LOCUS       NM_145092               2730 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus torsin 1A interacting protein 1 (Tor1aip1), mRNA.
ACCESSION   NM_145092
VERSION     NM_145092.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2730)
  AUTHORS   Rose,A.E., Zhao,C., Turner,E.M., Steyer,A.M. and Schlieker,C.
  TITLE     Arresting a Torsin ATPase reshapes the endoplasmic reticulum
  JOURNAL   J Biol Chem 289 (1), 552-564 (2014)
   PUBMED   24275647
REFERENCE   2  (bases 1 to 2730)
  AUTHORS   Santos,M., Rebelo,S., Van Kleeff,P.J., Kim,C.E., Dauer,W.T.,
            Fardilha,M., da Cruz E Silva,O.A. and da Cruz E Silva,E.F.
  TITLE     The nuclear envelope protein, LAP1B, is a novel protein phosphatase
            1 substrate
  JOURNAL   PLoS One 8 (10), e76788 (2013)
   PUBMED   24116158
  REMARK    GeneRIF: Data indicate that the protein phosphatase 1 (PP1) and
            nuclear membrane protein lamina associated polypeptide 1B (LAP1B)
            LAP1B:PP1 complex can be immunoprecipitated from cerebral cortex.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2730)
  AUTHORS   Zhao,C., Brown,R.S., Chase,A.R., Eisele,M.R. and Schlieker,C.
  TITLE     Regulation of Torsin ATPases by LAP1 and LULL1
  JOURNAL   Proc Natl Acad Sci U S A 110 (17), E1545-E1554 (2013)
   PUBMED   23569223
REFERENCE   4  (bases 1 to 2730)
  AUTHORS   Kim,C.E., Perez,A., Perkins,G., Ellisman,M.H. and Dauer,W.T.
  TITLE     A molecular mechanism underlying the neural-specific defect in
            torsinA mutant mice
  JOURNAL   Proc Natl Acad Sci U S A 107 (21), 9861-9866 (2010)
   PUBMED   20457914
REFERENCE   5  (bases 1 to 2730)
  AUTHORS   Pestov,N.B., Ahmad,N., Korneenko,T.V., Zhao,H., Radkov,R.,
            Schaer,D., Roy,S., Bibert,S., Geering,K. and Modyanov,N.N.
  TITLE     Evolution of Na,K-ATPase beta m-subunit into a coregulator of
            transcription in placental mammals
  JOURNAL   Proc Natl Acad Sci U S A 104 (27), 11215-11220 (2007)
   PUBMED   17592128
REFERENCE   6  (bases 1 to 2730)
  AUTHORS   Hewett,J.W., Zeng,J., Niland,B.P., Bragg,D.C. and Breakefield,X.O.
  TITLE     Dystonia-causing mutant torsinA inhibits cell adhesion and neurite
            extension through interference with cytoskeletal dynamics
  JOURNAL   Neurobiol Dis 22 (1), 98-111 (2006)
   PUBMED   16361107
REFERENCE   7  (bases 1 to 2730)
  AUTHORS   Segawa,M., Niino,K., Mineki,R., Kaga,N., Murayama,K., Sugimoto,K.,
            Watanabe,Y., Furukawa,K. and Horigome,T.
  TITLE     Proteome analysis of a rat liver nuclear insoluble protein fraction
            and localization of a novel protein, ISP36, to compartments in the
            interchromatin space
  JOURNAL   FEBS J 272 (17), 4327-4338 (2005)
   PUBMED   16128803
REFERENCE   8  (bases 1 to 2730)
  AUTHORS   Goodchild,R.E. and Dauer,W.T.
  TITLE     The AAA+ protein torsinA interacts with a conserved domain present
            in LAP1 and a novel ER protein
  JOURNAL   J Cell Biol 168 (6), 855-862 (2005)
   PUBMED   15767459
REFERENCE   9  (bases 1 to 2730)
  AUTHORS   Martin,L., Crimaudo,C. and Gerace,L.
  TITLE     cDNA cloning and characterization of lamina-associated polypeptide
            1C (LAP1C), an integral protein of the inner nuclear membrane
  JOURNAL   J Biol Chem 270 (15), 8822-8828 (1995)
   PUBMED   7721789
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC086987.1.
            
            On Oct 12, 2005 this sequence version replaced NM_145092.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086987.1, U20286.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2730
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q22"
     gene            1..2730
                     /gene="Tor1aip1"
                     /gene_synonym="Lap1b; Lap1c"
                     /note="torsin 1A interacting protein 1"
                     /db_xref="GeneID:246314"
                     /db_xref="RGD:628851"
     exon            1..672
                     /gene="Tor1aip1"
                     /gene_synonym="Lap1b; Lap1c"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..1940
                     /gene="Tor1aip1"
                     /gene_synonym="Lap1b; Lap1c"
                     /note="lamina-associated polypeptide 1C; lamina-associated
                     polypeptide 1B; torsin A interacting protein 1"
                     /codon_start=1
                     /product="torsin-1A-interacting protein 1"
                     /protein_id="NP_659560.2"
                     /db_xref="GeneID:246314"
                     /db_xref="RGD:628851"
                     /translation="MAGERWRAEGLGEGWAIYVTPRAPIREGRRRLATQNGDGSDAPA
                     YETHPSRHGRREVRFSEEPPEVYGDFEPRAAKERSPGERRTPPEKFRSDSAKEEVRES
                     AYNLRSRQRRQRGPQEAEEMKTRRSTRLEQHSQQAQQQLSPATSGRGLRDAQSLSEDR
                     GEDEPSSQPVTSQTVSKKTVRTPETSVMSEDPISNLCRPPLRSPRPDASIVQHINPFE
                     EGETEDDLESSYSDVTIRIRSRDSVESRDEAAVAAGHHPDSLWGLPHSRGDFTAHENQ
                     PSLLPTGCQKNPQEWVEQAVRMRTRMAYNNIQKSDFGNQSPSTSRQQAAVQPPDESSV
                     KIKWWLLILVAALAMGIYWFFHTPVVETTAVQEFQNQMKQLQSKYQSQDEKLWKRGTT
                     FLEKHLNSSLPRPQPAILLLTAAQDAAEVLKCLSEQIADAYSSFRSVRAIRIDGAGKA
                     AQDSDLVKHEVDQELTDGFRNGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVAL
                     VLTVLLEEQTLEASLGLKEIEEKVRDFLKVKFTSSDTANSYNHMDPDKLNGLWSRISH
                     LVLPVQPENALKAGSCL"
     exon            673..747
                     /gene="Tor1aip1"
                     /gene_synonym="Lap1b; Lap1c"
                     /inference="alignment:Splign:2.1.0"
     exon            748..807
                     /gene="Tor1aip1"
                     /gene_synonym="Lap1b; Lap1c"
                     /inference="alignment:Splign:2.1.0"
     exon            808..846
                     /gene="Tor1aip1"
                     /gene_synonym="Lap1b; Lap1c"
                     /inference="alignment:Splign:2.1.0"
     exon            847..927
                     /gene="Tor1aip1"
                     /gene_synonym="Lap1b; Lap1c"
                     /inference="alignment:Splign:2.1.0"
     exon            928..984
                     /gene="Tor1aip1"
                     /gene_synonym="Lap1b; Lap1c"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1029
                     /gene="Tor1aip1"
                     /gene_synonym="Lap1b; Lap1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1098
                     /gene="Tor1aip1"
                     /gene_synonym="Lap1b; Lap1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1155
                     /gene="Tor1aip1"
                     /gene_synonym="Lap1b; Lap1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..2703
                     /gene="Tor1aip1"
                     /gene_synonym="Lap1b; Lap1c"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaaacacacc atgggcccag aggctggttt gtggcacact agcgaggacg caggaggtgg
       61 cgccggcaac tctcaactgc ctccctgacc actgtgacaa cctcctcgaa gccatcgcca
      121 ccacctgcag tggaatcgaa ccgcggaaag tccatcgtcc ctatcgacca acagctacgt
      181 aaacaactat ggcgggagag aggtggcggg ccgaggggct gggagaagga tgggccatct
      241 acgtcacacc cagagccccc atccgggagg gaaggcggag gctcgccact caaaatggcg
      301 acgggagtga cgcgcctgcg tacgaaactc atccgtcgcg ccacggacga cgggaagtga
      361 ggttttcaga agagccgcca gaagtgtacg gcgacttcga gccccgggcg gccaaagaaa
      421 ggtctccggg ggaaagacga accccgccag aaaagttccg gtcggattct gcgaaagagg
      481 aagtgagaga aagcgcttac aatcttcggt ctcgacaacg gaggcagcgg ggaccccagg
      541 aagccgagga gatgaagacg cggaggtcta ctcgtctgga gcagcactca cagcaggcgc
      601 agcagcagct gtcaccggct acgagcgggc gaggattacg ggacgctcag tccttaagtg
      661 aggaccgcgg agaggatgaa ccttcttccc aacctgttac aagccaaaca gtctcaaaga
      721 aaactgtcag gacaccagag acttcagtga tgagtgaaga tcctatcagt aacttatgca
      781 gacccccatt aagaagccca agacctgacg cttccattgt ccaacacatc aacccctttg
      841 aggaaggaga aaccgaagat gatcttgaga gctcttacag tgatgtcact atcaggatca
      901 gatccaggga ctctgtcgag tctagagatg aagccgcagt agcagccggt caccatccag
      961 actcactgtg ggggttacca cacagtcggg gggacttcac agctcatgag aatcaaccct
     1021 cactgctgcc cacaggatgt caaaaaaacc ctcaagagtg ggttgaacaa gctgtgagaa
     1081 tgaggactag aatggcatat aacaacattc agaaatcaga ctttggaaac caatctccat
     1141 caacctccag gcaacaagca gctgtacaac ccccagatga gtcttctgtc aagataaaat
     1201 ggtggctgct gatacttgtt gctgctctgg ccatgggaat atattggttc tttcatactc
     1261 ctgtagtaga aaccactgct gttcaagaat tccagaacca gatgaagcag ctccagtcta
     1321 agtaccagag tcaagatgag aaactgtgga agagaggcac aacattccta gaaaaacatc
     1381 tgaatagctc cctccctcgg ccccagcctg ccatcctgct gctcactgca gctcaggatg
     1441 ctgcggaagt gctcaagtgt ctgagtgaac agatcgccga tgcctactct tccttccgca
     1501 gtgtccgtgc catccggatc gacggagcag gcaaagctgc tcaagacagt gacctcgtta
     1561 agcacgaagt cgatcaggaa ctgacagatg gatttagaaa tggccagaat gcagctgtgg
     1621 tccaccgctt cgaatccctg cctgcaggct caaccttgat cttctataaa tactgtgacc
     1681 atgaaaacgc agccttcaaa gatgtggccc tcgtcttgac ggtactgttg gaggagcaga
     1741 cgctggaagc cagtctaggc ctaaaggaaa ttgaggagaa agtgagggat ttccttaaag
     1801 tcaagttcac cagctctgac acggccaact cctacaacca catggaccca gacaagctca
     1861 atggactctg gagccgcatc tcccacctcg tgctgcccgt gcagcctgag aatgctctga
     1921 aagcaggcag ctgcttatga gggaaagaag cggaaatcct gtctcgagtt tgaaccattt
     1981 tcagactttg taaccagaga cggattttgg agcagttttt gaaaactggt ttctttttaa
     2041 aggaagtaaa gttcatacat aaaggtggaa taactaaatc atttatgcag cctacttctc
     2101 tgtgatttgg gagaatcgtt tttctatttc cacctagaac catgttaaag atatttagca
     2161 tagtgcacag tatatgcagt ccccgagtgt ctgctacctt gattctggcc gaatcattct
     2221 tgctgtgtga ccagcgagaa gggctaggtt cctctctcaa gcaatcagct ttctattgaa
     2281 ttttggattt gtgtttgtga ccttattaat gtctgacaac cccctaattg tagctatgga
     2341 tttccctgtt acttcttctc tcataccatt gaaatgtgtg gtccttagtt tctacctata
     2401 aaaataaaac tgggtgtgca gtttagccag cccctccccc actggtttgt agagagggag
     2461 acaagggtgt gggaggtaga aagagaagag aaattgttta atagagaagg gaaggaagga
     2521 aggtaaaaag atgttgcaag ctgggcatgg taagccagcc tgttatccca gtattgtccc
     2581 agtagtcagg aggagcagag gttcaaggtc agcctcatct atagagtgag ttttctgcca
     2641 cctggactac atgagacact gtcttaaaaa aaataaaaat aaaaaatttt aatttaaagt
     2701 tttaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
