaagt ttctccagaa
     1381 gcacctcaac gcctcaaacc ccagtgagcc agccaccgtc atcttcacag ctgctcgaga
     1441 ggggaaggag accctcaagt gcctgagcta ccacgtggcc aatgcctaca cctcttccca
     1501 gaaggtaact gccgtctcca tagacggagc ggagagagcc ctgcaggaca gtgacacagt
     1561 caagctgttg gttgacttgg agctcagcta tgggtttgag aatggccaca aggctgctgt
     1621 agtccaccac ttcgaatccc ttcctgcggg ctccaccctg atcttctaca agtactgtga
     1681 ccacgagaac gccgccttta aagatgtggc ccttgtcctg accgtcctgc tggaggagga
     1741 aacgttagaa gcaagtgtaa gccccaggga aacagaagaa aaagtgaggg atttgctctg
     1801 ggccaagttc accgactccg gaactcccag ctccttcagc cacatggact cagacaaact
     1861 gagtggactc tggagccgta tctcccacct cgtgctgccc gtgcagcccg tcaagaacat
     1921 agaagagcga ggctgccttt tgtgaagcca gccaccaagg tgacattgaa gggccaggcc
     1981 tgagggctct gttgcaatgg gaggaggtga ttggcacgtg agaggaaaca gctggtgcac
     2041 gagactttat gttggaaaag aagccttttt ttccttttac ttttataaaa actttctagt
     2101 ctgaactttg ataaaactaa caattggcct gatgtttttc tttgtctttt aaagccaatc
     2161 aggttgatgt atgtatggat cgtttaggtg tccagcccat tggtagaatc gttgcacagg
     2221 aagttctgat tctccgggaa ctgcactacc actgctgtcc tgcaaggact ctaaccggcc
     2281 accagggcca tgtttggacc tggactaggc gtaattccaa tgattttaga ggacacttct
     2341 accacatctt aagttctttc taagattcac tttaataatg cactcgtggg gttggttgta
     2401 tcttacacag atttgcactt tgactaggtg aaaacaggaa attacagttc agcccccccc
     2461 agacctacct aagaacctgg tgtgtgtatg cttttattcc gttaaggagc tgaggtagga
     2521 acagctgctc tcaaacgaac aaacaaaaat gttcccaagc atcaatgtag aaattgttag
     2581 taatcaccag aaataaaaaa atcccaactg gcgatatcat ttctctgtgc ctacccgcgg
     2641 cccctcctcc ctatgagagc atgcctgccc ttggctgctg ctggtatttt ggcttctctg
     2701 ttaagatttc ggtggaactg agtttcaccg aaaggaagtt taaaaaccct tgatgaagtg
     2761 aaagcacatt ctagaatagg aagttggata ggaagaaatg gcagggttag gagttgacca
     2821 gggttacaaa gacctgcagg tgagctagct actcgaggat gtctgttggt ctttctggct
     2881 tccccactgg aatttcacat ttgtctgtgg taagagtctg agtgctgttt cagaaaagac
     2941 ttgagtaata gcagctgctg caggaggatg ttctccatag gggacaggaa gaggaatcat
     3001 ggccagtgtc agttgttaag cttcgtccca tgatttcaga ctgggccaat agctgttgat
     3061 cagcacatga actctgaaag taaaacgcta gtaaaatgat cttgaccctc atccattaca
     3121 tgggtgggga aaaagccctt ggaacttggc actcagtttt gggtcatctg ctgctatgag
     3181 atcatgtatg tagttgagac attaagccac agagtctaga gggattttag gaaacactaa
     3241 gatttctatt gatagttaaa aggatcacag aggccctcgt gagaggtaat ctgaaaatat
     3301 ttaccataaa atggctttgg ccagagcctt tggtgttaag taagttaatt atgggggccc
     3361 aggtgaagca gtacgcattt ggaattttga aggtatcctg aaatagacgt aagaaaaaac
     3421 cctacacaaa atttaagcat ggtgaatggg gttttactgt taaaccagtg taaaacacag
     3481 ggactgtaga aaaatctgtc tgccatattt gatttttctt ttttcttctg tatttctaaa
     3541 ctcacttgtt tcgaatgcta gtggcttgtc atagagccat gctggcctgg tgcttaccct
     3601 gtggtgtagg ctgactttga acttacagtg atttttccta cctcggcttc ctgagtgctg
     3661 aggctatagg tgtgtaccgt tgtactcagc tcttagctac taacattaca tcacgtaaag
     3721 ccacgtcaga aggcgccttg cagagctgct gtgttggcct ttgacctgtg ctccagagga
     3781 actgtggaga ggacgctaga ggaactggtc agcagtattt gtatacagtc tgtgtcaggg
     3841 actcaggtca caggtgaact aggtaatcat ttcttcatta aaactgtaaa actacagcct
     3901 tacaaagttt gctgttaaca aaaattcagg atataataca ttctagaaat ttattttcat
     3961 ctttttccta tttaccttgt taaaaaacac ttttcctcat acgtgcaatc aactgagact
     4021 catcagtttt ctacactgtt tcaaatcctc cggccttaac attcattcaa ggagagtgcc
     4081 ctatcactaa gctgtattcc cagaccttta aaaaataatt ttgaaaaaaa accccaaaaa
     4141 acagtatatg tttgtttggg gtcagaacaa atgattttct gtttttgata cagagtctgt
     4201 acatagccca aagtagtaat tctcaagcct tagactttta cataatgaga ttctaggagt
     4261 gtgccgccat accagctcag tgcagttact tttaaaacaa aaatatactt taaaatgtat
     4321 acatatctat tttcaactga acacacacac acacacacac acacatacat acataacaca
     4381 cacacacata cacattggtg gtgtttttgt ttttttgttt tgttttgttt taaataggaa
     4441 tcccttcttg agtaatacca agtctctgaa acaagcaggg gaaatagaaa ctgtctttag
     4501 acttgagtct cgctttccct ttcaggtaaa atttagggtt cttagggttc ttttaggtag
     4561 ttctcagaga tcatcagaga agttctagag agttcttatc cctgaactaa tttgaacaaa
     4621 ttttatctgg aagttcggag gcttggggga gggtagtgag gatcagtgcc cttcctgtcg
     4681 gcccacccta acagtgctgg ctgatggagg ggacagcttt gtctcaaggc ctttggttca
     4741 cattctcgtt taaggccgga gcactgtgag cacagatgct gggtatggca gacagatgtg
     4801 aacacgagag aaatgcagca aaacgatgac cagcaacacg cttacattct ctatcaagga
     4861 tttcttagcc ccaagaatcc tgccttgatg tattcacaaa tttaacggct tgtcagactt
     4921 ttcaagtcac cataactgct tttttgcatt tgtttccata ttgatgatgt tgaatgtgcc
     4981 ttattcaaat caactgtcat ttacaataaa ttgccttgat ttttcctagt tgcttgattt
     5041 ttgactaaaa tttccaaaat aaagagttta tggaaatggg
//
